3NOY,4S3E


Conserved Protein Domain Family
GcpE

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pfam04551: GcpE 
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GcpE protein
In a variety of organisms, including plants and several eubacteria, isoprenoids are synthesized by the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. Although different enzymes of this pathway have been described, the terminal biosynthetic steps of the MEP pathway have not been fully elucidated. GcpE gene of Escherichia coli is involved in this pathway.
Statistics
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PSSM-Id: 428003
Aligned: 367 rows
Threshold Bit Score: 357.8
Threshold Setting Gi: 524215254
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3NOY_A        16 TRQIRVGNVKIGGDAPIVVQSMTSTKTHD-------VEATLNQIKRLYEAGCEIVRVAVPHKEDVEALEEIVKKS----- 83  Aquifex aeolicus
WP_013704576   6 tPTVWVGSVPIGSEHPVVVQSMTNTPTAD-------VEATVAQIRELVLAGSELVRLTVNTEAAARAVPEIKARLrdagi 78  Marinithermus h...
WP_013458170   5 tPTVRVGSVALGGGEPVRVQSMTNTDTAD-------AAATARQVAELARAGSEIVRITVNDEAAARAVPEIRMRLedegl 77  Oceanithermus p...
4S3E_A         8 tPTVYVGRVPIGGAHPIAVQSMTNTPTRD-------VEATTAQVLELHRAGSEIVRLTVNDEEAAKAVPEIKRRLlaega 80  Thermus thermop...
WP_011812949  18 SRTVHIGGLRMGGDAPIVVQSMTDTDTAD-------EVATAVQAADLARAGSELVRVTINNEEAAAAVPRIRERLarmgv 90  Halorhodospira ...
WP_014132192  10 tvGVDVGGVMVGGGNPIVVQSMTNTDTAD-------IDSTVRQVAALARAGSEIVRITVDRDEAAAAVPHIRDRLmvrgv 82  Pelagibacterium...
WP_013420631  11 TTAVKVGGVTVGGGAPVVVQSMTNTATSD-------VDGTVAQVAALVRAGSELVRVTVDRDEAAAAVPHIRDRLlaqgi 83  Rhodomicrobium ...
dbMIDI:1008    7 THQVDVAGVKIGGGAPIVVQSMTNTETAD-------HKATAAQVLELTEAGSEVVRITVNNNEAAKAVIRVKE-Lveakr 78  Candidatus Midi...
Q2GCX2         8 slVVDVAGVRIGGGNPIVVQSMTSGSRTNpndvsaiAVDESREAIALAKAGSELIRIAINSEKAAAAIPYIRENLdksgf 87  Neorickettsia s...
Q2GGR2        12 TYEVKVGDVVIGGNNPVVVQSMALGGSGD-------VYKDAHEVLELAQAGSELVRVAVNSEQAMKNVPYIRDVLvdhgf 84  Ehrlichia chaff...
3NOY_A        84 P-MPVIADIHFAP-SYAFLSMEKg--VHGIRINPGNIGK----EEIVREIVEEAKRRGVAVRIGVNSGSLEKDLLEK-YG 154 Aquifex aeolicus
WP_013704576  79 E-VPLVGDFHFNGhLLLRKYPETaqaLDKYRINPGTVGAgrqqDPNFRTMIEVALEFNKPVRIGVNWGSLDQGLLREiMD 157 Marinithermus h...
WP_013458170  78 D-VPLVGDFHFNGhLLLARFPEMartLDKYRINPGTVGAragaAGNFRTMVEAALEHGKPVRIGGNWGSLDQALLAEiMD 156 Oceanithermus p...
4S3E_A        81 E-VPLVGDFHFNGhLLLRKYPKMaeaLDXFRINPGTLGRgrhkDEHFAEMIRIAMDLGKPVRIGANWGSLDPALLTElMD 159 Thermus thermop...
WP_011812949  91 E-VPIVGDFHFNGhKLLRRHPECaeaLAKMRINPGNVGKgsrrDPQFAEMIEIACTYDLPVRIGVNWGSLDDSVLTRlMD 169 Halorhodospira ...
WP_014132192  83 N-VPLVGDFHYIGhKLLSDHPACaeaLAKYRINPGNVGFkdkrDKQFSQMIEIANRYEKPVRIGVNWGSLDQELLTVlMD 161 Pelagibacterium...
WP_013420631  84 D-VPLVGDFHYIGhRLLADHPACaeaLSKYRINPGNVGGrdsrDDRFSKIIEIALKHDKPVRIGVNWGSLDQDLLTAmMD 162 Rhodomicrobium ...
dbMIDI:1008   79 K-VPLVGCFHYNGhQLLRDFPECaaaLDKYRINPGNVGFgakrDKQFEMMVEYALKYSKPIRIGVNWGSLDQDLATKlMD 157 Candidatus Midi...
Q2GCX2        88 EkVPLVGCGQYEIkRVLETQTEAirsLGKIRINPGNIGFgskrDTNFDKVIELICKHDLPIRIGVNWGSLDQSVLRQiMD 167 Neorickettsia s...
Q2GGR2        85 SaKMIIGCGQYEIaRLVNEYPDCaaaLGKIRINPGNVGFgnkrDKNFEDIVEFAIKHDIPIRIGVNWGSLDKYLASKlMN 164 Ehrlichia chaff...
3NOY_A       155 Yp-S---A--------EALAESALRWSEKFEKWGFT-N-YKVSIKGSDVLQNVRANLIFAERTDVPLHIGITEAGMGTKG 220 Aquifex aeolicus
WP_013704576 158 QnaRrpnPksahevllETIVESAVRSAELAEAYGLPhDrIILSAKVSHAPDLWAVYRALARRVDYPLHLGLTEAGMGAQG 237 Marinithermus h...
WP_013458170 157 AnaRrpePktahevllETLVVSVLRSAELAEEIGLArDrIVLSAKVSAPADLWLVYRELA-KSPYALHLGLTEAGMGDRG 235 Oceanithermus p...
4S3E_A       160 RnaRrpePksahevvlEALVESAVRAYEAALEMGLGeDkLVLSAKVSKARDLVWVYRELARRTQAPLHLGLTEAGMGVKG 239 Thermus thermop...
WP_011812949 170 AnaArqqPlppetvmrDAVVTSAVESAQRAEELGLPgDrIVLSCKMSGVQDLVAVYRDLARRCDYPLHLGLTEAGMGVPG 249 Halorhodospira ...
WP_014132192 162 EnaGraePwsaahvqrEAIIRSAILSAERAEELGMGrDrIILSTKVSDVQQLISVYEELAARCDYALHLGLTEAGMGSKG 241 Pelagibacterium...
WP_013420631 163 EnsRatkPkdtrdvmhEAIVTSALKSAALAESLGMGkDkIILSAKTSSIQDLISCYTLLAARCDNALHLGLTEAGMGSKG 242 Rhodomicrobium ...
dbMIDI:1008  158 DnsKlsnPrsaeeimqEAIIQSSLTSAKKAEEIGMAaGqIVISAKVSRVQELVAVYRELAARSNYALHLGLTEAGIGLKG 237 Candidatus Midi...
Q2GCX2       168 DnaKnekPssyngvlrCALIQSALASAKRAEEVGLSpDkIILSCKVSSFQDLVAVYSSLAEQCRYPLHLGLTEAGMGTSG 247 Neorickettsia s...
Q2GGR2       165 DnaLlinPkpdyivlqKALVISAITSAKRAEEIGLSkNkIVISCKTSKIQDLIPVYTVLSNVCNYPLHLGLTEAGSGTKG 244 Ehrlichia chaff...
3NOY_A       221 IIKSSVGIGILLYMGIGDTVRVSLTDDP----VVEVETAYEILKSLGLRRRGVEIVACPTCGRIEV-DLPKVVKEVQEKL 295 Aquifex aeolicus
WP_013704576 238 IVASTAGLAVLLSEGIGDTIRVSLTPEPgtsrAREVEVAKLILQSLGLRRFAPSVTACPGCGRTTStFFQELAQTVQQHL 317 Marinithermus h...
WP_013458170 236 VVFSAAAVAPLLAEGIGDTLRVSLTPVPgeprTREVEVAKEILQAVGARRFAPSVSACPGCGRTTStFFQELAQEVSRYL 315 Oceanithermus p...
4S3E_A       240 IVASAAALAPLLLEGIGDTIRVSLTPAPgeprTKEVEVAQEILQALGLRAFAPEVTSCPGCGRTTStFFQELAEEVSRRL 319 Thermus thermop...
WP_011812949 250 VVASSAALAILLQEGIGDTIRVSLTPDPggarTREVEVAQQVLQSMGLRDFTPRVTACPGCGRTSSdFFQHLAEHIRNHI 329 Halorhodospira ...
WP_014132192 242 IVASSAALGILLQQGIGDTIRISLTPEPggdrTLEVKVAQELLQTMGFRQFVPVVAACPGCGRTTStTFQTLAKEIQDHL 321 Pelagibacterium...
WP_013420631 243 IVASAAALGILLQKGIGDTIRVSLTPEPggarTKEVEVAQQILQTMGFRTFVPIVAACPGCGRTTStLFQELGQNIQTHL 322 Rhodomicrobium ...
dbMIDI:1008  238 VVNISSALAILLQEGIGDTIRASLTPRVdesrTQEVTLCCEVLQALGVKTFNPQVSACPGCGRTSStYFQKLANDIQNFL 317 Candidatus Midi...
Q2GCX2       248 IIKTTAALSVLLSRGIGDTIRASLTQKPgesrVIEVETCQLILQSMGLRVFVPQVTSCPGCGRTNGnYFQQISSDLNDFI 327 Neorickettsia s...
Q2GGR2       245 MVSSAAGISYLLLNGIGDTIRVSLTQQPgearSIEVKLCQEILQSIGLRNFSAQVTSCPGCNRTNPkYFHQLAKDINDYI 324 Ehrlichia chaff...
3NOY_A       296 -SGVk---------TPLKVAVMGCVVNAIGEAREADIGLA-CGRGFA---WLFKHGK---PIKKvdeSEMVDELLKEIQN 358 Aquifex aeolicus
WP_013704576 318 eRRMlewkarypgvENLKVAVMGCVVNGPGESKHADVGISlPGTGEApraPVYVDGRlykTLQG---PRIAEEFMEILEA 394 Marinithermus h...
WP_013458170 316 aLKMdawrarypgvEELKVAVMGCVVNGPGESKHADVGISlPGSGEApraPVYVDGElytTLSG---EGIPEQFVQILEE 392 Oceanithermus p...
4S3E_A       320 kERLpewrarypgvEELKVAVMGCVVNGPGESKHAHIGISlPGAGEEpkaPVYADGKlltILKG---EGIAEEFLRLVED 396 Thermus thermop...
WP_011812949 330 dKRMpewrerypgvEGLRIAVMGCVVNGPGESRHADIGISlPGAGEQpsaPVFIDGErsvTLKG---DQIAEEFEQIVES 406 Halorhodospira ...
WP_014132192 322 sTSMpewrekypgvEAMSVAVMGCIVNGPGESKHADIGISlPGTGETpsaPVFVEGQkvtTLKG---PDVADQFKRMVAD 398 Pelagibacterium...
WP_013420631 323 lENMaewrktypgvETLNVAVMGCVVNGPGESKHADIGISlPGTGETpaaPVFVDGErvaTLRG---PTMADDFMVMVQE 399 Rhodomicrobium ...
dbMIDI:1008  318 qLAMqkwrtdykgvEDLKVAVMGCIVNGPGESKHADIGISlPGSGESpvaPVFIDGQkthTLRG---DNIAEEFKQILIe 394 Candidatus Midi...
Q2GCX2       328 kDNLvdwkrlylgvENFKLAVMGCIVNGPGESKHADVGISlPGYNENmvaAVFIDGKpsaKLIG---ENILEESKRIILE 404 Neorickettsia s...
Q2GGR2       325 kQRMpvwrndnpgsENMTVAVMGCIVNGPGESKHANLGISlPGYGERpvaAVYQNGEklcTLEG---GNIFEQFVSIIEN 401 Ehrlichia chaff...
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