Conserved Protein Domain Family
Phage_holin_1

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pfam04531: Phage_holin_1 
Bacteriophage holin
This family of holins is found in several staphylococcal and streptococcal bacteriophages. Holins are a diverse family of proteins that cause bacterial membrane lysis during late-protein synthesis. It is thought that the temporal precision of holin-mediated lysis may occur through the buildup of a holin oligomer which causes the lysis.
Statistics
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PSSM-Id: 398297
Aligned: 18 rows
Threshold Bit Score: 78.8991
Threshold Setting Gi: 524749741
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
BAK46124       4 INWKVRS--RSPQFWIGMVGVVASPVLAYFGLSYKDLTTWdSVSNVFMQFVRnpyligtVAVAVLSALGVITDPTTKGIT 81  Clostridium sp....
WP_015076713   3 VNWKVRF--KSKAFWVAIVPAFLLLIQLLLKPLGINLDIN-FLGGYFLDVVN-------AIFVLLTILGVVNDPTVFGFK 72  Carnobacterium ...
WP_015077668   3 INWEVRI--KSKTFWLSLIPILLVLIQQVSSWFGIEFAKE-LIENEVMQFVN-------TLFLLLGILGIVNDPTVPGIT 72  Carnobacterium ...
CBL42508       2 INWKVRV--KNKSFWIALIPAVLLLVQVIAAVFGYTLDLG-ELGDKLLAVVN-------ALFAVLTILGIVTDPTTAGIG 71  butyrate-produc...
Q2FX76         3 INWKLRF--KNKAVLTGLVGALLLFIKQVTDLFGLDLSTQ---LNQASAIIG-------AILTLLTGIGVITDPTSKGVS 70  Staphylococcus ...
AAX92447      14 INLSTRF--KSKTFWVATVSALAVFTNQLTGAFGLDYSSQ---VEQGVNIVG-------SILTLLAGLGILVDNNTKGIK 81  Staphylococcus ...
CCY59368       3 INWKVRFnrKNILFLSQVLLSVLVPILTYFGMQLSDFTSWqIVRDTLLQAVSnpyviimSLVSLFNAI---TDPTTQGIS 79  Clostridium sp....
CCY68604       4 INWKVRL--QSGSWWMGIISAVVVAVFAVLKICKVETSVT---ADEIMNVAM-------LILMIPAAIGITTDPTTKGVS 71  Clostridium sp....
CDA12922       3 INWKVRL--KSGSWWLGIISAVIVAVFAILNLFGVKTSVA---ASDIMNAAT-------LVLMIPAAIGIISDPTTKGVS 70  Anaerotruncus s...
CDE48326       3 INWSLRF--HNKVWLTTLLAVVCTFVFNLLDLFGIETTVA---QEQVMQLGA-------ALLSLLSTLGVVIDPTTPGVS 70  Faecalibacteriu...
BAK46124      82 DSNRSMA-YEYPK 93  Clostridium sp. SY8519
WP_015076713  73 DSEQALN-YEEPK 84  Carnobacterium maltaromaticum
WP_015077668  73 DSERTLKk----- 80  Carnobacterium maltaromaticum
CBL42508      72 DSKQALT-YETPK 83  butyrate-producing bacterium SS3/4
Q2FX76        71 DSSIAQT-YQAPR 82  Staphylococcus aureus subsp. aureus NCTC 8325
AAX92447      82 DSVIVQTdYHEPR 94  Staphylococcus virus Twort
CCY59368      80 DSRQAQS-YRSPK 91  Clostridium sp. CAG:632
CCY68604      72 DSQQVLT-YDAPK 83  Clostridium sp. CAG:678
CDA12922      71 DSTQALT-YEAPR 82  Anaerotruncus sp. CAG:528
CDE48326      71 DSQTVIErk---- 79  Faecalibacterium sp. CAG:74
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