Conserved Protein Domain Family
Rad9

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pfam04139: Rad9 
Rad9
Rad9 is required for transient cell-cycle arrests and transcriptional induction of DNA repair in response to DNA damage. It contains a Bcl-2 homology domain 3 (BH3).
Statistics
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PSSM-Id: 398008
Aligned: 10 rows
Threshold Bit Score: 299.619
Threshold Setting Gi: 74685290
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P26306        13 LARIFTNLSRIDDAVNWEINKNQIEITCLNSSRSGFSMVTLKKAFFDKYifqpdsvlltGLMTPTIRIRTQVKPILSVFR 92  Schizosaccharom...
Q058K5        13 LSRSIICLARVGNELVVQASPTQLALHTLNASRSAYQCITFQSSFFDVY----------TVSGPQAHFSVLLKAVCSVLR 82  thale cress
Q7QCA1         2 LARAVNCFSKIGNELYFEATPDGLDLKTINSTNTAYAVVQFRRDFFISFqq------gsSDTPDENCCKISVKPILKIFK 75  Anopheles gambi...
Q2M0E1        13 IAKAVQSLSKVGKEMFIEIEQQGLQMRAINATQSAVGSIFFKRSMFEVFd---------MPPSSDFYCKISMKGCLAVFR 83  Drosophila pseu...
Q5E9X8        32 FGKAIQALSRVSDELWLDPSEKGLALRSVNSCRSAYGCVLFSPVFFQHYqwsasvkmndTDIILNLNCRLGMKSILPIFR 111 cattle
Q6WBX7        14 FGKAVQTLSRVSDELWLDPSEKGLALRSVNSCHSTYGYVLFSSMFFQHYqwspfatmsdTDLPLNLNCKLAIKSVLPIFR 93  house mouse
Q5KH95        14 FVRLLQCASKFGDDLHICIGEGLWEMSAVDSSKSAFCLFKLNKDFFYKWe---------KRVSGQIICRILVKSVIAVLg 84  Cryptococcus ne...
EPY53466      13 LSRIFLNLSRIDDAVNWEINKDQLILTSLNSSRSGFGMVTLTKKFFDKFtfhpdtlfltGFVSPTVRLSTQIKPILSIFR 92  Schizosaccharom...
Q869Q1        13 FSKSLQCISRIGDDLYIEGRQEYIKFTTVNNSKSAFVVFQFSNSFFHSYs---------LEGDEGIQYKAKSKLCFQMFH 83  Dictyostelium d...
NP_001005810  17 LGRAVHSLSRIGDELYFEPLEDGLCLRSVNSSRSAYASFTLAPLFFHSY----------EATGGTCHCKIHMKTVISVFR 86  tropical clawed...
P26306        93 nkifdfiptvvttnskngygsesasRKDVIVENVQISIs---TGSECR-------------------------------- 137 Schizosaccharom...
Q058K5        83 -------------------------TPLASIDHMSVQLp---DHDASK-------------------------------- 102 thale cress
Q7QCA1        76 sl--------------------------aTIQTCKIWL----EVNQSK-------------------------------- 93  Anopheles gambi...
Q2M0E1        84 nm--------------------------nEVEYCELNL----IDNQTN-------------------------------- 101 Drosophila pseu...
Q5E9X8       112 cl----------------------nSLEKNVEKCKIFT----RSDKCK-------------------------------- 133 cattle
Q6WBX7        94 cl----------------------nYLERSVEKCTVVA----RADKCR-------------------------------- 115 house mouse
Q5KH95        85 k-----------------------sAQMSTVQRIDLRIidpsDELKSRlrrrrrggreangeeqkvfvddgpaypdddea 141 Cryptococcus ne...
EPY53466      93 nkifessllvtnnpnantgatdstsKKNVVVENVQIQIt---SGKECR-------------------------------- 137 Schizosaccharom...
Q869Q1        84 sl--------------------------sNIDKCAMKI-----DLEGK-------------------------------- 100 Dictyostelium d...
NP_001005810  87 sl----------------------pSLEKTVEKCLISL----NAEKSR-------------------------------- 108 tropical clawed...
P26306       138 -------IIFKFLCKHGVIKTYKISYEQTQTL-HAVFDKSLSHNNFQINSKILKDLTEHFGQRTEELTI----------- 198 Schizosaccharom...
Q058K5       103 -------VKWTLQCYSGMKKTYWITCNVEPDIqHLSLDRGRFPSTLVMHPRNLSKLLGNFQSSLQEITIiatdqtsfpsd 175 thale cress
Q7QCA1        94 -------IIFQFRCKSDVLKTHKIFLLESEHInSLNL-SQTFPSEIVGNHKVFSNILVHLYHSVDEISF----------- 154 Anopheles gambi...
Q2M0E1       102 -------LQVNLRCKLETTKEATISIIDDQNI-NTNVDTDQRPNIIRGDHKLFMDISNNFNSAEEELTM----------- 162 Drosophila pseu...
Q5E9X8       134 -------VVIQFFCRHGIKKIHNVCFQGSRPL-QVIFQKNMCANTLVIQPRVLAEAIVLFTSSQEEVTL----------- 194 cattle
Q6WBX7       116 -------VVIQFFGKHGIKRTHNVYFQDSQPL-KIIFEKSLCANILMIKPRLLTEAIALLTSNQEEVTF----------- 176 house mouse
Q5KH95       142 vggieakLIMRLVCDHGVIRKHSLHLGTSEFN-RADVDPETTPSGFTISSRTLRDWLDHFSISMPTSGSnasggl---sq 217 Cryptococcus ne...
EPY53466     138 -------VIFKFYCKHGVIKTYKIAYEQTQML-HAVFDKASCHNNWQINSKILKDLVEHFGQKTEELTI----------- 198 Schizosaccharom...
Q869Q1       101 -------ISFYLLCKNGIQKTYSINYELSQLQ-SAVYNKNS-PYKISVKPKQISDCLNYFASNTEEISI----------- 160 Dictyostelium d...
NP_001005810 109 -------LVIQLLCKYGITKTHNLSYQDCESL-QAVYNPDTCPNMLRAPARLLSDAVMHFPQTLAEITI----------- 169 tropical clawed...
P26306       199 ---QPLQ-ERVLLTSFTEEVVHNrdilKQPTQTTVSIDG-KEFERVALNEG-----------------VSVTLSLREFRA 256 Schizosaccharom...
Q058K5       176 aasEIGG-KAVEFRSYVDPTKDG----DSLLHTQLWIDPsEEFLQYTHAGDp----------------VDITFSLKELKA 234 thale cress
Q7QCA1       155 ---DLNE-EKTIVSNYVDNEQAD----RSTLRSTLSIDS-SAFQAYQLAGK-----------------ANLIFCYKEFKA 208 Anopheles gambi...
Q2M0E1       163 ---EANT-GSLVAKNYIEGARVN----DKFMRTQLKLKP-SEFDQYQVTKE-----------------TIITFCIKEFRA 216 Drosophila pseu...
Q5E9X8       195 ---AVTP-LKVCIKSSNEESMDL----TDSVYSEMFVGP-DEFDFFQIGID-----------------TEITFCFKELKG 248 cattle
Q6WBX7       177 ---SVTP-GNFCLKSLSGELLDL----TSSVYSEMSFGP-EEFDFFQVGLD-----------------TEITFCFKELKG 230 house mouse
Q5KH95       218 lgwMFAK-DHVKIKSWEGPGNGN-----AGLSTEITIDT-EEFEDYGLIETrylddeatqqggnlgprVDLTLPMKEFKA 290 Cryptococcus ne...
EPY53466     199 ---QPVH-GRVLLTSFTEEVIHNkdvlKQPTQTTVSIDG-KEFEQVSLNEG-----------------IVITLSLKEFRA 256 Schizosaccharom...
Q869Q1       161 ---NLQR-DRLLIKSSTDDKRGL-----KNLFTELVLDR-SDFDEYDFNGDg----------------EEISFNFKDLKT 214 Dictyostelium d...
NP_001005810 170 ---MASPcGKVTLRNYVEEDIDS----TKTMLTELSLSR-DEFLVYQLKKQ-----------------SDITFCLREFRG 224 tropical clawed...
P26306       257 AVILAEALGSSICAYYGVPGKPILLTFAk----gKNSEIEAQFILATV 300 Schizosaccharomyces pombe 972h-
Q058K5       235 FLAFCEGCEADIHLFFEKAGEPILMAPKfglgdgSSSSFDATLVLATM 282 thale cress
Q7QCA1       209 ITMFASLNKLNVRMSFSAPGSPLMLEMS------KGEVVHAKFIMGTM 250 Anopheles gambiae str. PEST
Q2M0E1       217 FLLFAECLNASLSLEFDDAGSPFMLKIK------KHGEIECLLIMSTL 258 Drosophila pseudoobscura
Q5E9X8       249 VLTFSEAIHAPIAIHFDFPGKPMALSID------D-MLLEANFILATL 289 cattle
Q6WBX7       231 ILTFSEVMHAPLAIYFDFPGKPVVLSVE------D-MLLEANFILATL 271 house mouse
Q5KH95       291 TLVLAEQLSINLNMAFSEAGQPLTITNLe----nELEYIELFCAIATR 334 Cryptococcus neoformans
EPY53466     257 AVLLAESLGTSIASYYSVPGKPALFTFNk----gKFMEVEAQFILATV 300 Schizosaccharomyces cryophilus OY26
Q869Q1       215 IMAYVDVINNPCTWFIERAGLPFHINLK------YSSTYEVDFVLATL 256 Dictyostelium discoideum
NP_001005810 225 LLSFAESTSLPVSIHFNTAGFPAVFSVD------D-TVLEVHFVLATL 265 tropical clawed frog
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