6FF4


Conserved Protein Domain Family
DUF382

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pfam04037: DUF382 
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Domain of unknown function (DUF382)
This domain is specific to the human splicing factor 3b subunit 2 and it's orthologues. Splicing factor 3b subunit 2 or SAP145 is a suppressor of U2 snRNA mutations. Pre-mRNA splicing is catalyzed by a large ribonucleoprotein complex called the spliceosome. Spliceosomes are multi-component enzymes that catalyze pre-mRNA splicing and form step-wise by the ordered interaction of UsnRNPs and non-snRNP proteins with short conserved regions of the pre-mRNA at the 5' and 3' splice sites and branch site.
Statistics
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PSSM-Id: 397929
Aligned: 72 rows
Threshold Bit Score: 157.663
Threshold Setting Gi: 74621061
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6FF4_8       470 ARPDVVEMHDVTAQDPKLLVHLKATRNSVPVPRHW--CFKRKYLQGKRGIEKPPFELPDFIKRTGIQEMRE--------- 538 human
Q6FJM3       125 lTPQLIEKHDCDAKEPYFLASVKTSFNVVQVPSHW--QSKRDYLSGRSLLEKKPFELPDLIKQTGVDSMRNtl------- 195 [Candida] glabrata
XP_003679457 133 iYPQVIEWYDCDAPYPYLLATIKSSKNVVPIPGHW--QMKREYLSGRSLMEKRPFELPDVIKQTDIEIMRKtl------p 204 Torulaspora del...
CCE63955     146 PYPQVIEWYDCDAHYPLYLADIKSSKNIVPVPSNW--QVKREYLSGRSSLEKKPFDLPDLIKETKIEEMRNil------- 216 Tetrapisispora ...
XP_001645752 127 PYPQVIEWYDCDALNPYFLASIKSSKNIVPVPDHW--QTKKEYLSGRSMLGKKPFELPELIKQTGIEEMRNtl------- 197 Vanderwaltozyma...
XP_002497739 122 PYPQVIEWYDRDSQYPYLQASIKSSKNMVPVPSHW--QNKKEYLSGRSLLEKRPFELPEIIKETDIEQMRQvm------- 192 Zygosaccharomyc...
CCC69068     134 AYPQLIEWFDCDSTSPYLLTKIKTSKNVVPVPSHW--QMKREYLSGRSLLTKKPFELPDIIKQTDIEQMRVtlpsnenms 211 Naumovozyma cas...
CCH60587     137 NYPENIEWFDCDAPYPYLLAGIKTSKNIIPIPPSW--QQKRGYLSGRSLLNKRPFQLPSIIRETGIEEMRKis------- 207 Tetrapisispora ...
Q6CKS4       137 PYPELIEWFDCDAQWPYFNAAIKTTHNTVGIPRHW--QMKRGYLSGRSMMERKPFQLPEIIRQTDIETMREtv------p 208 Kluyveromyces l...
Q8SQT5        56 PYPEIFETEDATCPDPMSHNRMKGCSG-VPVPRHWrsSSRRMFPH---GYHKPRYVTPRHVIGTGIPELRR--------- 122 Encephalitozoon...
6FF4_8       539 ALQEKEEQKTMKSKMREKVRPKMGKIDIDYQKLHDAFFKWQT--KP-KLTIHGDL------YYEGKE 596 human
Q6FJM3       196 -peDEEQEK-LKEQTRNAVRPKLGKLDLDYKKLYDVFFKLGKkwKPdTMLPYGDV------YYENRN 254 [Candida] glabrata
XP_003679457 205 dKEAAQNDKSLKEISRARVQPKMGSLDIDYKKLHDVFFKLGVnwKPeVLLSFGDV------YYENRN 265 Torulaspora delbrueckii
CCE63955     217 -nvTNEDEKSLKELSRASVQPKTGSLDIDLKNLHDIFFKIGVnwKPkSMLSFGDL------YYEKRN 276 Tetrapisispora phaffii CBS 4417
XP_001645752 198 -pgKQETDESLKELSRARMQPKLGSLDLDYKKLHDVFFKLGAdwKPeLLLGFGDL------YYERRN 257 Vanderwaltozyma polyspora DS...
XP_002497739 193 --pdETKDSTLKETARARVQPKVGTLDIDYKKLHDVFFKLGTnwKPdVLLPFGDL------YYEGRN 251 Zygosaccharomyces rouxii
CCC69068     212 GAEGDEKEKSLKEMSRARVQPKLGQLDIDYKKLHDIFFKLGStwKPgILLPFGDM------YYENRN 272 Naumovozyma castellii CBS 4309
CCH60587     208 lgEDISNEKSLKEITRSRVQPKTDTFDLDYKKLYDVFFKIGKnwKPsTLLPFGDL------YFENRN 268 Tetrapisispora blattae CBS 6284
Q6CKS4       209 sGNEKQAEK-LKDITRAKVQPKLGVLDLDYKRLYEAFFTLGKnwKP-ELLSFGDL------YYENRS 267 Kluyveromyces lactis
Q8SQT5       123 MMREREAGMSLRERIREKLHPRVGGSLVDQRILYEAFFSLGP--RP-YLSKYGEFfepvddYFEKKC 186 Encephalitozoon cuniculi
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