4U8T,5O8M


Conserved Protein Domain Family
YTH

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pfam04146: YTH 
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YT521-B-like domain
A protein of the YTH family has been shown to selectively remove transcripts of meiosis-specific genes expressed in mitotic cells. It has been speculated that in higher eukaryotic YTH-family members may be involved in similar mechanisms to suppress gene regulation during gametogenesis or general silencing. The rat protein YT521-B is a tyrosine-phosphorylated nuclear protein, that interacts with the nuclear transcriptosomal component scaffold attachment factor B, and the 68-kDa Src substrate associated during mitosis, Sam68. In vivo splicing assays demonstrated that YT521-B modulates alternative splice site selection in a concentration-dependent manner. The YTH domain has been identified as part of the PUA superfamily.
Statistics
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PSSM-Id: 398013
Aligned: 215 rows
Threshold Bit Score: 77.5251
Threshold Setting Gi: 124470732
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4U8T_A                          26 SRFFVIKSSSLEHVKKSFYNG-IWSSTFYGNKRLSEAYESLpqgAKIYLLFSVNASGRFCGVAEXS--------SNLRED 96   Zygosaccharomyces rouxii CBS 732...
Q4UE68                          26 CVYFILKGLSPESITTAIEYD-VWGTRSSVQRTLTKYYDDG---YKVILIFPLFATNTLAGYALMKsrpgeyskSRSKFS 101  Theileria annulata...
A0C791                         169 AVFFIVKSNTEQNVILAKTHD-VWATTRRNFGTLMDQFNNK----KVILIFIANRVEKFLGCAKMK---------NIQVP 234  Paramecium tetraurelia...
XP_002173827                   340 SRYFIMLVDNETAISHAKRSS-VWSLKQNYANAISEAYKQE---ANVYFIFINAKSYNALGYAQLT--------SDVGTV 407  Schizosaccharomyces japonicus yFS275...
5O8M_D                           8 SRYFIMLCDNETAIAHAKKTS-IWAVKKDSSKRISDAYKKA----SVYFIFVAQQTYNALGYAQVV--------SDLNST 74   Schizosaccharomyces pombe 972h-...
XP_013025346                   340 SRYFIMLCDNETAIAHAKKTS-IWAVKHEAASRVSDAYKKA----SIYFIFIAKPTNNALGYAQVV--------SDLNSA 406  Schizosaccharomyces cryophilus OY26...
WGS:AAGF:cds.TTHERM_00399440A  181 KKYFIIRNRNEYFRKIAQEQS-IFLIH-KNYEKLCEAFKNS---DDVYIIFSNIDQKHFYGYATMIse-----aDELRFI 250  Tetrahymena thermophila SB210...
A0E4N3                          17 SKFFTVKYKSKAQADSSLNNKhIFIQR-KFDKLIDRAMEKS---KSVGIFLNCVDEKSFIAFGILQsqs--iqfEMLTED 90   Paramecium tetraurelia...
A0BNI8                          17 NKFFIIKYKTRGQADLSLNNQ-VIFLQKRFDQQLRNAAQVC---EQVGVFLSCLDQQSFIAFGTIQ-----------NEP 81   Paramecium tetraurelia...
EGD82482                        26 CAFYLVRSHTEENIRLSQQHD-LWATPKRNMSKLKADFKNN---ENLYLIFIANGSSSYSGYARVE-----------GMD 90   Salpingoeca rosetta...
4U8T_A                          97 LDT-SIWG-DNSR----YR--------HAF----KVRWIVVRDVHNRSLKQFLIPA-NDXKPVTNSRDTQEIPATISKSI 157  Zygosaccharomyces rouxii CBS 732...
Q4UE68                         102 SVk-------------fDG--------PLF----DISWVRCLDLNPPEYAHISKYF-T-KAPVVNTKDGHELDKNTGYDL 154  Theileria annulata...
A0C791                         235 RD--PKWQ---------WCgtstiqlaDNF----SIEWLRKGTVDFAKLQDTINPK-TGDLVI-RSKDCQEVPADIGQRI 297  Paramecium tetraurelia...
XP_002173827                   408 AK--PFWAdTTYT--------------NGV----NVKWIKTCNLYSNEISEIVSRMdHG----ARARDGQEMMYDEGSRL 463  Schizosaccharomyces japonicus yFS275...
5O8M_D                          75 EL--PFWSdSSHA--------------GGV----RIKWIKTCNLFSAEISEIVSHMdHG----SEARDGMEMMYDEGSRL 130  Schizosaccharomyces pombe 972h-...
XP_013025346                   407 EL--PFWAdNAT-----YA--------GGV----RVKWIKTCNLFSAEISDIVGRM---NHGM-TAKDGMEMMYDEGCRL 463  Schizosaccharomyces cryophilus OY26...
WGS:AAGF:cds.TTHERM_00399440A  251 SSQlENYQnLKNK-----G--------EEYimysKIQWSSQTPLHYDHCKNILNPW-NSNKPINFSKEFQEVEPAAALQL 316  Tetrahymena thermophila SB210...
A0E4N3                          91 QK--INLSnLKGN----YE--------SFF----KVDWTLKGVLSYEKTQKIKNVL-NDLLPVNQGKEVEELSGSNAEEV 151  Paramecium tetraurelia...
A0BNI8                          82 TDF-EYLTeEQQQnlskLQ--------EFFqsfvKVEWIFKGVLNFEKTKNIKNDL-NEMKPVNHCKDVQELTCQTAEQL 151  Paramecium tetraurelia...
EGD82482                        91 DDIdFDWNtSVN-----LG--------STF----LVRWINTYGMPTAKASHLRNNLrR-RQEIHKCPDMTKIESVAAAKL 152  Salpingoeca rosetta...
4U8T_A                         158 LKLFK 162  Zygosaccharomyces rouxii CBS 732
Q4UE68                         155 CKIFE 159  Theileria annulata
A0C791                         298 CLLFE 302  Paramecium tetraurelia
XP_002173827                   464 CTLIN 468  Schizosaccharomyces japonicus yFS275
5O8M_D                         131 CTLIN 135  Schizosaccharomyces pombe 972h-
XP_013025346                   464 CILVN 468  Schizosaccharomyces cryophilus OY26
WGS:AAGF:cds.TTHERM_00399440A  317 LELLD 321  Tetrahymena thermophila SB210
A0E4N3                         152 LTYRN 156  Paramecium tetraurelia
A0BNI8                         152 LSLLQ 156  Paramecium tetraurelia
EGD82482                       153 LTLMD 157  Salpingoeca rosetta
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