1RQ1


Conserved Protein Domain Family
ERO1

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pfam04137: ERO1 
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Endoplasmic Reticulum Oxidoreductin 1 (ERO1)
Members of this family are required for the formation of disulphide bonds in the ER.
Statistics
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PSSM-Id: 398006
Aligned: 157 rows
Threshold Bit Score: 235.915
Threshold Setting Gi: 122050827
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1RQ1_A                         27 NIRDDLSALLKSDFFKYFRLDLYKQCSF--W-DANdGLC-------------LN---------------------RACSV 69  baker's yeast...
Q54IC1                         51 EINVLLNKIVKTRFFKYFKANLFSECPF--Wvv--tALC-------------GS---------------------EGCGV 92  Dictyostelium discoideum AX4...
EFA76699                       50 QLNQILNKLVKTRFFRYFRVNLFAECPF--Wvv--tQLC-------------GL---------------------EGCGV 91  Heterostelium album PN500...
Q8IIC3                         76 RAYPILKELKQKDYFRIFKVNLHLSCKV--F-LKGnEKC-------------KEi--------------------KKCSV 119 Plasmodium falciparum 3D7...
Q4MZU9                         82 TIHLKLSNILSDYYFRIFLVNLDSNCKS----KPRiNSCpsqthylsldknkTKngatpfsllntptpnsnktevAKCHV 157 Theileria parva...
EDO05839                       55 lVHSKLAPLMRSLYFRILKVNLDTPCPL----RERnDIC-------------SNgmdddglldn--akngdfeciPKCYV 115 Babesia bovis...
CAM67040                       71 sLLDILNRITVSPYFRYFKVNSAKPCPY--WaVSLlCTS-------------AE---------------------NTCDV 114 Leishmania infantum JPCM5...
Q57UW3                         73 gITGLLNNITSHPYFRYFKVNLDRECRY--WvAEAsCTC-------------DS---------------------NGCQI 116 Trypanosoma brucei...
WGS:AAGF:cds.TTHERM_00150029A  63 QTHLLLSHIQQQKFYRTIKVPKDQQCLYfkQ-QEEhAVC-------------KN---------------------KSCSI 107 Tetrahymena thermophila SB210...
Q24DE0                         73 KIYQKLDELSHTKFFRTFKVNIDTECKF----FSVeGIC-------------KS---------------------QGCSV 114 Tetrahymena thermophila SB210...
1RQ1_A                         70 DVvEDWDTL-PEYWQPE----ILGSFNN-DTmkeaddsddeckfldqlcqTSK-------KPVDIEdTI----------- 125 baker's yeast...
Q54IC1                         93 CE-CDDNEI-PLPWRIEd--tTSDKVDMsPPpp-------------------------gfQKWKDKkDD----------- 132 Dictyostelium discoideum AX4...
EFA76699                       92 CE-CDDNEI-PLPWRIEd---SSDKVDMsPPpp-------------------------gfTRWKDKkED----------- 130 Heterostelium album PN500...
Q8IIC3                        120 CE-CEQDEI-PYNFRTN----EIEIIENkMTn-----------------------------------EDlkktfieskly 158 Plasmodium falciparum 3D7...
Q4MZU9                        158 DR-CNSREV-PLSIMGN----------------------------------RKenyvlrfSEGLVGsTDgfg------fn 195 Theileria parva...
EDO05839                      116 GR-CQPQEVsPEP--------TLDGLEHfVLry--------------------------vDDDKLAeMDpkdlyvdnpwy 160 Babesia bovis...
CAM67040                      115 CK-CDENSI-PEALRADedmsELNTPDGsVAk----------------------------TVLQPVnLD----------- 153 Leishmania infantum JPCM5...
Q57UW3                        117 CT-CDDSGI-PETLKYPydmsDVSTVERrAAp----------------------------DKHAAKgFE----------- 155 Trypanosoma brucei...
WGS:AAGF:cds.TTHERM_00150029A 108 CK-CEQEDI-PLEWRKE---------------------------------DQNecyiknnDYEDETtQK----------- 141 Tetrahymena thermophila SB210...
Q24DE0                        115 CR-CDENNI-PLPWKKT------DFIQQsKY------------------------------------------------- 137 Tetrahymena thermophila SB210...
1RQ1_A                        126 -N----------------YCdVNDFNGKN---AVLIDLTANPERFTGYGGKQagqIWSTIY-----QDNCFtigET---- 176 baker's yeast...
Q54IC1                        133 ------------------MWvVVAGPDSE---STYVDLSKTPESNTGYDGSS---VWSAIY-----NENCF---HRp--- 177 Dictyostelium discoideum AX4...
EFA76699                      131 ------------------MWvIPYGSDAD---TSYVNLGETPEAYTGYDGSS---VWRSIY-----NENCF---TRp--- 175 Heterostelium album PN500...
Q8IIC3                        159 kD----------------ILgIY--APSNegfISYVDLVYNSPSFTAYEGRN---IWNMIY-----KENCF---QN---- 205 Plasmodium falciparum 3D7...
Q4MZU9                        196 rD----------------FLvRSNLVPDN---CVFVDLLRNPPSYTGYNGQD---DWRLMYdeidkYDNMS--------- 244 Theileria parva...
EDO05839                      161 kD----------------FLgIYSHNRDK---AVYVDLMHNPPSYTGYRGGE---DWNSIYd---lQSDCG---D----- 207 Babesia bovis...
CAM67040                      154 -D----------------WGdWLKADDG----AEYVDLASNPEGNTGYSGPLaaqVWRAIY-----AENCL---SSd--- 201 Leishmania infantum JPCM5...
Q57UW3                        156 -D----------------EIkPIDPDRD----ATYVDLLQNPEANTGYSGPKaarVWQAVY------NNCN---IDglps 205 Trypanosoma brucei...
WGS:AAGF:cds.TTHERM_00150029A 142 -Eky------------dwYWsLNQENDFKd--GEYVDLVENIEGYTANKEPN---IWKIIY-----TEDCF---Q----- 190 Tetrahymena thermophila SB210...
Q24DE0                        138 -DyadwaqepevkitdewQWrVEEFNESE---GSYVDLKDNVEAFTGYQGQN---IWKLIY-----EENCF---QG---- 198 Tetrahymena thermophila SB210...
1RQ1_A                        177 GE-----SLAKDAFYRLVSGFHASIGTHLSKEYLN---------------------TKTgkWEPNLDLFMARIGNFPDRV 230 baker's yeast...
Q54IC1                        178 VDq---mCLEERVFYKLISGLHSSITIHIALFYNQdktlst---------ydsngnEIEphWEHNSNLFKQRFANHPGRI 245 Dictyostelium discoideum AX4...
EFA76699                      176 LEq---mCFEERVFYKLISGLHASITTHIAYFYEKd--------------------RFSgeWQKNPMHFKTAFENHPDRI 232 Heterostelium album PN500...
Q8IIC3                        206 EKs---eCEEMNSFYKIISGMQSNIAVLSSEYFYLkndflfgeiq--innkfnndyFKNlnYDYSVTFFKEKIGLYPERI 280 Plasmodium falciparum 3D7...
Q4MZU9                        245 -------CKESLHFYKLISGMRGAISAFSALNYECtnaye-----------ayedqTELpsYQSNYHYYNNKLSKHKDRL 306 Theileria parva...
EDO05839                      208 EVp----CDQTEHLFRLISGMQSSVAAWSAWNYKCvnsva-----------ayqlkSELpkYESNPQFYFKMLGNHPERI 272 Babesia bovis...
CAM67040                      202 KDg---tCQELSILRTLLSGLHMSINIHVCTSFYKdpelsspqrnagiynnpnisfF------PNCQMYNKRIAPFPDFV 272 Leishmania infantum JPCM5...
Q57UW3                        206 NDtagvenREKALLRQLLSGLHTSITMHVAAFFYNdtkgdsplrslgvlnnpnisfY------PNCGMF-RRIVKNDEFI 278 Trypanosoma brucei...
WGS:AAGF:cds.TTHERM_00150029A 191 GQq---lSSEKMVLNSIISGFHASISSHICEFYQDl-------------------sKEEakLNPSWEFYFEKVGNYEDRI 248 Tetrahymena thermophila SB210...
Q24DE0                        199 EDl----CLEQRALNRILSGLHASVSTQLSELYIDf-------------------nKNRtkMYPNWKLYFEKVGNYPERI 255 Tetrahymena thermophila SB210...
1RQ1_A                        231 TNMYFNYAVVAKALWKIQPYLPE------FSFCD------LVNKEIKNKMDN--VI-SQLdt---------kIFNEDLVF 286 baker's yeast...
Q54IC1                        246 ENLYFTFLFILRSIGKLNHFFTD------YQFNTgn---qLEDQKTKELVQQllQTkLMCq----------pNFDETLLF 306 Dictyostelium discoideum AX4...
EFA76699                      233 DNLYFTFLFVMRAVSKIDGFLHE------YQFNTgn---eIEDKQTYQMVQTllKQqVSCt----------pSFDESLLF 293 Heterostelium album PN500...
Q8IIC3                        281 ENLYFTFAILLRSMCRLKSLFKQ----------CkcnsgyEQND--KEAVRLldDLlENFyhscsskeflepLFPQH--- 345 Plasmodium falciparum 3D7...
Q4MZU9                        307 ENIYYTYKYILSAVVRLKGYLDN--------FNS-----------NLQLVNNdlYL----------------HLKDFLTF 351 Theileria parva...
EDO05839                      273 ENMYYTFQAMLKTVCRLSPFLKG--------FAKnlgqhpEWAH-LQRSIFDflSVdYEFcrd------vepAYEQRSSE 337 Babesia bovis...
CAM67040                      273 GNLYILYQFTLRALAKSRSFFTNdvsifnTGARge---atLTDL----------QLhDNIkelfnsrlicspTFDEGAFL 339 Leishmania infantum JPCM5...
Q57UW3                        279 RNLFVVYQFVLRALAKTKRAFLAnsslynSGFNga---atDGDV----------RLySNIgelfssklfrvaTFDEQKFF 345 Trypanosoma brucei...
WGS:AAGF:cds.TTHERM_00150029A 249 KNLLFYYEFLLRAVQKSSEVFVN------FPYKTgd---lESDKEVVQLIKGfiSQiTSQnr--------vlQFDVN-LF 310 Tetrahymena thermophila SB210...
Q24DE0                        256 HNLYFYYSVLLRAINRAESVIRN------YNFTTgd---fQEDAKTYQLVGDilDYtTSQcd---------qPFHEEILF 317 Tetrahymena thermophila SB210...
1RQ1_A                        287 A--------------NdLSLTLKDEFR-----SRFKNVTKIMDCVQCDRCRLWGKIQTTGYATALKILFEINDADeftkq 347 baker's yeast...
Q54IC1                        307 Kd-------------TyDKDNLIGQFK-----EHFQNISSILNCVTCEKCKLYGKVQTMGLGTALKILFDDN-------- 360 Dictyostelium discoideum AX4...
EFA76699                      294 K--------------DtDKQNLISQFK-----GHFQNISSILNCVTCEKCKLYGKMQTLGLGTALKILFDEN-------- 346 Heterostelium album PN500...
Q8IIC3                        346 ----------------------GKDIL-----SKFMNITNILDCVPCVKCRLHGKLKTTALQIALVEGVSDEH------- 391 Plasmodium falciparum 3D7...
Q4MZU9                        352 InksnittdsngsnhNnLQTECGKEMV-----EKFDRLIELVNCVECEKCKLHGKLKLSAIQTSIKILMTDVDKLg---- 422 Theileria parva...
EDO05839                      338 Hc------------dAtDGCTASPQLRhpallKKFNSIADIVDCVGCEKCRLHGKLKLTALQIAVRAFGQTE-------- 397 Babesia bovis...
CAM67040                      340 E--------------SeKGRSLIPQFK-----AMMLNVTRLMDCVTCEKCRIWGKLETKGIAVAMKVIMNPENE------ 394 Leishmania infantum JPCM5...
Q57UW3                        346 E--------------SpGAHLLVRQMK-----RVVHNVTTLMDCVTCEKCRAWGKLETAALATALKIVFGSAEN------ 400 Trypanosoma brucei...
WGS:AAGF:cds.TTHERM_00150029A 311 K--------------DqDSVEIKRNYQ-----KYVKNIAQLMDCVSCEKCKLFAKIQVQGISLAMNIIFADNSDEr---- 367 Tetrahymena thermophila SB210...
Q24DE0                        318 N--------------TdQGRKYKKHYQ-----QYIHNITKIMDCVECEKCKVFGKMQVYGIGVALKILFSDDSSTq---- 374 Tetrahymena thermophila SB210...
1RQ1_A                        348 hiVGKLTKYELIALLQTFGRLSESIE 373 baker's yeast
Q54IC1                        361 --IQSIQRNEIIALFNTLRQLSNSIH 384 Dictyostelium discoideum AX4
EFA76699                      347 --QSSLQRNEIIALVNTLRQLSNSIK 370 Heterostelium album PN500
Q8IIC3                        392 --IGSLERNEITALINALYYFADSIL 415 Plasmodium falciparum 3D7
Q4MZU9                        423 --ELDLNRNDLVALFHGLDYFAQSIL 446 Theileria parva
EDO05839                      398 --RLVLERNEIAALLHALDYFAESII 421 Babesia bovis
CAM67040                      395 --RITLDRSEMVTLVNLARQLAFSVR 418 Leishmania infantum JPCM5
Q57UW3                        401 --VVELNRGERVALINFARQLAISVK 424 Trypanosoma brucei
WGS:AAGF:cds.TTHERM_00150029A 368 --VKYMKRNELIALINTLHKSSESIQ 391 Tetrahymena thermophila SB210
Q24DE0                        375 --IQKLQRNELITLINAFVKCASSLD 398 Tetrahymena thermophila SB210
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