Conserved Protein Domain Family
SPC22

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pfam04573: SPC22 
Signal peptidase subunit
Translocation of polypeptide chains across the endoplasmic reticulum membrane is triggered by signal sequences. During translocation of the nascent chain through the membrane, the signal sequence of most secretory and membrane proteins is cleaved off. Cleavage occurs by the signal peptidase complex (SPC) which consists of four subunits in yeast and five in mammals. This family is common to yeast and mammals.
Statistics
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PSSM-Id: 398327
Aligned: 94 rows
Threshold Bit Score: 128.47
Threshold Setting Gi: 388581383
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q57ZR2         4 LWVRVAEICSMAMMSCFTGVMLLVASSIVMSqlq------ppkPIIKDFNVGISplvqtrLPLVFAQGeypPPMQDVLLV 77  Trypanosoma brucei
B0G180         4 LSQRANTIVCFGGIVLVGVLLLNVLSRAFFSdhv-----------dvDIKL---------NEIHRFNT---QRNFEYSFI 60  Dictyostelium d...
EFA79926       4 VSQRANLIVCFGGVVLFGVLLLNVLSRSFFPdhidvnltgstiKFVK------------------------RNPVELAQV 59  Heterostelium a...
A0BS79         4 ITARFNQIVFFTSWTLVVLSLLNQGTAYFFKt----------gKPTVDLKILSAdkfqhyKATYYNGG---ATDWDQVTF 70  Paramecium tetr...
Q8I3A5         4 FLNRLNVLFYSMALCFLILCAFNYGTSFYLFde---------kEIKTNIQV---------KSIKRFVYn-rYINADEAVL 64  Plasmodium falc...
XP_001614583   4 VLNRLNVLSYSMALCFFTLCLFNYGTSFYLFde---------kEMSTSIKV---------KSVKRLVYn-rHIKGDEAVL 64  malaria parasit...
XP_680467      4 LLNRINVIFYSMALCFVTLCLFNYGTSFYLFde---------nSIVTDVKV---------KSVKRLVYn-kYINGDEAVL 64  Plasmodium berg...
XP_002141553   4 TLSRINILVCTFVAALATCAAGNFVTSLFYKp-----------NPSGVVEF---------HSVLDIGIs-pYLRNDQANI 62  Cryptosporidium...
BAN65251       4 pairCYTVLSTSLFALWAALALNYLSGQYYRan---------nPGSGSI-----------KHIRTFELktvTGQVDRAAF 63  Babesia bovis
Q4UAJ0         4 FLSRSYSVLHAGAMIGLIALFLNYYTGVNLRtn---------kHMIGDV-----------KHIKTHELtldKSKVDRALI 63  Theileria annulata
Q57ZR2        78 GISLKADFSAVWDWNTKHMYVACIGRYHTKSNmtvgGVNlqkthDVTIFDKVLRSKE-E-------AAnWTLDN-AKKYA 148 Trypanosoma brucei
B0G180        61 SIDLDANLEPLFNWNTKMLFLYVTAEYRTKQN----VLS-----QVVVWDHILTEKS-K-------AN-IHEKR-LSKYP 121 Dictyostelium d...
EFA79926      60 HMSLQADLTPLFNWNTKQLFLYITAEYQTKET----VVS-----QVVLWDYILKDKS-K-------AV-LKEKD-LIKYL 120 Heterostelium a...
A0BS79        71 KFSLEADFEPVYNWNLKQLFLYVNVHHEHQQKg---yES-----DCVIYDKIISRPD-DpsswstsSK-LVLKNqRAEYP 140 Paramecium tetr...
Q8I3A5        65 SLDVSYDMRKAFNWNLKQLFVYVLVTYETPKK----IKN-----EVIIQDYIVKNKK-Q-------AK-KNYRNfITKYS 126 Plasmodium falc...
XP_001614583  65 SLDLSYDMSKAFNWNLKQLFLYVLVTYETPEK----VKN-----EVIIQDYIITNKK-M-------AK-KTHKNfFTKYS 126 malaria parasit...
XP_680467     65 SLDLSYDMTKAFNWNLKQLFVYVLVTYKTPEK----AEN-----EVIIQDYIINNKK-S-------AK-KTYKNfITKYS 126 Plasmodium berg...
XP_002141553  63 AFNMKISLKDIFQWNTNQLFVYVYATYQNQDT----PIN-----NVIIWDHIISNPKlD-------AN-SDLIGiINEYP 125 Cryptosporidium...
BAN65251      64 ELNLSYDLRDVFDWSANVIFLYATVNYETPKH----PVN-----ELIIFDKIITSKE-E-------AY-EPGADiVSKYY 125 Babesia bovis
Q4UAJ0        64 ELNMRYDLRGAFDWSTHMIFIYVTANYITNRH----ERS-----EVIIFDKIINNKS-E-------AY-QPSINiFAKYF 125 Theileria annulata
Q57ZR2       149 LENEELgSLAGAAVELMILYHPMRHYGYSPYYTVQpgKNPVMFqlPTA 196 Trypanosoma brucei
B0G180       122 IINQGL-GLKNNTIKLTFNYNVVPISGILTRHQVG--TSEFKF--PTT 164 Dictyostelium discoideum
EFA79926     121 LIDHSG-DLRGQNVTLTFNYNVIPISGLITRHKEG--SYSFKM--PTE 163 Heterostelium album PN500
A0BS79       141 LKDIHK-QLRNATVNFEVWIEVMPYVGYIRREKLG----DFEYkmPQQ 183 Paramecium tetraurelia
Q8I3A5       127 LKDYYN-GLRNNLIHLQVCYKYMPIVGFSRSFEGA--KISYQL--PPE 169 Plasmodium falciparum 3D7
XP_001614583 127 LKDYNN-GLRNNNINLQVCYKYMPIVGLSRSYEGA--KISYKL--PAE 169 malaria parasite P. vivax
XP_680467    127 LKDYYN-GLRNNLINIQVCYKYMPLIGLSRTYHGA--KTSYMM--PDE 169 Plasmodium berghei ANKA
XP_002141553 126 IRDIGR-HLRNQKFKLNIAYCYMPIVGFIHYKQLGt-SKMAKL--PSH 169 Cryptosporidium muris RN66
BAN65251     126 MIDYAR-SLRKARVTLRLHYCFVPIGGLIKSYQLA--ESVFTM--PSD 168 Babesia bovis
Q4UAJ0       126 LYDFGR-SLRNRDISLKFFYELVPIGGFIKQYQLS--HNKFTM--PKQ 168 Theileria annulata
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