6VJA


Conserved Protein Domain Family
CD20

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pfam04103: CD20 
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CD20-like family
This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.
Statistics
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PSSM-Id: 427713
Aligned: 38 rows
Threshold Bit Score: 45.7139
Threshold Setting Gi: 75045739
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6VJA_C        15 LGAV---QIMNGLFHIALG--GLLMIPAGIyapiCVTVWYPLWGGIMYIISGSLL-AATEKNSR----KCLVKGKMIMNS 84 
Q3TRE0        29 LALL---QLALGIAVTVLG--FLMASISPS----LLVRDTPFWAGIIVCVVAYLG-LFMLCVSYq--vDERTCVQFSMKV 96  house mouse
Q1LVQ8        43 VALL---QLLLGIAVAAVA--FLMLAISSS----LLARETPHWAGIIMCVVSLLG-FVLFCITRvpdeR--ALLQFVIKL 110 zebrafish
2_pfamImport   1 VALL---QLLLGVAVTVVA--FLMLAISPS----LLARETPHWAGIILCLVSVLG-FILYCITYl--pDERTSAQFICEV 68 
EDO41456      21 FGVV---QVILGLSLTGLS--FAAFALSESd---RIRNACPYWAGFTVFFSGGVG-IVAWRHST----ILSMGLFTFFSA 87  starlet sea ane...
Q5HZJ5        37 LGLA---QVLLGILVITFS--MVASSVTTTe---SIKRSCPSWAGFSLAFSGLVG-IVSWKRPF----TLVISFFSLLSV 103 house mouse
Q9GYM6        46 LANV---HVFLGIIMIVLSglADYASTRINt---IRLHGLEEICSFYFVLVGLVG-ICGSASYR----RGLVITYLVMCI 114 Caenorhabditis ...
EDO34181       8 LGIIssfHLVFGVFSVVLG--IVTFKVAPYf---YGVFGMGIWLGAWMLITGVAGlLTASVPTN----MCRLGSFIGCSL 78  starlet sea ane...
Q5BLA7        17 LGIL---QVACAGLCVVCG--FMDAVFRKSt--tLSETRAPLWAGLIMAAPGVLA-LFASQKKN----PYLVNVMIVSSV 84  zebrafish
XP_012819541  17 LGIL---QIACAGISIVSG--FMDGAFRREs--tLGRTRAPLWAGLIMTIPGVLA-LFSSQKKN----PVLVNALIAASV 84  tropical clawed...
6VJA_C        85 LSLFAAISGMILSIMDILNIKISHFLKMESLNfirahtpyINIYNCEPANPSEKNSPSTQYCYSIQSLFLGILSVMLIFA 164
Q3TRE0        97 FYFLLSALGLMVCMLAVAFAAHHYSLLAQFTC--------ETSLDSCQCKLPSSEPLSRAFVYRDVTDCTSVTGTFKLFL 168 house mouse
Q1LVQ8       111 LYFFLCTMGLVMSVVVIAFQCYHYTLTNSFSC--------REMREDCICTLDPEDPIARMFVFSAVSDCSDITSTLPMYY 182 zebrafish
2_pfamImport  69 LYFILCSIGLVLSVLVVAFAGHHYSQASGFSC--------GPARGDCVCTLSQEDPIARTFTYEGVGDCQAITGTLTLYF 140
EDO41456      88 VCVVLHMIGTILTGEVGGLLKSVLECQFSEVDqsc---icCDSIMTCKQSVPSYKFEGVDDCDILTGLLKELMYGLCVLN 164 starlet sea ane...
Q5HZJ5       104 LCVMLSMAGSVLSCKNAQLARDFRECSMEGKVcvc--cppIPLHRPCPEWGQELKVALNSTCDEARGALKNLLFSVCGLT 181 house mouse
Q9GYM6       115 HSIFIFVPAIITVSSFDIHFYQHECWGECDWHlla---tsFPSNSKCQIMCGDHVDDAMRRRMTRLGTDYRLDAGLIAAA 191 Caenorhabditis ...
EDO34181      79 VGLVTLFVCAIIIGLGVLQHFKFESSINREYY---------IAKGPNYHKEYSRPQEHFDERNQNGENGVGIYGTLLALI 149 starlet sea ane...
Q5BLA7        85 VSLFAVVIVFVYACVTLSYGEEDDEI-----------------------FHAHPVPEVRFVLSRM---VKGANCTLLVAC 138 zebrafish
XP_012819541  85 FSCFTTLIVIVYASLTLGYGEDDDDI----------------------FSSPPHVIHARFILGKL---VQGANIAMLIAS 139 tropical clawed...
6VJA_C       165 FFQELVIAGIVENE 178
Q3TRE0       169 IIQMVLNLVCGLVC 182 house mouse
Q1LVQ8       183 LLQVLLNLAQAIVC 196 zebrafish
2_pfamImport 141 LVQIVLNLAQALVC 154
EDO41456     165 IFGSLVCFIATILG 178 starlet sea anemone
Q5HZJ5       182 ICAAIICTLSAIVC 195 house mouse
Q9GYM6       192 ILEFLLSIATCVVA 205 Caenorhabditis elegans
EDO34181     150 VMDVIVNLVTMAVC 163 starlet sea anemone
Q5BLA7       139 TGSLLFSSLIAYIG 152 zebrafish
XP_012819541 140 VSSLCVALCIAYMG 153 tropical clawed frog
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