Conserved Protein Domain Family
RTA1
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pfam04479: RTA1 
RTA1 like protein
This family is comprised of fungal proteins with multiple transmembrane regions. RTA1 is involved in resistance to 7-aminocholesterol, while RTM1 confers resistance to an an unknown toxic chemical in molasses. These proteins may bind to the toxic substance, and thus prevent toxicity. They are not thought to be involved in the efflux of xenobiotics.
Links
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Statistics
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PSSM-Id: 398267
Aligned: 253 rows
Threshold Bit Score: 137.595
Threshold Setting Gi: 511001844
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CCE79109  146 FTCGYGLEFGGFAARVASFGDmtaSDPFIAQLVMLTIAPAFIMGGIYFLFAQLVVIH----GRNYSLL-RP-LWYSYIFI 219  Millerozyma farin...
EMR82720  687 iISASIWGLTAFILRIESTYNqqdNALELMSSIFALTISPMINAYYFILLGHIIHHY----LPSRSLLsVRaHFIALPFL 762  Botrytis cinerea ...
EAQ70743  110 LIMGGIWESAAFTVHAIGAKDqqsEPLAVGYSMLYLLAPLWITAFVYMTFARQVWYWt--pDQRLFML-SA-HVLSKVFV 185  Pyricularia oryza...
EPE28658   63 iVASGMAQTLAYVLRILSILNpasFGFYAGWFVLILVAPLFTNAFVYMVMGRMIWNYv--pEKKIHRV-TA-WRFGMYFV 138  Glarea lozoyensis...
EMR84474   53 IIVSGIAQTLAYIFRVISIKNpasFGNYAAWFILILIAPLFTNAFAYMVMGRMIWNYv--iEAKIWKI-TA-WRFGLYFV 128  Botrytis cinerea ...
EHK48506   52 IIMSALWQTLTYIFRTISIQNpasYGNYAAWFVLILVAPLWTNAYAYTLFGRMVWAYt--aTHKLWRI-KA-WQFGFIFI 127  Trichoderma atrov...
EPE04416   52 IIMSSLWQFLTYIFRALSIQTpasFGNYAAWFVLILIAPLWTNAYSYMVFGRLVWNYt--pDRKVWGL-RA-QRFGVIFV 127  Ophiostoma piceae...
ERS95305   58 IVMSVLWQLLTYIFRTISIQTpasFGDYAAWFVLVLIAPLWTNAFAYMVFGRLVYNYt--pDRKLWGV-PA-SRFGLLFV 133  Sporothrix schenc...
EGU85649   78 AIMGATWETIGFAFKTLGSRNqqnMTYLIWGQLFFLLAPLWINAFVYMAVARMVYFRm--pDRKLLGI-KA-IRMTLLFV 153  Fusarium oxysporu...
Q2GRV8     74 LVMGALWEYACFMLRTLGAFDqqnGGLVVGGTVLFLLAPLWINAFVYMVVARLIHFLlpsnSQRILGL-SP-RWLAKAFV 151  Chaetomium globos...

CCE79109  220 TCDVLSLIIQAGGGGSASVASQNYEd-TDPGTYTMIAGIAFQVFAMSIFLIFWFDFLRRMYfhdlpmsekallevsdehg 298  Millerozyma farin...
EMR82720  763 VFNGAAFVLEVVGATMMEKRNFEWE--RRNADHVHIGGLVVQMLVVFVFLGVLVRFWREMSglkrrg------------- 827  Botrytis cinerea ...
EAQ70743  186 LADVLAFVLQFLGAALVTNHKAKTPeeIRRGAILHLAGLSLQLTVTAIFLVLMAAWHLKMIayeaerahldpy------- 258  Pyricularia oryza...
EPE28658  139 VLDVCALVIQIIGAVQATGENTTTKq-VLRGLHMYMGGVGVQLGFILLFLFFAVKFHRIVRqqnstsf------------ 205  Glarea lozoyensis...
EMR84474  129 ILDVAALLIQIYGAATAASDNASADe-TLQGLHVYMVGVGIQQFFIFVFLFFAFKFHQTLRsqsrqnv------------ 195  Botrytis cinerea ...
EHK48506  128 LLDIVAFVVQVVGAVQATGSNTTDQq-VLNGLHIYMGGVGLQLVFILIFCIYALRFYLETRqspda-------------- 192  Trichoderma atrov...
EPE04416  128 MLDIVAFIVQVYGAAAASAKDAATDd-VLRSLHIYMAGVGIQLFFLLICFVFGIRLWLMMRtdaimyp------------ 194  Ophiostoma piceae...
ERS95305  134 VLDIIAFVIQVYGAATASANGIPEDe-VLRDLHVYMGGVGVQLLFILICSVFGIKLWTVMRreakqsp------------ 200  Sporothrix schenc...
EGU85649  154 WLDIILFLVQGAGGSMLSNNDDMNV--IRIGQKLYMAGVGLQLAVIVIFIGITAFFYFKLRqlegr-------------- 217  Fusarium oxysporu...
Q2GRV8    152 AVDVLSFFIQAAGGGMLAGQDGGDT--VQTGQRIYMAGIGVQLAFVVIFAAITGLFTLRLErlmgagll----------- 218  Chaetomium globos...

CCE79109  299 niprcvamynkktvlnyiklllnvpsarefktlyleknynpgfaelrerrlFHWFPLFLTLGVIFIYIRCVYRVVELSM- 377  Millerozyma farin...
EMR82720  828 ----------------------------------------------vmgmgWKGLLVAMFGGSGLILIQIFFSLARFST- 860  Botrytis cinerea ...
EAQ70743  259 ---------------------------------------gdcspegpirrsWKFLHAAMYIAVLLIAIRLCFRLAESGQi 299  Pyricularia oryza...
EPE28658  206 --------------------------------------------gspglthALILLYNLYTVLGFIILRIIFRLIEYAQ- 240  Glarea lozoyensis...
EMR84474  196 ----------------------------------------------ytsrqawSLLYVLYAVILLITIRIIFRLVEYSQ- 228  Botrytis cinerea ...
EHK48506  193 -------------------------------------------------rqaqVLFYAQILALAMIVLRIIFRICEYSQ- 222  Trichoderma atrov...
EPE04416  195 -----------------------------------------------hlrpalMLLYVQFVVLVLIIVRIVFRIVEYSS- 226  Ophiostoma piceae...
ERS95305  201 ----------------------------------------------ralrpalLLLYVQFAVLALIIIRIIFRIVEYAS- 233  Sporothrix schenc...
EGU85649  218 -----------------------------------------------smgrMKWLILTMLAVLILIVIRIVYRLIEFGP- 249  Fusarium oxysporu...
Q2GRV8    219 -------------------------------------------eprhnltvTRHLVWFMLTVIGLIVVRIVFRFVEFSG- 254  Chaetomium globos...

CCE79109  378 --GF--NGYLITHEVYLMTLDALMIALNGIIFCFFHPTFVFGVT 417  Millerozyma farinosa CBS 7064
EMR82720  861 --GDktSSTLSTHEFYFYIFEIVPAVLAISTMNALHPGRIMIGE 902  Botrytis cinerea BcDW1
EAQ70743  300 vvGSt-RGGLASSQILQYLLDAAPVMLCLAVLAVAHPGRFLIGK 342  Pyricularia oryzae 70-15
EPE28658  241 --GL--DSGIPNKEGYQYGLDSLPMLIALVLLDAFHPGRIMKGE 280  Glarea lozoyensis ATCC 20868
EMR84474  229 --GL--KSSIPNHEAFQYSLDSVPMLFALVFLNIFHPGRIMADS 268  Botrytis cinerea BcDW1
EHK48506  223 --GL--DSKIPNHEAYQYCLDSLPMFIALVVYNVVHPGRIMRGK 262  Trichoderma atroviride IMI 206040
EPE04416  227 --GL--KSSIPLHEAYQYSLDTLPMFLALLMYNIVHPGRIMQGP 266  Ophiostoma piceae UAMH 11346
ERS95305  234 --GL--KSSIPNHEAFQYALDTLPMFVAIVLYNIVHPGSIMRGp 273  Sporothrix schenckii ATCC 58251
EGU85649  250 --GVneHNQLLIHEEYPLGLDATPILIALVLLNIMHPGFVLRGp 291  Fusarium oxysporum Fo5176
Q2GRV8    255 --GVssSNPILANEAYQLGLDALPMLIALLLINAVHPSKVLKGP 296  Chaetomium globosum CBS 148.51
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