3U97


Conserved Protein Domain Family
BrnT_toxin

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pfam04365: BrnT_toxin 
Ribonuclease toxin, BrnT, of type II toxin-antitoxin system
BrnT is a ribonuclease toxin of a type II toxin-antitoxin system that exhibits a RelE-like fold. The antitoxin that neutralizes this toxin is pfam14384. BrnT is found in bacteria, archaea, bacteriophage, and plasmids. BrnT-BrnA forms a 2:2 tetrameric complex and autoregulates its own expression, which is induced by a number of different environmental stresses. Expression of BrnT alone results in cessation of bacterial growth which can be rescued after subsequent expression of BrnA.
Statistics
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PSSM-Id: 398183
Aligned: 260 rows
Threshold Bit Score: 39.7942
Threshold Setting Gi: 557039216
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3U97_A          38 WDEPKRQTN---IAKHGLDFADLHFEFF-LSAKVFPTKa------DRLXAIG-EFNGLiIIAVIFKPV----GsEALSVI 102
jgi:Dbac_0729    8 WDSG----NwpkCGKHGVSREEIEQVLLgEPAVMPDPCpd----ePRMRAIGkTQAGR-YVFLVFMLReidgW-TKLRPV 77  Desulfomicrob...
WP_025374647    12 WDVG----NwpkCGKHGLSRAEVEEVFEgPLMLMTDPHlg----qQRMRAIGkTRSGR-YVFLVFVIRavngR-HLIRPI 81  Advenella mim...
CBL43737         8 WDNG----NwpkCGKHGVSREEIERLSLeGQVHVVPDLthttpaeSRHIAAG-GVDGR-PMFVAFAFR----G-NFIRPI 76  gamma proteob...
jgi:Anacy_2056   9 WDEG----NsakCWNR-VSQEEIEYLFHqNDILITPDIrhs-edeDRYLAIGvSCKGR-HIFVAFTFRnqqeQ-RLIRPI 80  Anabaena cyli...
Q9AAV4           9 WDDG----NrekCQKHGVSIAEIEAVLl-GDPLVAPDLahs-dveDRRIAVGkTPEGR-AMFIAFTLRtkdgK-LHLRPV 80  Caulobacter v...
WP_012509071     8 WDSG----NrakCQKHGVSIAEIESLFl-GTPLVAPDVlhs-sneQRFRAVGrTIKKR-YLFIVFTLRnkgeT-LLIRPI 79  Pelodictyon p...
WP_009546273    10 WEEG----NetkCQKHGVTLEEIEG-FFqTQIYVAPDIkhs-qdeDRFLAVGrLPSGR-PLFVAFTLR----N-NLIRPI 77  Crocosphaera ...
tigr:ACP_0633   18 WDEWNAKKN---WDRHAVTPEEAEDVFFnDPLIVRSESpsk-greKRYWALGqTSNGR-RLFVVFTVR----R-KLVRVI 87  Acidobacteriu...
jgi:Mnod_7347    9 WDGGKAAAN---LAKHNVSFPFAAAVFLdPERVEFDAShdg-dgeERRKAVG-QIGPR-LFTVVFTLR----G-DRVRLI 77  Methylobacter...
3U97_A         103 SXRSASQKE 111
jgi:Dbac_0729   78 SARYMHKKE 86  Desulfomicrobium baculatum DSM 4028
WP_025374647    82 SARYMHQKE 90  Advenella mimigardefordensis
CBL43737        77 SARYMHAKE 85  gamma proteobacterium HdN1
jgi:Anacy_2056  81 SARYMHEKE 89  Anabaena cylindrica PCC 7122
Q9AAV4          81 SARYMHAKE 89  Caulobacter vibrioides
WP_012509071    80 SARYMHTKE 88  Pelodictyon phaeoclathratiforme
WP_009546273    78 SARYMHEKE 86  Crocosphaera subtropica
tigr:ACP_0633   88 SVRDQNRRE 96  Acidobacterium capsulatum ATCC 51196
jgi:Mnod_7347   78 SARRSNRSE 86  Methylobacterium nodulans ORS 2060
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