2QX5


Conserved Protein Domain Family
Nic96

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pfam04097: Nic96 
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Nup93/Nic96
Nup93/Nic96 is a component of the nuclear pore complex. It is required for the correct assembly of the nuclear pore complex. In Saccharomyces cerevisiae, Nic96 has been shown to be involved in the distribution and cellular concentration of the GTPase Gsp1. The structure of Nic96 has revealed a mostly alpha helical structure.
Statistics
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PSSM-Id: 397976
Aligned: 103 rows
Threshold Bit Score: 356.124
Threshold Setting Gi: 21542465
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2QX5_B        74 QLLESWKIL-E---S---MKSKDI-N----------IVEVGKQYLEQQFLQYTDNLYKK----NMNEGLATNVNKIKSFI 131 baker's yeast
XP_011436563 221 PVMDLWEQV-RymvDvpmISSNSVkEsrtdyrtqaaFVQKGKEYLEQMYSKHIQNTIYSnlqqAQLGGIPSTYNQVKSYL 299 Pacific oyster
CAM44024     301 DLTVLWASI---------VQIIEPmQrrgsevdilsYVASSRRVMERKSLSRLLERMLR-------------MDPIR-FE 357 Leishmania braz...
XP_004984390 260 TMQKMWHLI-QalvGegsthrn--------vsrkmsLVIGARHHLEWGHEKYILETINShpalAALGGSVGNLQKIRAFM 330 foxtail millet
XP_009384164 250 TMQKIWHLI-QalvGeysnnrq-------kfsrkmsLVIGARRHLEWGHEKYILDMIKThpsqAALGGAVGNLEKIQAFL 321 wild Malaysian ...
KRH23559     249 TMRKIWHLV-QmlmGedsavqc--------vskrmsLIIGARRHLEWGHEKYIMDTIQShpaqAALGGGVGNLQRIRAFL 319 soybean
O22224       248 NMQKIWQLV-QaitGedsavrq-------gvskrmaLAIGARHHLQHGHEKFIMDTIQThptqAALGGSVGNLQRIRAFL 319 thale cress
XP_002638871 204 ALADVWNDVtSvlnRktvasrd-------dvtttanLLEDACRYLQKVFTDHMQTVVERnleiAERGGIPGKRGLVNAFL 276 Caenorhabditis ...
XP_008984160 219 NISDMWTMV-KqmtDvllTPATDPlKnrssvevrmeFVRQALAYLEQSYKNYTLVTVFGnlhqAQLGGVPGTYQLVRSFL 297 white-tufted-ea...
NP_998879    220 NVSDLWVMV-KqmtDvplIPASDSlKsrcsvqmqmaFLRQALHFLEQSYKNYTLMSVFAnlqqAQLGGVPGTYNLVRSFL 298 tropical clawed...
2QX5_B       132 DTKlkk-adKSWKISNLTVIn----GVPI-WALIFYLLRAGLIKEALQVLve-nKANIKKVeQSFLTYFKAYASSK---- 200 baker's yeast
XP_011436563 300 NVR------PPHIKGLEDGHv---dGHPV-WAMIYFCLRCGDLQAALQVT----EKASHSL-GDFPAFLREYVTDE---- 360 Pacific oyster
CAM44024     358 EV-------ENLSASHLLDIiarscGATNhWMHAFVAMRVGRYDVAQLATdaigIQSVRDAvAKVA----AAPPAE---- 422 Leishmania braz...
XP_004984390 331 RVRlrdqgvLDFDATDLRRQppvdtT----WQQIYFCLRTGYYDEARQVAqs------sRAaHNFAPLLADWISTNgavs 400 foxtail millet
XP_009384164 322 RVRlrdhgmLDFDTTDIRRQppidtT----WQQIYYCLRTGYYDEAKKVAes------sRAaHQFAPQLAEWIASGgsvs 391 wild Malaysian ...
KRH23559     320 RIRlrdygvLDFDAGDARRQppvdtT----WQQIYFCLRSGYYDEARNVAqs------sRTsHQFAPLLTEWINKGgmvp 389 soybean
O22224       320 RIRlrdygvLDFDSTDARRQppvdtT----WQQIYFCLRTGYYEEAREIArs------tRSsQQFAPLLTEWITTDgmva 389 thale cress
XP_002638871 277 KVGt-----EEPFQPEDDSId----GMPT-WQVTYHCVRAGDMQAAAETLn--rLKSFPQC-ATLVASLNHVAK------ 337 Caenorhabditis ...
XP_008984160 298 NIKl-----PAPLPGLQDGEv---eGHPV-WALIYYCMRCGDLLAASQVV----NRAQHQL-GEFKTWFQEYMNSK---- 359 white-tufted-ea...
NP_998879    299 NIRl-----PAPIPGLQDGEv---eGYPV-WALIYYCMRCGDLMAAQQVV----NRAQHQL-GDFKNCFQEYVHSK---- 360 tropical clawed...
2QX5_B       201 -----------DHGL-PVEYSTKLHTEYNQ---HIK-S-SLd-gDPYRLAVYK--LIGRC---------DLsrKNIP-AV 250 baker's yeast
XP_011436563 361 -----------DNRL-SAASETKINLHYRR---IIK-N-QN---DPYKRAVFC--VVGRC---------DP--AEDHsEI 407 Pacific oyster
CAM44024     423 -----------RNTMpPASDLQPVYAE------------AKtkeDPYRQAVLI--VLLAGrtgenpavvLRtlLNLAqRV 477 Leishmania braz...
XP_004984390 401 qdtalaaseecDKML------------------RMGdRpGRpgyDRKKLLLYA--IICGCrrqidrllkDLp------TL 454 foxtail millet
XP_009384164 392 petaavaseecEKLL------------------RMGdRaGRpgyDRKKLLLYA--IISGSrrqverllrDVp------SL 445 wild Malaysian ...
KRH23559     390 eeiataaseecERML------------------RTGdRvGRtayDKKKLLLYA--IISGSrrhidrllrDQp------SL 443 soybean
O22224       390 aesaaiaseecEKML------------------RMGdRlGRtayDKKKLLLYT--IISGSrrqierilrDLs------TL 443 thale cress
XP_002638871 338 -----------HKKL-DAELKKKLKVEWRHnvgHTK--------DKYKRALYA--ALLGG--------------LESaAL 381 Caenorhabditis ...
XP_008984160 360 -----------DRRL-SPATENKLRLHYRR---ALR-N-NT---DPYKRAVYC--IIGRC---------DV--TDNQsEV 406 white-tufted-ea...
NP_998879    361 -----------DRRL-SPTTenkLRLHYRR---AVR-A-ST---D--PYKRVVycIIGRC---------DVtdN--HsEV 407 tropical clawed...
2QX5_B       251 TLSIEDWLWMHLMLIKEKDAendp----vyeR---YSLEDFQNIII-SYGPSRF--SNY-----YLQTLL----LSGLYG 311 baker's yeast
XP_011436563 408 ADKIDDYLWIKLSQIQGDSDs---------sRqdgFTLQRLQSLLYeDFGESHF--NGYqnpflYFQILI----LTAQFE 472 Pacific oyster
CAM44024     478 TDSLEDALWLRLSCIRGVDKsaqvspvqslrTlqrAVLDDMQELVSiTQGNAYrla------sfFIHALLpstgLRLLLE 551 Leishmania braz...
XP_004984390 455 FNTIEDFLWFKLSALREHNNassss--vlneGlvpYTLDDLQSYLN-KFEPSYYtkSGkdp-liYPYVLF----LSIQLL 526 foxtail millet
XP_009384164 446 FGTIEDFLWFKLSAIRDCPGgsssi--vlseGlvpYNLDDLQGYLN-KFEPSYYtkNGkdp-lvYPYVLL----LSIQFL 517 wild Malaysian ...
KRH23559     444 FSTIEDFLWFKLSAVRDCPSgpssi--vlsdGlipYSLDDLQSYLN-KFEPSYYtkNGkdp-lvYPYILL----LSIQLL 515 soybean
O22224       444 FNTIEDFLWFKLSCIRDVTGgsssv--vlndGlapYSLDDLQAYLN-KFEPSYYtkNGkdp-lvYPYVLL----LSVQLL 515 thale cress
XP_002638871 382 ADTLENWIWFKLYPLHVDP------------QltpLLFQEVQKAVSiDYGEQYFmsNGPsefqyFFTALW----LSGQFE 445 Caenorhabditis ...
XP_008984160 407 ADKTEDYLWLKLNQVCFDDDgtss----pqdR---LTLSQFQKQLLeDYGESHF--TVNqqpflYFQVLF----LTAQFE 473 white-tufted-ea...
NP_998879    408 AdKTEDYLWLKLSQVCFEDEan-------ssPqdrLTLPQFQKQLFeDYGESHF--AVNqqpylYFQVLF----LTAQFE 474 tropical clawed...
2QX5_B       312 LAIDYTYT---FS--EMDAVHLAIGLASLKLFKI---DS---STRLTK--Kp---kRDIRFANILANY-TKSFRYSDPRV 374 baker's yeast
XP_011436563 473 AAIEFMSRi--DRl-LCHAVHVALVLYELKMLML---PPstqAQLLTKesSdegplRRLNFVRLITMY-TRKFEATDPRE 545 Pacific oyster
CAM44024     552 NSIT-----------HVDGFHMTLCFNAQNLLQGrlhSAle---------------apIDIARHMSRYcSVVLLDVDRRI 605 Leishmania braz...
XP_004984390 527 PAILYLSKeigEDgyHVDAVHISIALADHGVLPDgvgSGqkig----------vmdACAEAASIIRQYgSIYLRSGNIDL 596 foxtail millet
XP_009384164 518 PAVLYLFKevgEEgyNVDAVHISIALADNGVLSDgigTDrkig----------vmdACAEVASIIRQYgSVYLRQGNLEL 587 wild Malaysian ...
KRH23559     516 PAVLYLSKeagDEgyNIDAAHLSIVLADHGVLSEgagSGqklg----------vmdAYAEVSTIIRQYgSMYLRLGDLQM 585 soybean
O22224       516 PAIMHLSKeagDGgyNIDAVHIAISLVDHSVLSEgsgTGhkls----------vmdSNAEASSMIRQYgSMFLHHGDLQM 585 thale cress
XP_002638871 446 RAIYLLHEcg----qRVDSVHVAILAHKLGYLRMsvkST---DEMLVVdpNdat-kcHLNLARLIVAY-TKNFELIDVPR 516 Caenorhabditis ...
XP_008984160 474 AAIAFLFRm--ERl-RCHAVHVALVLFELKLLLK---SSgqsAQLLSHepGdppcmRRLNFVRLLMLY-TRKFESTDPRE 546 white-tufted-ea...
NP_998879    475 AAIAFLFRl--ERt-RCHAVHVALALFELKLLLK---STgqsAQLLSLepGdpqgvRHLNFIRLLMLY-TRKFEPTDPRE 547 tropical clawed...
2QX5_B       375 AVEYLVLITLNEGpt--------------dV-ELCHEALRELVLET--KE--FTVLLGKIGR-DGARIPGVIEErqplLH 434 baker's yeast
XP_011436563 546 ALQYFYFLNDLRTsq--------------gE-NLFMSCVSELVLET--RE--FEMLLGKMEP-DGTRRLGAIDK----FH 601 Pacific oyster
CAM44024     606 RATVFAGTAMFA--------------------YFHKSGLTEAFVECclKDliCARLLGPRNTvGG------HDSlllrAG 659 Leishmania braz...
XP_004984390 597 ALEYYAQAAAAMGggevswigqgnadqqrqRsLMLKQLLTEILL----RDggIQLLLGPS----GMGEEGELKKymmdWR 668 foxtail millet
XP_009384164 588 ALEYYAQAAAAMGggevswigrgssdqqrqRnMMLRQLLTEVLL----QDggISLLLGPR----GTGEEGALSKyimdWN 659 wild Malaysian ...
KRH23559     586 ALEYFAQAAAAVGggelswtgrgnvdqqrqRnLMVKQLLTELLL----RDggIYLLLGAR----GTGEEGELGRfvtdPK 657 soybean
O22224       586 TVEYYAQAAATVGggqlawsgrsnvdqqrqRnLMLKQLLTEILL----RErgIYFLLGAR----GSGEEGQLGRffpdSR 657 thale cress
XP_002638871 517 SLDYWFLLKGISTpt---------------gsDVFEMAVSRSVYLT--GQ--CDAILGTLTP-DGRREKGLIDEyl---- 572 Caenorhabditis ...
XP_008984160 547 ALQYFYFLRDEKDsq--------------gE-NMFLRCVSELVIES--RE--FDMILGKLEN-DGSRKPGVIDK----FT 602 white-tufted-ea...
NP_998879    548 ALQYFYFLRNEKDsq--------------gE-SMFLRCVSELVIES--RE--FDMLLGKLEK-DGSRKPGAIDK----FT 603 tropical clawed...
2QX5_B       435 VrdeKefLHTITEQAARRADEDGRIYDSILLYQLAE--------------EYDIVITLVNSLLSDTLSasdldQPLVGPD 500 baker's yeast
XP_011436563 602 H---D--TQRIIELVARDTENKGMFEEAVMLYDLGD--------------KHDKVLELLNRLISQVVS-----QPNTPQS 657 Pacific oyster
CAM44024     660 TgalSeeLLKALIQVAEAASARSEVAKATHVLLAVAclanqlhrpelqqrALRRAVQIMSPALAQVLH-----LPSRSSV 734 Leishmania braz...
XP_004984390 669 S------RQQFLLEAAHRCQEAGLYDKAVEIHKRVG--------------DFAMALQIINKCLSDAVC----------AM 718 foxtail millet
XP_009384164 660 S------RQQFLLEAARQCQEAGLYDKSVEIHKRVG--------------AFSVALETVNKCLSDVIC----------AM 709 wild Malaysian ...
KRH23559     658 A------RQQFLIEAACQCQEAGMYDKSIEIQKRVG--------------SFSTALDTINKCLSEAIC----------AL 707 soybean
O22224       658 L------RQQFLVEAAHQCQEAGLYDKSIELQKRVG--------------AFSAALETINKCLSEAIC----------SL 707 thale cress
XP_002638871 573 -----ddPSEVINRVASDTELTGEWDQAVSLYLLAS--------------KSTNAAKLLSSEISETLR------------ 621 Caenorhabditis ...
XP_008984160 603 Sd-----TKPIINKVASVAENKGLFEEAAKLYDLAK--------------NADKVLELMNKLLSPVVP-----QISAPQS 658 white-tufted-ea...
NP_998879    604 R---D--TKTIINKVASVAENKGLFEEAAKLYDLAK--------------NPDKVLELTNKLLSPVVS-----QISAPQS 659 tropical clawed...
2QX5_B       501 DN----SEtnpvllARR---------MAS--IYFDNaGIs-rQIHVKNKEICMLLLNISSIRELYFNKQWQETLSQMELL 564 baker's yeast
XP_011436563 658 ARdrlrAM------ALS---------IAK--RYRER-NN---EGSRSNTSTFYLLLDLLTFFDSYHEGNVDEAFEVMKQL 716 Pacific oyster
CAM44024     735 VSdvlsQA------AQL---------QQA--VNAVPhHLhdeAVGAQDYQTFAQLCRMADVYAFNVNGNVSDAVDTFLQL 797 Leishmania braz...
XP_004984390 719 ARnmldGE------SRAtalihsgneIMEtaRYSSEtSVqdkDLISEQQTVLRQLEAILHIYRLARAGQTVDALRETIRL 792 foxtail millet
XP_009384164 710 SRgrldGE------SRAasliqsgndILEnfKYSSGvSLqekEPVSEQQTVLRQLEAILHISKLARAGQHVDALREIIKI 783 wild Malaysian ...
KRH23559     708 FRgrldGE------SRTaglihsgneILEtySYYPDvRLqerEHVFDQQTVLRQLESILSIHKLARLGHYLDALREVAKL 781 soybean
O22224       708 ARgrldGE------SRTsglilagndILEtyKYYPEvSLqerERVMEQETILRELEAILSIHKLGRLGNHLDALREIAKL 781 thale cress
XP_002638871 622 --------------ADNkekigelvtVAE--QFKRVqK----GCQAAEYATLSLLVDLAVLFDHCRNDNADTAYGLVFDL 681 Caenorhabditis ...
XP_008984160 659 NKerlkNM------ALS---------IAE--RYRAQ-GI---SANKFVDSTFYLLLDLITFFDEYHSGHIDRAFDIIERL 717 white-tufted-ea...
NP_998879    660 NRerlkNM------ALA---------IAE--RYKSQ-GV---SAEKSINSTFYLLLDLITFFDEYHAGHVDLAFDVIERL 718 tropical clawed...
2QX5_B       565 DLLPFsdelS----ARKKAQDFSNLDDNIVKNIPNLLIITLSCISNMIHILneSKYQ-S-------------STKGq--- 623 baker's yeast
XP_011436563 717 KLLPL----Tad-aVEHKVNAFRHYTDEVRRCLPDILIATMNILHNQYKNA--KNSApRggysgqgrsedggRETY---- 785 Pacific oyster
CAM44024     798 PFVPPpn-tAvtggVDAYVEAYCNAPGSVQLGASAALRVAISAAGQLLQYYarn----------------stGDSAdvdd 860 Leishmania braz...
XP_004984390 793 PFLHL----Dpq-sPNVTVDIFRNLSPHVQACIPDLLKVALNCI----------------------------DNVRdtdg 839 foxtail millet
XP_009384164 784 PFLPL----Npr-vPDVHYDVFQKLSPHVQACVPHLLKITLNCL----------------------------DNVKdtdg 830 wild Malaysian ...
KRH23559     782 PFLPL----Dpr-gPDIAVDVLENLSPHVQACIPDLLKTALTCL----------------------------DNVTdsdg 828 soybean
O22224       782 PFLHL----Dpr-mPDATADVFQSASPYFQTCVPDLLKVALTCL----------------------------DNVPdtdg 828 thale cress
XP_002638871 682 RLIPT----Epd-qVTVIVNEFHMVPQKVREVLPDMCLHLMKCLVDHCIRQstsla-----------nrganAANTsmfs 745 Caenorhabditis ...
XP_008984160 718 KLVPL----Nqe-sVEERVAAFRNFSDEIRHNLSEVLLATMNILFTQFKRLkgTSPS-Sssr--------pqRVIEd--- 780 white-tufted-ea...
NP_998879    719 KLVPL----Sqd-sVEERVAAFRNFSDEIRHNLSEILLATMNILFTQYKRL--KGSGpNtl----------gRPQRaqed 781 tropical clawed...
2QX5_B       624 qIDSLKNVARQCMIYAGMIQYRMP 647 baker's yeast
XP_011436563 786 -LNYLRSQARALIMFAGMLPYRLP 808 Pacific oyster
CAM44024     861 kRLRLLHRMQTVLEWARQCCARTs 884 Leishmania braziliensis MHOM/BR/75/M2904
XP_004984390 840 tLRAVKSKIANLV--ANNMSRNWP 861 foxtail millet
XP_009384164 831 tLRALKSKIANLV--ANNMNRNWP 852 wild Malaysian banana
KRH23559     829 sLRALRAKIASFI--ANNLRRNWP 850 soybean
O22224       829 sIRAMRSKIAGFL--ASNTHRNWP 850 thale cress
XP_002638871 746 sSNRYVKQIKAIVLYSATVPYKFP 769 Caenorhabditis briggsae
XP_008984160 781 rDSQLRSQARTLITFAGMIPYRTs 804 white-tufted-ear marmoset
NP_998879    782 kDSVLRSQARALITFAGMIPYRMS 805 tropical clawed frog
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