1VL0,1KC3


Conserved Protein Domain Family
RmlD_sub_bind

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pfam04321: RmlD_sub_bind 
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RmlD substrate binding domain
L-rhamnose is a saccharide required for the virulence of some bacteria. Its precursor, dTDP-L-rhamnose, is synthesized by four different enzymes the final one of which is RmlD. The RmlD substrate binding domain is responsible for binding a sugar nucleotide.
Statistics
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PSSM-Id: 398150
Aligned: 23 rows
Threshold Bit Score: 323.059
Threshold Setting Gi: 81534189
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1VL0_B    15 ILITGANGQLGREIQKQLKG-KNVEVIPT-DVQ-----------DLDITNVLAVNKFF---------NEkKPN--VVINC 70  Clostridium acetobu...
Q5ZXH4     3 ILVTGANGQVGTEIIKRFSS-SEHEVYAC-TRD-----------ILDCSKLERVHDVL---------SEiKPD--LIINA 58  Legionella pneumoph...
Q8F5L8     2 IYYTGKNGQLGWELAERFKS-NGLEAVGF-GRE-----------EWDLADLDSAARIL---------KD-SPR--ILVHC 56  Leptospira interrogans
Q9K7J6     4 LLITGANGQVGMELSKQGK--QHFQVTAL-TKQ-----------ELNILDRNTVMNKI---------KGvNPD--WIIHV 58  Bacillus halodurans
O27820     3 ILITGSSGMLGSDLVDILSR-RHEVVTSG---------------SLDIRDLEGVMELL---------REtRPD--AVVHA 55  Methanothermobacter...
Q9YCT2     3 LLVTGGTGLLGYNLVQQLLK-KGYSVYPTyNKNtpfklagarwsKVNLEDPSQLTQLF---------RDiKPD--AVIHT 70  Aeropyrum pernix
Q99LB6    31 VLITGATGLLGRAVYKEFQQ-SNWHTVGCgFRRarp-----kfeQVNLLDSEAVHHLI---------HDfQPH--VIVHC 93  house mouse
CAM05648   8 VLVPGGRGQVGSELRRIVSGwSGALVHAP-GSG-----------ELDVTDAEAVADAVdsfaetardSDlRP---VVVNA 72  Saccharopolyspora e...
Q9CCK8     8 LVITGAGGQLGSALAAQATA-AGRDVLAL-TSS-----------QWDITDAAVAERMG---------RSaLKKndVVVNC 65  Mycobacterium leprae
P9WH09     8 LVITGAGGQLGSHLTAQAAR-EGRDMLAL-TSS-----------QWDITDPAAAERII---------RH--GD--VVINC 61  Mycobacterium tuber...
1VL0_B    71 AAHTAVDKCEEQYDLAYKINAIGPKNLAAAAYSVGAEIVQISTDYVFDGE--------AKEP-ITEFDEVNPQSAYGKTK 141 Clostridium acetobu...
Q5ZXH4    59 AAYTAVDKAEDEPDLAHIVNAEFVCRLVNYCTLKNVPLIHLSTDYVFDGE--------KEGA-YHETDIPHPVSTYGRTK 129 Legionella pneumoph...
Q8F5L8    57 GAYTAVDKAESDSENAYKINSLSVKKISEECLKRKIHLIYVSTDFVFDANset--igdTIRF-WKPDSTLSPKGIYGLSK 133 Leptospira interrogans
Q9K7J6    59 AAFTAVDQCEDEQRKAYHVNGLGAANVARAARETGAKLIYISTDYVFDGN--------KNSP-YETCDLPNPLNVYGNSK 129 Bacillus halodurans
O27820    56 AAFTDVDCAETERDKAYQVNVLGTRNIAAAASAVGSSILYISTDYVFDGE--------KGDG-YLEFDEPNPLNFYGKTK 126 Methanothermobacter...
Q9YCT2    71 AAYTDVDGCELHRERAYRINFLASMTVARLAARHGSLLIYVSTDYVFDGD--------KGM--YREEEAPNPINYYGLSK 140 Aeropyrum pernix
Q99LB6    94 AAERRPDVVESQPDAASQLNVGASGNLAKEAAAIGAFLIYISSDYVFDGT----------NPpYTEEDIPSPLNLYGKTK 163 house mouse
CAM05648  73 AAYTAVDAAEEEPDRSAAINVAGAAALADACGRRGVPLLHISTDYVFPGD--------ATRP-YEPDDETGPRTSYGRTK 143 Saccharopolyspora e...
Q9CCK8    66 AAYTNVDGAESNELAAYAVNATGPEYIARACRCAGAALIHVSTDYVFSGDfgsganrvAPRP-YEPTDETGPLGVYGRSK 144 Mycobacterium leprae
P9WH09    62 AAYTDVDGAESNEAVAYAVNATGPQHLARACARVGARLIHVSTDYVFDGDfg----gaEPRP-YEPTDETAPQGVYARSK 136 Mycobacterium tuber...
1VL0_B   142 LEGENFVKA---LNPKYYIVRTAWLY-GD----GNNFVKTXINLG--KTHDELKVVHDQVGTPTSTVDLARVVLKVIDEK 211 Clostridium acetobu...
Q5ZXH4   130 WEGEQAILS---QLKKYIILRVSWVF-GEq---GKNFVKTILNLA--SSRKELNIVSDQSGRPTSARDIARVLFEIVQKI 200 Legionella pneumoph...
Q8F5L8   134 AEGEKWIRNtfvDSKQANIVRTSWVY-SSh---GNNFPKTIVKLLqdSNRHELRVIEDQLGRPTWAGRLADFIIFLIYGI 209 Leptospira interrogans
Q9K7J6   130 WLGERLVQK---YVKTCTIARTSWLY-GHy---GGNFVKTMLRLL--RKGEPIEVVADQVGCPTYVNDLVYYLFALMEKP 200 Bacillus halodurans
O27820   127 YLGEVSVRQ---LSERFYIVRTSWLF-GRn---GRNFVGTMVELA--ERGHEISVVDDQYGSPTYTRDLAAAIGNLLERP 197 Methanothermobacter...
Q9YCT2   141 LLGEVATLSa-mDKENVLVVRVSGLY-GYsptgKRNFGINVLEKL--LRGEEVRAFYDQYLSPTYTYFLSRRLIDVLERE 216 Aeropyrum pernix
Q99LB6   164 LDGEKAVLE---NNLGAAVLRIPVLY-GEveklEESAVTVMFDKVq-FSNKSANMDHWQQRFPTHVKDVASVCRQLAEKR 238 house mouse
CAM05648 144 LDGERAVLD---SGARAWVVRTAWVY-GAg---GKNFVKTMARLE--SERDTLSVVDDQVGCPTWAADLAAGLLELAGRV 214 Saccharopolyspora e...
Q9CCK8   145 LAGEQAVLA---AMPEATVVRTAWVYtGGt---GKDFVAVMRRLA--AGDGPVYVVDDQIGSPTYVVDLAAALLQVADGS 216 Mycobacterium leprae
P9WH09   137 LAGEQAVLA---AFPEAAVVRTAWVYtGGt---GKDFVAVMRRLA--AGHGRVDVVDDQTGSPTYVADLAEALLALADAG 208 Mycobacterium tuber...
1VL0_B   212 N------YGTFHCTCKGICSWYDFAVEIFRLTGIDV------KVTPCTTEEFPRPAKRPKYSVLRNYXLELTTGDITrEW 279 Clostridium acetobu...
Q5ZXH4   201 RhssfdyWGLYHYAGQGVTNWHEFANVFLNMAKEKQllltltDLNPIKSQEYPTRATRPKNSVLDTTKIETILGIKScSW 280 Legionella pneumoph...
Q8F5L8   210 Lkge-syPEILHFSNSGVASWYDFALAVRDFSHSFSlienlkPIYPIPTEGYPTPAPRPRYSILDLEETRKIFGVVP-HW 287 Leptospira interrogans
Q9K7J6   201 S-------GIYHISNRGSCNWFEFARAIAKNAGYDPs-----LIRATTTKAFAAKARRPKYSVMSHQQLELAGLQPPrEW 268 Bacillus halodurans
O27820   198 A------YGVYHLTNSGQCSWYEFAIDIFNELGMEV------CLKPVKSHEFPRPARRPSFSVLRNYNWSMEGFKPLrNY 265 Methanothermobacter...
Q9YCT2   217 Ir------GVLHLAGER-LSRLEFAQLIAKVLGADAe-----LIKPISMKEANLPARRPRDSSLDTTMAKKL-GLELpSQ 283 Aeropyrum pernix
Q99LB6   239 Mldp-siKGTFHWSGNEQMTKYEMACAIADAFNLPSs-----HLRPI-TDSPVIGAQRPKNAQLDCSKLETLGIGQRtPF 311 house mouse
CAM05648 215 AerkgpeQRVLHCVNGGQSSWFEFARAVFAELGADPe-----RVRPCSSEEFPLPAPRPAYSVLSGRAWEASGLTPLrHW 289 Saccharopolyspora e...
Q9CCK8   217 Vh-----GSVLHAANEGEVSRFGQARAVFEECGADPl-----QVQPVSTAQNPRSAARPAYSALSGRQSVAAGLTPLrPW 286 Mycobacterium leprae
P9WH09   209 Vr-----GRVLHAANEGVVSRFGQARAVFEECGADPq-----RVRPVSSAQFPRPAPRSSYSALSSRQWALAGLTPLrHW 278 Mycobacterium tuber...
1VL0_B   280 KESLKEYIDLLQ 291 Clostridium acetobutylicum ATCC 824
Q5ZXH4   281 KNDLPDVIDHFT 292 Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Q8F5L8   288 REDLTLCLKELA 299 Leptospira interrogans
Q9K7J6   269 ELALKEFIQEET 280 Bacillus halodurans
O27820   266 RDALRDYLKDAG 277 Methanothermobacter thermautotrophicus str. Delta H
Q9YCT2   284 EESVKHFVNIYR 295 Aeropyrum pernix
Q99LB6   312 RTGIKESLWPFL 323 house mouse
CAM05648 290 REALAAAFAAdg 301 Saccharopolyspora erythraea NRRL 2338
Q9CCK8   287 RSALVEALAVSR 298 Mycobacterium leprae
P9WH09   279 RSALATALAApa 290 Mycobacterium tuberculosis H37Rv
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