1W7P


Conserved Protein Domain Family
EAP30

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pfam04157: EAP30 
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EAP30/Vps36 family
This family includes EAP30 as well as the Vps36 protein. Vps36 is involved in Golgi to endosome trafficking. EAP30 is a subunit of the ELL complex. The ELL is an 80-kDa RNA polymerase II transcription factor. ELL interacts with three other proteins to form the complex known as ELL complex. The ELL complex is capable of increasing that catalytic rate of transcription elongation, but is unable to repress initiation of transcription by RNA polymerase II as is the case of ELL. EAP30 is thought to lead to the derepression of ELL's transcriptional inhibitory activity.
Statistics
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PSSM-Id: 398021
Aligned: 213 rows
Threshold Bit Score: 85.7374
Threshold Setting Gi: 562972667
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1W7P_A         4 FGLAAF-D-E-LKDGKYndvnKTILEKQSVELRDQLMVFQErLVEFAKKHNSELQASPEFRSKFMh-------------- 66  baker's yeast
XP_007374681 112 GGIHALeMlDeQQRRQN----EIILSSSLNDLEQLMFKYQD-LIKLSGSFNQFIKPNEHNKRVPTss------------q 174 Spathaspora pas...
CCE43466     317 AGIHALeAfGeQQRKNN----EKILGSSLDDLEQLMFKFED-LIKLSSSFKRLLVSKDDKTiy----------------k 375 Candida parapsi...
EMG50831     299 VGIHALeQlGeLQRKEN----ERILSSSLDDLEQLMFKYQD-LLKLSTSFNKLVIKSQDNLnl----------------p 357 Candida maltosa...
XP_004204396 335 VGIHALeKiSeVQRKQN----EMVLASSLEDLEQMMYRAQD-LISLSNIFGRLIEARQVvq------------------g 391 Pichia farinosa...
XP_002175146 219 GGVHALqVsHqKQVKQS----GATLTRAFQDLNAFMSLAKQ-TNDLIKNLSQQSKETNLSPTNNDlemtvtrsyfdqfss 293 Schizosaccharom...
EPY53559     224 GGIHGLqQsHaLRLAQN----GQTLVRAFQDLDAFFSLTRE-TMELADQFVERIQNLAGFAKQSDrvqql--------lk 290 Schizosaccharom...
CCH62146     306 TGISTLeQsReTQLARN----DILLNNALSDLSNLMSFADD-IEKLYSRYNKNDISsskmnskqvpsl------------ 368 Tetrapisispora ...
CAR26586     335 IGITSLeKsGeTQLLNN----DIIFNNALTDLNRLMSLAND-IEQLYTGISPKLLgerkegghkpsl------------- 396 Zygosaccharomyc...
XP_003678488 305 IGITSLeRsReNQLLNN----DILFNNALSDLNSLISLANN-IERLYRSTKNSQQQTNssshriakkpal---------- 369 Naumovozyma cas...
1W7P_A        67 MCSSIGIdplslfdrdkhlftvndFYYEVCLKVIEICRQT---KDMNG------GVISFQELEKVHfr---------klN 128 baker's yeast
XP_007374681 175 AIPSLNLkhs--------------spqELSRHISEYLI--------NYeltttsSMITSQDLFANYnrflintqgfgcdL 232 Spathaspora pas...
CCE43466     376 NIPPLTIsrt-----------sklYHSELSRHMSEYLT--------SFvltkksSMITLPDLFAEYnrflvkcsgfgteL 436 Candida parapsi...
EMG50831     358 VIPALNIkkn-----------sslYPQELSRHISEFLI--------NFiltqrtSMISSQDLFAEYnrflirnqgfgtqL 418 Candida maltosa...
XP_004204396 392 IVPPLKIkks-----------sklYHQELSRHISEYLA--------NLqltkssSMVTVQEAFAFYnrylvstqgfgtdL 452 Pichia farinosa...
XP_002175146 294 YDVSLT------------------TTTELSKSVAQVLHSYfkkTSC--------AAVTLTVAWAIYnrtr------gidL 341 Schizosaccharom...
EPY53559     291 rtqQLGLlrnnyanmvsdssnarlFQVELCKSISELLL--------NHlks-dtDTITMTHAWAMYnrar------kteL 355 Schizosaccharom...
CCH62146     369 ------------ivdrdkfynkniFIEEIAREIYEFATSEfkdEQQREg----cVMISLVDLYAMYnkamr----igvgF 428 Tetrapisispora ...
CAR26586     397 ------------ildrekfynkslFLDEIAREIYEFAISEfkaEKERLg----yVMVTLVDLYAMYnkcmr----igtgL 456 Zygosaccharomyc...
XP_003678488 370 ------------iidrekfynkelFLDEIAREIYDFAMSEfneTTTTTqnenihIMVTLVDFYAIYnksmr----igtgL 433 Naumovozyma cas...
1W7P_A       129 VGLDDLEKSIDML--KSLE---------CFEIFQirgkkflrsvpNELTSDQtkilEICSIl---------G-------- 180 baker's yeast
XP_007374681 233 IKAADFNKSLELFaqLNLPvtmrkyeksGLLVIA-----------KTKLLQE----SYGKYivnfikdqehEyklnkcrh 297 Spathaspora pas...
CCE43466     437 VDIVDFRKSIDLFdtLNLPvvsnkyeksELVVI------------RPRVHAN----SYSEFiveflsqqehKykrsfira 500 Candida parapsi...
EMG50831     419 VTSSDFKKAIGLFdeLKLPvilkqytksDIYVV------------SSRSTSN----TYGEFivdylknqeyEykfmklkq 482 Candida maltosa...
XP_004204396 453 VAAEDFGKAVELFdeLKLPfrlqhykksDISVIC-----------YRNSFDN------SKLirdmleeqerSfkynslka 515 Pichia farinosa...
XP_002175146 342 INPSLFLSVCQEMvkMNLGirqi-tfpsGLIVLE-----------LVDDHRS----NVLELimst--------------- 390 Schizosaccharom...
EPY53559     356 VSPTDFAKACELFptLDLGihvs-klssGVSLFQ-----------LKLPNQRe---KFLSAlldt--------------- 405 Schizosaccharom...
CCH62146     429 VSPLEMREACESFerLGLTklkltkinqRILCLG-----------SDNALE-----IIKTKivqiieqfpgShllqisk- 491 Tetrapisispora ...
CAR26586     457 ISPQEMREACERFeeLGLKdlkltkingRVLCLA-----------SKNSFD-----FVKTKildivnesagCdpllltq- 519 Zygosaccharomyc...
XP_003678488 434 ISPLEMKEACQRFekLGLNnlkltrinnRVLCLS-----------TKDSFN-----FVKSQilstidqnpgSdllnltnl 497 Naumovozyma cas...
1W7P_A       181 -----------------------YSSISLLkanLGWEAVRSKSALDEMVANGLLW--IDY 215 baker's yeast
XP_007374681 298 dmmq-------gvivlehescfrGVTVGEIsstLNWSNNVTIEEVEICVNEGIIV--VDQ 348 Spathaspora passalidarum NRRL Y-27907
CCE43466     501 kmvdd-----gdndgldhengcyGATVSEIshaLNWSYNVTMEELDKSIDSGLVV--LDQ 553 Candida parapsilosis
EMG50831     483 ematg-----devmndlynaagyGKTVSEIstqFNWSYNITIEELDKCVEEGLVV--IDH 535 Candida maltosa Xu316
XP_004204396 516 kllaqyqssedsnywherfayfkGSTIPEIcnaLGWSYAITVEEIDTCVEAGLVV--VDK 573 Pichia farinosa CBS 7064
XP_002175146 391 --------------------mkpyTSALECavtLGWPVNVALEHLHQAEIEGSIV--RDM 428 Schizosaccharomyces japonicus yFS275
EPY53559     406 --------------------mqptVTISQCamkLHWSIGVTMEQLESAESEGYILppKTT 445 Schizosaccharomyces cryophilus OY26
CCH62146     492 ----------------klneysqS----------DWTIGVITEVLQNCIDSGILV--VDE 523 Tetrapisispora blattae CBS 6284
CAR26586     520 ----------------llnrdssN----------AWTFAIITEVLQNCIDHGDIV--IDE 551 Zygosaccharomyces rouxii
XP_003678488 498 ----------------intpstkTANNNKMet-nNWTIGVIMEILQNCVDEGDLL--IDE 538 Naumovozyma castellii CBS 4309
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