Conserved Protein Domain Family
Init_tRNA_PT

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pfam04179: Init_tRNA_PT 
Rit1 DUSP-like domain
This enzyme (EC:2.4.2.-) modifies exclusively the initiator tRNA in position 64 using 5'-phosphoribosyl-1'-pyrophosphate as the modification donor. As the initiator tRNA participates both in the initiation and elongation of translation, the 2'-O-ribosyl phosphate modification discriminates the initiator tRNAs from the elongator tRNAs. This C-terminal domain shows similarity to dual specificity phosphatases.
Statistics
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PSSM-Id: 398034
Aligned: 109 rows
Threshold Bit Score: 69.5324
Threshold Setting Gi: 74682294
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EJT80503     398 TTLEVGLGKGKIASRNLRQALPDICAFVQKAAAAAAatqeggsaasvRVLVACESG-RDVSVG--VALALACRSF-DDRg 473 Gaeumannomyces ...
EPB81732     357 HYLHLPIPDGKKGQIIFGACIQKAIDFVRDPILENK-----------KILVYCATG-KDHSVG--ILLSILIHYY----- 417 Mucor circinell...
EGF83950     373 LYVYLDIPEGKKGQNKLFDCIPAAIQCVQGKFMSqg----------rRILVHCMQG-RDRSVG--ICLALLVEYM----- 434 Batrachochytriu...
XP_004352453 386 KFLSIQLKEGKKSKDGLHAKLQEAESEILNTLSQDR-----------KILIHSLSGnGDLPNCmvILLVVLAKYF----- 449 Cavenderia fasc...
EGC37555     383 NYLHLPIREGKIGKNDLQQQLPLAEKFIIDRIKENKd---------yKILLHSTTG-KANCVS--ILLSIITKYF----- 445 Dictyostelium p...
XP_004251633 405 AHLNLSIVSSKFDRSSLLRNLPSAVNFAKNNLRKGK-----------KLLVCCNSG-EDISIC--VCLAILMSLFdDKGn 470 tomato
Q5Z9S3       423 SYLELPMVGSKDDRFSLMKNLPKAVSFANRNLIAGK-----------KLLICCQNG-EDISIC--VALAIITRLFdCDGf 488 Japanese rice
KQK11203     428 SYLEIAIVGSKNDRFSLLKNLPKAINFAQRNLIARR-----------KILLCCQTG-EDISIC--VALAIITRLFnDSGc 493 stiff brome
XP_005850679 380 RYCWLPVRSSKLERHSLLQQLPAVLRCARAQLQQGR-----------RLLVCCDSG-LDVSVC--VAVACLLAFY----- 440 Chlorella varia...
XP_004990534 411 SILPVRMPAGKRHKKELEDHLEQVLLFVRHHLAQDH-----------RILVASGDS-NDRAPT--VATAVLAAFF----- 471 Salpingoeca ros...
EJT80503     474 dvlPAAaaattt---------ttaqqDAACRPGPTKDFIRTKLGRIVTAMPEANPSRATLQSVNSFL 531 Gaeumannomyces tritici R3-11...
EPB81732     418 ---TLDfe-----------------lNTAEKPRVDKKMIQHQLVQIISNWEKAAPSRVTLKRINTHF 464 Mucor circinelloides f. circ...
EGF83950     435 ---DANwim--------------sptGKSCRGQLDKDTIRNRLLYIQRFRMVASPSRATLKKINLYf 484 Batrachochytrium dendrobatid...
XP_004352453 450 ---KILkvegeege----qvfikmndKLQQNKNITKFDISNLYLFIDKYCPQCLPPRTIRNNINSYL 509 Cavenderia fasciculata
EGC37555     446 ---LRYpdtnnnnnnlsqdqnfyfnfSENPRSNINKDDIKVSYLFIEKYCSQSLPCKAMRNSINRHL 509 Dictyostelium purpureum
XP_004251633 471 fde----------------------grffNETRINKLELRRRLVFICQFAVNARPSRGNVKQVFSYL 515 tomato
Q5Z9S3       489 fdh----------------------gnsfLKGDVTKLEMRKRLVFVCKYAVNARPSRGNLKQVYGFL 533 Japanese rice
KQK11203     494 fdd----------------------gdsfVKRNITKLEMRKRLVFICKYAINARPSRGNLRQVYGFL 538 stiff brome
XP_005850679 441 ---RLH--------------------EQPGGGSRLKLAVRQHLAAVSAHYPAARPTRGSLRQVFNF- 483 Chlorella variabilis
XP_004990534 472 ---TPDlsvnw----------iggapPDIHQPQLTKQDFTRALHCIRQRVPSACPSRHNMRKLTSFf 525 Salpingoeca rosetta
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