2IML,3B5M,2PTF


Conserved Protein Domain Family
DUF447

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pfam04289: DUF447 
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Protein of unknown function (DUF447)
Archaeal protein of unknown function. A fungal member UniProtKB:M2LN89 is clearly a Flavine-reductase enzyme by homology, and UniProtKB:O28442 has been shown to bind riboflavin 5'-phosphate (unpublished structural Xray analysis).
Statistics
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PSSM-Id: 398125
Aligned: 28 rows
Threshold Bit Score: 153.189
Threshold Setting Gi: 74520677
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2IML_A        15 NEIIAITENEDg-SWNAAPIGIIVedsSSDT-AKAKLYR-NRTRANLERSGVLFANVTDdALVFAVSSFGNLNDDWYASP 91  Archaeoglobus f...
WP_011973582   3 YEVVITSKNSKtnENNGAPIGVYY---KNDKtVVAHLYEgSHTYENLKNNDYFVINITA-PYEIAKFVLDDGIKEDYGHI 78  Methanococcus a...
WP_011921233  14 YEVLLGTTGVS---DNISPVGLRY----FKE-YRLRLYEgSITSRNISVHPYCSILITQdPTLFYQGLKGGLRPTSFMYG 85  Metallosphaera ...
WP_009991288  15 YEVLVGTSGIK---PIIKPLGIIV---EANE-LRSKIYKsTLTYSNLEKNNKCSIHVTLdTTFFILSMLDKLTFS-IDSD 86  Saccharolobus s...
Q975H8        18 YEVILGSNGVK---PNLAPIGIIK---DGNT-LKSKVYKdTLTFSNLIKYQKCSLNIITdSRVFFEAFFNELKIEDYIDN 90  Sulfurisphaera ...
Q4JB36        17 YEVILGTNGVR---LNLSPIGIIR---EGQE-LKSRIYEdTLTFQNVMKNNKCSINITLdPFQFYYGFTNNIDKLRFRLM 89  Sulfolobus acid...
Q5JF58        11 YELLLVSKS------NVTPVGVVR---RGAT-LHFKLFPg-KSFRDLLENNRIALQMTWdAELLVKTALNLDVELSFESH 79  Thermococcus ko...
Q8U0T2        18 YEVLLSTKS------NFTPIGVRR---QGRV-LKFRIFEg-RSFRDLEECNYAIIQVVDdTELLAGLAYNLDVKFDVTQG 86  Pyrococcus furi...
Q2NER7        14 YEVIITSFNKQ---VNFKPFGIKF---NNKK-VILNLYP-NRTLKNIKTNPEFLIQFTTnPLVYTKALLNKLTPSDYNKE 85  Methanosphaera ...
Q58848         3 SEVVVTTRKNN--RDNKAPIGVYF---KDKK-VIMHLFSgSHTYENLLTEDYFSVNVVP-PIEIAKAVLDDEDDYLYYND 75  Methanocaldococ...
2IML_A        92 Np---------pIIKGAXAWCRFEAEXR--------SGVA-----HLKLTDGEIIE-KRVRAINRGLSAVIEALVHATRY 148 Archaeoglobus f...
WP_011973582  79 Kga--------pYLLNSHKIQLVKIENYkitklndkYGDShlmiiNGNIELEKELNpPKIGPYNRANGLIVEMAVLYSRL 150 Methanococcus a...
WP_011921233  86 Lp----------VIDVSCVFIAKCNLET--------LGNPseytlNFLEFKGECRE----KSFSRGDGLFVDLLVHLTRL 143 Metallosphaera ...
WP_009991288  87 Ynv--------pVLKNLNVIYAECMK----------TSSTdpsifTINPLDLEINS-NLTRAYNRGDYISVDFLVNYTRL 147 Saccharolobus s...
Q975H8        91 Ip----------IIPVGVVFLANCYY----------EKLEnptyfFYDLIDYKKYG-EFYHAFNRGNSMLIDLLIHVSRL 149 Sulfurisphaera ...
Q4JB36        90 Eev--------pVLENSLVILSELTPI---------SRDQnpiifKYNRLHVVSNA-PVHQALSRGDFLLVDLLVHMSRL 151 Sulfolobus acid...
Q5JF58        80 Dqyrwi--qglpGWLGEARCRRDVWTDG--------LGTTevlkcEFFPEKRLVGN-ARPIPFSRADCVLVEMAVLFTRY 148 Thermococcus ko...
Q8U0T2        87 IkvpirriegypWVEGEVKCRIVKVKDS--------IGESiakdcTLTPIYIGIEK-RVPRPISRADNVLLELAVLGTRL 157 Pyrococcus furi...
Q2NER7        86 Y-----------FLLDSNIVIKANVYSIceyvhednYGKVtltqiTANIEEIHEIN-NQPPVINRATNKIIDLLVDYTRI 153 Methanosphaera ...
Q58848        76 Ip----------YLKSSYYAIFYKVIERkfvdredkFGKNrlmilEGEEIKRIYLN-NIPKPYNRADGLLVEIAVIYSRL 144 Methanocaldococ...
2IML_A       149 ---VAik-sdERRKELLERIHYYREIVQKCGSERE--KRAFEIIXE 188 Archaeoglobus fulgidus
WP_011973582 151 ---NIvd--nETKLKLKNEMNYYFKTIKKVGSEKH--IELAEKMLK 189 Methanococcus aeolicus
WP_011921233 144 ---DIl---pQEREKLLEIMSYEIGVIKRTSPYLE--GYLREILET 181 Metallosphaera sedula
WP_009991288 148 ---DIyk--gEDLEKLVRILEYEWSVIKRTSQYTS--SLLEEILNk 186 Saccharolobus solfataricus
Q975H8       150 ---DIys--kEDIEKYLPIIKYEIDIIRKTMPND---IKIIEKIKE 187 Sulfurisphaera tokodaii
Q4JB36       152 ---HIys--qDQIKQYLPVIEYEIKTIKRLSPNLS--GIIQELIGI 190 Sulfolobus acidocaldarius
Q5JF58       149 ---LV-----KPTLELKNRILDLYALYRHLGGNSE----AAEYIVG 182 Thermococcus kodakarensis KOD1
Q8U0T2       158 ---IVkkkrgLQIKDVAQKIEELYELYRKLGGKSEiaGKIMDILRK 200 Pyrococcus furiosus
Q2NER7       154 ---PYmn--sTQKNDYINKLQNLSSFIKKSGNNQH--IQSLKLLKK 192 Methanosphaera stadtmanae DSM 3091
Q58848       145 ankNIki-neDDKKEMINDIRKYFSIIKKVGGREH--KQLAEIMLR 187 Methanocaldococcus jannaschii DSM 2661
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