Conserved Protein Domain Family
Gb3_synth

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pfam04572: Gb3_synth 
Alpha 1,4-glycosyltransferase conserved region
The glycosphingolipids (GSL) form part of eukaryotic cell membranes. They consist of a hydrophilic carbohydrate moiety linked to a hydrophobic ceramide tail embedded within the lipid bilayer of the membrane. Lactosylceramide, Gal1,4Glc1Cer (LacCer), is the common synthetic precursor to the majority of GSL found in vertebrates. Alpha 1.4-glycosyltransferases utilize UDP donors and transfer the sugar to a beta-linked acceptor. This region appears to be confined to higher eukaryotes. No function has been yet assigned to this region.
Statistics
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PSSM-Id: 398326
Aligned: 107 rows
Threshold Bit Score: 74.1984
Threshold Setting Gi: 302792002
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFX82279     192 SPLMALSVQDFAANYSAGLWTHNGPLLLLRVLRRwcnvddLQSMD--YIRCQG---FHVLPSSSFCPVHYTQLGRLFDnq 266 common water flea
XP_006605509 522 SLFVKECLEEFYMTYDDTSLRGNGADLLTRVARK------YLGDEnkSVKHLE---LKVEPSYIFFPVSSQNITRYFIap 592 soybean
XP_009382810 498 SSLMLECLNEYYSTYDDTLLRWNGADLMTRVIKR------ISDKAgkSSLQLD---IKMEPQFAFHPISSINITRYFAep 568 wild Malaysian ...
KQK15678     496 SPFLVECLNEFYSTYDDTLLQWNGAELMTRVIRN-------HSDSdqDRGHLA---IKLEPSVIFYPINSTDITRYFSvp 565 stiff brome
XP_006658707 339 SPFLAECLKEFYATYDDKLLQWNGAELMTRVIRN------MSDNAdqNNGHLD---IKFEPSIAFYPISSADITRYFSea 409 malo sina
XP_002881567 625 HPLMREFLQEYATTFDGNRWGYNSPYLVSRVIKR------LGNKPgyN--------LTIFSPDAFYPVNWIKIQKLFKkp 690 Arabidopsis lyr...
XP_006349536 294 HPLLYKFMEEFALSFDGNKWGQNGPYLVSRVVGR------LKMMSteKYQLN----FTVLPPISFYPVDWVRIPGFFMkl 363 potato
XP_013656820 322 HPLLKSFIDEFSRTFNGNKWGHNGPYLVSRVVARf-----------nVSNCSSdmgFSVLPPSSFYPVDWTRISGFYRas 390 rape
XP_002888110 309 HPLLKRFIDEFSRTFNGNKWGHNGPYLVSRVIARi------------NISSSSdlgFSVLPPSAFYPVDWTRIKGFYRap 376 Arabidopsis lyr...
AQK44997     337 HQLVHEFIAEFAAAFDGSKWGHNGPYLVSRVAAR------LRHLSpgLA-------FTVLPPRAFYPVHWSKIGGLFVap 403 Zea mays
EFX82279     267 qqqqqrrrrRPdnnetstdetimttrpeWLTDQVLGIHTWNKLSynRPIHKNSTQTYNRLARHHCPLTYSL 337 common water flea
XP_006605509 593 t------teTEkaqqd--------vlleNILHNSLTFHFWNSVT--FSLIPEPDSLVSKLLNYACIRCSEl 647 soybean
XP_009382810 569 a------dqFEraeqd--------dllkRMLNESITFHFWNGMT--SALVPEPNSLMERLLNQYCLHCLDv 623 wild Malaysian banana
KQK15678     566 d------neVEraqhd--------alfsRIVNDSTTFHLWNSIT--SSLVPESNSLVERILNRYCLHCLDv 620 stiff brome
XP_006658707 410 d------stDEraqhd--------alfsRIVNESTTFHLWNSIT--SSLVPESNSLVERILNRNCLRCLDv 464 malo sina
XP_002881567 691 a------ttREakwve--------ktvqDMNKGSYMIHLWNKVT--RKIKIEEGSVMHTLISTHCTVCRNI 745 Arabidopsis lyrata subsp...
XP_006349536 364 n------trTHsrwid--------akllQLSGETYGVHLWNKQS--SNMRIEKGSIIGRLISDHCLFCKDI 418 potato
XP_013656820 391 v------ngREanwsr--------krlmHLRKHSLSVHLWNRES--KSFRIEEGSIIQKLMSDSCIFCNSS 445 rape
XP_002888110 377 t------seTEanwlr--------krltHLRKNTFAVHLWNRES--KKLRIEEGSIIHQLMSYSCIFCNSS 431 Arabidopsis lyrata subsp...
AQK44997     404 k------drKGerwvk--------akveNIKGQSFGIHLWNRES--SRMEMEVGSVIETLISDSCLFCNSS 458 Zea mays
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