Conserved Protein Domain Family
Gpi16

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pfam04113: Gpi16 
Gpi16 subunit, GPI transamidase component
GPI (glycosyl phosphatidyl inositol) transamidase is a multi-protein complex. Gpi16, Gpi8 and Gaa1 for a sub-complex of the GPI transamidase. GPI transamidase that adds glycosylphosphatidylinositols (GPIs) to newly synthesized proteins. Gpi16 is an essential N-glycosylated transmembrane glycoprotein. Gpi16 is largely found on the lumenal side of the ER. It has a single C-terminal transmembrane domain and a small C-terminal, cytosolic extension with an ER retrieval motif.
Statistics
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PSSM-Id: 397988
Aligned: 48 rows
Threshold Bit Score: 328.433
Threshold Setting Gi: 552841831
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005850415       7 PVIVLLLRWGVGSAA----AYTEELALQQLSDGSVLAHFEFS---AAAPLh------AE-----HAGSFPAALLALARRH 68  Chlorella v...
1_pfamImport       1 -IILFTAYFSLTASSpikdEYHEELFMKPL-GGYVYSYFQFS---TLWEIpf----lTKhnafdHCHIFPRPMGELIQRY 71 
XP_006681170      12 aLVASSSIRSLLASTlafePYSERLELSQMADGKVLAQFAFT---TLTDLs------NSasqdnHYGLLPRSIGEVVQTF 82  Batrachochy...
Q5KE79             9 LLFAPVFVAAVPSSN----SFHESLTLHPLPDGKLSVLFEFTtyfTQTKPt------SSip-qyHHSITPPSLLLPLQTN 77  Cryptococcu...
Q949U5            15 QSFLVAIAFGSKEVE----EFSEALLLKPLPDRKVLAHFHFE---NRAPPs------NShg--rHHHLFPKAISQLVQKF 79  thale cress
XP_004247080      15 KSFGSIIAEEEDQIE----QFSEALLLRPLPDRKVLAHFHFE---SKVPPt------RThg--sHHHLFPKSIYQLVHKF 79  tomato
KRH65825          53 FLVFLLSATSTQQEE----EFTEELLLKPLPDRKVLAHFHFQ---SDSPPlaaadesSSfd--rHHHLFPKSISQLVQKY 123 soybean
XP_002273696      14 FSSIASASLSQEEEE----EFSEELLLKPLADRKVLAHFHFE---SKAPPt------RTyg--hHHRLFPKALYQLVQKF 78  wine grape
jgi:MICPUN_58571   4 aFLLVVLAASVGAAResreTFQEEALVRPLPDGRIAFVAHFR---QETSLv------AR-----HHETFPKAIAQIARAT 69  Micromonas ...
XP_030831586      14 killglitFQLSLASvtddNFKEDLLITPLENGFVNSYFKFT---TEWNTg------LPle-rlHYNLFPKSLGQVIRKH 83  purple sea ...
XP_005850415      69 GVRQLELSLTQGRWTWEQQRQvAAGAGGSAAasrPAG-LELKVSfdgs-trdtQAAYSALTQALGGMLCAGIATAPRLAV 146 Chlorella v...
1_pfamImport      72 NVQELHVSLTKGLWRYEDWGY-----PVQTA---PPG-AELWAWfkhd-tidiDSKWRELTSALSGLLCASLNFIDSHNT 141
XP_006681170      83 DIDELHLTFTQGRWSYDRWGH-----SDFTA---PIG-VELWAWfnst---spdtKWKGLTNALAGLFCSSLNFLDQAVT 150 Batrachochy...
Q5KE79            78 DISELSISFVAGRWDQRRSSQsGPLHYLSGG---GGGeVRGWVRngneg-gseeeRWGTVTHALGGLFCAGLGPREAGEN 153 Cryptococcu...
Q949U5            80 RVKEMELSFTQGRWNHEHWGGfDPLSSMNAK---PVG-VELWAVfdvp-qsqvDTSWKNLTHALSGLFCASINFLESSTS 154 thale cress
XP_004247080      80 RVQEMELSFTQGRWNYARWGGyDPISSRNAK---PPG-VELWATfdvp-qhqvDASWRNLTHALSGLFCASINFLESSTA 154 tomato
KRH65825         124 HIKAMELSFTQGRWNYERWGGfDSISSCNAK---PPG-VELWAVfdvp-phqvDASWKNLTHSLSGLFCASINFLESSTT 198 soybean
XP_002273696      79 RIREMELSFTQGRWNYERWGGfDPISSSNAK---PPG-VELWAVfdvp-hdlvDASWKNLTHTLSGLFCASINFLESSTA 153 wine grape
jgi:MICPUN_58571  70 GVADAELSFTQGRWMYRRWGR----PPVGAK---PIG-AELWAAfaaesdevaDEGWANLTAMFGGQFCASLSALRDEQV 141 Micromonas ...
XP_030831586      84 QVQELHLSLTQGLWRHDKWGY-----PPAGA---PPG-TQLWVWftee-trdvDQAWGDLVNALSGLFCASLNFIDETNT 153 purple sea ...
XP_005850415     147 MAaPAVGwfaqQQPAAVggGAASsgkqrrqgQRAQQIYAWLPQEGLCSENLAAWRRLLPCRHHAGLGALL-QPVQLAAAP 225 Chlorella v...
1_pfamImport     142 LS-PELS----LKPTGI--EDASrp-----lNHTHLRYATLPREIVCTENLTPWKKLLPCNLKRGLSALL-NSDNIYNTV 208
XP_006681170     151 SQ-PLLS----FLPSGS--HSKR--------EGLQIRYGSLPREAVCTENLTPWIKLLPCQAKSGLASLL-NAYKIFDGN 214 Batrachochy...
Q5KE79           154 VK--TFGr--iYPPHRG--NP----------DGLTHFLLSHPHHNLCTENLTPFLFLLPSKGLSGLSALLsQPGIIFSWG 217 Cryptococcu...
Q949U5           155 YAaPTWG----FGPNSD-----------------KLRYGSLPREAVCTENLTPWLKLLPCRDKDGISALM-NRPSVYRGF 212 thale cress
XP_004247080     155 YSsPQWS----FKSFAT-----------------NIRYGTLPREAVCTENLTPWLKLLPCRDKAGLSALM-DRPSIYRGF 212 tomato
KRH65825         199 YSaPEWA----FQSALG-----------------SLRYGTLPREAVCTENLTPWLKLLPCRDKAGLSYLM-DRPSIYRSF 256 soybean
XP_002273696     154 YSaPDWG----FQPFSG-----------------SLRYGSLPREAVCTENLTPWLKLLPCRDKAGLAALM-DRPSIYRGF 211 wine grape
jgi:MICPUN_58571 142 VVePALV----FRPWDG--SARVdrd--gisSDNRRRHGSLPAEAVCTENLTPWLKLLPCRDRAGIAALLgSRSSVFGAE 213 Micromonas ...
XP_030831586     154 VK-PELS----FRPQGI--ASEAya-----rNTSLLRYASLPREVVCTENLTPWKKLLPCDSKAGLASLF-KADKLYNAH 220 purple sea ...
XP_005850415     226 YHSLGLQLwvpqgaplanasaSASSasARSQGGQqewLELRQVLTAVlpaad--------qqeqqQEQQGRglLEALFGS 297 Chlorella v...
1_pfamImport     209 YHSLGIHF-------------RPVCmdPSCTRTG---VELVQSVSLVydlv----------iigrDETHWS--IQRQFGQ 260
XP_006681170     215 FQSIGVHI-------------QPKCmtPDCVTMG---VEYRQTFAVVldpi-----------rtnSQKDWS--LESLFDR 265 Batrachochy...
Q5KE79           218 FQSEGIEV-------------IMPNddHPEGKWT---GWWEGVVDLMppg------------agvKNVKREtgLEKLFKK 269 Cryptococcu...
Q949U5           213 YHSQRLHL-------------STVEsgQEGLGSG---IVLEQTLTVVlqpett-------svesnMQPSWS--LSSLFGR 267 thale cress
XP_004247080     213 YHSQRLHL-------------ISNEfdLAAASSG---MVLEQTLTVVlqpvtlgsg-mtssvgsiQQPSWS--LSTLFGR 273 tomato
KRH65825         257 YHSQRLHL-------------TMSTdpSDGSRSG---IILEQTLTVVvqpseqkag-mnhvsetkIQPSWS--MSSIFGR 317 soybean
XP_002273696     212 YHSQRLRL-------------SSTEfgSTELESG---IALDQTLTVVlqpttsqrasmtyssdsvLQPSWS--LSSIFGR 273 wine grape
jgi:MICPUN_58571 214 YVSFTARV-----------------------RVRgdaLELTQSATLVvdan-----------kiaREPEGGhrLTSLLGV 259 Micromonas ...
XP_030831586     221 YHSLAVDL-------------RPVCr-SGETPCVesaVELTQSLTVVfrplv--------qsqqgPRQDVS--LRALFGK 276 purple sea ...
XP_005850415     298 SPPA------ACPA--------------ADSSTLYLpggrsaAAAHYMakavaasrgACRQh------------------ 339 Chlorella v...
1_pfamImport     261 GLGL------TCPL--------------ATTSSVIVditsnaTGNTFKlypstydrkVSNR------------------- 301
XP_006681170     266 TFPK------ACPFslsttvhldilniqPDTVVILPdphidqSTSTA--------------------------------- 306 Batrachochy...
Q5KE79           270 RLPP------SCPEtessv----irlilPENEKVNVepqgrvVGEWR--------------------------------- 306 Cryptococcu...
Q949U5           268 QVVG------RCVL--------------AKSSNVYLqlegllGYESKNvdteieahqlwkn---------------aefe 312 thale cress
XP_004247080     274 KVSG------RCVL--------------SNASNVYVqlepdlVSELKTtsetqqqsdVGNLiseawsdmsfemse-savr 332 tomato
KRH65825         318 KISG------RCVL--------------AKLSNVYLhaerglVSQLENlqkntakfaANDTgpedfrrnagfe----lsv 373 soybean
XP_002273696     274 KVSG------RCVL--------------AKSSNVYVqverglVSELKNlhaedegsgAGNVtfektwnnpgfelsiapnr 333 wine grape
jgi:MICPUN_58571 260 DRGGgangirACAA--------------ATSTAVHVqtkggtAFAFGGrkvhtavadEGRRvdta--------------- 310 Micromonas ...
XP_030831586     277 VLSG------PCPM--------------ASSSRVMVdlsknhSSNPLTlspppsetiIKST------------------- 317 purple sea ...
XP_005850415     340 ---------DTPAgplLACDIaqqvqQAQQpEQQQAQISGqqqQQHlhppasllqagqgggAEGGPpqagalHLLPLQVV 410 Chlorella v...
1_pfamImport     302 ---------GGQRtvlAIYNLf---kQRTDaRYNIEVVYD------------------------KIrqnvanVPPVIYAN 345
XP_006681170     307 ----------------VSYTY-----HLSTdPFQLNVRWN---DATv--------------NYRNP------KLAPIQTH 342 Batrachochy...
Q5KE79           307 ---------DGKWrqvMEWNAk----DREMvGKDLKVWWD----------------------EERFeyprtiDPPAISVM 351 Cryptococcu...
Q949U5           313 lslkperviRESCsflFIFDId---kSSDSePFDLGLTWKrpsKWSc--------------QQAP-----------LHSS 364 thale cress
XP_004247080     333 vikeangflKESSl-lYEFSLe---nYSDSrPFDLEFRWKrpvTWSs--------------QLAP-----------LQAR 383 tomato
KRH65825         374 tpervhaelEKSSsilYEYPIk---eYTDTeQFDLGLMWKhpiVWSs--------------PHGP-----------LYAS 425 soybean
XP_002273696     334 vikevnilhDETSivlYEYLId---nYSNSePFDLGFTWKfpvVWSs--------------PQAP-----------LHAS 385 wine grape
jgi:MICPUN_58571 311 -----vaadEASRpawLSWDV------SAAeDFDVAVRPGggdEGT--------------------------VAPELYAE 353 Micromonas ...
XP_030831586     318 ---------GERSivyAVYDVke--wSARKeTLNVALRWTqa------------------lKYGPV------DSPPLLAY 362 purple sea ...
XP_005850415     411 QHTIQRGPLSGTLVVGIRVPAaAAaraaa--eaagpQLLLHVMQLLPWQLRVDATSLQVLLDGQ-------PLHPRSPQL 481 Chlorella v...
1_pfamImport     346 RYITGYGQEFGGIKTKIFNRY-RQ------------PLKVLFLENIPWFVPIYFHTLKVFSGDK------------ELQP 400
XP_006681170     343 RYLSGVGQEHGGVVIVFINDL-DV------------PMAATYMDSIPWIIKLFMHTFKVELENP----------SSNISD 399 Batrachochy...
Q5KE79           352 KTVIDSQASDGTFQIKISNHEnI-------------TREAIYSEIWPWWVKGWMSEMAVCIEDE-----------GPRAD 407 Cryptococcu...
Q949U5           365 RFLMGSGNERGAIAILLKATEsQEklsgrdltngqcTIKANIFQIFPWYIKVYYHTLQIFVDQQ----------QKTDSE 434 thale cress
XP_004247080     384 RFLMGSGNERGAIAISLKSVGrSEyakssvneegrcLLRVDVFQVVPWYVKVYYHTLKVFLDER----------LHSLAD 453 tomato
KRH65825         426 RFLMGSGNERGAIAISLKSTPglvaan---nveercKLKVNVLQIVPWYVKVYYHTLQLVVDER----------PQALTD 492 soybean
XP_002273696     386 RFLMGSGNERGAIAISLKATEpSDglwvadtienscMLRFNVFQVVPWYVRVYFHTLQVFVDGK----------PQSVTD 455 wine grape
jgi:MICPUN_58571 354 RVVTGSGYHRGGISIELRRPEgSKsa---------sGTRARLFQTLPWYVRVFIHTLAVEMDGVpvpvptsGADVGANGG 424 Micromonas ...
XP_030831586     363 RYLSGYGQEKGGVSCLLRNNL-DQ------------PLKVIYTETIPWYMRLYLHTLQIRTGDK--------------TI 415 purple sea ...
XP_005850415     482 VWQSLDVRP---DRT--ATLELLLRLPSTaAApagsdalqagrwheVRVQVGYRAAFVSVFDHAPDASRGVDIPPALATL 556 Chlorella v...
1_pfamImport     401 LVKR--YFPg-kERVrpYYLELLIELPPR-SV--------------TSVSVEFDYAFLKWQEYPPDANHGFYMGAASVTA 462
XP_006681170     400 IIRQTYYQPa-iDRIrpNVLELDLVLGPK-SK--------------TTLTFDFDYTFLKYTEHHPDANHGFELGFGVLTL 463 Batrachochy...
Q5KE79           408 LLKSISYNPsnpPDIppTTIHLSIQLPPR-ST--------------LVLTIPFTKLTLKYTDHRPDAERGQEIPAGVLTL 472 Cryptococcu...
Q949U5           435 VLKKINVSPs-tDKVssGMMEMMLELPCEvKS--------------VAISIEYDKGFLHIDEYPPDANQGFDIPSALISF 499 thale cress
XP_004247080     454 VVERTNVSPs-eDKVspGLMEIALRLPCDvHS--------------VILTLEFDKGFLHIDEYPPDANQGFDIPSALIRF 518 tomato
KRH65825         493 FVERMRVSPs-lDKVspGVMEMALQFPCEmKS--------------AVLSIEFDKGFLHIDEYPPDANQGFDIPSAIISF 557 soybean
XP_002273696     456 FIERMRISPs-eDKVspGVMEMALKLPCCvKS--------------VTLTLEFDKGFLHIDEYPPDANQGFDIPSAVISF 520 wine grape
jgi:MICPUN_58571 425 AVEALRWVPg-vDRRrpSTMELQVLMPASaSV--------------ARVSFKFEKAFLRISEFPPDANRGFDLPAALLSL 489 Micromonas ...
XP_030831586     416 EPDNVVYVPg-rDRSnpYMLEVVLTLPAT-SD--------------TTLRIDFDKAFLRWTEYPPDANIGFFINSAIVSV 479 purple sea ...
XP_005850415     557 apdha----------------ctspsSPSSSSGDGSsgpaappllrrlqagcaprqqYSGSGGGGLAPLPLPDLSMPFNV 620 Chlorella v...
1_pfamImport     463 --------------------------LLPLARNYTApprdrsllid-sinasrngypVRITTEVLIISLPTPDFSMPYNV 515
XP_006681170     464 --------------------------FPDSGLTFDKhhsq--------------sdqRRIYTESLLVRLPTPDFSMPYNV 503 Batrachochy...
Q5KE79           473 ldlv------------------gergVPEAESEASPsswtspqi------nalrsnrARVYTQRILLDIPTPDFSMPYNV 528 Cryptococcu...
Q949U5           500 pdhhasldfqe-----elsnspllssLKEKSL-------------------------VRSYTEVLLVPLTTPDFSMPYNV 549 thale cress
XP_004247080     519 pgiktkmdlfed---ksackspilskLQEESP-------------------------VLWYTEVLLVPLTTPDFSMPYNV 570 tomato
KRH65825         558 pdfhaglqfsd----ksqskspllskLQEKSP-------------------------VLSYTEVLLVPLTTPDFSMPYNV 608 soybean
XP_002273696     521 pdfhasmhflkd---dslnkspllskFQEKSP-------------------------VLCYTEVLLVPLTTPDFSMPYNV 572 wine grape
jgi:MICPUN_58571 490 ppvsprdghefgesrlldlvegvaseVGDTHS-------------------------EGVYMQGALLTLPTPDFSMPFNV 544 Micromonas ...
XP_030831586     480 --------------------------MLPRASNISGagiigtavs---dvnmassffLRLYTEPLLIQLPTPDFSMPYNV 530 purple sea ...
XP_005850415     621 ICFTSTLLAILLGGVANVVLRSPaeLAGQAASEGGAPAWRRK-L 663 Chlorella variabilis
1_pfamImport     516 ICLACTVVALAFGPLHNITTKKFvlTSAEK------KSFIKK-T 552
XP_006681170     504 ITLTCTLFALFFGSVFNALTREFrpVEVTGGKVSPLQRIKTM-L 546 Batrachochytrium dendrobatidis JAM81
Q5KE79           529 IIMSSTVMAVFFGLMHGGLTRRWgwVEVPEDPEEPKEGVRMGek 572 Cryptococcus neoformans
Q949U5           550 ITITCTIFALYFGSLLNVLRRR---IGEEERFLKSQAGKKTGgL 590 thale cress
XP_004247080     571 ITITCTVFALYFGSLLNALRRR---VDEEERLLKNKAAKPSGpI 611 tomato
KRH65825         609 ITITCTVFALYFGSLLNVLQRR---VGEEERLLKDKVANKAVfL 649 soybean
XP_002273696     573 ITITCTVFALYFGSLLNVLRRR---VGEEERFLKRKDSKKTGrL 613 wine grape
jgi:MICPUN_58571 545 TTMVCTLMSLLAGALLTTLTRRPgwEGFGKLKAEQRKRLKslek 588 Micromonas commoda
XP_030831586     531 ICLACTVVAIGFGSLHNLTTRKFdfVDKSSSDG---GNLVTR-L 570 purple sea urchin
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