Conserved Protein Domain Family
Got1

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pfam04178: Got1 
Got1/Sft2-like family
Traffic through the yeast Golgi complex depends on a member of the syntaxin family of SNARE proteins, Sed5, present in early Golgi cisternae. Got1 is thought to facilitate Sed5-dependent fusion events. This is a family of sequences derived from eukaryotic proteins. They are similar to a region of a SNARE-like protein required for traffic through the Golgi complex, SFT2 protein. This is a conserved protein with four putative transmembrane helices, thought to be involved in vesicular transport in later Golgi compartments.
Statistics
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PSSM-Id: 398033
Aligned: 247 rows
Threshold Bit Score: 37.0991
Threshold Setting Gi: 20532308
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EAX96866      29 GiacAVISaifcFLSFIPFWqdnmvgfAILYALGSIGAIASTFFFSGWKKQWKNIKSSVpCLIAAIVVIVCILLLLIvGI 108 Trichomonas vag...
XP_018644010  14 GlglLAFGvgflCLGVLFFFd------GALLALGNVLFLGGIGCLIGLQKACTFFFRRT-SLKGAVFFFGGITVVLF-GF 85  Schistosoma man...
XP_003202556  11 GmglTGFGvfflFFGMILFFd------KALLAIGNVLFVAGLAFVIGLERTFRFFFQKH-KMKATGFFLGGVLIVLI-GW 82  turkey
XP_012662055  39 GvgiTGFGiffiLFGILLYFd------SVLLAFGNLLFLTGLSFIIGLKKTFTFFFQRH-KLKGTSFFLGGVVIVLL-RW 110 small-eared galago
XP_003770627  11 GmgiMGFGiffiLFGILLYFd------SVLLAFGNILFLCGLSFIIGLRRTFGFFFQWH-KLKGTSFFLGGVIIVLM-RW 82  Tasmanian devil
Q9DCQ3        11 GvgiTGFGvffiLFGILLYFd------SVLLAFGNLLFLTGLSLIIGLRRTFAFFFQRH-KLKGTSFFLGGVAIVLL-RW 82  house mouse
XP_002130219  11 GiglTGFGafflFLGMIFFFd------RVLLAFGNLLFISGLSFIIGLQRTFNFFFQRH-KIKSSGFFFTGIFVVLL-GW 82  vase tunicate
Q20263        13 GvglTTFGfffiFLGVLMFLd------SALLAIGNLLFIVGITFIIGVQRTLVFFFEFR-KLKGSILFFGGILVVLF-GY 84  Caenorhabditis ...
XP_002175233  10 GaslTALGllffVIGLFMLFd------GPFLSLGNILLMSGISLLMGISRMSYFFLRKE-KALGTIGFFTGALLIFF-HF 81  Schizosaccharom...
Q9USJ2        10 GvgtTALGflfmIMGIFMFFd------GPLLSLGNLLLVFGFFMIAGFSKSVSFFLRKD-RMLGSISFFSGLLLTLF-HF 81  Schizosaccharom...
EAX96866     109 ItkskalcVICVICQWVAQVFYIICSFPGGWTAI---KTTCG 147 Trichomonas vaginalis G3
XP_018644010  86 P-------FIGILLEIYGMINLFSKFIPVAIKFL---YGVPV 117 Schistosoma mansoni
XP_003202556  83 P-------LIGMILEIYGFFLLFRGFFPVVIGFI---RRVPV 114 turkey
XP_012662055 111 P-------LLGMLLETYGFFSLFKGFFPVAFGFLgntSSIPF 145 small-eared galago
XP_003770627  83 P-------LLGMALETYGFINLFRGFFPVAFGFLa--SNIPF 115 Tasmanian devil
Q9DCQ3        83 P-------LLGMLLEAYGFISLFKGFFPVVFGFLgsaFNIPF 117 house mouse
XP_002130219  83 P-------LIGMLIETYGFFLLFSGFFPVIINFL---RRIPV 114 vase tunicate
Q20263        85 P-------LFGMIAECWGFIVLFGGFLPGIVNLL---RSIPG 116 Caenorhabditis elegans
XP_002175233  82 P-------IAGFFIQLFGFINLFSSSFPLVKGFL---RGVPF 113 Schizosaccharomyces japonicus yFS275
Q9USJ2        82 P-------IIGFFVECLGFFNLFKVFYPLIISFL---RTVPY 113 Schizosaccharomyces pombe 972h-
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