6DVE,4NQW,2Z2S,1RP3,4CXF


Conserved Protein Domain Family
Sigma70_r2

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pfam04542: Sigma70_r2 
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Sigma-70 region 2
Region 2 of sigma-70 is the most conserved region of the entire protein. All members of this class of sigma-factor contain region 2. The high conservation is due to region 2 containing both the -10 promoter recognition helix and the primary core RNA polymerase binding determinant. The core binding helix, interacts with the clamp domain of the largest polymerase subunit, beta prime. The aromatic residues of the recognition helix, found at the C-terminus of this domain are though to mediate strand separation, thereby allowing transcription initiation.
Statistics
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PSSM-Id: 398303
Aligned: 205 rows
Threshold Bit Score: 32.1561
Threshold Setting Gi: 81622809
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6DVE_F            18 LYDEHAAVLWRYALRL----TGDAa--QAEDVVQETLLRAWQHPEVIG-DTArPARAWLFTVAR----NXIIDERRSAR 85  Mycobacteriu...
Q03474            28 LLQRHQVMVKRVVNQLrv-hATSHc--SIEDMQQIGLIALVEAGRRYGdIDDtHFPAFAVCRVR----GAILDELRRLD 99  Vibrio parah...
CCA58586          28 LILHYSPLVKYVAGRVsv-gLPSNv--EQADFVSSGVFGLIDAIEKFDvERAiKFETYAITRIR----GAMIDELRALD 99  Streptomyces...
Q9KA59            28 LIRQYLPLVHYHVQRIsv-gLPRSv--SKDDLISHGMLGLLDALEKFNpDRDlKFDTYASFRVR----GAILDGLRKED 99  Bacillus hal...
Q97H70            13 LIKKYIPLVKYIASRVii-gKSKYi--EYEDLVGYGMIGLMDALKKFDqSKGmKFSTYSSIRIK----GAMIDELRKNS 84  Clostridium ...
Q97I83            24 LIQEYKPFIASLLQKK----TGKYlqyGYDDELSIGMIAFEEAVESYDrNKG-KFLSFAKRVII----LRAIDYYRKNQ 93  Clostridium ...
O31654            36 LIQQYKPFIAKTVSSV----CKRYi-dEKDDEFSIGLIAFNEAIEKYSpEKGnSLLAFAELIIK----RKVIDYIRKEA 105 Bacillus sub...
P23672            27 IFNYFGPFIKSFTKNI----YIRNf--DKSDIYEECNFSILLSIKKCD-IKKyNFTAYTISSIK----NNIYYKIRNQA 94  Clostridium ...
Q98R31            31 LYEDYYPQIKSLARKVlssfYSCSl--EVHDLLNIAFFNWEKLVQDYDpTRNiVFEFYILKWMRllfyQGIKNDISKRN 107 Mycoplasma p...
REF_PBI:SPO1_159  18 lFKKYELLRKSVYKKFkd-kMINQs--DREDLMGTIDQIFLQLVSEYNpNRGvDFPYYIKRMLE----LRTYHHITKyl 89  Bacillus vir...
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