4U3Q,3LHN


Conserved Protein Domain Family
NlpE

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pfam04170: NlpE 
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NlpE N-terminal domain
This family represents a bacterial outer membrane lipoprotein that is necessary for signalling by the Cpx pathway. This pathway responds to cell envelope disturbances and increases the expression of periplasmic protein folding and degradation factors. While the molecular function of the NlpE protein is unknown, it may be involved in detecting bacterial adhesion to abiotic surfaces. In Escherichia coli and Salmonella typhi, NlpE is also known to confer copper tolerance in copper-sensitive strains of Escherichia coli, and may be involved in copper efflux and delivery of copper to copper-dependent enzymes.
Statistics
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PSSM-Id: 398027
Aligned: 100 rows
Threshold Bit Score: 64.1575
Threshold Setting Gi: 495798163
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4U3Q_B            17 FRGTLPAADCPGIDTTVTFNADG-----TAQKVElAL-EKKSaP--SPLTYRGTWM-------VREDGIVELSlvssEQS 81  Treponema p...
WP_008522742      87 WHGVFPAASGSGVDVTVSFAGNG-----LYRRVD-KY-LTDRpY--STFVEMGTWN-------VASGKLAALVs---SSG 147 Jonquetella
WP_014993430      33 YSGMLPCADCSGIRTSLTLYSDEkdrptQYELRE-EY-MDSSrAg-RTEVERGQWAygnkemdGTAYRTVVLNpqseDVE 109 Alcanivorax...
WP_014237386      45 YIGEMPCANCVGVDWQLDLEADH-----SFQLSQ-AY-RGKGvT--AAVRRNGRWSl------DAKGDVLTLEa---PGS 106 Dechlorosom...
WP_052346066      50 YTDTVPCNDCRGIATRLTLKPDS-----LYELQE-VY-LGRPdP--TNYRR-GPWR--------VRGQVVTLAp--sGNN 109 Hymenobacte...
BAH40863          51 YNGTLPCADCSGLITTLTVWPDS-----LYRLRE-TY-DGKS-K--TPFVRMGRYQ--------FDGKTLTLEg---DTG 109 Gemmatimona...
jgi:CAP2UW1_2595 170 FVGVVPCADCPGIAQTLTLRADG-----LYRLRR-TY-LSKP-E--GPFSELGRWTe------EAGGKVLRLR----SGS 229 Candidatus ...
jgi:Mpe_A0410     42 FAGVLPCADCAGVAQTLTLRADG-----LYRLRR-TY-LGKP-E--GPFSELGHWKl------NAAGTLLMLRg---ETD 102 Methylibium...
Q0VN34            36 YSGILPCADCSGIHTTLILYRDQydtptRFELSE-EYmSGSTvK--LNVVERGEWTshkyqegVSQEDVYTINp--eDDD 110 Alcanivorax...
WP_012987207      45 FTGVVPCADCTGIETTLQLSSDG-----SYILGQ-IY-LEAK-NeeNTFFETGHw--------IKSGKKIDLTh---EDG 105 Xenorhabdus...
4U3Q_B            82 kaphEKELYELidSNS-------VRYMGA 103 Treponema pallidum subsp. pallidum str. Nichols
WP_008522742     148 ----DKTWFMLdkKGS-------LVLSDE 165 Jonquetella
WP_014993430     110 ----SQLRYLEtaLNA-------LEMLDI 127 Alcanivorax dieselolei
WP_014237386     107 ----DSTRLSVqnPER-------LRLLDG 124 Dechlorosoma suillum
WP_052346066     110 ----PVRRYQVeaARK-------LRLLDA 127 Hymenobacter swuensis
BAH40863         110 ----VVGRWALmpGDS-------LRMLDQ 127 Gemmatimonas aurantiaca T-27
jgi:CAP2UW1_2595 230 ----QATLFAVhdDAS-------LRLLDR 247 Candidatus Accumulibacter phosphatis clade IIA str. UW-1
jgi:Mpe_A0410    103 ----TL-LFAV--MPSgaedeggLRLLDR 124 Methylibium petroleiphilum PM1
Q0VN34           111 ----ARRQYIKdaINA-------VEQLDS 128 Alcanivorax borkumensis SK2
WP_012987207     106 ----KKSYYQM--KGEn------LVMLDI 122 Xenorhabdus bovienii
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