1SO9


Conserved Protein Domain Family
CtaG_Cox11

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pfam04442: CtaG_Cox11 
Cytochrome c oxidase assembly protein CtaG/Cox11
Cytochrome c oxidase assembly protein is essential for the assembly of functional cytochrome oxidase protein. In eukaryotes it is an integral protein of the mitochondrial inner membrane. Cox11 is essential for the insertion of Cu(I) ions to form the CuB site. This is essential for the stability of other structures in subunit I, for example haems a and a3, and the magnesium/manganese centre. Cox11 is probably only required in sub-stoichiometric amounts relative to the structural units. The C terminal region of the protein is known to form a dimer. Each monomer coordinates one Cu(I) ion via three conserved cysteine residues (111, 208 and 210) in Saccharomyces cerevisiae. Met 224 is also thought to play a role in copper transfer or stabilizing the copper site.
Statistics
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PSSM-Id: 398241
Aligned: 208 rows
Threshold Bit Score: 165.358
Threshold Setting Gi: 215454031
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1SO9_A          1 MVPLYDMFCR-VTGYNGTTQRVEQA------SDl----iLDEkIKVTFDANVAAGLPWEFVPVQRDIDVRIGETVQIMYR 69 
jgi:Tgr7_3008  32 LVPLYNLYCQ-VVGIQSADQqralnvqa---rvdplgevQDRwVTVRFDTTVHPSLPWALESNERSLRVRPGEMHEVMFV 107 Thioalkalivibr...
WP_013533869   32 LVPLYRIACEkVFGIRLEGGTGQARgvvagaGAr-----KDRvVTVQFDGGVNSKLPWAFSPEQLTMQVVPGELNEAVYF 106 Pseudoxanthomo...
Q8P481         31 LVPLYRIACEkVFGIRMERAPGSARegassaVAa-----GKRtVRVEFDAGVNSKLPWTFHPEQMTMDVVPGELNEAQYF 105 Xanthomonas ca...
WP_012914956   31 LVPLYRIACEkVFGIRLERGPGEGQqa--raPLv-----DKRtVKVQFDGGVNSKLPWSFHPEQMTMEVIPGQLNQALYY 103 Xanthomonas al...
jgi:Rmag_0036  32 MVPIYDVFCE-ITGFNGTTGrvdseq--------kyvvdETRkIEVSFFAMTMSGFPIQFGPKVSSMEVVPGRFYTTSYI 102 Candidatus Rut...
WP_013819755   30 LVPIYDVLCN-ITGQNAKLTESVEA-------DqafavdENReVNVEFITSVNESTPLDFRVETHSMKVHPGQYYTVNFY 101 Methylomonas m...
CCE23994       30 LVPIYDVFCD-ITGLNGKTASVAAA-------EtarevdESReVTVEFVTSLNQAAPMEFRAETYKMKVHPGQYYTVNFY 101 Methylomicrobi...
WP_013031180   52 MVPLYNVFCD-ITGLNGKPDNVAVS------AAkagtvdTSRtVTVELLANVNSQLSWEIKPEVSKISIHPGEVTKVSYY 124 Nitrosococcus ...
Q3J6R0         52 MVPLYDVICE-IAGLNGKPENVAVS------VSeagaidTSRtITVQFLASVNSQLSWEFKPEVQEIRVHPGEVAKVTYY 124 Nitrosococcus ...
1SO9_A         70 AKNLASTPTTGQATFNVTPMAAGAYFNKVQCFCFTETTLEPGEEMEMPVVFFVDPEIVKPvetqgIKTLTLSYTFYP 146
jgi:Tgr7_3008 108 ASNRSSAKVTGQALPTVIPWQANDFFNKTECFCFVKQTLDGGERREMPLRFVVSPALPDG-----VTSLTLSYNFMh 179 Thioalkalivibrio ...
WP_013533869  107 ARNESDRAIVGSAVPSVAPARASGYFTKTECFCFTAQTLQPGEQRDMPVRFIVDPDLPAD-----VKTITLSYTFFR 178 Pseudoxanthomonas...
Q8P481        106 ARNDSARAVVGSAVPSVAPSRASGYFNKTECFCFTAQTLQAGETRDMPLRFIVDPALPPE-----VTTITLSYTFYR 177 Xanthomonas campe...
WP_012914956  104 ARNESGRAIVGSAVPSVAPARASGYFTKTECFCFTAQTLQAGEQRDMPVRFIVDPNLPRD-----ITTITLSYTFYK 175 Xanthomonas albil...
jgi:Rmag_0036 103 AKNNTDEVVVGQAIPSVAPTDAALYFKKLECFCFNKQVFKPHEQVEMTLRFVIEPELDER-----IKDVSLSYNFFK 174 Candidatus Ruthia...
WP_013819755  102 AKNNLPRQIKVQAIPSITPGLAEEFFKKVQCFCFELQTFEANEEKIMPVRFVVNPKLPER-----YKTITLSYTFFD 173 Methylomonas meth...
CCE23994      102 AENLTDKPMIARAIPSITPGQAAEFFTKTQCFCFDEQSFEAHESKTMPVRFVVDPKLPEK-----YKTITLAYTFFD 173 Methylomicrobium ...
WP_013031180  125 ASNLADHSVTGQAIPSISPGLAAKHLHKTECFCFNEQVLQAGEKKEMPVVFFIDPKLPND-----YSVVTLSYTFFD 196 Nitrosococcus hal...
Q3J6R0        125 ASNLNDHSVIGQAIPSVSPGLAAKHLHKTECFCFTEQTLQAGETREMPVVFFVDPKLPQN-----YSEMTLSYTFFD 196 Nitrosococcus oce...
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