5ZR1


Conserved Protein Domain Family
ORC2

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pfam04084: ORC2 
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Origin recognition complex subunit 2
All DNA replication initiation is driven by a single conserved eukaryotic initiator complex termed he origin recognition complex (ORC). The ORC is a six protein complex. The function of ORC is reviewed in.
Statistics
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PSSM-Id: 397966
Aligned: 136 rows
Threshold Bit Score: 194.674
Threshold Setting Gi: 557738096
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5ZR1_B       260 RHTMSMA--PDVTREEFSLVSNFFn--ENFQKR-PRQKLFEI--------QKKM-------------FPQYWFELTQ-GF 312 Saccharomyces c...
EPS98601      92 aavfSQLv-PALDAPAYARALAG------SRALrSPHVLESTrlwtderaRAAL-------------FAQWADELRE-GF 150 Fomitopsis pini...
EMD34387      38 SNVFSDLv-PPLTPEEHTAAIKR------VSESdAPANFTPLwqd--dflRKPF-------------FSRCFTELHE-GF 94  Gelatoporia sub...
Q5K9N9       168 GNSYSLLa-DPLSKQAYERYIAE---------------------------SSEVratlippetfmgkFRQWEKELEA-GF 218 Cryptococcus ne...
EKD03078     163 glSYSALa-RPLSQAEYEGIVSGAr-gKTKAVQeKLEELARF-------------------------FPQWASELET-GF 214 Trichosporon as...
XP_009269763  66 rpsnslfpyPPLTAKETRTALEN--------AP-QKPCVPRQs-------HKRR-------------YLQWKAELFLlHR 116 Wallemia ichthy...
XP_015788471  21 kpskyedtlPDFDPDESDGCKNK----YENHVK-EKLQLLNLy-------KENL-------------CPKIHALLIN-NY 74  two-spotted spi...
XP_001025157  31 KQAADEV--IEFNNKNLISYLED-----KYQVE-DTEKVKED--------KAKA-------------IVKSCFMIQS-GF 80  Tetrahymena the...
Q8IC17       508 QENLDNL--DHIQKLQY--LIKNL---PYTHIK-EKRSLYHY--------NIKQ-------------FIKWKVYLLN-NI 557 Plasmodium falc...
XP_002140259  14 gklpmKSflPIIEESLYIRLLTEEkicQQSESK-KWKELHYS-------------------------IMMWSLS----GF 63  Cryptosporidium...
5ZR1_B       313 SLLFYGVGSKRNFLEEFAIDYLSpkiaysqlayenelqqnkpvnSIPCLILNGYNPSCNYRDVFKEIT-D--LLVPAelt 389 Saccharomyces c...
EPS98601     151 SLLFYGFGSKRTVLNAFARALTKrrrvp-----------ggserGGHVVIANGYLPGFALKDLLNSIE-AipALQEAsda 218 Fomitopsis pini...
EMD34387      95 NLIFYGFGSKRYVLNAFAKAASAr--------------------GGHVIVANGFQPSFGLKDLLGSIE-QipMVEDA--- 150 Gelatoporia sub...
Q5K9N9       219 NLLFYGFGSKRPALNLFAQNRLAk--------------------KGHVVVVNGFFPGLGIRDVLSEVE-DrlEVPQNvs- 276 Cryptococcus ne...
EKD03078     215 NLLLYGYGSKRRLVNRFATETLNd--------------------LGDVVVVNGTFPGLGLKEVLAALE-ArlPLSDEvp- 272 Trichosporon as...
XP_009269763 117 PLIFTGFGSKRGAIDDFVREls---------------------gEYDVITIDAFNPSITFRGVLEGLL----AVHQKs-- 169 Wallemia ichthy...
XP_015788471  75 NVILYGVGSKRGIIDEFITSYLN---------------------QNIVIVFYGYKEDVNPRKILSAFR-Ealn------- 125 two-spotted spi...
XP_001025157  81 NVCLHGYGSKRQIIQEISDQFI----------------------NYPKLIIQGYSAATQIQQILQKLKyIvvKITGQn-- 136 Tetrahymena the...
Q8IC17       558 NICLYGIGSKFHLLNLFTNICLN---------------------DGNKCIILGFEDEINFEEILVRIL-Eyh-------- 607 Plasmodium falc...
XP_002140259  64 SVLIHGYGSKRRFMNEFIHKMLKp--------------------QFLTLVIRGYCKHVKFKSSLVELI----NYLEDp-- 117 Cryptosporidium...
5ZR1_B       390 rsetKYWGNHVILQIQKMIDFYKNQPLDi------------KLILVVHNLDGPSIRK--NTFQTM--LSFLSVI-RQIAI 452 Saccharomyces c...
EPS98601     219 --qqGTAGTGLEAQVQRIYGYFSGADDKagg--------geRLYLVIHNIDGPGLRG--SKAQVV--ISRLATA-PRIHV 283 Fomitopsis pini...
EMD34387     151 ----SLTGAGVEAQSQRIHEVFSSSQNDa------------KLYLIIHNLDSPALRT--AKAKAC--LSLIALS-SRIHI 209 Gelatoporia sub...
Q5K9N9       277 --vpAYCSTPLERAAHRIYAYLLPPAAIqshsrkhwptasaPLYLVIHNIDAQSLRT--PRSIAT--LSLLASS-PRIHI 349 Cryptococcus ne...
EKD03078     273 ---aPLGASPLERAAYRVYQSYrsg--------------kdHLYMIIHNIDAPGMKA--PKSLAA--LSLLASC-PGIHI 330 Trichosporon as...
XP_009269763 170 ----SIPSSTPTDELMRSVQLQYSRASTp------------RIVAVLHSMDALTLHA--RKNVDVdkLKRVLGS-ERISV 230 Wallemia ichthy...
XP_015788471 126 --cdKMDEDVIMKKIDKLKEPI---------------------FLVIHSFDRLCIKH--NKIKPL--VNKILNRsSQIHL 178 two-spotted spi...
XP_001025157 137 ---------SGQKRIEGILEYLKQQEENmgkis----sqvpFILILFHNIDSKQFIE----QDSVkiLSAVLNL-PYIKA 198 Tetrahymena the...
Q8IC17       608 ---yKYKSSKTLKSFDLLYELI---QRVnds--------nvPLYFIIHNLDNTKLYPyyEY------FSFLSQY-ENIYF 666 Plasmodium falc...
XP_002140259 118 ----EEAVNMSEWSLDMLTSKIrklyklqt----lnfspkkRVFIIINNIDCISLRPylST------IAQLAQI-PILSI 182 Cryptosporidium...
5ZR1_B       453 VASTDHIYAPLLWDNMKA-Q------------------NYNFVFHDISNFEPSTVESTFQD-VMKMGKsd---------- 502 Saccharomyces c...
EPS98601     284 VASIDNVQAMGRWSLSEMfTrkrtqps----sydvprrGYAWLWHDLTTLAPYDAELASADpSSISGAstsgrranla-- 357 Fomitopsis pini...
EMD34387     210 VASVDHINASQRWSFTELfArkpdpgvpe-qstkvpsrGFAWLWHDLTTLAPYDFELAFADpTSIYGVsalrggrardaa 288 Gelatoporia sub...
Q5K9N9       350 IASFDHVHTPIIFSTSLSnSpphsypdggwrgtpqkdrGFNWIHHSLTTYAPYDLELSYLRlSAQSLTpsgs-------- 421 Cryptococcus ne...
EKD03078     331 VATFDHVHTPLLFSATLSnApphpptk----deipssrGFNWIYHSAPTFDDYDVELSYARlSSSAALgqs--------- 397 Trichosporon as...
XP_009269763 231 VASVDHLNAPLLFPAHDAaV------------------GLPWLWHDLSTLEPHLMEM--AQrATSLLHssqaasst---- 286 Wallemia ichthy...
XP_015788471 179 LTSVDHLNSPLLFTCSET-V------------------TLNLVWLNCPTFQDYNIEKSFAQlSTSRTSgsskhr------ 233 two-spotted spi...
XP_001025157 199 VCSIDHVKYPIILTSKVL-E------------------SFNFSFIEVHTHQCYLHEFKVSQnTFNLKK------------ 247 Tetrahymena the...
Q8IC17       667 VCSIDDVSFELNMNFKNI-S------------------SINFFYIKCHTWLDYRHEIlrqwnkflpe------------- 714 Plasmodium falc...
XP_002140259 183 LVTVDNIRWPFLWSTSLL-H------------------KMNFIYIQVHTKDNYSVELkhqwegtnpqw------------ 231 Cryptosporidium...
5ZR1_B       503 ----------tSSGAEGAKYVLQSLTVNSKKMYKLLIETqmqnmgn---------------------------lsantgP 545 Saccharomyces c...
EPS98601     358 --tgtaaggprIVSETAARHVLASVTQKARRLFVLLGSKqlelma-----------------------------paageV 406 Fomitopsis pini...
EMD34387     289 vagangapgtvLVTESAARHVLASVTDKAKKLFVLLGARqleimp-----------------------------egagaG 339 Gelatoporia sub...
Q5K9N9       422 --------gtggISEEGALQILKSVPVKAARLLKLILTQqlsrlpshpk--------------------whvaypapssG 473 Cryptococcus ne...
EKD03078     398 ---------sgtISEEGALQILHSVPPMAARLLKLILLKqldnge-----------------------------gplmgV 439 Trichosporon as...
XP_009269763 287 ---------givptvsGARHVIASVPDRARRLFVAIAQLqlercsege----------------------ksdataqntS 335 Wallemia ichthy...
XP_015788471 234 ---------saaatiMAVSNVYDNLPDNSRKIFLLILNYystqlsngelsksskraikgknedtetesdeeadegdkldN 304 two-spotted spi...
XP_001025157 248 -----------EKEGESLKYIFRSLTKVQKEIIQFVAKYiqdkldqnp-----------------------gtaiqingL 293 Tetrahymena the...
Q8IC17       715 --wvfnkkceeIDIKKNIETILNALSINHKRLFKIIASIql--------------------------------------e 754 Plasmodium falc...
XP_002140259 232 -lnlliedtnsKSKLDRFDTILKCLTPSHVQLTKLIATLql--------------------------------------- 271 Cryptosporidium...
5ZR1_B       546 KRGTQRTGVELKLFNHLCAADFIASNEIALRSMLREFIEHKMANIt---------------KNNSGMEIIWVPYTYA 607 Saccharomyces cere...
EPS98601     407 GAAGQDAAYDYERLFGAAREEFIATSDTALRALLGEFRDHGLVVSavap---------vgaGGTGGGEALWIPMRRE 474 Fomitopsis pinicol...
EMD34387     340 AMQPAEGAFDYERLFGAARDNFVATSDTALRALLGEFRDHGLVVSn--------------aGTAGAGEMLWIPMRRD 402 Gelatoporia subver...
Q5K9N9       474 SGIAPPFAVDGYLLNKTAKDKFIATEDERFEAFIGEYKDHGLVAEasvasdvdenhdgavtEGRKEGRWFWVPLGKA 550 Cryptococcus neofo...
EKD03078     440 GGAAPAYALDVDLVQKAARDKFIAREEERFNALLGEFKDHGLVVTae------------ldAEGRQGRWAWVPLPRa 504 Trichosporon asahi...
XP_009269763 336 TTLTPSHASPRHALVSMAKQSFIATSEDAFEAALAEFRDHGLIQSsssp--------psntHVDGPEQYIWIPLDQR 404 Wallemia ichthyoph...
XP_015788471 305 SGKKGFEGYSFNKLYLDCMDAFYVNSEGTLRSQLVEFIDHKLIRCk---------------SGTDGSEYVElliqpk 366 two-spotted spider...
XP_001025157 294 TEDGQIIGLTLKELLEMLIDEMILNSEQQLKENLLEILDHKVIIs----------------IENQQKTYYTMNFSRQ 354 Tetrahymena thermo...
Q8IC17       755 NLDKGIYGVEKESLLQDKRIFTVGASSIRINSLLVEFVSHNVITEt---------------RLKEGNTFLKINADKE 816 Plasmodium falcipa...
XP_002140259 272 ---nSPHGITEDQIFKDAKSSMLVTTKDALSHLLVELYTHDILVk----------------EHNNGKQIVKLSLSTD 329 Cryptosporidium mu...
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