5L3Q


Conserved Protein Domain Family
SRP-alpha_N

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pfam04086: SRP-alpha_N 
Signal recognition particle, alpha subunit, N-terminal
SRP is a complex of six distinct polypeptides and a 7S RNA that is essential for transferring nascent polypeptide chains that are destined for export from the cell to the translocation apparatus of the endoplasmic reticulum (ER) membrane. SRP binds hydrophobic signal sequences as they emerge from the ribosome, and arrests translation.
Statistics
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PSSM-Id: 397968
Aligned: 108 rows
Threshold Bit Score: 120.983
Threshold Setting Gi: 514698574
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5L3Q_B        27 GPVNALIRSVLLQERG-GNNSFTHE----ALTLKYKLDNQFELVFVVGFQKILTLT--YVDKLIDDVHRLFRD------- 92 
EPB83665      26 SPVEDLIRNVLIEERA-GtDSYFKE----NYALKWTFANELDLVFVVAYQKILQLN--YIDELLETVKRMFLEtnkdlia 98  Mucor circinell...
XP_004996856  27 DPINGFIQDVLVEGRgatADSYTVQ----NYNIKYRIDANNNLVFAAVYNKSVESEsgYIDNLLNVVKKDFVT------- 95  Salpingoeca ros...
KRH03040      28 SPIDTLIRSCLLEERS-GaASFNYDapgaAYSLKWTFHNDLGLVFVAVYQRVLHLL--YVDDLLAAVKREFSR------- 97  soybean
XP_006854510  28 SPIDALIRSCLLEERS-GdSAFNYDaagaSYTLKWTFHNELGLIFVAIYQRILHLL--YVDDLLSMVKREFSE------- 97  Amborella trich...
KIS71342      32 NPVNSLIKQAFLEQRT-AdQKFEKD----GYTLRWTFANELDLTFVVVYQRILQLS--YIDELLDTIRTLFTD------- 97  Ustilago maydis...
GAC72537      32 NPVNALIKQAFLEQRT-AdHKFDKD----GYTLRWTFANELDLTFVVVYQRILQLS--YIEELLDNVRSLFTD------- 97  Moesziomyces an...
CCA67186      33 SPVNNLIREALIEGRS-SeDRYEKD----GYAVRWTLANDLELIFVVAYQRILQLS--YVEDLLTAIKTLFIK------- 98  Serendipita ind...
EMD38485      33 SPVNSLIREALIEGRT-AeDKYEKD----GYAVKWSFVNDLELIFVVAYQRILQLT--YVDELLAALKTLFVK------- 98  Gelatoporia sub...
XP_007395939  33 SPVSSLIRDALIEGRS-AeSQFEKD----GYALKWTFVNDLELIFVVAYQRILQLT--YVDDLLAALKTLFVK------- 98  Phanerochaete c...
5L3Q_B        93 -------KYRT---EIQ--------QQSALSLLngtFD----------------FQNDFLRLL-----REAEESSKI--- 130
EPB83665      99 qgqlvdgDFAS-------------------------------------------FGPIFDQLL-----QQIEDKYSSqnr 130 Mucor circinell...
XP_004996856  96 -------RFQD---ELQqgti-----------------------------tgldYTNVFQKALgkaqqDYAEETSRGmr- 135 Salpingoeca ros...
KRH03040      98 -------LYHP---QKTay---------------------------------rdFDEIFQQLQ-----IEAESRSENfkk 129 soybean
XP_006854510  98 -------LYHP---KRTyy---------------------------------edFDDIFRQLQ-----KEAEARAEEmkk 129 Amborella trich...
KIS71342      98 -------LFAPfvrKLTlss---ksAISSGASR---VItlsesarlefaaalkeWDDIFTRTL-----RNLEKAAAQskr 159 Ustilago maydis...
GAC72537      98 -------LFASfvrKLAlss---ksAVASGTSK---AAtlpesarlefsaalkeWDDIFSKTL-----RSLEKAAAQskr 159 Moesziomyces an...
CCA67186      99 -------LYAPfltKFVaslhaqanAAPTEVAD---ASpswdfa-----safkdWDKVFDKVL-----RELEQKANQerr 158 Serendipita ind...
EMD38485      99 -------LFEPflaTFVaslhavngAKSVAAAG---TAaaswnf----aqafhnWDNVFDKLL-----RGLEDKASQsrr 159 Gelatoporia sub...
XP_007395939  99 -------VFQPflaTFVaslhaassSTTLLGAS---GSgsetafawdftstfekWDTVFDNLL-----KTFETKAAQerk 163 Phanerochaete c...
5L3Q_B       131 ----RAPTTmk----kfEDSEKAKKPVrsm-ieT---RgEkpKEKAKNSKKkgaKKEG-------------SDGPLATSK 185
EPB83665     131 qr----------aprkfENTKKFENSLkgs-qaQ---NmG---------------------------------------- 156 Mucor circinell...
XP_004996856 136 ---------------tfEETERFAHTAkgs-nlT---RkA--REQLRKERQqarGGSHgedelssgegdddDGSSGGDED 194 Salpingoeca ros...
KRH03040     130 p-------------npvPALAPNRKQNgtw-qgQ--------GLGQNAGSEkksD-------------------GDGKKG 168 soybean
XP_006854510 130 skpqAkp---------vESLTKKEGQIank-kkGvllA----GKEKVSSKDdasE-------------------GNHTNG 176 Amborella trich...
KIS71342     160 kgvlGERKGatnqaqttASSDKESGQNtpi-skE---------------------------------------------- 192 Ustilago maydis...
GAC72537     160 kgvlGEKKGitnqaqaaDASDKDSGLDtpksikE---------------------------------------------- 193 Moesziomyces an...
CCA67186     159 lrtrQLTGSta-----lGASMSGNESFnee-hpE---------------------------------------------- 186 Serendipita ind...
EMD38485     160 nrlsHPTPR-----------------------------------------------I----------------VEGPSPP 176 Gelatoporia sub...
XP_007395939 164 srlkHIDPA-----------------------------------------------VH--------------TPVESTPP 182 Phanerochaete c...
5L3Q_B       186 PVP----A-------EKSG--LP------------VGPENgVELskEELIRRKR----------EEFI-------QkhGR 223
EPB83665     157 -----------------------------------ALPVAnTNTvdEDEITKNI----------KALKlqasprvGgrPR 191 Mucor circinell...
XP_004996856 195 TTTgg----------------------------daTKTGSgNGPavSAEEQRRR----------RALAlknkgvrGrrSG 236 Salpingoeca ros...
KRH03040     169 RKLendnFsvansnsNANVnhSGgkssvnnnigkeNESSN---VgaFDVNRLQKlkgkkgngngKKKDalvvaaaKg--- 242 soybean
XP_006854510 177 HKLengnSngrelg---------------tktthaDVKKSvPESgaFDVSKLRKlrs----kasKKMDtfska------- 230 Amborella trich...
KIS71342     193 -----------------------------------VKDSAdISKsvEALKSRLKl---------EASPggrrvvrGkkSA 228 Ustilago maydis...
GAC72537     194 -----------------------------------GKDSAdIAKsvEALKSRLKl---------EASPggrrvvrGkkST 229 Moesziomyces an...
CCA67186     187 ---------------RGSGatTPakd------atsPLDGQeIAKniAHLKTRMKg----------------------rNS 223 Serendipita ind...
EMD38485     177 SDDlstiP-------TESVa--------------vVVDEEqIARnvHSLKNRLRgrg---------------graGrrGS 220 Gelatoporia sub...
XP_007395939 183 SDDqstfP-------SQSNp--------------tTVDEEqIARnvQALKNRLK----------PKGPggaagrkGrrGV 231 Phanerochaete c...
5L3Q_B       224 G------MEKSN--KStks-----dapKEKGKKapRVWELG--GCA-N--KEVLDYSTPTTNgTPEa-aLSe--dINLI- 281
EPB83665     192 KgkssksTSAAAspSMnddt---ttqkKKKSQKqaRVWDGQiaKGEmE----ALDFSNNKSSnNNEgddEEadadAIAAq 264 Mucor circinell...
XP_004996856 237 GgkkprsAAQQPssSSsssp---anppPRSRVSt-RVEPTK---------HTQLSYCDPDDRpEAAda-------iSADd 296 Salpingoeca ros...
KRH03040     243 --------------------------ePKKVDKpnRVWDQPapQt-------KLDFTDHVDGdGDR-----------SAd 278 soybean
XP_006854510 231 ----------------------pkveqNKKTTKknRVWDDSpsEs-------KLDFTDPMAEkGTE-----------AVv 270 Amborella trich...
KIS71342     229 SgisasnGGSAPgtPGnasgtespsgkKAKATKemRKWDGSrsVSAqQ--VAALDFSGATEKsGDNga--------dLDs 298 Ustilago maydis...
GAC72537     230 PgisasnGGSAPgtPGhasgtespcgkKTKAAKemRKWDGSrsVSAqQ--VAALDFSGATEKdADDaa--------gLDs 299 Moesziomyces an...
CCA67186     224 TsgkkgkGGGAGsgSDsdvs---krqsSLRGAKskRTWGDV---VPtEddMSALDFSTDKPSdLPSag--------vLDt 289 Serendipita ind...
EMD38485     221 GradpgsGDSL---PGsdtd---tqskRKAKAKvqRKWGDE---APsEsdMASLDYSYEKVDsARPgtsH------DVSa 285 Gelatoporia sub...
XP_007395939 232 Gga--gsGLESVpgSDsdtp---skakKSKTKAr-RKWGDE---APsEsdMASLDFSYIQVDsPSTkqtT-----MSLSa 297 Phanerochaete c...
5L3Q_B       282 --------RGTGSG-GQLQDLDCSSS 298
EPB83665     265 fvdesklgQKNEKGiYEVQDVMQEED 290 Mucor circinelloides f. circinelloides 1006PhL
XP_004996856 297 iaeakrqaARMAEG---VQDVDFGFD 319 Salpingoeca rosetta
KRH03040     279 flakeqgeSMMDKEeILSSDSEVEDd 304 soybean
XP_006854510 271 vvd--qgeSMMDREeIVSSDSEIDED 294 Amborella trichopoda
KIS71342     299 wideksmgKKRSDGvYEIADVLEEEE 324 Ustilago maydis 521
GAC72537     300 wideksmgTKRSDGvYEIADVLEDDE 325 Moesziomyces antarcticus T-34
CCA67186     290 lvdeksrgVKK-DGvYEIRDWefskq 314 Serendipita indica DSM 11827
EMD38485     286 lvdksslgVRNEEGlYEVKDWefsss 311 Gelatoporia subvermispora B
XP_007395939 298 lvdqasmgTRTNEGmYEVKDWDfdvp 323 Phanerochaete carnosa HHB-10118-sp
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