4YKE


Conserved Protein Domain Family
Mre11_DNA_bind

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pfam04152: Mre11_DNA_bind 
Mre11 DNA-binding presumed domain
The Mre11 complex is a multi-subunit nuclease that is composed of Mre11, Rad50 and Nbs1/Xrs2, and is involved in checkpoint signalling and DNA replication. Mre11 has an intrinsic DNA-binding activity that is stimulated by Rad50 on its own or in combination with Nbs1.
Statistics
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PSSM-Id: 398018
Aligned: 143 rows
Threshold Bit Score: 104.597
Threshold Setting Gi: 154799108
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4YKE_A       293 EKIPLRTVRPFVIREITL-------ATDKrf----------kgLekKQDNRQEVTKRLMQI-VEE-MIAEANEMWrslhe 353
EGI60927     297 KPLKLQSVRPFIFDNLVL-------HDHDik----------mrN--CVSLANAISQYVDQY-IENnIMPKVAEQI----- 351 Panamanian leaf...
XP_011266692 298 KPLKLKSVRPYIFENLIL-------SDHDik----------ihD--CISLADSVSQYVDRY-IENeLMPKVAKQL----- 352 Florida carpent...
EFN86093     298 KSIKLNSIRPFVFDNMIL-------RDHHdi-----------kV--GISLAESISQYVDQY-IENnIMCKVAEQL----- 351 Jerdon's jumpin...
XP_028027412 297 TPLPLQTVRPFIFKTIVL-------SEENig-----------sE--DVNENEKVQEFLKNR-VNE-AIDEASKLK----- 349 wild silkworm
9_pfamImport   4 KPIPLKTVRPMIVDELVL----------DkippgckptlkterP--KRKDGRYVDELAIEAkLNE-MIGRAKANR----- 65 
Q23255       358 KPIPLQTVRPMVCDELLL----------DkippgsrpilktdrP--KHTDGRYIDEIAIEAkINE-MITTAKAKR----- 419 Caenorhabditis ...
EGT55264     359 KPIPLQTVRPMVCDELVL----------DkippgcrpvtrterP--KNRDGRYIDEIAIEAkLNE-MIARATSGR----- 420 Caenorhabditis ...
EFX72660     300 EKLPLRTTRPFVFDTLSLdefcdigYQFAnd---------------------eVVEKIRSK-IND-MLDFSKTLL----- 351 common water flea
XP_001603902 321 NYLKLKTVRPFVFEDLVL-------NDYNde----------isS--YKSRQDAVEEFVDNY-IENtLITKATEQL----- 375 jewel wasp
4YKE_A       354 dsqDDEDEEQPLPLIRLKVEYSspegtKFEVENP--QRFSNRFAGKVANQNDVVHFYRKKTGTTRKPKEGKRELPegiae 431
EGI60927     352 ---TGYPGQPLQPLIRLRIFYDh----DSEQFDT--LSLAQRYCDEVANPMDMILFRKRKTGDKGKRTIEDEIDDpddia 422 Panamanian leaf...
XP_011266692 353 ---TGYPNQPSQPLIRLRIFYNd----DNEQFDT--LSLAQKYCDEVANPMEMIIFRKMKSGEKSKRF-NDEIDDlddit 422 Florida carpent...
EFN86093     352 ---TGYPDQPLQPLIRLRIFHEd----DNQIFDT--LSLARKYCDEVANPMEMIIFRKIKNVEKIRRAIRDGLEDveeit 422 Jerdon's jumpin...
XP_028027412 350 ---TADLRQPLLPLIRLSIFYEr----ESQNFNR--IRFGQNFNGLVANPNDLLIMKKEKKIREKRERDPEEEGDmtgv- 419 wild silkworm
9_pfamImport  66 -----RPTQPELPLIRLKVTYDad-wlDVTPANA--KRIGLRYESQVANAADMVVIRKNTKSTDSKGKKQQGNSKgddis 137
Q23255       420 -----RPRQPELPLIRLKVIYDgd-wlNITPANA--KRIGLRYENVVANAVDMVFIKKNNKPKEGKLQTENEKNItemad 491 Caenorhabditis ...
EGT55264     421 -----GPRQPELPLIRLKVIYDgd-wiNVLPANA--KRIGLRYENTVANAVDMVTIKKVSSNQAKEKKMKDDETQfkdel 492 Caenorhabditis ...
EFX72660     352 ---SGHPDQPTLPLLRLRIEHEs----DQQFLNTrdLHVELGLEKLVANPEDVVKLLRKRSAQDKIKVDVDEEAWdavfn 424 common water flea
XP_001603902 376 ---TAHPKQPQAPLIRLRVFYSe----DRDVFDT--LQLSQKYYHVTANPNDMILFRKCSSKLKKKDIKVQEQDLgevse 446 jewel wasp
4YKE_A       432 a-----ledsdsISVDALVQEFFAQQ----SLKILPQAPFGDAVNQF 469
EGI60927     423 elfegdkgenwtSTVQGGIKKYFDMEenkdKLTILTVTAMNEALNRY 469 Panamanian leafcutter ant
XP_011266692 423 elfqadigqdwiSTVPGGIKKYFDMEenkdKLTVLTVTALNEALNRY 469 Florida carpenter ant
EFN86093     423 elfqgnleqdwnRTVPGGIKKYFDMEenkdKLTVLTVTALNEALNRY 469 Jerdon's jumping ant
XP_028027412 420 --------aaeaADVESLLRAYYEAQpkdkRLSVLSVRVITDAVRDF 458 wild silkworm
9_pfamImport 138 de----lghvsvANLQNIINDYFSGKkfeeRMTVLKPSGIGKALEHY 180
Q23255       492 e-----mgqvsaTNLQTIINDYFINQplvdQMTVLKPIGIGRALEQY 533 Caenorhabditis elegans
EGT55264     493 -------ghvsaANLQTIINDYFINQpiaeQLTVLKPFGIGKALDQY 532 Caenorhabditis brenneri
EFX72660     425 me----sinmveGHLENLLVDYYKESk--kPLLVMHERTLAEAVRYY 465 common water flea
XP_001603902 447 ifrfdenekdwkRTVQGGMTEYFNKPdkvnKLTVLSLTGLNESLARF 493 jewel wasp
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