Conserved Protein Domain Family
Gly_transf_sug

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pfam04488: Gly_transf_sug 
Glycosyltransferase sugar-binding region containing DXD motif
The DXD motif is a short conserved motif found in many families of glycosyltransferases, which add a range of different sugars to other sugars, phosphates and proteins. DXD-containing glycosyltransferases all use nucleoside diphosphate sugars as donors and require divalent cations, usually manganese. The DXD motif is expected to play a carbohydrate binding role in sugar-nucleoside diphosphate and manganese dependent glycosyltransferases.
Statistics
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PSSM-Id: 398274
Aligned: 21 rows
Threshold Bit Score: 73.5217
Threshold Setting Gi: 75169644
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O80440 110 GKREMLAVESVF-KAHPQGCLMIVSGSLDslqgdsilkplndrgykvfaATPDMSLLLEN-TPaksWFQeMKSckrdpgR 187 thale cress
Q10323  71 PEKWVGAQKSCI-DLHPDYEYVLWTDESM------------------------REFIATD-YP---WFLtQYD------S 115 Schizosaccharomyces p...
P33300  69 PEHWKEGRQKCL-DLHPDYKYILWTDEMA------------------------YEFIKEE-YP---WFLdTFE------N 113 Saccharomyces cerevis...
Q9UT67  96 PEGWKGAQQSCI-DLHPDYEYILWTDEMS------------------------RNFIADN-YP---WFLpYFD------A 140 Schizosaccharomyces p...
Q9CLU0  75 PVYCNYLFNRLL-SLSYDYRYVSTEARAD--------------------------YLKTHaDE---RTFnAYS------K 118 Pasteurella multocida
Q9KVB2  72 PVYLNYLFNRLM-SLNCDYRYVSTEARGE--------------------------FLKEHtSP---EVYdAYS------R 115 Vibrio cholerae
P31755 114 PSSFRTYQKTWSgSYSPDYQYSLISDDSI------------------------IPFLENLyAPv-pIVIqAFK------L 162 Saccharomyces cerevis...
P47124 144 PERVQDIKGMWE-SKNPGFAHEVLNHDVI--------------------NALVHHYFYS--IP---EILeTYE------A 191 Saccharomyces cerevis...
Q9UTR6 155 DREVMKYTRFWR-INHPSYSHAVLDDEQS--------------------KALVISSFGDSsVS---KISqAYA------M 204 Schizosaccharomyces p...
Q8DZD7  17 PDNLKKYIKTWR-EQCPDYEIIEWNE---------------------------HNYDVSK-NV---FMReAYT------- 57  Streptococcus agalact...
O80440 188 IPLHQNLSNLARLAFLYKYGGVYLDTDFIVTRSFkglkNSIGAQTVVE 235 thale cress
Q10323 116 YPYNIERADVVRYFILYKYGGIYLDLDVGCNRTL----DPLL-HYPAW 158 Schizosaccharomyces pombe 972h-
P33300 114 YKYPIERADAIRYFILSHYGGVYIDLDDGCERKL----DPLLAFPAFL 157 Saccharomyces cerevisiae S288C
Q9UT67 141 YPFNVQRADVIRYFVLYHYGGNYIDLDDGCRQRL----DSLL-YYPVW 183 Schizosaccharomyces pombe 972h-
Q9CLU0 119 LTDGAAQADFWRIFTLYHEGGIYMDIDGHLVWCL----DSIIDEEDSE 162 Pasteurella multocida
Q9KVB2 116 LTNGAAQADLWRLVVLNTYGGVYMDIDATLVWPLdk---lLGDSQELY 160 Vibrio cholerae
P31755 163 MPGNILKADFLRYLLLFARGGIYSDMDTMLLKPI----DSWPSQNKSW 206 Saccharomyces cerevisiae S288C
P47124 192 LPSIILKIDFFKYLILLVHGGVYADIDTFPVQPI----PNWIPEELSP 235 Saccharomyces cerevisiae S288C
Q9UTR6 205 MPLPVLKADFFRYLVLLAKGGIYSDIDTAPLKHI----NNWIPREYRK 248 Schizosaccharomyces pombe 972h-
Q8DZD7  58 KKNFAYVSDYARLDIIYTYGGFYLDTDVELLKSL----DPLRIHECFL 101 Streptococcus agalactiae serogroup V
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