Conserved Protein Domain Family
Bul1_N

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pfam04425: Bul1_N 
Bul1 N-terminus
This family contains the N-terminus of Saccharomyces cerevisiae Bul1. Bul1 binds the ubiquitin ligase Rsp5, via an N terminal PPSY motif. The complex containing Bul1 and Rsp5 is involved in intracellular trafficking of the general amino acid permease Gap1, degradation of Rog1 in cooperation with Bul2 and GSK-3, and mitochondrial inheritance. Bul1 may contain HEAT repeats.
Statistics
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PSSM-Id: 398229
Aligned: 18 rows
Threshold Bit Score: 464.53
Threshold Setting Gi: 74602596
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001482231 115 TDVNVNADLTTTLSG-TRTEYFHVLPSFQMF-QSILKR-DDAQFNESLSGEPPTYEDSRSASPVLsp---sLSPQTSATS 188  Meyerozyma gui...
CCC68197      99 sstetsRNLKNGTHGsTDNLLVDVLPSFDMY-NVLHRHiPQGNVNPDIHDFPPTYQEVQTHRDPV-------LSHDIADV 170  Naumovozyma ca...
Q6FP46       103 VAKSSTELNQMNTDSkDPNMIIDVLPSFEFY-NVLHKHiPQGNVDPDIHDFPPTYQEVQTQRLPA-------LQGSSSSQ 174  [Candida] glab...
EDK46067      66 NNSSATNIVATTSSN-TQTEYFDILPSFEMF-QSILKR-DDQQFQEDLTTVPPRYGDTAHSRSSRp-----TSPRLHAQL 137  Lodderomyces e...
EAZ63488      92 SSDSPIAPLSSVSSN-TQTEYFDVLPSFQMF-QSILKR-DDAQFSEDLQTLPPVYGDTTNSSPTP-------PGGLSPTT 161  Scheffersomyce...
Q6BJG5        93 SNSNETNLLSPASSN-TQTEYFDVLPSFQMF-QSILKR-DDSQFSENLSVNPPIYGDVTNSSPTPpsglspISSNRDNNL 169  Debaryomyces h...
EDK41712      36 DGGEFNEDDILRSEQaNQAPVWSILPSYHMY-KSLYMGmNAPTE--NIHE-PPTYEDVSHTSVSH-------TSVTTSSI 104  Meyerozyma gui...
Q6BVD1        28 SQNYFSQKDIELTKTtNEAPVWNILPSYHMYtTTIYKGfNVSDE--SLTE-PPSYETSSIHSAGRls---sVSTARSNSV 101  Debaryomyces h...
Q6BSG0         5 SKEKLKEKHNERILNeEDDLINNILPSYHMHqSTISKNlTPTNE--NFRVDPPMYEMTPVNSLST-------TPSVALSA 75   Debaryomyces h...
Q5ABB5        19 TPSRQASVSSRNQGDdEANELINILPSYQMYrSTITKNlTPSVE--DLRTAPPSYEVTPDLSTVQl-----HDYFASVPT 91   Candida albicans
XP_001482231 189 QSGHENHIDGLLLSTADRLN----------------------------EY---QMNDSAYQeqnfyfddsnd-------- 229  Meyerozyma gui...
CCC68197     171 GAATTATTTPNTTSLDHRVEilqdstqaaptls---stmvnlnnlhplNTr--HYNISNGAdlnssqs------------ 233  Naumovozyma ca...
Q6FP46       175 SGSELNVESPLRMNGSQTSIhgnfrnsssntllpttsgifggsslqpySTr--HYSLNPNQnnplhpt------------ 240  [Candida] glab...
EDK46067     138 S------IDQNLLQVSRRLEdtlqm------------------erdrqQEqmhEHAMVFVDetglmpvt----------- 182  Lodderomyces e...
EAZ63488     162 SATQGNSIDTIINDVSSRLE---------------------------------EYQLEREHeergdylfedddsehthts 208  Scheffersomyce...
Q6BJG5       170 DSMMENVSERINEYALDNNDeeenyffg-------------gdendtnQA---NEHLINEE------------------- 214  Debaryomyces h...
EDK41712     105 TASSLSLHNSDTTAPSSNDP------------------------------------------------------------ 124  Meyerozyma gui...
Q6BVD1       102 VAQASSVASTRETEDSNDNS---------------------------------QRLIIADE------------------- 129  Debaryomyces h...
Q6BSG0        76 IQSPTSNSSVDEFPFPNQEI---------------------------------HLGLEGGP------------------- 103  Debaryomyces h...
Q5ABB5        92 SPTLDPMLSEPLDAESAAVQ------------------------------------------------------------ 111  Candida albicans
XP_001482231 230 qpgpasstpryRGINEPT----DTYG-----HTVLDNIDRLPKSH------SsPIDVQIYVTKKVPLPNQ-KNELETRLK 293  Meyerozyma gui...
CCC68197     234 ----rasltmhDLNMQIE----DDLNds--dSIIIDRLYTLPKLA------T-PVDVEIRVTKDVSKPHA-KNEEESILK 295  Naumovozyma ca...
Q6FP46       241 ----vsgstavNDNTNIE----DDVNda--dNIAIDKLYSLPKFS------T-PLEIDIRITKHVPKPHE-KPEEESVLK 302  [Candida] glab...
EDK46067     183 ----stadansQVHNENLaitsDSYG-----HSPLDNIDRLQKAT------KsPFDIQIFVTKDVPRPNQ-ENELETKLK 246  Lodderomyces e...
EAZ63488     209 sdaesdhadehTHNENVA----VTMDry--gHSPLDNIDRLPKLT------NsPIDIAIYVTKSVPQPHH-KNELETRLK 275  Scheffersomyce...
Q6BJG5       215 -----------NTPVATN----DTYG-----ETVLDNIDKLPKLN------NsPIDIQVYVTKRVPQPNL-PNDLETRLK 267  Debaryomyces h...
EDK41712     125 ------------RVIVAD----ENTNdw--qNTLLDNIHQLKNLTfsnnkyAkSLNVSVHFTKEVGKLGKkPTYIDPSVY 186  Meyerozyma gui...
Q6BVD1       130 -----------------------DTNlw--rETILDNVHKLTNLTyfnkevSnAVKISIQFTKEVGELGKePILIDSRLH 184  Debaryomyces h...
Q6BSG0       104 -----------------------NFWe----NTILANAHKLPNLNrsdnkiCqDLEIDMKVTEKVCQKGVkPTIIDPLEY 156  Debaryomyces h...
Q5ABB5       112 ------------------------QDgeqddETILENAHKLKRLTstnkeiSkSLEVKIRLTEHIGKVGEpYTLVDPLTL 167  Candida albicans
XP_001482231 294 EYSSGDVVNGYIIITNTSDSVVNFGLFTVSLEGTIKATERmdndgtqsphRYKKVLMKKFLKMYDLNASYGYTHIPSSVG 373  Meyerozyma gui...
CCC68197     296 EYTSGDIIHGYCTIENRSSKRLKFEMFYVTLEAYISIIDR----------KKGKRVVKRFLRMVDLSASWSYTTIDLGSG 365  Naumovozyma ca...
Q6FP46       303 EFTSGDIIHGYCVIENRSTQPLKFEMFYVTLEAYISIVDK----------QKGKRTIKRFLRMVDMSASWSYSSMQVSSG 372  [Candida] glab...
EDK46067     247 EYTNGDHVNGYVIVTNTSSKPVKFGLFTVSLEGTIKSLERsanp---lqqRYRKILMKKILKMYDLCAGYSYGYVPSSAG 323  Lodderomyces e...
EAZ63488     276 EYTSGDMVNGYIIITNNSNKPVDFGLFTVSLEGTIKATERnthaeaneahKYNKILMKKFLKMYDFNASYGYTDVPNSAG 355  Scheffersomyce...
Q6BJG5       268 MYSSGDLVNGYIIITNTSDEPVDFGLFVVTLDGTIKTTHSnpnanpadihKYDKVLIKKFLKMYDLNASYGYTQIPNSAG 347  Debaryomyces h...
EDK41712     187 EYKQGDTVNGHILIENTSDEKIRFDMMYVVFEGSFLVANAkn------kkDRVPVKVKQFLQMFDFTASWNHGNIDRLIT 260  Meyerozyma gui...
Q6BVD1       185 EYKQGDLINGFVLITNESNEPIPFDMFYVLFEGNLTVANTld------vnDRKPSKVERFLQMFDFSASWNHAYINRLIT 258  Debaryomyces h...
Q6BSG0       157 EFKQGDYIHGYVTMKNKSPVPILFDMVYVVFEGMLVVLENnrg----lmdVKKPSKVHKFLTMLDLFASWSYANIARLST 232  Debaryomyces h...
Q5ABB5       168 ELKQGDYIYGFVLITNKTSNVIPFDMFSVQLEGCAIFGKtnn-----stlVEQPSHIDRFLNMFDFNASWNDAFLDRLVT 242  Candida albicans
XP_001482231 374 VE-----YKEYTRD-NEGCILGLPNERILQPHQKYKKFFTFTFPEKLLDNNCM-HLILPHVLPPPSFGFDKSSFYHRGEN 446  Meyerozyma gui...
CCC68197     366 IN-----VLPGQLDrYDNTIIGLENNRILEPNTKYKKFFMFKLPNQLLDVTCK-HEQYAHCLLPPSFGIDSYKNGGKYSQ 439  Naumovozyma ca...
Q6FP46       373 IE-----YVPGDVD-FDDSILGLSNSRTFLPKTKYKKYFMFKIPDQLLDVTCR-QEIFPHCSLPPSLGIDKWKDNGKYSI 445  [Candida] glab...
EDK46067     324 IE-----FVPFTEDsYDGCEIGLPDDRILQPHRKYKKFFTFRFPQRLLDNDCP-DAIFLHLLPPPSVGVDKTSFYNRGEG 397  Lodderomyces e...
EAZ63488     356 IE-----YEAFSIDaSDGCVIGLPNERVLKPSTKYKKFFTFRFPNRLLDNSCI-HSILPHILPPPSMGVDSTCFYNRGQS 429  Scheffersomyce...
Q6BJG5       348 IE-----YEAFTKDlHDGCELGLPNERVLRPHTKYKKFFTFKFPHKLLDNNCI-HDVLPHILPPPSMGLDKTCFYNRGGT 421  Debaryomyces h...
EDK41712     261 ESsh-pyTCPNIVDpIDNAKLAV-KDRTIHPGNVYKRFFTFKIPAQLLDSECS-HNLSGHTHIPPSLGSSRQEQAKYSSK 337  Meyerozyma gui...
Q6BVD1       259 EYan-ayECPLITDsYDDTKMGF-SNRKLLPGVTYKRFFTFKIPENLLDSECG-HSLLDHTQIPPSLGKSRSEDYVNLTY 335  Debaryomyces h...
Q6BSG0       233 DDgdphdWCYGETDpYDNTVLSIDVKRFFQPNVTYKRFFTFKIPEKLLDNTCEeHTFSIHTEIPPSIGISRTSTTPSSLL 312  Debaryomyces h...
Q5ABB5       243 EHnd-ptHIGTIYDpIDGTYYHLDHRKILEPGITYKKYFTFKIPEKLLDSACE-HSLIKHLQIPPTFGVCKNEVISSLRH 320  Candida albicans
XP_001482231 447 VSLNKALGYGYLDIRGTPL-----------LTRDYSFDDISVSYAIEAKFIDKIdakdqneav-feheindpSSDSSYTI 514  Meyerozyma gui...
CCC68197     440 IKVNSVLGCGHLGVKGSPI-----------LTSDLCDEDVSINYTIDARIVGKD------------------KKSQKLNI 490  Naumovozyma ca...
Q6FP46       446 IKVNNVLGCGHLGTKGSPI-----------LTNDITDENLSINYTIDAKIVGKE------------------KKTSKLNI 496  [Candida] glab...
EDK46067     398 IVINKALGYGSLNLRGTPI-----------LTKDYSFEDMSVSYAVEAKIIDNVrtkdavs-----hdeindAKRQDYVI 461  Lodderomyces e...
EAZ63488     430 IQMNKALGYGFLNIRGTPL-----------LTKDYSFEDVSVSYTIEAKFIDRIdgkeqhnel-sereindpNSEADYAI 497  Scheffersomyce...
Q6BJG5       422 IVLNKALGYGFLNVRGTPL-----------LTKDYSFDNISVSYTIEAKFIDKLnaknqkdpl-sqheindpNSQADYVI 489  Debaryomyces h...
EDK41712     338 QMQTMR-------------------------VRDLSFVDTSISYGVMTRIIGRSsmynldendesegtrlinSTGDEFVI 392  Meyerozyma gui...
Q6BVD1       336 KPDATK-------------------------TKSLSFIDTSISYGVQARFIGRAskynvnqsk-kndpvlinSKGDEYVI 389  Debaryomyces h...
Q6BSG0       313 VSNNGQ-------------------------IKDFSILDTSISYSVNARVIGKAsdy------------khsLDRDQYVV 355  Debaryomyces h...
Q5ABB5       321 KWKDQQ--------NGAPeetaskkykyaslTNDFAFNDTSISYCVSARVIGRAsgyqhlfgs-lggvhainDKNDEYVV 391  Candida albicans
XP_001482231 515 SRSQQYFLRFIPDIKEqildyynqGYQYGFETFGTlgiggkLFHDYIHQSTWQAikDLNHQIEKEIDTKLN-KEAt-qDE 592  Meyerozyma gui...
CCC68197     491 MKEKEYNLRVIPFGFT--------STMTNRNVYSK------QLKDLQLLIQERI--NALEAVFAKLKNNEP-ITT---SD 550  Naumovozyma ca...
Q6FP46       497 MREREYNLRVVPFGFNt------pSPVQSNLRSKS------QLKELKRLLNERI--AALERVFERLKKNEP-IQN---AD 558  [Candida] glab...
EDK46067     462 SKSAQYYLRFIPe----------qIPFQGISNARK------FLEQYQDDQTWMSirEQNNRLEKDIEKKLTgNVSveeMK 525  Lodderomyces e...
EAZ63488     498 SKSSQYFLRFIPDLKEqfqy-yntSFHYTPESYENsgidgkLFLDYLHLSTWRFvnLQNYQLEKEINDRLA-RQDltqEE 575  Scheffersomyce...
Q6BJG5       490 SKHSQYFLRFVPDFKEkfky-yneGFQYGTETFGAigidgkLFESYLHLSTWRQiyELNYNIEKEIDSKLA-REEfkdDD 567  Debaryomyces h...
EDK41712     393 LKEQNEFMRMVPEPMGns----ldEHLMKVTESKM------LHDNLVNRLQQKI--DMGNSILEAMKNGNY-DFA---ID 456  Meyerozyma gui...
Q6BVD1       390 LKETNRFLRIVPQVRYlt----pnQKAIKRKGSQI------LYKNLINRCKEKI--KIGHELIQSIEANKM-DNA----- 451  Debaryomyces h...
Q6BSG0       356 AKEATCSIRVIPQNSIny----ihYNNPRNQGNIL------YYKAFVDSIKSKI--EYGNALLNLPSEQRD-APD----- 417  Debaryomyces h...
Q5ABB5       392 ATEDYKYLRVIPVTKAiv----qlNRSMIHQEARL------LYTNMVDKIKEKI--ALGRDIMIANQQQNS-LSP----- 453  Candida albicans
XP_001482231 593 LKELNLVVHS 602  Meyerozyma guilliermondii ATCC 6260
CCC68197     551 LHSTDLSGTi 560  Naumovozyma castellii CBS 4309
Q6FP46       559 IYGTDISGTI 568  [Candida] glabrata
EDK46067     526 MKNFRISGSH 535  Lodderomyces elongisporus NRRL YB-4239
EAZ63488     576 IKNKNLMSIN 585  Scheffersomyces stipitis CBS 6054
Q6BJG5       568 VKKKNLSIDR 577  Debaryomyces hansenii
EDK41712     457 ISDQER--TL 464  Meyerozyma guilliermondii ATCC 6260
Q6BVD1       452 ------IDLI 455  Debaryomyces hansenii
Q6BSG0       418 -----ISPLV 422  Debaryomyces hansenii
Q5ABB5       454 --------VS 455  Candida albicans
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