Conserved Protein Domain Family
SIMPL

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pfam04402: SIMPL 
Protein of unknown function (DUF541)
Members of this family have so far been found in bacteria and mouse SwissProt or TrEMBL entries. However possible family members have also been identified in translated rat (Genbank:AW144450) and human (Genbank:AI478629) ESTs. A mouse family member has been named SIMPL (signalling molecule that associates with mouse pelle-like kinase). SIMPL appears to facilitate and/or regulate complex formation between IRAK/mPLK (IL-1 receptor-associated kinase) and IKK (inhibitor of kappa-B kinase) containing complexes, and thus regulate NF-kappa-B activity. Separate experiments demonstrate that a mouse family member (named LaXp180) binds the Listeria monocytogenes surface protein ActA, which is a virulence factor that induces actin polymerization. It may also bind stathmin, a protein involved in signal transduction and in the regulation of microtubule dynamics. In bacteria its function is unknown, but it is thought to be located in the periplasm or outer membrane.
Statistics
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PSSM-Id: 398209
Aligned: 622 rows
Threshold Bit Score: 29.5844
Threshold Setting Gi: 159889606
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EHY54739        19 DGRATICKVAERASLTVDISDSGYDKEKVAKNVIETANTLQEEldrlCP------------RiDwavVgQHstIagdDfs 86  Exophiala der...
AGN26246         9 KGIGRMSVKPDQIQLNLELKAENKDYSLMMNEANAKLDSLTAS----LVsagfsaddlktgAiSidaKyDYvrK------ 78  Candidatus Me...
jgi:Ilyop_0758  29 QGNSQVSAVPDTVTITAMAETRDIELSKAANENNKIIRNAREF----LLr-----------E-G---I-RK--D---E-- 81  Ilyobacter po...
jgi:Solca_0164  30 DGNASLKVQPDIAVINFQIEALDTVQAKSLSKLNLETQKVLEI----LT------------SgGfs------dK---S-- 82  Solitalea can...
jgi:EAT1b_0973   8 KGTGNVSSRPDLIVIHMDLVSKAPRYEDTMTEAASAVSHLQKA----IT------------RaGfd------kT---D-- 60  Exiguobacteri...
CDC74576         8 IGEAEISAKPDTVVLDLSVSAHERDYEPTARAAAEQADRLYGA----VR------------KaGfs------dS---D-- 60  Firmicutes ba...
CDA51515         8 RGVGNISAKPDFIVIEMHIMGQSKNYSEALAEASSAVEAVCNA----AV------------SaGhs------kD---A-- 60  Clostridium s...
CBK98828         7 KGTGNVSARPDYIILSLNIETLSKTYDHAMSEATERIERLQGA----AV------------CvGyh------kE---D-- 59  Faecalibacter...
9_pfamImport     4 TGKGKLAVKPDLIELTLSIKDIKKEYNELLKRSSSATNEVKEL----LE------------KiGfe------rK---N-- 56 
WP_012291091     8 KGKGKISVKPDTIKVTIKAEGLRWNYDETIEQSTYDTKMLRDA----LE------------KaGld------pK---N-- 60  Finegoldia magna
EHY54739        87 tedfggggsTalDNDHispdAPV-SFYSIsslttssrteqlkrdddsdddddsdddmsdndnnrrkVRKRKI---YT--- 159 Exophiala der...
AGN26246        79 ----------------------------------------------------------------------------Ddga 82  Candidatus Me...
jgi:Ilyop_0758  82 ---------I--YTSR----YTVsQQIERl------------------------------------SKNVPGvrkYF--- 107 Ilyobacter po...
jgi:Solca_0164  83 ---------I--KISE----YTIeSTSDSeie--------------------------------nkKNYTSK-------- 107 Solitalea can...
jgi:EAT1b_0973  61 ---------L--KTSD----FSIdTEYESyrd--------------------------------rdENYRSRfvgYV--- 90  Exiguobacteri...
CDC74576        61 ---------L--KTAD----FSVnTAYKNvrd--------------------------------enGNYGSVfdgYR--- 90  Firmicutes ba...
CDA51515        61 ---------L--KTIN----FGVsSEYDSvrn--------------------------------skGTYQRVfvgYN--- 90  Clostridium s...
CBK98828        60 ---------L--KTTS----FDVqTRYENvkd--------------------------------rqGNYKREfvgYA--- 89  Faecalibacter...
9_pfamImport    57 ---------I--KTKS----FDInIEYDSyrd--------------------------------knDKWVEEfkgYS--- 86 
WP_012291091    61 ---------L--KTTH----FSIdSKYERyhd--------------------------------knDDYKDRfvgYK--- 90  Finegoldia magna
EHY54739       160 ---------AETSIDV---RF---RDFvkLGEVV--------------VQWsAtpyvqLSgiDWsltdDSA------AVM 204 Exophiala der...
AGN26246        83 qireftgyvYSQTISVkfpMS-----LdlLSEAVs------------sISCsS-----VSpeLSisfmLADrdsirdDLL 140 Candidatus Me...
jgi:Ilyop_0758 108 ---------VKNQIVI---TSk-kIDK--IGEIItalekak-innvqgLSY-S-----SS--KS----KKYe----kEAM 155 Ilyobacter po...
jgi:Solca_0164 108 -----------NSLNI---EFllnRNA--INELIkqiersklsnttfyVSF-K-----IS--------EQKs----qEIK 153 Solitalea can...
jgi:EAT1b_0973  91 ---------CKQKTKL---EFaldTSK--LSDVIeqisqsr-anpklsIRF-T-----MK--------DPn------AIE 135 Exiguobacteri...
CDC74576        91 ---------CVQRFTL---GFptdMAR--LAQTLsyigscg-adpdvrISF-T-----VR--------DTe------MLK 135 Firmicutes ba...
CDA51515        91 ---------CSYNTRL---SFdfdRDM--LERTLnaiaesk-aepelsIRF-T-----VR--------DDs------AVK 135 Clostridium s...
CBK98828        90 ---------CSYRLKL---AFdfdSKQ--LAKIIsaiadcg-akpelsIAF-T-----VR--------NPS------AVS 134 Faecalibacter...
9_pfamImport    87 ---------FIHKMKI---EFeanNKM--LGRVLytlskst-sypsfsISY-T-----VS--------NPe------KYK 131
WP_012291091    91 ---------YEHRTYI---EFendNKI--LGKVLyelancn-vkvkfeINH-T-----VK--------DKe------KVK 135 Finegoldia magna
EHY54739       205 DEqvrvtALRNAIRRAKKYAA----IIaEdcnsgpgkavpvhvhPvKIqddrsiwakgltkqtarkata----------- 269 Exophiala der...
AGN26246       141 KL-----AAEDARHKAEVITKasgtLL-G-----------------SVkeisydiegckihapanrmv------------ 185 Candidatus Me...
jgi:Ilyop_0758 156 VL-----AYKDAKEKAEAIAA----LE-N---------------Y-SIipmsinssvyfprntnymvqa----------- 198 Ilyobacter po...
jgi:Solca_0164 154 QElt-rlAITDAKRKADLIAEs-----lK---------------L-TIkgiklidsstdsplyglnrsgyrnvkftppvv 211 Solitalea can...
jgi:EAT1b_0973 136 DQll-vsAAENAKKRAELLAKg-----aG---------------A-ELgdllqidytwgeihlfsptnvly--------- 184 Exiguobacteri...
CDC74576       136 ERll-teCTVSARKKAEILCRg-----lG---------------V-MPgevisvkcgdcqpdfmsatgfsvg------dr 187 Firmicutes ba...
CDA51515       136 SAll-eaAAENAREKAQILCRa-----sG---------------V-ELgrlltvnydwseidlisptgyai--------e 185 Clostridium s...
CBK98828       135 EKll-isATENARAKAEILCKa-----sG---------------S-TLgqllnidynwgelnvysrtsyeved-----ci 187 Faecalibacter...
9_pfamImport   132 NKll-enAINNSKEKAIVLANa-----sG---------------V-KLgnilsidyswselrissspfenkk------wf 183
WP_012291091   136 NDll-ekAVEDSTTKAKVLAKa-----sG---------------V-KLkeilnidyswgeieiysepmdd---------- 183 Finegoldia magna
EHY54739       270 --naafgigagidfepkviegtVDIKVEF 296 Exophiala dermatitidis NIH/UT8656
AGN26246       186 --lrscsseamadmtpeeivveESVFFVW 212 Candidatus Methanomassiliicoccus intestinalis Issoire-Mx1
jgi:Ilyop_0758 199 --dsfskaapapiytpktiditGNINVTF 225 Ilyobacter polytropus DSM 2926
jgi:Solca_0164 212 iknegihdsafkttdieeieisENIRITF 240 Solitalea canadensis DSM 3403
jgi:EAT1b_0973 185 sqdvvysesrmpelepddidvsDSATFVW 213 Exiguobacterium sp. AT1b
CDC74576       188 vmplmakagcaenmtpedvkisESVSFVF 216 Firmicutes bacterium CAG:272
CDA51515       186 raslkrsaavpdciepedikvrDTVAFVW 214 Clostridium sp. CAG:138
CBK98828       188 qplmamskcsapeiepddidvsDTVAFTW 216 Faecalibacterium prausnitzii L2-6
9_pfamImport   184 feedndesdyvidveiddidvtDTVTVIW 212
WP_012291091   184 lmvceaassydidieaddidvqDTVTITW 212 Finegoldia magna
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