1SMY,4QIW,2PMZ,1I6H,3H0G,5IYD


Conserved Protein Domain Family
RNA_pol_Rpb2_7

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pfam04560: RNA_pol_Rpb2_7 
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RNA polymerase Rpb2, domain 7
RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain comprised of the structural domains anchor and clamp. The clamp region (C-terminal) contains a zinc-binding motif. The clamp region is named due to its interaction with the clamp domain found in Rpb1. The domain also contains a region termed "switch 4". The switches within the polymerase are thought to signal different stages of transcription.
Statistics
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PSSM-Id: 398317
Aligned: 45 rows
Threshold Bit Score: 101.888
Threshold Setting Gi: 1710670
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1SMY_M   1028 GGQRFGEMEVWALEAYGAAHTLQEMLTLKSD----DIEGRNAAYEA------------IIKGEDVPEPS-VPESFRVLVK 1090 Thermus thermophilus
1I6H_B   1126 GGLRFGEMERDCMIAHGAASFLKERLMEASDafrvHICGICGLMTViaklnhnqfeckGCDNKIDIYQIhIPYAAKLLFQ 1205 baker's yeast
EHY56448 1168 GGLRFGEMERDCMIAHGASSFLKERLFDVSDpfrvHVCDICGLMTViaklkkntfeckNCNNKNKISQIyLPYAAKLLFQ 1247 Exophiala dermati...
P08266   1084 GGLRFGEMERDCQISHGAAQFLRERLFEVSDpyrvHICNFCGLIAIanlrnn-tfeckGCKNKTQISQVrLPYAAKLLFQ 1162 fruit fly
P25167   1049 GGLRLGEMERDCLISYGASMLIMERLMISSDafevDVCRTCGRMAYcsw-------chFCQSSANVSKIsMPYACKLLFQ 1121 fruit fly
Q9NW08   1043 GGLRLGEMERDCLIGYGASMLLLERLMISSDafevDVCGQCGLLGYsgw-------chYCKSSCHVSSLrIPYACKLLFQ 1115 human
Q27492   1064 GGLRLGEMERDCLIAYGASMLLIERLMVSSDefkvDVCTGCGVIGSkgw-------cqKCRSSKSMANIkIPYACKLLFQ 1136 Caenorhabditis el...
Q10233   1074 GGLRLGEMERDCLIAYGASQLLLERLMISSDacdvDVCGQCGLLGYkgw-------cnSCQSTREVVKMtIPYAAKLLFQ 1146 Schizosaccharomyc...
EGZ70570 1062 GGLRLGEMERDCLIAYGASQLLLERLMISSDgtelDVCQECGLFGYkgy-------cnACKSTRNVTQMtMPYACKLLVQ 1134 Neurospora tetras...
CBZ08599 1043 GGLRVGEMERDCMVGYGASNLLNERLLISSDmftaDICHVCGNLGYnnr-------ctYCKTKGTTSKVnMPYAFKLLIQ 1115 Leishmania infant...
1SMY_M   1091 ELQALALDVQTL 1102 Thermus thermophilus
1I6H_B   1206 ELMAMNITPRLY 1217 baker's yeast
EHY56448 1248 ELWAMNIAARLY 1259 Exophiala dermatitidis NIH/UT8656
P08266   1163 ELMSMNIAPRLM 1174 fruit fly
P25167   1122 ELTSMNVVPKMI 1133 fruit fly
Q9NW08   1116 ELQSMNIIPRLK 1127 human
Q27492   1137 ELQSMNIVPRLD 1148 Caenorhabditis elegans
Q10233   1147 ELLSMNIVPRLA 1158 Schizosaccharomyces pombe 972h-
EGZ70570 1135 ELISMNVGVKLK 1146 Neurospora tetrasperma FGSC 2509
CBZ08599 1116 ELQGMGVSLRLT 1127 Leishmania infantum JPCM5
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