3VP7


Conserved Protein Domain Family
APG6

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pfam04111: APG6 
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Autophagy protein Apg6
In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway.
Statistics
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PSSM-Id: 397986
Aligned: 119 rows
Threshold Bit Score: 116.482
Threshold Setting Gi: 219112335
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3VP7_A         1 INIFNATFKISHS--GPFATINGLRLGSIPESVVPWKEINAALGQLILLLATINKNLKInlVDYELQP--MGSFSKIk-- 74  Saccharomyces c...
Q22592       196 TNVLDLCFHIWVD--GIVGEINGFRLGYLKDAPVEFTEINAALGQIVLLLEILLERIGV--QHHELMPvaMGSHSYI--- 268 Caenorhabditis ...
XP_012655476 176 YNTINSVFFI--EvsEQVGLINNLMIGKKLNEDINWDETNAGLGQVILLFLYLMNKFGYqsSYIKDIQv-CGNESYIc-- 250 Tetrahymena the...
EGR28025     167 YNTLNQVFNI--QcdEQAGTINNIIIGKKLNQEIVWDETNAGLGQIAMLFSYLVKKYGYemKFIKDINl-CANESQIc-- 241 Ichthyophthiriu...
XP_002140137 216 INIFNTTFYI--NqiNGIGTINNLRLGLLDNSDENWREINGALGYTSLLLCCIAEKLNI---EVTLNP--YGNYSTItdr 288 Cryptosporidium...
Q5CPI7       267 SDFLNLSFYI--QviEGGACINGLRPALFEADFDNWNEVNAALGVSAMLLYTILERHKL---PLSIYP--NGSYSTI--- 336 Cryptosporidium...
EEQ40535     292 LNIYTKLFSISFE--DKWGRINGFRIGY----KVPWPEINVALGQIVQLITFLQKQLSVnlHSYELIP--LGSKSYIl-- 361 Clavispora lusi...
XP_001524202 355 FNIYKLMFDINLD--EKYGMINGLRIGY----KIVWPEVNAALGQISLLVAFILRRLHLklEAYKLVP--MGSQSHIv-- 424 Lodderomyces el...
XP_001387950 286 MNIYTKMFSIRFDeqDKYGSINGFRLGY----RIVEPEINAALGQIVMLLMFLTSRLNLklRHYKLVP--MGSRSQIi-- 357 Scheffersomyces...
EEY63744     299 LNILTDMFVIGYD--GAFGTINQFRMGQSAGSTLEWNEINAAFGECALLLQTLANMIGLefPDFRIVP--LGSFSKVi-- 372 Phytophthora in...
3VP7_A        75 -KrmvnsveYNNsttnapgdwliLPVYYD-ENFnlgrifrKETKFDKSLETTLEIISEITRQL---ST-----IAssyss 144 Saccharomyces c...
Q22592       269 -KlrrngidMET-----------YALYGQgTPLs------GSSGIDPGIRRFLQLLEFLLKEL---KD-----RNk---- 318 Caenorhabditis ...
XP_012655476 251 --------eANKse--------qLYLRGPfSNKg------DEAKFNRAMKMILDEFSLFVDYLqqtYL------------ 296 Tetrahymena the...
EGR28025     242 --------eIEKnq--------iLQLYGPlNYQs------EYSRFDQAIKLLLKEFYCFYEFLinqVKigdyvEEv---- 295 Ichthyophthiriu...
XP_002140137 289 cIpeylsnfVKEey-------siLPLYGNtSANsn---ynQCIKFDSAIKALLSNISNIAKYMncsDk------------ 346 Cryptosporidium...
Q5CPI7       337 ---------KDSes-------siWPLHGNtLCNsd---ynECTNFDKGILSFVFLIDTVYNIIpgtNEt----------- 386 Cryptosporidium...
EEQ40535     362 -KdvvgsndSTGnspsk--nhsvLPLFSS-NEFtlgk-lfnFNKLDVSMMALLDIVSQLELRL---MN-----LDn---- 424 Clavispora lusi...
XP_001524202 425 -K--------FTkhedgsrskkiLNLYSS-DEFtlgr-lfnFNKMDVSLIALLEILSIISIKL---RE-----LDt---- 481 Lodderomyces el...
XP_001387950 358 -K-------YSArer-----ttvLNLYSS-DEFslgk-lfnFNKLDVSLITLLDVVAQVEARL---IQ-----IDp---- 410 Scheffersomyces...
EEY63744     373 -R-------TSNlr-------meYSLHGS-DQQn-----fAESHFNLGLGAWITCLGQLMAFV---RA-----RDp---- 419 Phytophthora in...
3VP7_A       145 qtlttsqdessmnnandvenstsilE---LPYIMn--KD--KING-------LSVKLhgsspN---LEWTTAMKFLLTNV 207 Saccharomyces c...
Q22592       319 -------------------------Nf-kPPYQI---HAdsLVDNgvkynavMTLNT-----D---VRWTRAMALMLTDL 361 Caenorhabditis ...
XP_012655476 297 -------------------------QniqLPFKId--QSnsSIDGl-----lLTTQTaanaqYkglDNWTQAFKKLLINF 344 Tetrahymena the...
EGR28025     296 ----------------------------kLPYNId--IQkcEIDY-------VEISImk-----niDLWTSGMKKFLINF 333 Ichthyophthiriu...
XP_002140137 347 -----------------------------LPFIIn--YDmnTIDG-------VSYNLlf-ndK---QTWNNAMKMLLINL 384 Cryptosporidium...
Q5CPI7       387 -----------------------------LPYSVd--QRngTIGG-------ISLNLlfn----erESWNRAMSMNLINL 424 Cryptosporidium...
EEQ40535     425 -------------------------El-eLPYKIsakHD--SVGG-------KSIRVt---sN---GQWTEACRYLLIDL 463 Clavispora lusi...
XP_001524202 482 -------------------------Di-eLPYKIk--ND--SIGG-------KSIRVt---sN---SEWTQSCKLLLTNL 518 Lodderomyces el...
XP_001387950 411 -------------------------Di-eLPYKIsphRD--SIGG-------RSIRVt---sK---SEWTQACKFLLTDL 449 Scheffersomyces...
EEY63744     420 -------------------------Si-rLPYKV----AkhSIGG-------YSVLFlk-nkQ---KEWTKALKYALTNL 458 Phytophthora in...
3VP7_A       208 KWLLAFSSN 216 Saccharomyces cerevisiae S288C
Q22592       362 KAACAQCDA 370 Caenorhabditis elegans
XP_012655476 345 KFLISFNAQ 353 Tetrahymena thermophila SB210
EGR28025     334 KYIIYINEL 342 Ichthyophthirius multifiliis
XP_002140137 385 KYLIINLCE 393 Cryptosporidium muris RN66
Q5CPI7       425 KWLLVRSSE 433 Cryptosporidium parvum
EEQ40535     464 NWILAYVSA 472 Clavispora lusitaniae ATCC 42720
XP_001524202 519 NWMLIFVQA 527 Lodderomyces elongisporus NRRL YB-4239
XP_001387950 450 NWILSYTSV 458 Scheffersomyces stipitis CBS 6054
EEY63744     459 KWLLTWVSA 467 Phytophthora infestans T30-4
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