1IHN,2K2E,2GM2


Conserved Protein Domain Family
DUF498

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pfam04430: DUF498 
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Protein of unknown function (DUF498/DUF598)
This is a large family of uncharacterized proteins found in all domains of life. The structure shows a novel fold with three beta sheets. A dimeric form is found in the crystal structure. It was suggested that the cleft in between the two monomers might bing nucleic acid.
Statistics
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PSSM-Id: 398231
Aligned: 275 rows
Threshold Bit Score: 39.4393
Threshold Setting Gi: 74529048
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1IHN_B            7 CRFGSVTYRGREYRSDIVVHvdgsvtprrkeisrrkyGtSHVXAEEELEELleekpESIIIGSGVHgAL----------- 75  Methanotherm...
jgi:TOPB45_0251   5 YSFGSLSFKDKTYHKDLIIIktpkeek---ifpdwwrKeGHRLQVEDLEEVwkyslEYLIVGTGAHgVMkvdsevekkak 81  Thermodesulf...
WP_012546371      6 YSFGKIVVDGNEYTQDLIVFpdkif-------pswwrKeGHCLCIEDLAEVlknnvNILVVGTGAYeRMrvpaslieelk 78  Thermodesulf...
jgi:Ferp_2498     6 YSFGRIVVGGREYRSDVVVGdeiiv-------enwwrKeGHRVCVEDLDWLdkvdaEAVIFGTGAYgRVkvdeevvrlle 78  Ferroglobus ...
O30206            6 YSFGRIRIGGRDYTSDVIVGpdflk-------pnwwrKeGHRVFLEDIEEVfdlrpEVVVFGTGASgRVvvddavieklr 78  Archaeoglobu...
jgi:Arcve_0089    6 YGFGRIVVKGRTYTSDVIVFwdgsv-------kewwrKkGHYADINDVKSVldakpEVIVFGTGKYgAMkvdenavkele 78  Archaeoglobu...
WP_012940803      6 YSFGYIKLDGQEFRHDVIVYgdfvk--------kwwrKeGHRVQIEDIEDIlrlkpEIVVIGTGYYgVVkvdrdvierlr 77  Archaeoglobu...
WP_015591638      5 YDFGKLYIDKKLYTSDLILGregiin------krwwrKeGHRVQKEDIDDIlnrnsDIVIFGTGYHgVVkideevinlik 78  Archaeoglobu...
jgi:Igag_1034    13 YDFGVIVIDNKEYNRDIIISpslgii------enwwrEeGHRLKLIDIRDYllekaDLVVIGTGYDgMMyvdneviqwfn 86  Ignisphaera ...
jgi:Tpen_1116    19 YKFGRLVVGGRAYERDVIITpsgvv-------pnwwrLeGHRLQLEDVKKYlgldvDAVVVGTGYHgFMrvdsevvesfr 91  Thermofilum ...
1IHN_B           76 ETGFRsdATVLPTCEAIKRYNEERSAGRRVAAIIH 110 Methanothermobacter thermautotrophicus
jgi:TOPB45_0251  82 SLGIK--IEIYKTDLAVKRFNELYSSGVSLAGAFH 114 Thermodesulfobacterium geofontis OPF15
WP_012546371     79 QKGIE--TFVSNTEKAVDLFNQFMDEGKNVAGAFH 111 Thermodesulfovibrio
jgi:Ferp_2498    79 EKGVE--VIIEESSKAVEKFNELKKKGKKVVLAIH 111 Ferroglobus placidus DSM 10642
O30206           79 NLGAE--VIVERTDEAVKRYNKLLKAGRRVVLAAh 111 Archaeoglobus fulgidus
jgi:Arcve_0089   79 KMGIH--VEVDITERATKIFNDLVAAGKRAVLAAh 111 Archaeoglobus veneficus SNP6
WP_012940803     78 SEGIE--VVCEESRKAVETYNKLLEEGKKVALAIH 110 Archaeoglobus profundus
WP_015591638     79 QKGSE--VEVAKSRVAVEIFKKALSEGKNAILAIH 111 Archaeoglobus sulfaticallidus
jgi:Igag_1034    87 SRGIE--VKIARSREAVEIYNKAVEEGKKVLLFIH 119 Ignisphaera aggregans DSM 17230
jgi:Tpen_1116    92 RMGRE--VYVLETGRAVEKYNELVARGRRVLAMLH 124 Thermofilum pendens Hrk 5
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