2G5G


Conserved Protein Domain Family
Cofac_haem_bdg

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pfam04187: Cofac_haem_bdg 
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Haem-binding uptake, Tiki superfamily, ChaN
This is a family of putative bacterial lipoproteins necessary for the uptake of haem-iron. The structure of UniProtKB:Q0PBW2, Structure 2g5g, comprises a large parallel beta-sheet with flanking alpha-helices and a smaller domain consisting of alpha-helices. Two cofacial haem groups (~3.5 Angstom apart with an inter-iron distance of 4.4 Angstrom) bind in a pocket formed by a dimer of two ChaN monomers.
Statistics
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PSSM-Id: 398040
Aligned: 191 rows
Threshold Bit Score: 111.185
Threshold Setting Gi: 220974069
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2G5G_X        36 ILELLKADVILLGEKH--DEVKHKISQVXIFNAL---EgnlssqNinFDVALEXLASTEQNHLDKAFKNkktikanelTN 110  Campylobacter ...
ERM95571     153 WDKLLNSRIVYLGEAEqvPVRDDKDLELEIVKNLrnkCfeq-qrP--ISLALEAFPCDIQEQLNQYMSKr--------ID 221  Amborella tric...
Q8RWG3       153 WEKLLNARVVYLGEAEqvPTKDDKELELEIVRNLrkrCves-erQ--ISVALEAFPLDLQDQLNQYMDKr--------MD 221  thale cress
EEF41514     126 WEKLTNARIVYLGEAEqvPVKDDKELELEIFKNLtkrCven-ekS--ISLAMEMFPCDLQPQVNQFIDGr--------ID 194  castor bean
XP_003552200 161 WEKLMNARVVYLGEAEqvPVRDDRELELEIVKNLhrrClek-ekL--LSLALEVFPANLQEPLNQYMDKk--------ID 229  soybean
XP_002278231 158 WEKLMNARIVYLGEAEqvPIRDDRELELEIVKKLrkrCaen-erP--LSLALEAFPCNLQEPLNQYMDYr--------ID 226  wine grape
XP_015166813 156 WEKLMNARVVYLGEAEqvPTQDDKEVELEIVKNLrkrCaea-erS--ISLALEAFPSNLQEQLNQYLAKr--------ID 224  potato
EMS53536     351 WDKLAAARVVYLGEAElvPDPDDRVLELEIVTKLaarCadv-erR--MSLALEAFPCDLQQQLDDFMSGr--------ID 419  Triticum urartu
XP_002458700 135 WEKLMAARVVYLGEAElvPDRDDRVLELEIVRKLaagCaea-grS--ISLALEAFPCDLQEQLNQFMDGr--------ID 203  sorghum
XP_006654538 340 WEKLTAARVVYLGEAElvPDPDDRVLELEIVKGLatrCaea-erG--VALALEAFPSDLQQQLDQFMDGr--------ID 408  malo sina
2G5G_X       111 A------LNWdkvWK---WKDYEQFVNVVFYSKSKILGANLSRSEITSIYNG------AqplKGYVST-----------T 164  Campylobacter ...
ERM95571     222 GetlksfVPH---WPperWPEYEPLLRYCCDNGVRLVACGTPLEVLRTVQAEgmrglsKa-dRNKYAPpngagfingftS 297  Amborella tric...
Q8RWG3       222 GetlksyVTH---WPaqrWQEYEPLLSYCRDNSVRLIACGTPLKVLRTVQAEgirglsKs-eRKLYTPpagsgfisgfsS 297  thale cress
EEF41514     195 GetlksyLTH---WPvqgWQEYEPLLNYCRDNRVRIVACGTPLKVIRTVQAEgirglpKa-dRKLYAPpagsgfisgftS 270  castor bean
XP_003552200 230 GdtlksyTLH---WPpqrWQEYEPILSYCRENGIHLVACGTPLKILRTVQAEgirgltKd-eRKLYAPpagsgfisgftS 305  soybean
XP_002278231 227 GetlksyASH---WPpqrWQEYEPLLSYCRDNGVRLVACGTPLEVLRTVQAEgirglsKa-eRRKYAPpagsgfisgftS 302  wine grape
XP_015166813 225 GeslksyVAH---WPtqyWHDYEPLLTYCRENGVRLVACGLPLEVLRTVQAEgirglsKa-dRKKYAPpagsgfisgfsS 300  potato
EMS53536     420 GsilklyTSH---WPserWKEYEPLLNFCRDKGIKLVATGTPLQVKRTVQAEgigglsKa-eRKEYAPpagsgf--isgf 493  Triticum urartu
XP_002458700 204 GnslrlyTSH---WAperWQEYEPILNYCRDNGIKLVACGTPLEVVRTVQAEgirslsKa-qRKLYAPpagsgfisgftS 279  sorghum
XP_006654538 409 GsilklyTLH---WPqdrWEEYEPLLNYCRDTGIKLIACGTPLKVKRTVQADgirglsKa-dREEYAPpagsgfisgfsS 484  malo sina
2G5G_X       165 NEVKKQLFDIISLSHKlnpeENKELLDKLVEIQQFKDRRXADVLVhh--vNk----VLLLAGSYHTSK---KIGIPLHI 234  Campylobacter j...
ERM95571     298 ISRRSPIDMISPNPSL----SFGPSSYLSAQARVIDDYTMSQAITqamqdGgsvgvLVVVTGASHVLYgsrGVGLPARI 372  Amborella trich...
Q8RWG3       298 FSRRSTFDMSLPTQIV----PFGPSSYLSAQARVVEDHTMSQVILqavadGggtglLLVVTGASHVEYgsrGTGLPARI 372  thale cress
EEF41514     271 ISRRS-IDMNYPYQSV----PFGPSSYLSAQARVVEDYTMSQIILqavadGgatgmLVVVTGASHVMYgprGTGLPARI 344  castor bean
XP_003552200 306 ISRRSSVDSTQ-NLSI----PFGPSSYLSAQARVVDEYSMSQIILqnvldGgvtgmLIVVTGASHVTYgsrGTGVPARI 379  soybean
XP_002278231 303 ISRKSSIDTNSPNQSV----PFGPSSYLSAQARVVEDHTMSQIILqemvdGgttgmLVVVTGASHVMYgsrGTGLPARI 377  wine grape
XP_015166813 301 MSRRSSVDVNMLNQPT----PFGPSSYLSAQAKVVEEYNMSQIVLkavmdDgtagmLVVVTGATHVMYgsrGTGVPARI 375  potato
EMS53536     494 rSGRSFIENITSTRDS----PFGPNSYLSAQARVVDDYTMSQIIMkelngKdppgiLIVVAGASHLIYgsrGTGVPARV 568  Triticum urartu
XP_002458700 280 ISGRSLIDKISSNRGS----PFGPSSYLSAQARVVDDYTMSQTIMkeitnGdpsgmLVVVTGASHVMYgsrGIGVPARI 354  sorghum
XP_006654538 485 ISGRSLIDKISSSRDS----PFGPTSYLSAQARVVDDYTMSKIILkelngGdtsrmLIVVAGASHVIYgsrGIGVPARV 559  malo sina
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