3LM8,3MEL,3CQ9,3IHK


Conserved Protein Domain Family
TPK_B1_binding

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pfam04265: TPK_B1_binding 
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Thiamin pyrophosphokinase, vitamin B1 binding domain
Family of thiamin pyrophosphokinase (EC:2.7.6.2). Thiamin pyrophosphokinase (TPK) catalyzes the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the coenzyme thiamin pyrophosphate (TPP). Thus, TPK is important for the formation of a coenzyme required for central metabolic functions. The structure of thiamin pyrophosphokinase suggest that the enzyme may operate by a mechanism of pyrophosphoryl transfer similar to those described for pyrophosphokinases functioning in nucleotide biosynthesis.
Statistics
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PSSM-Id: 398104
Aligned: 234 rows
Threshold Bit Score: 43.5932
Threshold Setting Gi: 122019436
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3LM8_B       143 EYDIe--KDEN---K-RYISFIPFsEDIHeLTLTGFKYPLNNCHITLGSTLCISNELI-HSrG-TFSFVKGIL 207 Bacillus subtilis
XP_008178441 181 THRIhvpQSLRlhpEnNYVGFFPMgSACNvCTTTGLKWNLSGTLMEMGGLTSSSNTFNgEP-IvTITNSSPLL 252 pea aphid
XP_002808952 325 NHVIqinLNA----FqKGCALLPI-GGKCkVKTEGLKYNLNYEYLSFDSLISSSNEIIqN--EiKISNDTPLI 390 Plasmodium falciparum 3D7
XP_001614776 306 SHIIhvsPDV----FcKGCGILPF-GGKCtIKTEGLKYNLNDECLSFDTLISSSNEVVqR--EvKIFNDSPVV 371 malaria parasite P. vivax
6_pfamImport   1 ESLIdlnLPM----CtKMCGIIPLaQKPTiVTSKGLKWELAAHSLEFGKLISSSNEVTtDQi--SFNSNAHLM 67 
P30636       162 DSNLdvnLEM----TtKMCGIIPIvQKETiVSSIGLKYEMENLALEFGKLISTSNEVTtSQv--FLKSSSSLI 228 Caenorhabditis elegans
CAP27110     149 TSEIhveLEK----TsKMCGVIPItQKETiVTSKGLKYEMANLPLAFGKLISTSNEVTiNQi--SLQSTAPLI 215 Caenorhabditis briggsae
XP_003098204 176 ESKIyvdLEK----TtKMCGVIPIaQKETiLTSNGLKYEMDSLPLAFGELVSSSNEVVtNEi--KLKSTAPLI 242 Caenorhabditis remanei
PDM74763     172 AHRFhldRAH----LtDVCGIVPItQTETrVTTRGFRWNLDNKPVSFGTLISTSNELAsDEi--SVTNTAPVI 238 Pristionchus pacificus
PDM79119     144 SHRFefdHSH----LtGTCGIAPIcQSETlVTTDGYRWNLERTPLAFGSNISTSNELIsEQv--MVNTSAPLI 210 Pristionchus pacificus
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