2JKS,2JKS,5WA2,5WA2,1KZQ,1KZQ


Conserved Protein Domain Family
SAG
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pfam04092: SAG 
SRS domain
Toxoplasma gondii is a persistent protozoan parasite capable of infecting almost any warm-blooded vertebrate. The surface of Toxoplasma is coated with a family of developmentally regulated glycosylphosphatidylinositol (GPI)-linked proteins (SRSs), of which SAG1 is the prototypic member. SRS proteins mediate attachment to host cells and interface with the host immune response to regulate the virulence of the parasite. SAG1 is composed of two disulphide linked SRS domains. These have 6 cysteines that form 1-6,2-5 and 3-4 pairings. The structure of the immunodominant SAG1 antigen reveals a homodimeric configuration. The SRS domain is found in a single copy in the SAG2 proteins. This family of surface antigens are found in other apicomplexans.
Links
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Statistics
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PSSM-Id: 397973
Aligned: 92 rows
Threshold Bit Score: 40.9507
Threshold Setting Gi: 557735209
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2JKS_A   172 NVVTCayGKGs--nPn--PVEVEMS---TEKNTLTINCGS--DGSLQPTTY--A-EEy--Cva---dsK--------DVN 226
ESS34747  34 NVISCk--------NgtdFVATSLK---QANSKIVLKCSE--GATILPAIDsk-----kfC----------------KDA 79  Toxoplasma gondii VEG
ESS28162  42 NIFMCsa-----dkEkqtVITVPLN---GEGVSIRFACPK--DSVLFPALPeaSaRTq-fC----------------TDS 94  Toxoplasma gondii VEG
ESS28177  42 KIFMCst-----dkKnqtVVSVSLK---NVNESIDFACPK--DSVVFPAITgvSqq---fC----------------TDS 92  Toxoplasma gondii VEG
ESS28339  42 DVAMCsa-----dkKnqtVVSVSLK---NVNDSIQFACPE--NFVVFPAFQepSeAAq-fC----------------KDS 94  Toxoplasma gondii VEG
ESS28185   2 KIFMCsa-----dkEnqtVVSVSLK---NVSDSIQFACPK--DSAVFPAITddSqq---fC----------------KDS 52  Toxoplasma gondii VEG
ESS28375  36 gVPTCd--------SnrnGITVDFP---EDGMKFQFKCGPa-FKTLVPAELenVyEVqavTsariswlIvgageevdLET 103 Toxoplasma gondii VEG
ESS29478  20 QFILC--SSSdttaEvkeCTNESLAltgGAQVSLKFKCAA--TYTMGPTSDadVyAY--------------------TNG 75  Toxoplasma gondii VEG
ESS28376 191 DVVTCt--------ArsrNPKVTVS---KDNQRVQLICGPkdTSSLKPDGAlhVfDN--------------------KNG 239 Toxoplasma gondii VEG
PIM00415 193 NVVTCt--------ArsgNPKVTVS---KENQTVQLICDPrdTSTLNPQNLieVfDN--------------------KDG 241 Toxoplasma gondii COUG

2JKS_A   227 RCSt--TRFVEIFpkFLKswWVTET------------QkRTSATLTI----PQTDLPEADQQFLVGCVPKktapedpkkd 288
ESS34747  80 GCTq-qDQLTQVG---------VSAgaasevevagvsQkTDELTLTLtk-nPT-----NSQTAYFQCIEPkklreesglt 143 Toxoplasma gondii VEG
ESS28162  95 WCSa-qAPLGEAF----TiaQEKAPaekmdkktepelKnLYVYRFTMnkqdV------ASTKLYFQCRPEtppvearvdt 163 Toxoplasma gondii VEG
ESS28177  93 WCSa-qGPMGEAF----AiaQKEPAaqqkdpekeqslEnLSVYTVTMkkqnL------TSSTLYFQCRPGkepvgarvdt 161 Toxoplasma gondii VEG
ESS28339  95 WCTa-qARMGEAF----TisHKKPAaqqkdtkkeqqlEnLHVYTVTMkqqnL------TSSTLYFQCRPEeervearvdt 163 Toxoplasma gondii VEG
ESS28185  53 WCSa-qATMGDAVs-----iKLSKNteekdekkkptlEgLNIYTVTMdkqsL------TSSTLYFQCRPEkkpvearvdt 120 Toxoplasma gondii VEG
ESS28375 104 QGHt-kKRLSELY--AEAtlTEAg------------eSdNKVYTLQI----PDTSRIQEKKTLRYFCKKAeeqern---- 160 Toxoplasma gondii VEG
ESS29478  76 QCStttQTLDALV--PGSkrSKSEEgskamrstkseaQtQSVYTLALgp-aPK-----EKQVFCYTCSATpaaaaatt-- 145 Toxoplasma gondii VEG
ESS28376 240 KCNe-qATLSELV--PGAtrSDk-------------dSgNGAYTVTFpk-lPS-----EKQALCYSCSASghpgl----- 292 Toxoplasma gondii VEG
PIM00415 242 TCAq-iAALSELV--PEAtrSDk-------------dPdNGAYTVTFpk-lPS-----EKQALCYSCSASghpgl----- 294 Toxoplasma gondii COUG

2JKS_A   289 kesgtetaaptsCTVLVTV 307
ESS34747 144 ---eqdsatqvaCTIQLai 159 Toxoplasma gondii VEG
ESS28162 164 p-ggkfdpnttkCVIQVaa 181 Toxoplasma gondii VEG
ESS28177 162 p-ggkfdpnttkCVIQVaa 179 Toxoplasma gondii VEG
ESS28339 164 p-ggkfdpnttkCVIQVaa 181 Toxoplasma gondii VEG
ESS28185 121 p-ggkfdkdttkCVIQVaa 138 Toxoplasma gondii VEG
ESS28375 161 -------avenyCLVTINV 172 Toxoplasma gondii VEG
ESS29478 146 ----aaekskkpCNIIVTV 160 Toxoplasma gondii VEG
ESS28376 293 -------lrtepCQIHIEV 304 Toxoplasma gondii VEG
PIM00415 295 -------lrtepCQIHIEV 306 Toxoplasma gondii COUG
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