Conserved Protein Domain Family
DUF364

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pfam04016: DUF364 
Putative heavy-metal chelation
This domain of unknown function has a PLP-dependent transferase-like fold. Its genomic context suggests that it may have a role in anaerobic vitamin B12 biosynthesis. This domain is often found at the C-terminus of proteins containing DUF4213, pfam13938. The structure of UnioProtKB:B8FUJ5, Structure 3l5o, suggests that the protein has an enolase N-terminal-like fold and this Rossmann-like C-terminal domain. Structural and bioinformatic analyses reveal partial similarities to Rossmann-like methyltransferases, with residues from the enolase-like fold combining to form a unique active site that is likely to be involved in the condensation or hydrolysis of molecules implicated in the synthesis of flavins, pterins or other siderophores. The protein may be playing a role in heavy-metal chelation.
Statistics
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PSSM-Id: 397911
Aligned: 50 rows
Threshold Bit Score: 114.622
Threshold Setting Gi: 81833439
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q24YG7        120 DN-LEF---INTEDRVVLVGYgaliketLARcsVIDVCDmR---SLSSLRTVSIGRTIEYGPPGIrfhGAAENQTLLADA 192 Desulfitobacte...
Q7MRP2        108 LLpQKLlelTKEGDEIVFVGN-------LEP--VIKKMR-Q---EGRKPLVFCRQKNRLSDEVH----SDIFEYEALASS 170 Wolinella succ...
Q5JG54        102 DV-VEL---VEGFSEVAVIGN-------MPP--VVRALR-E---KGVKTLVFERNPKLWDRETL----SDALEYILLPEV 160 Thermococcus k...
Q6M0S0        104 DV-LDLivsDKDIKKIGFVGN-------IAP--VVNELR-EidgKNYEIYVFERNSSSCGAELL----DDTFEYRLLPEM 168 Methanococcus ...
Q0AWB4        147 DP-LDm--vFSRDKNVAVVGA-------LGP--LLKKLK-T---GEVSYRVLEMDISTLKPEEIPyfcPPEKAAETLPWA 210 Syntrophomonas...
WP_011747485  134 DA-FDIa-rIRPDETAVVVGA-------FGP--FLKALR-G---IGARHFVLEKDPATLRPDEMGhfrPAESYPRIVPQA 198 Paracoccus den...
Q2FMG3        130 DA-FDLldtIDPATPVVVVGA-------LWP--VIHRLK-L---RGAQYRLFELNKGALREEELPffvPPEEQNVVLSRA 195 Methanospirill...
jgi:Clos_0216 131 KD-IDF---ILPEDIVVIIGYgrlidqvYGRckELHVMDmR---PKHKLTSMCIDKNIGYGSKNTfihSSEENEEILSKA 203 Alkaliphilus o...
Q3A6G7        123 DL-FDIl-rLDKSSRVGVVGF-------FRP--MMDKLV-E---KAGEVVVVELSEDLREGSHPF---TMTDDPEALRGC 184 Pelobacter car...
Q2FME8        134 NA-IDMvrdAAARVPTCFVGY-------FKE--GAEWRE-----MGWPVDIVELFP-----RPGDi--HWNDADEVLSRA 191 Methanospirill...
Q24YG7        193 DIVLISGSTLVNGTYRDLIRYARkARVIGMFGPSAQLIPEFLQGGGINYITTSGITDADRFYQVLSNPYAGEGESGTYKY 272 Desulfitobacte...
Q7MRP2        171 KIAVITGAALIGSTVDAISAISPkGSVRILAGFSAGVHPSWLSGSGFTHVASML------LEPSIKESLFRHQWEEIFSY 244 Wolinella succ...
Q5JG54        161 EAVIVSGSALVNGTLEMILDRAKkAELVILTGPTAQIHQELVKGTGITHLAAMKVIDLERALLGLKLGSFRGFEKGNRKY 240 Thermococcus k...
Q6M0S0        169 DAVIITGTTLVNDTIDVVLERSKnAKLKILTGPTAQINPDFLKNSGITHTASTRVINIDKTVTDLKHGSSFGIFSRNSSK 248 Methanococcus ...
Q0AWB4        211 DIIISTGTTLINDSLEELLKAARpDAEFIVVGPSASILPGPLFDRGVSSVGGVLVTDADQLLDILGEAGAGYHFYGRCAD 290 Syntrophomonas...
WP_011747485  199 DVLLITGTTLVNDSLPGLIACARpEARVVLVGPTVPMLPDAFLDRRGMILGTVRVADAEALHEVLAQGGSGYHFFGKYAP 278 Paracoccus den...
Q2FMG3        196 GCVVLTGATLVTGTLENLLARIPqGIPVIIGGPTVSMIPDAFFSRGVTAIGGDIVTRPDEILSTVMQGGSGYHFFGKAAD 275 Methanospirill...
jgi:Clos_0216 204 DVVLITGATLVNGTFLELIKYSKvARVIGMYGPSAQILPDILLNSGINYIGSSIVTKPDVLESILMDNFSTRHMFKDCMD 283 Alkaliphilus o...
Q3A6G7        185 DKILITATTVLNDSLLTVIPHCIdAAFVAMMGPTAGFLPDTVFALGVDAVGFTRVKDLDLFLERFSSGGKWGEATSKIWA 264 Pelobacter car...
Q2FME8        192 QVVLMSGLTVVNETLAAVIRRTPhAKIRIMMGPTVPPSP-ALFACGLDLIGVTLVQNMELMARYAELGGGSIAYSPPGAL 270 Methanospirill...
Q24YG7        273 TIRM 276 Desulfitobacterium hafniense Y51
Q7MRP2        245 PAYF 248 Wolinella succinogenes
Q5JG54        241 VVEV 244 Thermococcus kodakarensis KOD1
Q6M0S0        249 YSMK 252 Methanococcus maripaludis
Q0AWB4        291 KITL 294 Syntrophomonas wolfei subsp. wolfei str. Goettingen G311
WP_011747485  279 KIVL 282 Paracoccus denitrificans
Q2FMG3        276 KILI 279 Methanospirillum hungatei JF-1
jgi:Clos_0216 284 NYVI 287 Alkaliphilus oremlandii OhILAs
Q3A6G7        265 MPAR 268 Pelobacter carbinolicus DSM 2380
Q2FME8        271 ERVN 274 Methanospirillum hungatei JF-1
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