3MAM,4WEP,4ND9,3TMG,4XZ6,3PPP


Conserved Protein Domain Family
OpuAC

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pfam04069: OpuAC 
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Substrate binding domain of ABC-type glycine betaine transport system
Part of a high affinity multicomponent binding-protein-dependent transport system involved in bacterial osmoregulation. This domain is often fused to the permease component of the transporter complex. Family members are often integral membrane proteins or predicted to be attached to the membrane by a lipid anchor. Glycine betaine is involved in protection from high osmolarity environments for example in Bacillus subtilis. The family member OpuBC is closely related, and involved in choline transport. Choline is necessary for the biosynthesis of glycine betaine. L-carnitine is important for osmoregulation in Listeria monocytogenes. Family also contains proteins binding l-proline (ProX), histidine (HisX) and taurine (TauA).
Statistics
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PSSM-Id: 397954
Aligned: 86 rows
Threshold Bit Score: 73.13
Threshold Setting Gi: 81669202
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3MAM_A   1 ERVVIGSKPFNEQYILANMIAILLEENGYkAEVKEGLGGTLVNYEALKRNDIQLYV-EYTGTAynvilrkqppelwdqqy 79  Archaeoglobus fulgidus
Q47537  23 VNVTVAYQTSAEPAKVAQADNTFAKESGA-TVDWRKFDSGASIVRALASGDVQIGNlGSSPLAv---------------- 85  Escherichia coli K-12
Q6W2B0  31 VTLNIGYQPIVEPSRVPQADGTYEKATGA-KINWQKFDGGADVIAAIASGSLDIGYvGSSPLAa---------------- 93  Sinorhizobium fredii ...
Q6D701  28 DEIRVAYSGGSQVLVLAKADGSLQKALGA-PVKWVQFASGADALNYFASNAIDIANfGSSPATa---------------- 90  Pectobacterium atrose...
Q8EFL2  23 PLIRLGVTDLSFHRVTAAVVAQVMHLMGK-RVELSYALH-EANFNRLKLGQIDLLCsAWLPHS----------------- 83  Shewanella oneidensis
Q5DYM6   3 NKIILGVTDLSFHRITASIISHILINMGF-DVERIYSPH-QDNFTKLKSGEVDMIAsAWLPSS----------------- 63  Aliivibrio fischeri E...
Q88R30  39 KNVRLGVVNWTDVIATSAMAQVLLDGLGY-QTKQTSASQ-QIIFAGIRDKRLDMFLgYWNPIM----------------- 99  Pseudomonas putida KT...
Q7MF11  26 QTVRFADVGWTDITATTAVTSQLLKGMGY-QTKTDLLSV-PVTYSSMANGDVDVFLgNWMPTM----------------- 86  Vibrio vulnificus YJ016
Q7CXZ0  55 KMVRMAEPGWNDLAFTTGIAMTLLKSLHY-QPQSQLLGI-DVIYTSLKSKDLDVFMgYWDPAM----------------- 115 Agrobacterium fabrum ...
Q88B53  28 STVKMADTGWSDIAATNAITGVVLEGLGY-KAKVDTLAV-PIAYGGLKDGKLDVFLgNWMPAQ----------------- 88  Pseudomonas syringae ...
3MAM_A  80 iFDEVKKGLLeADGVVvaA-KLGFRDDAALAVRADWAEeNGVEKISDLAEFADqlVFGSDPEFASRPDGLP------QIK 152 Archaeoglobus fulgidus
Q47537  86 -------AASqQVPIEvfLlASKLGNSEALVVK------KTISKPEDL-----------IGKRIAVPFISTthysllAAL 141 Escherichia coli K-12
Q6W2B0  94 -------AASrELPIEtiAlVGLISEAEALAV-------RGIDKPEQL-----------AGKKIATPFVSTahysllTAL 148 Sinorhizobium fredii ...
Q6D701  91 -------GIVrKLPVEivGvSGVIATYERLIAK------SGITTLKDI-----------EGKRVAYPPNSTaqyaleAAI 146 Pectobacterium atrose...
Q8EFL2  84 -HGVYRQEVEtQVTTRelG--LHYEPYALWGVPDYVPE-DAVSRIEDLLKPEV--KQRMRPIIQGIGEGAGitrfskNIM 157 Shewanella oneidensis
Q5DYM6  64 -HGIYKADVEeKVELLelG--LHYKPYALWGIPDYIPE-SAVSEIKDLLKPNI--LSRMNRRIQGINPGAGitrfsiKMM 137 Aliivibrio fischeri E...
Q88R30 100 -TQTITPFVDaNQFKVldK-PSLEDARATLAVPKYLYD-KGLKTFADIHKFEK----ELGGKIYGIEPGSGantqikAMI 172 Pseudomonas putida KT...
Q7MF11  87 -EGDIAKYRDsGEVETv-K-ANLEGAKYTLAVPKYVYE-QGVQSFADISKYAD----KFKNRIYGIEPGNDgnrliqSMI 158 Vibrio vulnificus YJ016
Q7CXZ0 116 -VNYYKPYKEdGSVEKv-R-TNLVGAKYTFAVPTYVWE-AGVKDFSDLQKFAD----KFDRKLYGIEPGSNql--mlDAV 185 Agrobacterium fabrum ...
Q88B53  89 -QGFYDKFVAtGDVTQl-A-RNLEGTEFTLAVPDYVWE-AGVHDFTDLSKFAE----KFDKKIYGIGSGAPanlslqEII 160 Pseudomonas syringae ...
3MAM_A 153 KVYGFe-------fKEVKQMEPtLMYEAIKNKQVDVIPAYTTDSRVDLFN-LKILEDDKGALPP-----YDAIIIVN-GN 218 Archaeoglobus fulgidus
Q47537 142 KHWGIkpgq----veiVNLQPP-AIIAAWQRGDIDGAYVWAPAVNALEKD-GKVLT--DSEQVGqwgapTLDVWVVR-KD 212 Escherichia coli K-12
Q6W2B0 149 NHWNVdpks----veiLNLRPP-EIAAAWSRGDIDGAYVWDPVLAEIKKT-GTVLA--TSADVGnwgspTFDAWIVS-KT 219 Sinorhizobium fredii ...
Q6D701 147 AVNKLdrsk----itlIPLRPA-EMVAAWKRGDIDAGYVWAPFAQELEASaGHAIF--ATKDLQkdgylIYNNYVVR-KA 218 Pectobacterium atrose...
Q8EFL2 158 EQYGLtaagyqfrtGTQADCVA-AFESAVSVRDWVIVPLWHPQFLHHQYG-IRDLQDPKGLLGGk----DKAVLLAReRE 231 Shewanella oneidensis
Q5DYM6 138 NSYGLtragytfytGSEEDCFT-AFEAAIENKEWVVVPLWKPQFLHHKHN-IREISEPKGLLGVi----DRAVLLLR-QD 210 Aliivibrio fischeri E...
Q88R30 173 TKNQFdlgkfqlveSSEAGMLA-AVDRAVRRKEAVVFFGWAPHPMNVNID-MAYLGDSQDALGPde-grATVWTVTA-PD 248 Pseudomonas putida KT...
Q7MF11 159 DQNAFdlkgfslveSSEAGMVS-QVARAVRRNQWIVYLGWAPHPMNSNVE-MVYLSGGDDFFGPny-ggANVYTNVR-EG 234 Vibrio vulnificus YJ016
Q7CXZ0 186 KDPALglkdwevveSSEQGMLS-QVARFNRNKTFIVFQGWAPHPMNAKFD-IKYLTGGDKFYGPdf-gaATVDTQVR-RG 261 Agrobacterium fabrum ...
Q88B53 161 KKNEFdlgqwklveSSEQAMLA-EVNRNVKKKAFVVFLGWTPHPMNVQIKgMHYLKGGEKYFGDt----GSVFTLTR-KG 234 Pseudomonas syringae ...
3MAM_A 219 TAKDEK--LISVLKLLEdrIDTDTMRALNYQYDVEKKDAREIAMSFLKE 265 Archaeoglobus fulgidus
Q47537 213 FAEKHPevVKAFAKS-----AIDAQQPYIANPDV-----------WL-K 244 Escherichia coli K-12
Q6W2B0 220 FAEAHPdvVAAFVKV-----TGDATAAYRANPEA-----------WDAK 252 Sinorhizobium fredii NGR234
Q6D701 219 FAQQYPetVARFLRV-----HQQKVDEFRQDPEK--------AAAIVAK 254 Pectobacterium atrosepticum
Q8EFL2 232 LAINFSpeQIQVLDNIV--LSNQIVAELDYAVNRQGMTEDEAAANWLAV 278 Shewanella oneidensis
Q5DYM6 211 KSIDFTqeQIKQLDSLK--FSNEIIAALDYQVSREGKAIDEVTKQWLIN 257 Aliivibrio fischeri ES114
Q88R30 249 YAERCPn-ALRLLANLK--FSAEDESRMMQPLLD-HKDALESARQWLKD 293 Pseudomonas putida KT2440
Q7MF11 235 YLSACPn-VGQLLQNLT--FSLEMENQLMEAILNQKKKPAKAALNWLKQ 280 Vibrio vulnificus YJ016
Q7CXZ0 262 YLQECPn-VAKLLQNLE--FDVEFENKGMDLIMNGGLSPEDAAAQAIKA 307 Agrobacterium fabrum str. C58
Q88B53 235 YAQACPn-VGKLLTNLS--FTLDMENSIMAEVTNKKLSNSAAAKAWIKA 280 Pseudomonas syringae pv. tomato
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