Conserved Protein Domain Family
Upf2

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pfam04050: Upf2 
Up-frameshift suppressor 2
Transcripts harbouring premature signals for translation termination are recognized and rapidly degraded by eukaryotic cells through a pathway known as nonsense-mediated mRNA decay. In Saccharomyces cerevisiae, three trans-acting factors (Upf1 to Upf3) are required for nonsense-mediated mRNA decay.
Statistics
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PSSM-Id: 397938
Aligned: 113 rows
Threshold Bit Score: 55.8281
Threshold Setting Gi: 220975230
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
GAC73050     1038 EE-----LAARR-------------EADDEFDRELARMMVESSapgtataqssagaST---SQRPHQ-----FfsRAALP 1091 Moesziomyces ...
ESS34235     1222 DEaedlrDYVREhv---------qkEEELRFGADFAQMMLASLn------------EAktlRRPTSS--------EMKIP 1272 Toxoplasma go...
CBN74240     1458 DDgedeqEVVLNgwgvgverteedgEAEDEFEALLSKTMSESV------------------EKTKIArattqVmgHMAVP 1519 Ectocarpus si...
EED93559      935 DEeesdnEEEDGideaaaeaayirqLQDEAFESELRKLTMDAL-------------ER---GKMSARtgaggKv-SSQMP 997  Thalassiosira...
EEC43505     1247 EEeeefde-----------eaymrqLEEEAFERELRRVTIEAL-------------EK---GKNTSR------------- 1286 Phaeodactylum...
XP_014342624  973 EVmikggGLKHIpcae------deeFIQALDKMMLENLQQRTG-------------ES---VKVHQLdv-aiP--LHLKS 1027 coelacanth
ESN94504      981 DEdddnhVTLDVgpkf------ikcQEDDDFLSALDKMMSDSV-------------QA---RQQEIVki-pvV--EIAVP 1035 Helobdella ro...
XP_003057638 1130 NAansapVELAPeervkrvvpkvskEVEADFDREMSKFLGPGI----------------------VAaktpvVasYGQTP 1187 Micromonas pu...
CAP25938      940 egeqefedsdeerqrglsmsnavtkEEDDDFQRELDRMMGEGF------------------RQSAAPaaavqY--DVTLP 999  Caenorhabditi...
EGT55990      940 dgdldeedsdeeqqklyiatntvtkEEDEDFQRELDRMMGEGF------------------RQSGAPvtapqY--DVTLP 999  Caenorhabditi...
GAC73050     1092 SGGAsygpahs-hahahaSGSSlseiglPIKKKAAEQANGgveaEagSHMKFSLLSK-KGSKQVTHEVYVPATASIAINT 1169 Moesziomyces ...
ESS34235     1273 ANVLketeslseaprpssEEASsrevltSGDADDGDLDPDgplpRptTAMRLVLRRPdKRNRFVVRPLAVPTDASLAEHS 1352 Toxoplasma go...
CBN74240     1520 r---------------------------VLKNTNVRTATHqaplTggSGVAFKLLKRgNKGKMEAQEVVVPESTSLAAQV 1572 Ectocarpus si...
EED93559      998 AA-----------------PQFakkpgvAEPKQESEVDPTtnpfGgsEGMSFKLLKKgNKGKMEEKQFLVPTSTNLARRA 1060 Thalassiosira...
EEC43505     1287 KLVAenmv-------sgsQTFKkkptdlSKPVGASSAVAPtfglAgtPGITFQLLKKgNKGKVEAKEIVVPSDTNFAKVA 1359 Phaeodactylum...
XP_014342624 1028 QLKKa-------------PPPS----------GGGEGDAEntetMpfVMLTRKGNKQ-QFKILNVPMSSQLAANHWNQQQ 1083 coelacanth
ESN94504     1036 MAQKn-------------NLNGki---iGPNSKSQTYVTDeeedEkvSLIPFTVLTR-KGNKPQLSTLSIPLSENFASKF 1098 Helobdella ro...
XP_003057638 1188 ----------------------------STVARAAPTTRGpgmnGpgPTVAFKMLVK-KDGKPASRTLDVPAEAEFVARV 1238 Micromonas pu...
CAP25938     1000 AAAKnrfsrnikfaedtkARSSpsrsseMDFDDEPSSSTGvaasGrqKQGRVTLMVRgKANKPALKTVNI-DDGELQRRW 1078 Caenorhabditi...
EGT55990     1000 AAVKnrfnrnikfaentkVESSsnsrlyEVNDDDEPSTSHtsasGrpKQSRVTLMVRgKANKPSLKTVNI-DDDELQKRW 1078 Caenorhabditi...
GAC73050     1170 RTKQLK---EEAERRQLKQQILA 1189 Moesziomyces antarcticus T-34
ESS34235     1353 RRKDQQarqEKAERADLKKFVIE 1375 Toxoplasma gondii VEG
CBN74240     1573 NRNEEA---SREESFIIKARVLA 1592 Ectocarpus siliculosus
EED93559     1061 TKVDDE---AVKEKEMIKARVLQ 1080 Thalassiosira pseudonana CCMP1335
EEC43505     1360 SKQDDA---AARERNFIKQRVLQ 1379 Phaeodactylum tricornutum CCAP 1055/1
XP_014342624 1084 AEQEER---MRMKKLTLDINERQ 1103 coelacanth
ESN94504     1099 KEQIKH---DQEEKERMKRMVLE 1118 Helobdella robusta
XP_003057638 1239 KEQAEA---EQRERAELKRLVLM 1258 Micromonas pusilla CCMP1545
CAP25938     1079 KEEKAR---EEEERADMKRLTLG 1098 Caenorhabditis briggsae
EGT55990     1079 KEEKAR---EEEERAEVKRLTLG 1098 Caenorhabditis brenneri
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