5JKN


Conserved Protein Domain Family
MINDY_DUB

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pfam04424: MINDY_DUB 
MINDY deubiquitinase
This entry represents a group of deubiquitinating (DUB) enzymes known as the MINDY family (MIU-containing novel DUB). Ubiquitin (Ub) is released one molecule at a time from the distal end of proteins with Lys48-linked polyubiquitin chains. Long polyubiquitin chains are preferred. The catalytic Cys and His residues have been identified by site-directed mutagenesis, as has the Gln that participates in formation of the oxyanion hole during catalysis. Despite the structural similarity to papain-like cysteine peptidases, a residue corresponding to the Asn that orientates the imidazolium ring of the catalytic His has not been identified. Members of the MINDY family of DUBs contain an MIU (motif interacting with Ub) motif, which is a helical motif that binds mono-Ub.
Statistics
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PSSM-Id: 398228
Aligned: 89 rows
Threshold Bit Score: 73.7229
Threshold Setting Gi: 122022786
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5JKN_A          49 NILFLQWK--------VKLPPQKEVITSDELMAHLGNCLLSIKPqekseglqLnfqQN----VDDAMTVLPKLATGLDVN 116
Q6FS58          35 NALVLSQGhnrvtsqlKSIFDNCNEIAVEDLLDELANIGLQLGV--------M---SNygqdKEQLIATLKEFRKGLHIN 103 [Candida] gla...
XP_001647270    35 NILLISPAhaafatdlVNFVQRSEIVSLQDLVQVLANIGIQNPN--------G----Anv-dVNQLLQLLPQLHTGLNIN 101 Vanderwaltozy...
XP_002498360    35 NTLLLAPRyaaearelATLAQHS-SVKLEDLVQVLANIAIMSPN--------G----Ant-dVNQLFQILPQLHTGLNVN 100 Zygosaccharom...
XP_003682729    35 NVLLLAPRqasvaqelIYLVRRSDTVYLQDLIQVLANIGIQDQN--------G----Ads-dVTQLLQLLPRLHAGMNIN 101 Torulaspora d...
XP_002556083    35 NVLLLSPQyaryvgalSRLVETRTDVGLDELITTLANIGMQMPR--------G----Aqs-dVNRLLELLPQLHTGLTIN 101 Lachancea the...
ybcl:Ecym_2223  35 NVLLICPNnskhseelKKLV-EQPVIKLQDLVTALADIAVQNTG--------E----Syk-dTDQLLRLLPQLHTGLSVN 100 Eremothecium ...
Q754Y2          35 NVLLLSPNyaettsqlRNLA-QAPTVTLRDLVAVLADIAMQLGG--------D----Shr-dMDRMLELLPKLQTGLLID 100 Eremothecium ...
Q6CML6          33 NVLVLSPQhkldanelIQLINSNRKVTLEDLITTLANIGVMMDN--------G----Qse-dVNELLQLLPQLHTGLNVN 99  Kluyveromyces...
XP_004178862    33 NVLLLSPAhrpaaqllVTLVNQSNTISLDSLVQTLSELGLYAHG--------S----Std-dISSLLQLLPKLHKGLVID 99  Tetrapisispor...
5JKN_A         117 VRFTGvsDFEYTPECSVFDLLGIPLYHGWLVDp-qSPEAVRAVGKLSYNQL 166
Q6FS58         104 PKFNG--SFTDSLETSVFSGFNVALVHGWVVDgdrDPTSYYHLSKYSYEEA 152 [Candida] glabrata
XP_001647270   102 PTFNG--SFAEGIEMSLFRLYNVGIVHGWIIDpevDPIAFQHVSRYSYEEA 150 Vanderwaltozyma polyspora DSM 70294
XP_002498360   101 PIFNG--SFEDGIEMAIFRLYNVGIVHGWIIDgdsDPIAREHVSKYSYESA 149 Zygosaccharomyces rouxii
XP_003682729   102 PKFNG--SFGDGVEMSIFRLYNVDIVHGWIIDsssDPVAYEHVSKYSYEEA 150 Torulaspora delbrueckii
XP_002556083   102 PVFNG--SFEDGDEMALFRLFNVSIVHGWVADyaeDRGQYEHVSKYSYEGA 150 Lachancea thermotolerans CBS 6340
ybcl:Ecym_2223 101 PAFDG--SFTDGAEMSLFRLFQVSLVHGWLLGpenFPQDYEKLSRYSYEDA 149 Eremothecium cymbalariae DBVPG#7215
Q754Y2         101 PAFNG--TFREGDEMALFRMFQVGLVHTWLMDvsqAPQDYSRLSQCSYEEA 149 Eremothecium gossypii
Q6CML6         100 PAFNG--TFQDDQALALFRLFQVSLVHGWIVDptrNEQQYHSVSHYSYDDA 148 Kluyveromyces lactis
XP_004178862   100 PAFNG--SFTDTKEMALFRLFGVGMVHGWVIDpqlDPLAYDIVSKYSYDST 148 Tetrapisispora blattae CBS 6284
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