Conserved Protein Domain Family
DpnII

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pfam04556: DpnII 
DpnII restriction endonuclease
Members of this family are type II restriction enzymes (EC:3.1.21.4). They recognize the double-stranded unmethylated sequence GATC and cleave before G-1. http://rebase.neb.com/rebase/enz/DpnII.html
Statistics
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PSSM-Id: 398313
Aligned: 46 rows
Threshold Bit Score: 244.4
Threshold Setting Gi: 81452217
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q3AA10           12 ADLFVRSLLETNRAFNFYVNWKNV-EEYKKFDIELNAMNVLIR--NEDFDNTFKRLLKKMPTVVATFPYLFALSkA---- 84  Carboxydothe...
Q58017            3 FEYIINSLLETIKTYNFFVDWEKIeNNIKKIEKRLHILNYLIG--KENFKEEFFELLKEYPEVITVFPILIAVR-D---- 75  Methanocaldo...
jgi:Arnit_2984    3 FRNFKNTLKDSIFTWDYFTNFNKVrLNVKKVEKELNILNYLIG--KENLEREFISLIEEYPNVRKALPLLIAVRtNkliv 80  Arcobacter n...
jgi:Dester_0101  14 FDYFFRTLKDNINTWDYFVNWNKVrENLRKIEKELHLLDYLIG--KKNLEDELKSLIREYPKVTRAIPYLIALR-K---- 86  Desulfurobac...
jgi:Tlie_0307    16 FSYFIKNLKVKITKWDYFVNWEKViKNVKPIERELNLLNCLIG--KEDFIREASELILEYPQVIKAIPKLLAIR-E---- 88  Thermovirga ...
jcvi:MCRO_0752   10 IDKFVNTLLETNRSFNFFVDWNNL-IEIEKYDVELNALNSLIR--VKNFKERFIELLTKVPSVIATFPLLFALSrN---- 82  Mycoplasma c...
WP_016358605     16 llDFLKSVLTTNHTFNYFVNWDKVfEKVNNNRTEIYILNSLCKvdESNLEEEFKKIITKYPEVVSVLPSILAIRfK---- 91  Methanobrevi...
Q2NHS1           16 KEDFFNNLLPTNHSFNYFVNWNKVfKNVKQYSIEISILNSLSKvdEEDLEVEFRKIINCYPEVVPLLPAILAIRfK---- 91  Methanosphae...
CDG64611         16 LKYFVDSLIPTNRTYNYYVDWEKIqSNLEKKITEINILNSLIHisPDERKNKLKDIIYKYPGVVSVIPLIIAVR-D---- 90  Methanobacte...
CDG64612         16 FDYFFDTLLPTNRTYDYYVNWEKVkGNVVTYLTEISLLNSLTKidNDNREEKFVEIISKYPEVIPVIPLIIAIR-E---- 90  Methanobacte...
Q3AA10           85 ----EREKTWNGTEkLLIindkigesdileydfslKTLKKGLSde--------------qiENYLYFFEKMGLKHLFLNL 146 Carboxydothe...
Q58017           76 ----NKITILNENMeLET-----------------LEFKEKKYltd------------eeiERYYKFFKETGLEDLLKNR 122 Methanocaldo...
jgi:Arnit_2984   81 tpvlTNIETLIPENkHYIfydel---------------------------------ndeikRELIIFFNQTGLKEVFENK 127 Arcobacter n...
jgi:Dester_0101  87 ----NRIQLLTDIKs--------------------FQYRNFNFgkeey--------segeiDKIVEFFVKCGLKEVFQTE 134 Desulfurobac...
jgi:Tlie_0307    89 ----NSIEILVDVTk--------------------FIYKAFDFtinkp--------nrekaTDFARFLLDSGIGKFLKDR 136 Thermovirga ...
jcvi:MCRO_0752   83 ----ERKVLEKGKSkLKIlnlaksf----yykysfIEYKSNSFlss------------dekELYYALFKDMGLENLFTNL 142 Mycoplasma c...
WP_016358605     92 ----NNNKYLDILDeEYMqv-------------etCDFDKNNFn----------------iDVITKFSKQTGLLNLF--N 136 Methanobrevi...
Q2NHS1           92 ----SKNLTVDILEkTFKt----------------YNFNDEEFd----------------eDEIVTFSKKTGLLKLF--T 133 Methanosphae...
CDG64611         91 ----SNLLILEISDdIY--------------------FKEFDFtskysiqqkldsnvvdnvDDLVDFCDKSGIIDLL--G 144 Methanobacte...
CDG64612         91 ----KNVVVLDIGEqLF--------------------YKKFKFnqklk---------tgeiLDIVEFCKKSGILDLF--G 135 Methanobacte...
Q3AA10          147 AQNNIIDYVIGVLVGLDSNGRKNRGGHAFELACYPIIRDLCDKYe-iILIEQKQFKVLKEEYGFEISD----NISERKAD 221 Carboxydothe...
Q58017          123 KIKNLVDYVFGVEVGMDTNARKNRIGDLMENIVKKYIENLCKQNknlDYIFQATKDKIKQKWGINLTL----DKTNRKFD 198 Methanocaldo...
jgi:Arnit_2984  128 CIKNLVDYSFGVEVGFDTNARKNRTGTLMENIVAKFLDEFCEENpefTYIEQATQKRILNTFNYNIDI----DKNSRRFD 203 Arcobacter n...
jgi:Dester_0101 135 -IKNVADYVFGVEVGLDSNGRKNRTGKLMESIVEFFIRDITNELn-aDFISQANREKIKKKWNLEVKL----DKADRRID 208 Desulfurobac...
jgi:Tlie_0307   137 EIKNLVDYVTGVEVGLDSNARKNRTGSLMESIVEVFVADACAVNn-aDYISQATASKIKNKWGINIQI----DKSSRQID 211 Thermovirga ...
jcvi:MCRO_0752  143 LEKSIKDYVSGVLVGLDSNGRKNRSGRAFEDICQPLIAEICKKYd-iTLLQQKKLGEL-ANFGIPIND----DFRNRKAD 216 Mycoplasma c...
WP_016358605    137 KIDNLYSYLVGTEVGLDTNARKNRSGTNYENLIETLLN---------RKLNDLNRNFGKEVFNLKSQDyvknISRRKRAD 207 Methanobrevi...
Q2NHS1          134 KINDLYAYLLGTEVGLDTNGRKNRSGTIFETLIEENIN---------SILDGTN-------YKIQSQGyvdgISRKKRAD 197 Methanosphae...
CDG64611        145 RIKDLYTYLTGVEVGLDSNARKNRSGKIFEQIIELFLK---------SELKKLGKD-----YSLKCEDssimIGKSKRID 210 Methanobacte...
CDG64612        136 EINDLYAYLLGMEVGLDSNARKNRSGKIFEQLVGLLLKD--------KVRDRAGFI-------LREEDssleIKRNKRAD 200 Methanobacte...
Q3AA10          222 FILLKD--KKCLNIEVNFFGGAGSKPEEIIDSYINRQRDLK--ENNIDFAFITDGkKCWgNSTKPQLQKAFREIKYFMNF 297 Carboxydothe...
Q58017          199 FAVFNKntKKLYLIEVNFYSGGGSKLKATAGEYRSLNEFIKnnNNNVQFIWITDG-KGW-NTAKNPLKESFNSGVVILNL 276 Methanocaldo...
jgi:Arnit_2984  204 FALFNRkkKKLYLIEVNYYSGGGSKLKATAGEYQYLHNFLK--MQNLDFIWITDG-KGW-LTALNPLEETFNHNDYVVNL 279 Arcobacter n...
jgi:Dester_0101 209 FAVLYQ--DTLFFIEVNFYSGGGSKLKSTAGEYIEISKFWK--EQEIIFVWITDG-KGW-LSAKAPLIEYFEKSNYLLNL 282 Desulfurobac...
jgi:Tlie_0307   212 FAINKN--NKLYFIETNFYGGGGSKLKSTAGEYITMNQFWN--KQGIEFLWITDG-QGW-VSTQLPLREYFNQADYLLNL 285 Thermovirga ...
jcvi:MCRO_0752  217 FILIKN--RKALNIEVNYFFAGGSKPEEIIDSYINRNNELN--LRGIKFLLITDG-LCWdNNSKNQLEKAFKYI-TLMNY 290 Mycoplasma c...
WP_016358605    208 FIIYKNn-QQKYIIECNFYNSTGSKPIEVASAYQELQEELS--LVDLNFIWITDG-SGW-LKMVNTLKNVCPDIDYILNY 282 Methanobrevi...
Q2NHS1          198 FIITDDd-EQVLAIECNYYNATGSKPIEVTNAYIELQNEIS--NTNIKFLWITDG-LGW-NKMTSTILKGMENIDFIINY 272 Methanosphae...
CDG64611        211 FVVYKKh-RPLIAIECNFYWWSGGKGIEVAGSYADLQRRFR--DKGLEFIWVTDG-PGW-AGMKSTLKSAFEDIDFLLNY 285 Methanobacte...
CDG64612        201 FVIYHNn-IPKIAIECNFYSSTGSKPIEVANAYIDLNRKCK--DENLKFIWVTDG-PGW-LKMRNTVEKTFREIDFPMNY 275 Methanobacte...
Q3AA10          298 FLAKEGMLEE 307 Carboxydothermus hydrogenoformans Z-2901
Q58017          277 KMVKEGLLKE 286 Methanocaldococcus jannaschii DSM 2661
jgi:Arnit_2984  280 EMLKNGILDE 289 Arcobacter nitrofigilis DSM 7299
jgi:Dester_0101 283 EMLKEGCLKE 292 Desulfurobacterium thermolithotrophum DSM 11699
jgi:Tlie_0307   286 DMLQKGYLNK 295 Thermovirga lienii DSM 17291
jcvi:MCRO_0752  291 NMSNDGYLET 300 Mycoplasma crocodyli MP145
WP_016358605    283 NMLKDNFeki 292 Methanobrevibacter sp. AbM4
Q2NHS1          273 TMLENSIRKl 282 Methanosphaera stadtmanae DSM 3091
CDG64611        286 RILEKNFVNi 295 Methanobacterium sp. MB1
CDG64612        276 TIIDEKMdsf 285 Methanobacterium sp. MB1
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