2J4B,6HQA


Conserved Protein Domain Family
TFIID_NTD2

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pfam04494: TFIID_NTD2 
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WD40 associated region in TFIID subunit, NTD2 domain
This region is an all-alpha domain associated with the WD40 helical bundle of the TAF5 subunit of transcription factor TFIID. The domain has distant structural similarity to RNA polymerase II CTD interacting factors. It contains several conserved clefts that are likely to be critical for TFIID complex assembly. The TAF5 subunit is present twice in the TFIID complex and is critical for the function and assembly of the complex, and the NTD2 and N-terminal domain is crucial for homodimerization.
Statistics
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PSSM-Id: 398277
Aligned: 111 rows
Threshold Bit Score: 87.9301
Threshold Setting Gi: 156117163
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2J4B_D          5 KDQMETSYVSLKTWIEDSLDLFKNDLLPL-LYPLFIHIYF---DLIQQNKTDE--AKEFFEKYRG--DH-------YNKS 69   Encephalitozo...
XP_003687126  244 YRTYLRSFILLKNWISKSLSIHKPILTDLvLYPVFVIMLI---KFYRLKNIEI--LKKFYEENVKlvIGesnkliiINLY 318  Tetrapisispor...
XP_004933726   61 PFTYELAYDGLKKFIENSLDLYKYELSTL-LYPVFVHMYL---LLILYDHVEH--AVSFLEKFGI--EQ-------EDYY 125  domestic silk...
EDO43158       72 SSTFDEQFGNLKSFILDVNPAYRSELAKL-LFPMFAVCYL---ELIAKGHLIS--AQNFFSKYSG--DL-------ALEH 136  starlet sea a...
EEN44450       67 PTLYEDQYSGLKVLIDDAPQAHQSELTVL-LYPMFVHLHL---DLVCNGHRDA--AEAFFTRHHG--NF-------LVDN 131  Florida lancelet
Q4SVI5         66 PQQYETQYARLRTFLSETEISWAKEVSCI-LYPLFVYLHL---DMVLCGLKGA--VDGFYSRFHGafLQ-------DSEQ 132  spotted green...
OCA33728       67 AHQYEVQFARLRNFLSDADSPHSQEVTTL-LYPLFVYLHL---DMVQNSLKSA--VDSFYSRFHGmfMQ-------HPGQ 133  tropical claw...
XP_006255874  102 PQQYEVQFGRLRNFLTDSDSQYSHEVMPL-LYPLFVYLHL---NLVQSGPKST--VESFYSRFHG--MFl-----qNASQ 168  Norway rat
XP_006920781   67 PQQYEAQFARLRNFLTESDSRLSHDVMPL-LYPLFVYLHL---SLVQGSPKGT--ADSFYSRFHGmfLQ-------NAGQ 133  black flying fox
EDO18628      227 ERTLTRSYALLKSWIDRNLSIYQEHLKNIiLFPIFIHTYIkmkKLVKTNTISSsrCEAFYSKYNEftSNgtnkdtiEALH 306  Vanderwaltozy...
2J4B_D         70 E----EIKqfesiYTVQHIHENNFA--YTFKNSKYHLSMGRYAFDLLINFLEERNLT---YILKILNQ 128  Encephalitozoon cuniculi
XP_003687126  319 Dd---LIK-----SSNDNLEDEKKEktNEFDQYNFQISISQQLFFSLISHLMNNYKLggqIILGCIFS 378  Tetrapisispora phaffii CB...
XP_004933726  126 Qe---DLKklsivKHKDQIKGNELA--EIYSTNKFTVQLSRDASSQLKRYLHEQKNSs--VIINIINN 186  domestic silkworm
EDO43158      137 Ke---DIQhlqaiTDSERLKSSDIA--ANFRRSKYVLRLSSKVFTYFMQYLRSSDRV---LLLQLLSR 196  starlet sea anemone
EEN44450      132 MewyeLIEelagvMCKQDLFTKPKV--KAFRETKYAISLSDKAFQYLLRYLQSDDNL---ILLRLFNT 194  Florida lancelet
Q4SVI5        133 Ra---TIEqlrhvLTAQDIAANSKL--SALLEHKYVVHMTEPAYSYLLRYLQSEDNS---TVCRALST 192  spotted green pufferfish
OCA33728      134 Rd---IVEqlqttMTMQDIHSNCKL--RAFLDNKYVVCLQEDSYHYLLRFLQSDNNT---ALCKALAL 193  tropical clawed frog
XP_006255874  169 Kd---IIEqlqttQTIQDILSNFQL--RAFLDNKYVVRLQEDSYNYLIRYLQSDNNT---ALCKVLAV 228  Norway rat
XP_006920781  134 Kd---VVEqlrstQTVQDVLGNLQL--RAFLDHKYVVRLHEDSYHYLARFLQSDNNA---ALCKVLAL 193  black flying fox
EDO18628      307 Kl----------vSDIDE---------EDF---KYVVIVSGRLFYPLLTHILENEMIggnLLMDIIDK 352  Vanderwaltozyma polyspora...
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