6EZN


Conserved Protein Domain Family
Ribophorin_I

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pfam04597: Ribophorin_I 
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Ribophorin I
Ribophorin I is an essential subunit of oligosaccharyltransferase (OST), which is also known as Dolichyl-diphosphooligosaccharide--protein glycosyltransferase, (EC:2.4.1.119). OST catalyzes the transfer of an oligosaccharide from dolichol pyrophosphate to selected asparagine residues of nascent polypeptides as they are translocated into the lumen of the rough endoplasmic reticulum. Ribophorin I and OST48 are though to be responsible for OST catalytic activity. Both yeast and mammalian proteins are glycosylated but the sites are not conserved. Glycosylation may contribute towards general solubility but is unlikely to be involved in a specific biochemical function Most family members are predicted to have a transmembrane helix at the C-terminus of this region.
Statistics
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PSSM-Id: 398338
Aligned: 171 rows
Threshold Bit Score: 191.637
Threshold Setting Gi: 74882788
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6EZN_A                    32 ENVDYKRTIDVSNA-YISETIEITIKNIaSEP-ATE------YFTAFESgifs-kvsfFSAYFtN--Eatf--------- 91   Sa...
ESS32972                 261 VIEKLERRLDMKRQ--VKVTIRTTVANHgASA-VEN------LAFLLPFheav-qvgwMAAKQnGqtVsfdaiserpris 330  To...
CAQ39702                  56 VYEHITKNMHLKKN-YVEVIIQGDLKNK-GDKcVDSfvfllpYHEAFQA---------STLRVrDqnQselryqvl---- 120  Pl...
O77351                    56 IYEHVSKYINLKNN-YVEIVIKGKLKNV-QDTlVENflfllpYHEAYQG---------TNLYAlDdeGnvlkhni----- 119  Pl...
XP_001318855              16 RNTKVERQYKITDG-FVAVSLDITFTNFgDKA-TSE------YVLSFDPreaahmntvIAVMNrKhiR------------ 75   Tr...
WGS:AAFB:cds.EHI_029540A  18 tneiaNVDIDITTA-YPGIKMDITVTSE---QpLHS------YAFYLPKsyeisslvfLNKET----------------- 70   En...
Q7RNU8                    56 IYEFINKNVYLKNN-YVEINVKGAIKNI-STTlVDKiifllpYHEAFQG---------ANLQIkDekNselnykv----- 119  Pl...
EFN51949                  22 VIEEAQRRIDISTF-RSGHKTRLVIRNDgSAG-EDV------VVLCQAAglld-kvaiTEVALsGa-------------- 78   Ch...
Q9SFX3                    28 VLSKVERRIDVTSQ-IARVTKTLKVVNSgSES-VSE------FALTFPKflgn-nlayLSVAPsEgkGkskr-------- 90   th...
EFC49357                  32 EILSIDRSIDTTQNvVVRHEVKLTIQNVgSSD-AKF------FYLAFPKelalnnvayVSARQqSt-------------- 90   Na...
6EZN_A                    92 -----------------------lnsQLLansttap-gddgesEIR--------------YGI-------IQFPNaISPQ 126  Sa...
ESS32972                 331 sfsphtpaslshdallveevdqalqvAAGvaadspsggrgganDLArstreegedecrplLLE-------LHLRKpLEPQ 403  To...
CAQ39702                 121 -------------------qeprhdaREIqvdtfnedydleqfQVK--------------AYR-------VTLKRrLHKD 160  Pl...
O77351                   120 -------------------lkdtkdiEEMnidpfnddvdlshfNLR--------------VYE-------IILSRkLKLE 159  Pl...
XP_001318855              76 -------------------------------------------NTQks-----------lVIKdqngqkvVTLLSpLEPG 101  Tr...
WGS:AAFB:cds.EHI_029540A  71 --------------------------EKEltftthneteytqfIVE------------------------------FEDT 94   En...
Q7RNU8                   120 -------------------lrnvidiDKInidkfnndydielfNVK--------------IFE-------IYLNKkLKKN 159  Pl...
EFN51949                  79 --------------------------NLPwsaapp--pagvpaGVG--------------CRS-------YKLPEaLAPG 109  Ch...
Q9SFX3                    91 -----------------------tlvNLSvreadq---kglpdSIS--------------VYS-------VALPKpLSKG 123  th...
EFC49357                  91 --------------------------TLNvpkhkf--ndelnkDAL--------------FYE-------IELASpLSPK 121  Na...
6EZN_A                   127 EEVSLVIKSFYNTVGIPYPEHVGMSEEQHLLWETN-RL---------------PLSAY-DT-KKASF------------T 176  Sa...
ESS32972                 404 GRTHIEITYILGRAYRPVPRAAPLGAVQSVLFVST-SA---------------WPSPYpVLhGSSTAv-----------A 456  To...
CAQ39702                 161 EKVSLHFGYVLGQPYFPFPVDISPEEGQKVMFYLS-SK---------------ILLPYeVEeKEELKiflck---ncsiV 221  Pl...
O77351                   160 ENVLVKLSYTLGQPYFPYPLEIDFINKQNVLFYLS-SK---------------ILLPYqVEkYERIEinlce---acdiV 220  Pl...
XP_001318855             102 ASQTIYVGYTI---------------GQYILFTTNgVTlknlrvdcyfnttigFVSPY-QTeEVSLE------------I 153  Tr...
WGS:AAFB:cds.EHI_029540A  95 PKISLTMAYIQINNYLPVPKFISQFDSQEFDY----TL---------------LLCPLtQSkTKSCQvllhhydklkviS 155  En...
Q7RNU8                   160 EKILINLSYILGQPYFPFPIDINLNEKQNVLFYIS-SK---------------ILLPYnVEnEEKIIihmce---dcilK 220  Pl...
EFN51949                 110 ARATLEAEALFTHVLRPEPAKIRQSEPQRVVYQDS-AL---------------LASPY-RVeKQSTEvgarlvprlrtrV 172  Ch...
Q9SFX3                   124 DTLTLEVVAAFTNVLQPFPEKITQGEIHLVMLQES-AQ---------------YLSPY-AVeSQSLS------------I 174  th...
EFC49357                 122 QKVDLVVNIALTNVISPFPKEIKQDEHQKVVYEDN-AY---------------FFTPY-KVkSQITL------------V 172  Na...
6EZN_A                   177 LIGSSSFEE-YHpp---------------------ndESLLg----kANGNSf---EFG------PW-E--DIprfs--- 215  Sa...
ESS32972                 457 LAPGTSLGP---------------------------------------AGATrimkKYGfkqesqPDgPwmIVap----- 492  To...
CAQ39702                 222 RIEDDNFLRsFVkvnddtyvcektegrtvgelprgveETFRddqkefVAKES----KLG------PF-MlgQK------- 283  Pl...
O77351                   221 SLDDACFLKgLKkindkn-------------yiieyeHNIE------S------------------F-NlgNK------- 255  Pl...
XP_001318855             154 SGISKNSVTsMTknld-----------------------------itqKSNTi------------------SMqsiktvp 186  Tr...
WGS:AAFB:cds.EHI_029540A 156 DIKHSTIKNt---------------------------------------------tAFG------PF----DDlspm--- 177  En...
Q7RNU8                   221 EFDDVNYMNwFEkidtnk-------------yvhtknNDIRns--ekFNKLN----NDN------RF-SlgNK------- 267  Pl...
EFN51949                 173 VTGTSAVPS-FTd-----------------------vPPSK------KSGSSl---QYG------PY-Q--DTqpft--- 207  Ch...
Q9SFX3                   175 KLPNARIES-YTk-----------------------fENTK------LQGSEl---KYG------PY-K--NLqsys--- 209  th...
EFC49357                 173 KLGTSAVES-YTnt----------------------vKPVE------NKGNGi---QYG------PF-R--DVvpft--- 208  Na...
6EZN_A                   216 snetLAIVYSHNAPLNQVVNL----------RRDIWLSHWaSTIQFEEYYE-LTNKAAKLSKg----------------- 267  Sa...
ESS32972                 493 ---gpTLPFEVGQPFVLHMPLplhlgyflsaERFVEVSHF-GNIFFHEWYR-LHNDAAKLEGsydaitaaalqgiqpgap 567  To...
CAQ39702                 284 ----VLFYFRSNNHLGYFEQV----------TKDIKLSQL-GFVYEREEYI-LRNDAGRIHT------------------ 329  Pl...
O77351                   256 ----ILLYFVCDYNLGYFEKV----------IKNINISSL-GYIYEKEEYF-LKNNAAKINK------------------ 301  Pl...
XP_001318855             187 knneLYVEYFIYKALPYVSAV----------NTSTHISHW-GISKQESFME-VHNDGPEFVGe----------------- 237  Tr...
WGS:AAFB:cds.EHI_029540A 178 -eviETTVHSNSLPHIKVNKM----------IHSVDLPTIsSFVKVEDWFEdFTNEGAQLSSg----------------- 229  En...
Q7RNU8                   268 ----VLFYFTSDYNLGYFEKV----------VKDIKISQL-GYIYEQEEYI-LKNNSAKINK------------------ 313  Pl...
EFN51949                 208 -lkpISVHYENFAAFAHVPEL----------EREIEISHW-GNVYFEERYH-LRHAGAKITGe----------------- 257  Ch...
Q9SFX3                   210 -yspIVVHFESKAAFAVAEKL----------VREIEVSHW-GNVQVTENYN-VVHRGAQLKGe----------------- 259  th...
EFC49357                 209 -tagVRLHYVNDRPCFVVSSV----------ERTVEISHW-GNLAVEEHYE-IKHTGAKLVGp----------------- 258  Na...
6EZN_A                   268 -FSRL---ELMkq-------------------------------------------iqTQ-NmrQTHF--VTVLDMLLPE 297  Sa...
ESS32972                 568 rFSRH---MKKd---------------------------------------------eVNdPrePPAShmLTHLVAALPK 599  To...
CAQ39702                 330 -FDRYllsDYEnrhtseekg--------------------------------ngtdtdtdtDdqSTTI--IYSMKSKINY 374  Pl...
O77351                   302 -FDRYilsDYEsrytspggsntgeaingsdnigfinmenkndtvnnipiknnskshfpRNkTdkHNSI--IYSLESKIDY 378  Pl...
XP_001318855             238 -FNRI---DFRe-----------------------------------------------------SSNcyFQTVPVRPPA 260  Tr...
WGS:AAFB:cds.EHI_029540A 230 -FSRF---DFQqni------------------------------------------------gnyPNA--IGFFEINLNT 255  En...
Q7RNU8                   314 -FDRYllsDYEnkytseedrekngq--------------------kkqtkltkqakltKHnNknHSSI--IYSMQSKINY 370  Pl...
EFN51949                 258 -WSRY---DLM-----------------------------------------------TRpNdfARGA--IAAVGATLPP 284  Ch...
Q9SFX3                   260 -FSRL---DFQ-----------------------------------------------ARpNprGASA--FRHLLARLPP 286  th...
EFC49357                 259 -FSRF---EYS-----------------------------------------------KNpGqtSPAS--FRKITATLPL 285  Na...
6EZN_A                   298 GATDHYFTDLVGLVSTSHAERDh----------FFIRPRFPIFGGWNYNFTVGWTNKLSDFLHvSSg--sDEK--FVASI 363  Sa...
ESS32972                 600 RAFSLEVFDQIGNVSSTRAARVgpeaq-piyteLELYPRFPLLGGWNTDFQVQYNLPARTVMVkHAd---AHR--YTLNL 673  To...
CAQ39702                 375 DIYDYEYFDDLGKIYLIQAEEIfdrkkrkshiqFDLRPRYPLLGGWRAHFFNAFYHESNLYRIkNK----ENY--YAYRI 448  Pl...
O77351                   379 NIYDYNYFDDLGKIYLIRGEEIyddekkknilkFDVKPRYPLLGGWKFHFFNTFYHFSNLYKIkNK----RNV--YAYKV 452  Pl...
XP_001318855             261 DSYHFWANDESGQLQREINLEDk---------dLSIPLRGPVLPSWKVTYTTGWTVKTSNFVRtE-----GNT--YIFSA 324  Tr...
WGS:AAFB:cds.EHI_029540A 256 RASSIQYKDTSGNISTSSLLLNddn------lvLIALPRYPLLTGWKTEFMIGYSLPNKVVIS-------KGK--AIITL 320  En...
Q7RNU8                   371 NIFEYNYFDELGKIYLIRAGEFydthkkkniikFDLKPRYPILGGWKTQFCNSYYHSSNLFKIkNK----KNY--YAYQV 444  Pl...
EFN51949                 285 TAHSLYYRDAIGNISSSEARFGres------vdVKLTPRFPLFGGWALQFLFGWSMPLQECVRkLP----SGR--LLFEA 352  Ch...
Q9SFX3                   287 RAHSIYYRDDIGNISTSEMKSDskk------teLLIEPRFPLFGGWKTFFTIGYGLPLTDFLF-AS----EGK--RFLNI 353  th...
EFC49357                 286 LANDIYFRDRIGNISSSDIRVSgkn------leVDFHPRFPLFGGWKIRFYIGYNLPINDYLTvAMnnpeKHKlrYKFSV 359  Na...
6EZN_A                   364 PILN---GPPDTVYDNVELSVFLPEGAEIFD-IDSPvp-fTNVSI---ETQK----SYFDLnKGHVKLTFSYRNLISqVA 431  Sa...
ESS32972                 674 TLAP---PFRDIYTEDVFLNIALPSGAQNVT-VTSPrkvdWNMNE---KLH-----SWLDVfTFRPLLKLHFPSSFVpDR 741  To...
CAQ39702                 449 DISP---SIKSFFIKQLKVRISLPPFSDDVAvVSRD------DRV---NVQTskqkGWLDLfSFRNVVEIQIEKFFPpMD 516  Pl...
O77351                   453 DISP---TIKSFYIKQLIINICLPSYSYDVL-INNDn---LKNYV---HVQTtkkkEWIDFfSERNVVTLQIYKFFPsSD 522  Pl...
XP_001318855             325 PLFPkpyADRGVSVSHIRSEYVFPEGAEIKK-ITYP----QAING---RHHFgqevCNLDF-KGRSVVVIEADRLSSiDE 395  Tr...
WGS:AAFB:cds.EHI_029540A 321 PSIK------TAMAKEVIVRVYLPDNAKYLKveg---kniENIEV---KDCD----AFLSF-AGRKEVLITMKNINImDE 383  En...
Q7RNU8                   445 DISP---SIKSFYIKEMHINIYLPPYSNNIS-INNN----NLKEM---SVKNgkakDWLDLiSHRDTIQIQIQKIFPqHE 513  Pl...
EFN51949                 353 PIGP---SVHNLVVDKLTVKVVLPEGARDVR-LVSAsgl-glAQDpafETKY----TYLDV-VGRPVLVLRADNVVD-EM 421  Ch...
Q9SFX3                   354 SFGS---PILDLVTEKLIVQVVLPEGSKDIS-VTTPfa--vKQSQ---EIKY----SHLDI-AGRPVVVLEKNNVVP-DH 418  th...
EFC49357                 360 PF--------DAPVEDLTLRVVVPEGADDVE-FKTSfp-iDSESK---ENLK----TYLDV-SGRTVSVINKKNVVP-EH 420  Na...
6EZN_A                   432 NG---QVLIKYDYPKSSFFK--KPLSIACYIFTALMGVFVLK 468  Saccharomyces cerevisiae S288C
ESS32972                 742 NIlqfKVQVSYDYPPFLAVEvfKQLQICLLVFVLFLLLILSr 783  Toxoplasma gondii VEG
CAQ39702                 517 ENyyqDFLVMYKYKFFNLFW--KPLLVILITFAAILLLCFLR 556  Plasmodium knowlesi strain H
O77351                   523 EKymnNFLVMYNLPITHIFI--KPLMLIIITFFIIILSFVMK 562  Plasmodium falciparum 3D7
XP_001318855             396 TT----VQIEYTIEGKYALY--KIAYLSAGFGAIFLAIVVLR 431  Trichomonas vaginalis G3
WGS:AAFB:cds.EHI_029540A 384 VQ----LTLYYEESVSGSIN--TFIVFGCYVLLFFLGFFLfi 419  Entamoeba histolytica HM-1:IMSS
Q7RNU8                   514 ENnykNFIVMYELKFFNIFL--KPLIIILITFIVILFFYFIN 553  Plasmodium yoelii yoelii
EFN51949                 422 NV---PFKVEYSYSPMGLLQ--KLLLLVAAFGALFAAAIMLN 458  Chlorella variabilis
Q9SFX3                   419 NQ---HIQVYYKFSNINLLS--EPLMLISGFFILFITCIIYT 455  thale cress
EFC49357                 421 NE---NFLLSYTFPASAVYF--EPLLVISALFGFCLFVMVYV 457  Naegleria gruberi
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