Conserved Protein Domain Family
DUF444

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pfam04285: DUF444 
Protein of unknown function (DUF444)
Bacterial protein of unknown function. One family member is predicted to contain a von Willebrand factor (vWF) type A domain (Smart:VWA).
Statistics
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PSSM-Id: 398121
Aligned: 96 rows
Threshold Bit Score: 361.445
Threshold Setting Gi: 521282228
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q18G01           1 MGLREDLERF-REVGEDRRQDLESFIRYGDLSN-SDADNIEIPIKVVDLPEFEYDqLDRGGVGQGQGDTpDVGQPVGQPe 78  Haloquadratum...
WP_014256096    13 DRSAEDRRRHrELVEEAIKKNIGNIIAEESIIGqSKDKKIKIPIKGIKEYQFIYG-NNGTFAGSGDGSE-KRGDRIGQDk 90  Hungateiclost...
jgi:Cthe_1204   31 DRAAEDRRRHrELVEESIKKNIGNIIAEESIIGqSKDKKIKIPIRSIKEYQFVYG-KNGPSVGSGDGTE-KRGEKIGEEk 108 Hungateiclost...
WP_013624315    13 DRSVEDRRRHrRLVENSIKKNLADIISEESIIGeSKNKKIKIPVRGVKEYEFIYG-KNSGGVGSGDGSE-KRGDKIGSAr 90  Syntrophobotu...
A5N5W4          14 DRSLEDRRRHrQLVEKSIKDNLADIISEESIIGqSKNKKVKIPIKGIKEYQFIYG-DNSSGVGSGDGSQ-KKGDRIGKAi 91  Clostridium k...
JLU:CLAU_2438   14 DRSLEDRRRHkQLVEKSIKDNLADIISEESIIGqSKDKKIKIPIKGIKEYHFIYG-GNSPQVGSGNGSQ-KRGDKIGRSl 91  Clostridium a...
jgi:Clopa_4105  15 DRAVEDRRRHrQLVEKSIKDNLGDILSEESIIGqSKDKKIKIPIRGIKEYQFIYG-KNVPGVGSGDGSE-KRGQVIGKDk 92  Clostridium p...
Q97LI1          15 DRTIGDRRRHrELVEKAIKDNLADIVSEESIIGeSKSKKIKIPIRGLKEYKFLYG-NNSSSVGSGTGNE-KKGDIIGKEq 92  Clostridium a...
WP_044035791    15 DRSIEDRRRHrQLVEKSIKDNLGDILSEESIIGeTKNKKFKIPIRGLKEYQFIYG-KNSGGVASGTGEE-KRGDKIGSEk 92  Clostridium b...
WP_022749637    15 DRSIEDRRRHrQLVEKSIKENLGDILSEESIVGeSKNKKFKIPIKGIKEYQFVYG-SNSKGVATGVGDE-ERGDKLGNGk 92  Clostridium s...
Q18G01          79 pGEADGDgdeDGDEeGEPG--DgSDDHGYYEMDPEEFATELDEALGL-DLEPKG-KEVVEEIEGDFTDVTRTGPNSTLDF 154 Haloquadratum...
WP_014256096    91 tGKNGNG------E-GQAGnqE-GEDIYETEVTIEELINYLFEDLNLpDIDRKKmAEIESVKSFKNLGYQRKGIPPRLAK 162 Hungateiclost...
jgi:Cthe_1204  109 tANGGQG------V-GQAGnqE-GEEIYETEITIEELINYLFDDLNLpDIDKKRiAEQESIRSYKNLGYQRKGIPPRLAK 180 Hungateiclost...
WP_013624315    91 eRRQGGD--------GGAGnqE-GEDIYETEVTIEDVINYLFEDLDLpDLNKAKaSEEIRASARKKSGYQRKGIPPRLAK 161 Syntrophobotu...
A5N5W4          92 kDRDGKG------N-QGAGnqE-GEDMYEIEVTIEDVLDYLMEDLELpLMDKKKfSQILSNNSPKKSGYQRKGINPRLAK 163 Clostridium k...
JLU:CLAU_2438   92 eENGSKG------K-GGAGneE-GEDMYETEITLEELMNYLLEDMELpLMDKKKfSELLSKKSLKKSGYQRNGINPRLAK 163 Clostridium a...
jgi:Clopa_4105  93 sQNGGKG------N-QGAGndE-GEDIYETEITLEDVMNYIMNDLELpKMDKKKfAEVLTENGTKKAGYQRHGINPRLAK 164 Clostridium p...
Q97LI1          93 mGNGSKG-----KG-KGAGnsE-GEDIYETEVTIEEVFSYLLEDLNLpNLDKKKySEIVTDSSKKKAGYQKYGIRPRLAK 165 Clostridium a...
WP_044035791    93 -GGKGKG---PGKG-QGAGndE-GEDYYETEITLDEVFDYLAEDLELpHMDRKKySEIITESSFKKKGYQKHGINPRLAK 166 Clostridium b...
WP_022749637    93 -KQLANG------N-KGAGnqE-GDDVYETEITLEELMDYISEDLDLpNLDQKKySEIVTETTGRKRGYQTHGIRPRLAK 163 Clostridium s...
Q18G01         155 ERLFKQGLKRKLAMDF---DESFVREamrvadqtpesvyrwcreqnvlvsfswieaewkdipddergrWADfEELEANVE 231 Haloquadratum...
WP_014256096   163 RRSVIEKIKRKQAFLRtqkEIGVEDE------------------------------------------PDEnIVTGDIEQ 200 Hungateiclost...
jgi:Cthe_1204  181 KRSVIEKIKRKQAYLRnsrELGDLDE------------------------------------------SAEe----DIAA 214 Hungateiclost...
WP_013624315   162 KRSMAEKIKRRQGLKK---ALREENP-------------------------------------------------AEDDR 189 Syntrophobotu...
A5N5W4         164 KRTVVEKLKRQQGTKR---ALREIHG----------------------------------------------ELESDPKN 194 Clostridium k...
JLU:CLAU_2438  164 KRTVIEKLKRQQNSKR---AIREASK-----------------------------------------------------D 187 Clostridium a...
jgi:Clopa_4105 165 KRTTVEKLKRQQGKKR---ALREEDI------------------------------------------------------ 187 Clostridium p...
Q97LI1         166 KRTVIEKIKREQSRKR---AIKELGK------------------------------------------------------ 188 Clostridium a...
WP_044035791   167 KKTVMTKIERLQSKKR---ALKEANI------------------------------------------------------ 189 Clostridium b...
WP_022749637   164 KKTVMSKIARKQGKKR---ALREMEE------------------------------------------------------ 186 Clostridium s...
Q18G01         232 HTPVGQRIRRnglkeIPLRKDDERYRQPEIEETRQKNVVVVNIRDVSGSMRETKRELVERTFTPLDWYLTGTYDNAEFVY 311 Haloquadratum...
WP_014256096   201 E------RKR-----FPFMEDDLRYRRVREDHKKDFNAVVICIMDVSGSMDQTKKYLARSFYFLLYQFVRLKYSNVEVAF 269 Hungateiclost...
jgi:Cthe_1204  215 QETLDGVRKR-----FPFSEDDLRYRRVREDRKKDFNAVVICIMDVSGSMDQTKKYLARSFYFLLYQFIRLKYANVDVVF 289 Hungateiclost...
WP_013624315   190 EGRENAEAER-----FPFIEEDLRYQRMKETVRKKSNAVVFCLMDVSGSMDQTRKYLARSFFFLLCQFIQMKYDGVDVVF 264 Syntrophobotu...
A5N5W4         195 KLPENTTIKSr----FPFKQDDLRYFRVKRKPKLELNAAIICVMDTSGSMDSTRKFLARSFFFVLYRFIKMKYNNVEVKF 270 Clostridium k...
JLU:CLAU_2438  188 PLFQNKTISKdidsrFPFRQEDLRYFRIKEKKKRELNAAVICVMDTSGSMDSTRKFLARSFFFILYQFVKAKYNNVEIKF 267 Clostridium a...
jgi:Clopa_4105 188 ----DEEIER-----FPFKNEDLRYYRIKKTMKRECNAVIICVMDVSGSMDNTKKYLARSFFFILSQFIRTKYSNVEIAF 258 Clostridium p...
Q97LI1         189 ----DDKVER-----LPFSEEDLRYHRIKEKPKKECNAAIMCVMDCSGSMDSTKKYLARSFFFILSKFIRMKYVNVEIAF 259 Clostridium a...
WP_044035791   190 ----NEEIDR-----FPFIEDDLRYYRVKVQPKRESNAAIIFVMDVSGSMDNTKKYLARSYFYVLSRFIKNKYNNVEVAF 260 Clostridium b...
WP_022749637   187 ----EQELDR-----FPFREEDLRYYRVKLKPRKDSNAVMIFIMDASGSMDITKKYLARSYFFVLATFLKRKYNNIAFEF 257 Clostridium s...
Q18G01         312 IAHDAEAWEVEREDFFGIRSGGGTRISSAYELAKEILEDEYPWSEWNRYVFAAGDSENAANDTTQNVVpLMESI--PANQ 389 Haloquadratum...
WP_014256096   270 IAHTTSAKEVNEDEFFHKGESGGTYISSGYEKALEIIEQRYNPASWNIYAFHCSDGDNWSEDNKKAVE-YAQKLceVCNL 348 Hungateiclost...
jgi:Cthe_1204  290 IAHTTTAKEVSEDEFFHRGESGGTYISSGYEKALEIIEQRYNPNSWNIYAFHCSDGDNWSEDNKKAVE-LGLKLcdVCNL 368 Hungateiclost...
WP_013624315   265 IAHTTTAAEVSEREFFHKAESGGTNISSAYAKALEIIEKRYPVEQWNIYAFHVSDGENWEQDNEKAVR-YAQELclLCNL 343 Syntrophobotu...
A5N5W4         271 ISHSTSAKVVTENEFFHKVESGGTYISSGLKKALEVIEENYNPAYWNVYTFYVSDGDNWSEDNSLALK-CAKDLckVCNL 349 Clostridium k...
JLU:CLAU_2438  268 ISHSTKAKVVTENEFFHKVESGGTYISSGLNKALEVIEENYNPAYWNVYTFYVSDGDNWDEDNERALK-AAKDLceVCNL 346 Clostridium a...
jgi:Clopa_4105 259 VAHSTVGREVNEFEFFHKVESGGTYISSGLNTALEIIEKRYNPVYWNIYTFYVSDGDNWTEDNNRAVA-SAKKLceVCNM 337 Clostridium p...
Q97LI1         260 ISHSTVGREVTETEFFHKVESGGTYISSGLNTAMDIIKERFNPATWNIYGFYVSDGDNFTEDDERAIK-SMRKFceIANM 338 Clostridium a...
WP_044035791   261 VAHSTTAKEVGENEFFHKGQSGGTYISSGLNKALEIIEERYDPAMWNLYTFCVSDGDNWSEDNDKTIK-AVKDLceVCNL 339 Clostridium b...
WP_022749637   258 IYHTTVAKRVDEYEFFHKSESGGTYISSGINEALNVIKEKYPPSAWNIYSIYASDGDNWSEDNERAIA-AVKNIceISNM 336 Clostridium s...
Q18G01         390 HAYVETQPgg-tAINATHAEEVDRALGddGNVVVVSVTGPEDVTGAIESILSTD 442 Haloquadratum walsbyi DSM 16790
WP_014256096   349 FGYGEIVPgy-ySSSSTIKSEFQKNINn-KNFAVITMTKKEDILPGLKKLLDKE 400 Hungateiclostridium clariflavum
jgi:Cthe_1204  369 FGYGEIVPgy-ySTGSTIKDEFQKSIKr-DNFSVITITNKDDVLPGLKKLLEKE 420 Hungateiclostridium thermocellum ATCC 2...
WP_013624315   344 FAFAEVLPsayyT--DTIIKVFRARIKa-DHYLTASIQEKEDLWPALKKILKKE 394 Syntrophobotulus glycolicus
A5N5W4         350 FSYAEIIPs---PYGSSIKHIFQNKITd-NNFTVVTIHEKQDLWKSLKKILNKE 399 Clostridium kluyveri DSM 555
JLU:CLAU_2438  347 FSYAEIIPs---YFGSNIKNIFRRGIDk-NNFSTVTINEKQDLWISLKKILKKE 396 Clostridium autoethanogenum DSM 10061
jgi:Clopa_4105 338 FGYSEIMSg---YYSTNIKDKLVKEVQn-KNFIAVSIKQKNDLWNALKDMLKKE 387 Clostridium pasteurianum BC1
Q97LI1         339 IGYAEILPy---SYSGTMKYKFDNYVKd-KNFISSTIRNKEDLWPVLKKMLIKE 388 Clostridium acetobutylicum ATCC 824
WP_044035791   340 FGYTEILPi---TYATTMKYKLNNEIKn-KNYLSASIKQKSDLWVALKTMLKKE 389 Clostridium bornimense
WP_022749637   337 FGYAELLPs---TYTTTMYHKFKKEITd-EKFVPVIIKEKKDLWDALKIMLRKE 386 Clostridium saccharobutylicum
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