3FHN


Conserved Protein Domain Family
RINT1_TIP1

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pfam04437: RINT1_TIP1 
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RINT-1 / TIP-1 family
This family includes RINT-1, a Rad50 interacting protein which participates in radiation induced checkpoint control, as well as the TIP-1 protein from yeast that seems to be involved in a complex with Sec20p that is required for Golgi transport.
Statistics
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PSSM-Id: 398236
Aligned: 61 rows
Threshold Bit Score: 272.236
Threshold Setting Gi: 74605758
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3FHN_A              244 WNFKSLANNFNVRFTYHFHAt---SSSSKIETYFQFLNDYLAENLYKCINIFHD--DCNGLTK--PVihEQFINYVLQPI 316 baker's ...
XP_015787512        225 LPLQLMVKPLRKRFTYHFMTnvrtNQLSKPEWYLTQIMNWIKDHENFLSEHVTVlfKDQETEFasLK--IQFTCALLELA 302 two-spot...
EDO38509            241 LPLDWLLKPLRKRFKFHFYGkkqtNNLEKPEWYFTQILNWIKSHGDFLQHTVQPvlDKAELSFidAK--LEFIRGLLAVT 318 starlet ...
ELK01327            290 LPIQIMLTPLQKRFRYHFRGnrqtNVISKPEWYLAQVLLWIGNHTEFLDEKIQPilDKVGSSi-nAR--LEFSRGLMMLV 366 black fl...
Q5RGZ9              285 LPIQIMLLPLSKRFRYHFTGnrqtNSLSKPEWYLTQILIWMGNNSNFMDEKVQPilDRAGGNv-nAR--VELCRGLLTLA 361 zebrafish
XP_003972690        284 LPIQIMLLPFRKRFRYHFCGnrqtSSLSKPEWYLTQVLLWMSNNSTFMEEKIQPilEG-AETHlsAR--VELCRGLLALV 360 torafugu
XP_003455706        288 LPIQIMLLPLNKRFKYHFYGnrqtNSLSKPEWYLTQVLMWMGNNSTFMEETIQPilDRGGVTl-sAK--VELCRGLLSLV 364 Nile til...
XP_015207675        211 LPIQIMLLPLSKRFRYHFTGnrqtNTPNKPEWYLTQVLMWMGNHSAFMEEKIQPilDRDGARi-nAR--VELCRGLLSLA 287 spotted gar
WGS:AATM:SJAG_01166 196 L-MKCICRPFNIQFKYHFMTekktNTPSKPEWFYEFALKVFRSSLSFI-QLFQQimPEGMIAV------HEFMKVMQELM 267 Schizosa...
Q9C0W8              200 LFMQVYITPYVNQFRYHFMSqkqtNVLSKPEWFFEFLLKVFRSNRSFYMLMRDIkfFPGVPPF------FTFINLLNNVA 273 Schizosa...
3FHN_A              317 RDKVRST----LfqndLK--TLIVLISQILATDKNLLN-SFHYH------GLGLVS-LISdEV--WEKWINYEVEXANRQ 380 baker's ...
XP_015787512        303 ADKLAKDltklS----ADdkLFSHAFDEVLLTQRELEDiNQDWLslfrenCNLLS--LFA-VEpyFTRLRNIERRRSMEY 375 two-spot...
EDO38509            319 TEKMIHSlpelL----ADeaVFSHFVDETLLFHKELHE-LYNYPltd---hsCLK--VLT-RKqcLGKWVELERKYAIEN 387 starlet ...
ELK01327            367 LEKLAADipclL----YDdnLFCHLVDEVLLFERELHS-VHGYPgtf---anCLH--ILS-EEtcFQRWLTVERKFALQK 435 black fl...
Q5RGZ9              362 QEKLAHDaprlL----YDdaLFCHLVDEVLQFEKELRS-THSYPray---pgVLH--ILL-EEsvFQKWLSVERKMAVEK 430 zebrafish
XP_003972690        361 QEKVASDalrlL----YDdaLFCHLVEEVLQFEKELRS-KLSYPp----aLPGLLH-LLL-ENtvLQKWLTVEKKMAVEK 429 torafugu
XP_003455706        365 QEKVASDasklL----YDdvLFCHLVEEVLQFEKELRS-NHSYPael---pgVLH--LLL-EDavLQKWLTMEKKMAVEK 433 Nile til...
XP_015207675        288 LEKLAADaprlL----FDdaLFCHLVDEVLQFERELRG-THAYPstl---pgALH--ILL-DDavFQKWLSVEKKLAVEK 356 spotted gar
WGS:AATM:SJAG_01166 268 KEKINLImd------lDV--HLAHLIRETLYYSTKLKQ-LYNFPq-----KDSLSLyLLK-QPmvYSRWLDIEAADVKMQ 332 Schizosa...
Q9C0W8              274 KEKLTHIik------yDD--YLVHLVHETLQYSVRLEQ-HFHYT------QDPLIIfLFE-QNgtYDKWLGLETQLSLTK 337 Schizosa...
3FHN_A              381 FINITKNPE-D-----F-------------PKSSQNFVKLINKIYDYLEPFYDLDFdllvryKLXTCSLIFXNLTSSYLD 441 baker's ...
XP_015787512        376 IETIISSETaWsplvtSiddedededilkvPEIADNFILMLQSITDRFSHLSKISH------QYAFIVL-ELEMLADFHL 448 two-spot...
EDO38509            388 MESLLASENaWr---pKyedvecgademraPECAEGFITILTVMTDRYRHLPGLDE------QSRFLAV-QLDLLKDFIT 457 starlet ...
ELK01327            436 MDSTLSSEAaWi---sQykditd-vdemkvPDCAETFMTLLLVITDRYKNLPTASR------KLQFLEL-QKDLVDDFRI 504 black fl...
Q5RGZ9              431 VDAMLSAEGaWs---sQykditd-mdelkaPDCAETFMTLLLVITERYRSLPCQRA------QLSFLAL-QKELVDDFRI 499 zebrafish
XP_003972690        430 MDAMLSSEGaWs---cQykemcd-mdelraPDCAETFMMLLQVITERYRYLTCPSA------QLKFLGL-QKELLDDFRI 498 torafugu
XP_003455706        434 MDAMLSAERaWs---sQykdisd-mddlkaPDCAETFMTLLQVITERYRTLPCPSA------QLKFLEL-QKELVDDFRI 502 Nile til...
XP_015207675        357 VDALLAAEGaWs---sQyrdiad-ldelkvPDCAETFMTLLLVITDRYRSLPSPRA------RLSFLAL-QKELVDDFRI 425 spotted gar
WGS:AATM:SJAG_01166 333 LNAIESSKDaWe----LarddveelytavpIKSFVLYRNAMASLKSILEMIPCEEF------CRGFFHTLQLKPSIQFVD 402 Schizosa...
Q9C0W8              338 LEDIKIASDaWe----LesdqsddfssavpTKMTVRFRDMIETTFSVLQNLPSLDY------QFNFWRSVQLKPMMQYVN 407 Schizosa...
3FHN_A              442 YI--------LTVDSL--Net-rTKEQEL-------YQTXAKLQH-VNFVYRKIKSLSSNFIFIQLTDIV---NSTESKk 499 baker's ...
XP_015787512        449 RLsq-----------------iyRSLDSEglnqwpfTQRFFSIINtLNYVILLLNNWKNLPVFQDMSEFSlk-------- 503 two-spot...
EDO38509            458 LLsl-----------------taEESASNp-----vDACFISVLNaTSYIGFLLEDWNDQTLFLQLHGYFssend----- 510 starlet ...
ELK01327            505 RLtq-----------------vmKEETRAs-----lGFRYCAILNaVNYISTVLADWADNVFFLQLQQAAle-------- 554 black fl...
Q5RGZ9              500 RLtq-----------------vmKEESRQp-----lSSRYSAILNaANYISTVLSDWGDNVFFLQLQQAAvs-------- 549 zebrafish
XP_003972690        499 RLtq-----------------vmKEDSRYp-----lSARYCAILNaVNYISTILRDWGDNVFFLQLQQAA---VSLNDEv 553 torafugu
XP_003455706        503 RLtq-----------------vmKEESRCp-----lGVRYCAILNaVNYISTILGDWGDDVFFLQLQQTAvs-------- 552 Nile til...
XP_015207675        426 RLtq-----------------vmKEESRCp-----lGPRYCAILNaTNYVSAVLADWADNVFFLQLQQAAvd-------- 475 spotted gar
WGS:AATM:SJAG_01166 403 WLesyyqn-hegstTLipGgahvTSEQSFs-----eVRRMCKLYGaFKLLLDWHLDLEDEEVYI-LSQETnleKPVDKQv 475 Schizosa...
Q9C0W8              408 WLeafyesheSSSSIHlpGslqtDKSKFDia----eVERMCKLYSnFKLLMDWLDDIEDEDVYIRIGHKMgseNYA---- 479 Schizosa...
3FHN_A              500 y---nS----------------------LFQNVENDYEKAXSTdXQNSIVHRIQKLLKETLRNYFkiST--WSTLEX--S 550 baker's ...
XP_015787512        504 --------------------------dsIFEDSLSLYNHMVNE-MKKRIVDSLMKLIMEKIKAY---ASlrWHCFTL--L 551 two-spot...
EDO38509            511 -----------------------sgdcgVFDEPLKSLCELQKY-MSGLIVEDVVKGFRAKCKAY---RKerWHSLPS--P 561 starlet ...
ELK01327            555 ----vFaenntlskle--lgqlasmessVFDNMINLLERLKHD-MLTRQVDHVFREVKDAAKLY---GKerWLSLPS--Q 622 black fl...
Q5RGZ9              550 ----vGeeilgplgate-sgrlaslegsLFEELLALLERLRGD-MLGRLLDAVMRDVKEKAQPY---CKdrWISLPS--Q 618 zebrafish
XP_003972690        554 llgglGlmelgql---------aalegsLFDSLLALLDRLKGD-MMGRLLDWTMREFKEKAKPY---SQnrWLSFPS--Q 618 torafugu
XP_003455706        553 ----lGeeaipgglgimemgrlaslegsLFDGLLALLDRLKGD-MLGRLLDFLMREIKEKAKPY---CQerWLSLPS--Q 622 Nile til...
XP_015207675        476 ----mGeevlgnlgvte-tgrlaslegsVFEGLLGLLDRLRGD-MLGRLLDAVLRDVKDKAQPY---CRekWLSLPS--Q 544 spotted gar
WGS:AATM:SJAG_01166 476 laeesS----------------------VFLPLRKRLSKLCNQ-TFELLMHRVTQYLEATFDSFA--SIntWtlqekpps 530 Schizosa...
Q9C0W8              480 ----------------------------AFYQVKPRLSTLTNG-SFRMILRAVSQTLRPLLDNYS--DLdtWvikeqlpg 528 Schizosa...
3FHN_A              551 Vd-eNIGPSSvpsaELVNSINVLRRLINKLDSXDiPLAISLKVKNELLNVIVNYFTESILKLNKFNQNGLNQFLHDF-KS 628 baker's ...
XP_015787512        552 Dd----DMQY----ISYQLFYLISKSLELLKRKL-SHNILEELIETIADSIKTAIMKEVIYNNSFNGEGAQQLHRDVnIN 622 two-spot...
EDO38509            562 KelaVMVLSS----GACDFLVYLKDRLNTLQKLL-AYKLFSALWVDLARALNMLIYQEVIQECRYNEGGAAQLQFDM-KN 635 starlet ...
ELK01327            623 SeqaVMSLSS----SACPLLLTLRDRLLQLEQQL-CISLFKIFWQMLAEKLDIYIYQEIILANHFNEGGASQLQFDMtRN 697 black fl...
Q5RGZ9              619 SdqaTMSLSS----SACPMMLCLRDHLLQLQQML-CLPLFQMFWQGLAERLDCFIYEDLILYNHFNEGGAAQLQYDMtRN 693 zebrafish
XP_003972690        619 QdqsSMSLSS----SACPMMLCLRDRLLSLHQLL-GLSLFQLTWQGLAERLDHFLYQDVILANHFSDGGAAQLHFDMsRN 693 torafugu
XP_003455706        623 QdqsTMSLSS----TACPMMLCVRDRLLNLHQVL-GFSLFHLAWQGLAERLDNFLYQDVILCNNFSDGGAAQLQFDMtRN 697 Nile til...
XP_015207675        545 AdqaTMSLSS----SACPMMLCLRDRLLQLQQLL-CVPLFQSCWQGLAERLDLFIYQEVILSSHFNEGGAAQLQFDMtRN 619 spotted gar
WGS:AATM:SJAG_01166 531 dksyEGSISP----EAVGFDIALRRLINSIHEII-LGAPFFEIVCRIADIVEDWLLH-IMHTHQFSNRGAVQFARDSlQF 604 Schizosa...
Q9C0W8              529 aallSTSVSA----EIVGFQSRLKEIIALLQKLL-IGSSQCEAIYQIGTLVESWMIK-IVMTHQFSVRGGVQFAMDAmQI 602 Schizosa...
3FHN_A              629 LSSilsLPSHATN---YKCXSLHELVKILKLKYD------PN-NQQFlnpeyiktgnfTS-----LKEAYS--------- 684 baker's ...
XP_015787512        623 LFS---VFRVYTPnpeSLIIELVEACQLLNLAKGnslllqDTlRKGNvs--------------ddILKDFN--------- 676 two-spot...
EDO38509            636 LFT---LFGEYTQkpeNYYKEVKECCILLNQMPGsailliESlQAAHahdest-------napqaTLNEMG--------- 696 starlet ...
ELK01327            698 LFP---LFSHYCKrpeNYFKHVKEACIVLNLNIGsalllkDVlQsasgq-----------ppataALNEVG--------- 754 black fl...
Q5RGZ9              694 LFP---LFGHYCKrpeNFFKHVKEACIILTLKVGpallllDVlK--Qseedslpn--hqqsspesALNELG--------- 757 zebrafish
XP_003972690        694 LFP---LFGQYCKrpeNFFKHVKEACIILRLSVGsaillrNVlEEAEeetd---agdhERptlmsTLHELG--------- 758 torafugu
XP_003455706        698 LFP---LFGHYCKkpeNFFKHVKEACIILCLNVGsaillrSLiKESDmtrdcagt---gdpppesALNELG--------- 762 Nile til...
XP_015207675        620 LFP---LFGHYCKrpeNFFKHVKEACIVLSLSVGsalllrDVlQQGDsgsdvtsd--psqpspvaALNEVG--------- 685 spotted gar
WGS:AATM:SJAG_01166 605 LTA----FSDYPl---VQMKRLTSSLPLLTFEqtekl------------------------cikdLLRQINngdye---- 649 Schizosa...
Q9C0W8              603 VLE----FSDYPl---LKFERLMSTVELLSLESGenkl------------------------ikkLIIEINqknydfide 651 Schizosa...
3FHN_A              685 ------IK-Y--LKDTKIQDALYRI 700 baker's yeast
XP_015787512        677 ------VH-H--LSAKVAHKILSKR 692 two-spotted spider mite
EDO38509            697 ------VY-K--LSSHDALRILNLR 712 starlet sea anemone
ELK01327            755 ------IY-K--LAQHDVEILLNLR 770 black flying fox
Q5RGZ9              758 ------IY-K--LAPSDVQILLNLR 773 zebrafish
XP_003972690        759 ------VY-C--LAPCDVLYVLRLR 774 torafugu
XP_003455706        763 ------VY-C--LAPCDVLILLSLR 778 Nile tilapia
XP_015207675        686 ------IY-K--LSPGDVLILLNLR 701 spotted gar
WGS:AATM:SJAG_01166 650 --tlktINpEntLSPSESLDVLYRR 672 Schizosaccharomyces japonicus yFS275
Q9C0W8              652 ffktkeIT----LSYEDALGVLYRR 672 Schizosaccharomyces pombe 972h-
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