1SZ7,2J3R,2BJN,6AQ3,2C0J


Conserved Protein Domain Family
TRAPP

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pfam04051: TRAPP 
Transport protein particle (TRAPP) component
TRAPP plays a key role in the targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment. TRAPP is a large multimeric protein that contains at least 10 subunits. This family contains many TRAPP family proteins. The Bet3 subunit is one of the better characterized TRAPP proteins and has a dimeric structure with hydrophobic channels. The channel entrances are located on a putative membrane-interacting surface that is distinctively flat, wide and decorated with positively charged residues. Bet3 is proposed to localize TRAPP to the Golgi.
Statistics
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PSSM-Id: 397939
Aligned: 313 rows
Threshold Bit Score: 84.8418
Threshold Setting Gi: 121916118
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1SZ7_A        28 FTLTYGALVTQLCK---DYE-NDEDVNKQLDKMGFNIG------VRLIEDFLARSN--VGr-cHDFRETADVIAKVAFKM 94 
XP_003109935  24 FAVLFSEMVLYAQN---RSE-TVTDIHDKIASYGKQVG------LRMFDIIVLREK--GYkreTKLLGMLMFIKSTVWKN 91  Caenorhabditis ...
CDS36382      29 FMYLFSEIVKYAMQ---TSK-NLDDAQSKLASFGAPIG------RQMLDLVFLRER--LQkreIRLLNFLVFLKSTFWRC 96  Echinococcus mu...
ESO07809      30 FALLFSEIVQYCHN---RVN-TIPELQQKLSDLGFHVG------QRYLDLIVLREK--GHkreTKLVNMLVFIKSNVWKN 97  Helobdella robusta
XP_015791340  32 FAFLFSEVVQYCHS---KVY-TVPELQKKLSEMGYHVG------QRLVDLTFIREK--NYkreTKLINILIFIKTNLWKT 99  two-spotted spi...
XP_001708336  27 MVCLLNEYFQYAQR---TCK-TVEEIENKMSKLGVDAGrplwtyVRMLDRMRSKTQdtVCk-lTRPDTVLYYLKETVWPI 101 Giardia lamblia...
Q38DI4        28 FSFLFSELCTRAHStptKAR-DIEEIEQRLTSLGAIVG------AKLMMLSSLKDPleLQrrpTTIDEALKLLQEKFWTR 100 Trypanosoma brucei
CBZ12960      35 FSFLFSELCVRAYTfptKVK-NVEEVEARLTSLGAHVG------TRLIMLSSVRDPvdLQrrpLTIDAVLKLMQEKLWAR 107 Leishmania majo...
A0C1N5        23 FNYVFAEYICYLKR---KHGnDYNEMNSKMEQLGVSVG------IRLYEVVSLRE---RNkreTKLVEQLRFIQGIFWKH 90  Paramecium tetr...
XP_001009640  24 FGFLFSSIIQYHSS---KKRnVEDELKS----MGEGIG------VRLLELIYFRNN--KLkkeTKHLDMIQFIANTVWKT 88  Tetrahymena the...
1SZ7_A        95 YLGITPSITNw--sPAGDef----sLILENN--PLVDFVELPDNHs-------SliYSNLLCGVLRGALEMVQMa--VEA 157
XP_003109935  92 LFGKEADKLEr--sNDDHc-----tYLLIEKdpLVNTYISVPRDKg-------VlnCAAFAAGIVEAILESASFkckVTA 157 Caenorhabditis ...
CDS36382      97 IFGKEADDLEr--dGLDEh-----tYYMIERepVVNKFTRFTYDHseserkivPlnLAAFNCGIIESALTCAGFpceVAI 169 Echinococcus mu...
ESO07809      98 LFGKEADKLEh--aNDDEk-----iYYIIEKdpLVNRFISNPRRQs-------SlnCASFMAGIIEAILTTSNFpakVTA 163 Helobdella robusta
XP_015791340 100 LFAKDADKLEh--sNDDPt-----tYYIIESdpIVNKYISYNRDKg-------SlnCASFIGGIIEAALNETGFnakVTV 165 two-spotted spi...
XP_001708336 102 LFGKPAADIKkpateDLE-------YYLVDEwpVLEYYTSYPPNYg-------GalPSMFVAGLVEGFLTCCGFrtkILA 167 Giardia lamblia...
Q38DI4       101 WFGKAANDLQqe-gESTR-------YFLVDSnpMVLQHVYPSPEYmdse-gqwSinYASFMGGIVEGALRAVGFdadVLT 171 Trypanosoma brucei
CBZ12960     108 WFGRPASEIQre-sNSDR-------FFLFDSdpIVLRYVHPSPDYvdse-grwNvnYAGFMGGIIQGALQSMGFeaeVQA 178 Leishmania majo...
A0C1N5        91 LFGRQAESIEk--lKDRPn-----dYLIRDEnpLLLKYIS---EEg-------HisPAQFMCGILKGVLNASGFtcqVSy 153 Paramecium tetr...
XP_001009640  89 LFGKNADGI-------FPedgvkygYLIRDDnpTVLRYIS---EVq-------GqnGAAFVAGIIQGMLNHSGFeaeVVH 151 Tetrahymena the...
1SZ7_A       158 kf--------vqDTLKGDGVTEIRM 174
XP_003109935 158 hw-------------hNGTAYVIQF 169 Caenorhabditis remanei
CDS36382     170 tw-------------hKGTTYVIKF 181 Echinococcus multilocularis
ESO07809     164 hw-------------hEGTAFRINF 175 Helobdella robusta
XP_015791340 166 hw-------------hKGTTFMIKF 177 two-spotted spider mite
XP_001708336 168 yn--------vlDEPNPNITFHISF 184 Giardia lamblia ATCC 50803
Q38DI4       172 yhh-------pePDKPQQSIFAISF 189 Trypanosoma brucei
CBZ12960     179 yhq-------pePGKPHQSLFVIAF 196 Leishmania major strain Friedlin
A0C1N5       154 qfkt----dergVSYYPHTVFILSF 174 Paramecium tetraurelia
XP_001009640 152 dtiyqdtennseISMYPATYFSIkf 176 Tetrahymena thermophila SB210
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