Conserved Protein Domain Family
Strep_his_triad

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pfam04270: Strep_his_triad 
Streptococcal histidine triad protein
All members of this family are proteins from Streptococcal species. The proteins are characterized by having a HxxHxH motif that usually occurs multiple times throughout the protein. The histidine triad is predicted to bind metal cations, in particular Zn2+. The zinc is transferred, on the surface of the streptococcus from the Strep_his_triad protein, a zinc scavenger, to apo-ADCAII, a cell-surface lipoprotein transporter that leads to Zn2+ uptake into the bacterium.
Statistics
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PSSM-Id: 398109
Aligned: 17 rows
Threshold Bit Score: 64.6271
Threshold Setting Gi: 81533324
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
bgi:05SSU0332  178 RTDDGYVFNPTDVIEDTGD-----GFIVPH--GD----HFHFIPKKDLSA-AELKAAQDYWNQ 228  Streptococcus suis 05ZYH33
Q99XV4         666 ATPDGYIFDPRDVLAKETFvwkdgSFSIPRadGS----SLRTINKSDLSQ-AEWQQAQELLAK 723  Streptococcus pyogenes seroty...
CAR41966       344 keEDGLIFDPNQVTKLTSR-----GYVIPH--GN----HWHVVPEDQLSP-LEIYLARMHLSG 394  Streptococcus uberis 0140J
Q99XV4         331 veEDGLIFEPTQVIKSNAF-----GYVVPH--GD----HYHIIPRSQLSP-LEMELADRYLAG 381  Streptococcus pyogenes seroty...
Q8DPQ2         557 TTSDGYIFDEHDIISDEGD-----AYVTPH--MG----HSHWIGKDSLSD-KEKVAAQAYTKE 607  Streptococcus pneumoniae R6
Q8CWR4         560 TTEDGYIFDPRDITSDEGD-----AYVTPH--MT----HSHWIKKDSLSE-AERAAAQAYAKE 610  Streptococcus pneumoniae R6
Q8DQ07         437 heEDGYGFDANRIIAEDES-----GFIMSH--GN----HNHYFFKKDLTE-EQIKAAQKHLEE 487  Streptococcus pneumoniae R6
WP_013669059  1020 TGSEGYVFSKDNIIGVDDH-----GVTTEH--REdghaHTHYIEFGELKG-YELAKVEEWmee 1074 Aerococcus urinae
WP_153049885    36 ATNDGYIFSAEDVVDPASFvf-sqAFSLPRatGG----SLRSISKKDLSK-EELEAVQTLLDk 92   Streptococcus suis
WP_153057960     8 TTKDGYIFDPADLLDPKVKig-tdNYRIPRviTD----GYRRINKSDLNYlSELIPAEAMVAQ 65   Streptococcus suis
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