5C74


Conserved Protein Domain Family
RNA_Me_trans

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pfam04252: RNA_Me_trans 
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Predicted SAM-dependent RNA methyltransferase
This family of proteins are predicted to be alpha/beta-knot SAM-dependent RNA methyltransferases.
Statistics
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PSSM-Id: 398093
Aligned: 93 rows
Threshold Bit Score: 129.584
Threshold Setting Gi: 121727091
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5C74_A           2 KYIIEHMEEGFSEWVILE------------YSQILREVGAENLILSSLPEsTTEkdIPQRLLklGLRWTTKDlkGINEDF 69  Saccharomyces...
EGF79921         2 KYIVEHLEEEIEGWPELE------------YRNMLLNVGKGNLWLSHVSE-SVAqsPPASLE--GAIVSTHS-------I 59  Batrachochytr...
WP_011839583     5 IIIIEHLEPEFSIWLFLE------------YRHSSLIYGSDYIWYTSLPLr-YHkiM-------KKYGKTYEe-SIIDLV 63  Staphylotherm...
Q8TZ44           3 vAIVEHLD-RWSPWLDLE------------YMEAYRTARKHGWEFTVTNAd--PevL-------AKAKYPALpySASKLP 60  Methanopyrus ...
Q5JHH1           3 YLIIEHLE-DISDWLWLE------------YSHVAQWW-GDKLIFTNVRE-DERerL-------AKLGSVITe-SVTKFP 59  Thermococcus ...
Q8U0J9           3 YLIIEHLE-KISEWLLLE------------YRHTAQWW-GDKLIFTNVKEpEERkiL-------AEIGSVVAe-SVTKLP 60  Pyrococcus fu...
Q9YC91          72 AIVVELLEDTPSRWLLEEllesylfavqmgYRFAVTGA-TNPLVYAAVRRa-----------------------GVPVFM 127 Aeropyrum pernix
imbp:Hbut_1107   8 LIVIEHLEPVLSRWILAE------------YRHAARLA-HGRLVFTNAGRc--CkeL-------SMIAPCYEk-SIVELE 64  Hyperthermus ...
jgi:Igni_1183    1 mIIVENLE-EFSEWLLYE------------YEHAYELV-GDELLITNVKDeRLKesL-------KELGIPFEerSVVEII 59  Ignicoccus ho...
jgi:Igag_1526    4 KVVIEHLEPCLNQWLLTE------------YKYVSDLF-RERLIFTNVKKeNHKaiL-------SKLGQIISq-SVIEYL 62  Ignisphaera a...
5C74_A          70 KDlellkDGRVCLLDPRATIDLQPEDATKFDYFVFGGILGDHPPRDRTKELKTAYpn--lLISRRLGDKQMTTDTAIRTT 147 Saccharomyces...
EGF79921        60 QSwpdvdMSRVILADPAAKTPLCPADAESYDYILFGGILGDDPPKDRTKELRVMG-----FATRHLGKEQMTTDTAVLVS 134 Batrachochytr...
WP_011839583    64 KQgy-vdENKIIILDPAAEEKLSFKDLVENDYVIIGGILGDHPPRKRTEALLSKRlr--nVKRRNIGDGQYSIDGAVYFV 140 Staphylotherm...
Q8TZ44          61 LRg-----DRVIVLDPDAEDPLTPED--DPDVVIVGGILGDYPRRHRTREELTPRfp--dAEVRHLGPYHFSIDGALRVA 131 Methanopyrus ...
Q5JHH1          60 f-----dRSKLIVLDLQAEEELKPEDIEEDTMIVVGGILGDAVPRGRTREFITSKme--gVKVRHIGKPQYSIDGASIVA 132 Thermococcus ...
Q8U0J9          61 f-----dKSKLIILDPFAEEELKPEDIEEDSLIVVGGILGDFEFTGKTKEFITSKie--gAKARHIGSVQFSIDGASIIA 133 Pyrococcus fu...
Q9YC91         128 ERgyslnRPGCILLDLWSPKRLEPEEASSASYIIVGGIMGDHPPKGRTYLLSSQVyt--aCAKRNLGPEQLSVDGAVKTA 205 Aeropyrum pernix
imbp:Hbut_1107  65 GTly-tsRSNVIILDPQAEKLLDPQEAANAEAIVIGGILGDHPPRGRTRELLTRRas--gMKARSLGPHQFSIDGAVYAA 141 Hyperthermus ...
jgi:Igni_1183   60 DHm----PRPWVVLDPKGEGELTPDEASGT--VVVGGILGAHPPKGRTWELLTSKllpkgVLVRNLGPEQFSIDGAVAVA 133 Ignicoccus ho...
jgi:Igag_1526   63 KDl-----PEVIVLDPKASEPLKRQDLTNAKYVIIGGIMGDHPPKGRTWKFITSRlr--nAISRNIGPYQFTIAGTAYIL 135 Ignisphaera a...
5C74_A         148 QLIIKDRIAFEDIKFIDYPEFRFNK-----NEATEMPFRYVLDKEGKPI-LPEGMLDLIKKDSLE 206 Saccharomyces cerevisiae S288C
EGF79921       135 QLVLEKQIPLDKIDYVDRPDIKLGR-----REIVEMPFKYIRLPNGEPK-LPLGMIEHLKQGndi 193 Batrachochytrium dendrobatid...
WP_011839583   141 NSLWY-NKSSEKIQYIDGVTLETEYg------YIRLPFRYPI-IDGKPL-LSSELVEYLKTGRIp 196 Staphylothermus marinus
Q8TZ44         132 LTVLECGVPLEEIQVVERPEIEVAP-----GHTVRLDCDYPS--EGKPM-LPEGLVEYLKEGIVD 188 Methanopyrus kandleri
Q5JHH1         133 KLIAD-GKRLEEIEYEEHPTIKLDE-----FSEITLHYAVPK-LDGKLL-LTPGLIDLQKRELGY 189 Thermococcus kodakarensis KOD1
Q8U0J9         134 KLISE-GKRLEEIEYVESPTIKLDE-----FSEITLHYAVPK-VNGKLL-LTPGLIELQKKELGY 190 Pyrococcus furiosus
Q9YC91         206 ILVAE-GYRLDEIEFEEGVEVEVESpvrgvSARVELPYAYPK-VGGRIL-VSQRLLSLLSRGIIY 267 Aeropyrum pernix
imbp:Hbut_1107 142 VKTLE-GVAPDRLEVVLNPVVSIDLgd-lgVIEVELPYAYPK-VNGEPL-MAPELRELLAAGLAL 202 Hyperthermus butylicus DSM 5456
jgi:Igni_1183  134 WLIKR-GKKLSEIEKVVGLEVEVGEvm-gmKVVEELPYAYPV-IGGGVF-FSEKVKEYLKRRrla 194 Ignicoccus hospitalis KIN4/I
jgi:Igag_1526  136 KQIER-GLDLKDIRYVYGLKIEKKLsn-eiIIEIELPYAFPL-DEHNNIvLPENYIDIVYRYTTT 197 Ignisphaera aggregans DSM 17230
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