Conserved Protein Domain Family
Hus1

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pfam04005: Hus1 
Hus1-like protein
Hus1, Rad1, and Rad9 are three evolutionarily conserved proteins required for checkpoint control in fission yeast. These proteins are known to form a stable complex in vivo. Hus1-Rad1-Rad9 complex may form a PCNA-like ring structure, and could function as a sliding clamp during checkpoint control.
Statistics
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PSSM-Id: 397902
Aligned: 26 rows
Threshold Bit Score: 236.005
Threshold Setting Gi: 123453379
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5AYL4         1 MRFRTQVVN---TATLTKLIGSLSSLGKLCWMRLEESVVRFTII---------PDQGTQVWAQLPVYSIFEdaDYILESN 68  Aspergillus nid...
Q4DCF3         1 MKFKATVRD---QRTLASVCQECRGIQCRCVIKLHPTRIRFFTSt-------qFADGMQVWAGCRTQAIFS--DFQSQSQ 68  Trypanosoma cruzi
XP_001314695   1 MRLLATVN----TEVFSQLVSVLSACGGEVVLHFSKTTLSLVVSq--------GINQIALWIGCSVQLCFS--KYQVSSR 66  Trichomonas vag...
Q6BMW1         1 MKLKLRTQN---IEALKTTLSLISHIRKFVILRFTPTQLLIILVng-----ssITQEPQVWCKLQINNMFD--QIEIQSL 70  Debaryomyces ha...
XP_001384914   1 MKLKLRTQN---TETLKSTLSLVNPLRKFIVLRFCPEKLYIISVng-----qsVTQEPQVWCNLKISSIFD--QIEISSL 70  Scheffersomyces...
Q59P51         1 MKLKLMTKS---SEKLKETLSLISHVRKFVVLKFTPSELSVISIng-----qaVKSEPQVWCKLPVSELFQ--SCEIQSV 70  Candida albicans
EDK43697       1 MKLKFMTRN---TEKLKETLLLISHLRKFVILKFTPEELCVILVng-----gsANLEPQVWCKFPTARHFE--LMEIQSM 70  Lodderomyces el...
Q7XS44         1 MKFKAFFTDdgiALLDKRFLPAMDKVGRLCHVYLTPTHAMLLHNllgptgtgpDGGGPQCVAQFAKDLLFR--EYSVSSR 78  Japanese rice
Q709F6         1 MKFKAFLTEngvNLLEKRFLPAFDKMGKNCHLLLTKEHLFFLHNl-------lNGDGVQCIAQFRKDVLFD--DYRISSQ 71  thale cress
XP_010654812   1 MKFKAFLTDngtSLLEKRFLPALDKMGKVCHLYFTRDHTIFLHNl-------lNGDGVQSIAQFRKEALFD--NYRISSQ 71  wine grape
Q5AYL4        69 -T-GVINLEV-PLPALHRALRSAAG--------------AK--WVQLRLTKK------------GKVPLLALTIRTKSWt 117 Aspergillus nid...
Q4DCF3        69 lQeNAIFCEVaDLSQLFHIMRQAEHc----------------pNVTIKLTKNa-----------ARRPALRVSMQGVRP- 120 Trypanosoma cruzi
XP_001314695  67 -NdDIITLKC-NSKQLAQALTVDAA--------------PT---INMSLTRQ------------GDTNTLQFDHRSNDS- 114 Trichomonas vag...
Q6BMW1        71 -RdNTILLEI-NIEQLLQTLHNFNR--------------ANsdGLNIRLQKKdtsggqginisnGRIASLALFYSNINIn 134 Debaryomyces ha...
XP_001384914  71 -RdDTISLEI-NLELLLQTLRNFDR--------------ANsdGLNIRLQRKdssggsgtntgnGRTASLALFYANVNAn 134 Scheffersomyces...
Q59P51        71 -RdNTISMEI-NIDLLVQTLKNFDK--------------ANseGLNIRLQRTdtsgakgtstttGRTASLALFYSNLNIn 134 Candida albicans
EDK43697      71 -ReNTILMEI-NIDLLLQTLKNFDK--------------ANseGLNIRLQRTdttgeqgvatksGRTASLALFYSNINIn 134 Lodderomyces el...
Q7XS44        79 -NgNRVAFAV-DVALLHRALRSALAvhaqsp---aagdaSA--AIQVKLVNKlpa------gsrSASPFLTFETKGARS- 144 Japanese rice
Q709F6        72 -NeDRIAFSL-DVALLYRAVKSSVSictef----sgglaSN--RLQIKLVKKlpp------nctQPMPFLTFETKGYKS- 136 thale cress
XP_010654812  72 -NdDRIAFTI-DLSLLQRAIRSSVSiyaemgggddvgtgSN--RLQIKLVKKlpp------nshQPLPFLTFESKGYKS- 140 wine grape
Q5AYL4       118 kgvnplgigsgnesmplpseeaganiaaeagageglmgppvapasasrsagtgrrerETFITQ--EIPVKVM-HESAVEG 194 Aspergillus nid...
Q4DCF3       121 ---------------------------------------------------------HLDISH--DVPVRVL-RELEVRN 140 Trypanosoma cruzi
XP_001314695 115 ---------------------------------------------------------TKQLLQ--RVAVVLL-STRATED 134 Trichomonas vag...
Q6BMW1       135 ---------------------------------------------------------SNAINHtfRLPVKILkNTDDIML 157 Debaryomyces ha...
XP_001384914 135 ---------------------------------------------------------SNTINHtfRIPVKILkNTHDMML 157 Scheffersomyces...
Q59P51       135 ---------------------------------------------------------ANVVNHtfRIPVKILrDAQD--M 155 Candida albicans
EDK43697     135 ---------------------------------------------------------SNVVNHtfRIPVKILrEAQD--L 155 Lodderomyces el...
Q7XS44       145 -----------------------------------------------------------AVVQ--DVPISRPlSRSDVER 163 Japanese rice
Q709F6       137 -----------------------------------------------------------AVIQ--DVPITKPlSRSQVIE 155 thale cress
XP_010654812 141 -----------------------------------------------------------AVIQ--DVPISKPlSRADVLE 159 wine grape
Q5AYL4       195 LHEPHCRDPDVH---IILP-DLFQLKSISERFTRLaadstpktaalaattsttadavlgsvgagvSPKLELSAN----MH 266 Aspergillus nid...
Q4DCF3       141 ISAPPLESEVVQ---IVLP-CLAELSKFVDKVRSTs-----------------------------CDRMTFTVRdnerAD 187 Trypanosoma cruzi
XP_001314695 135 YQEPEWGTPSVS---VRFP-QIRQVINWVNEMKDI------------------------------NQMVTLKAT----KE 176 Trichomonas vag...
Q6BMW1       158 LKEPELTEVDLM---MRLPkEFLSTYKRLEKFKKTs----------------------------sNDLVNIKSSr--rNG 204 Debaryomyces ha...
XP_001384914 158 LKEPELNDVQLI---MKLPnEFVSIYKRMDKFKKTt----------------------------nNEIITIKASr--rQS 204 Scheffersomyces...
Q59P51       156 LHEPTHSDLGLI---MRLPnEFVTMFKRLEKFKKVp----------------------------sSESVTIRASr--rNG 202 Candida albicans
EDK43697     156 LREPLHTDHGLI---MRLPnEFVTMFKRLDKFKKTa----------------------------fNDRVVIQASk--rDG 202 Lodderomyces el...
Q7XS44       164 LQAALDSAQELPqtlVQVP-DLPQLQSLVDRLKNV------------------------------GDLLTVAVT----QY 208 Japanese rice
Q709F6       156 LQTALDSAQDLPptlVQVQ-DSNQLQNFVDHMRHV------------------------------GDVLNVTIS----KH 200 thale cress
XP_010654812 160 LQSALDMAQDLPrtlVQVP-DLNQLQNYVDRMKHV------------------------------GDLLNISIS----KY 204 wine grape
Q5AYL4       267 GSLR-----LAIATD-TLRISSVW-SDLVNPALdpsqlsqtqmd-------------------qlpsermralpGDN--- 317 Aspergillus nid...
Q4DCF3       188 GAAAtsctlVVLAECfLASFALKY-SSVQKCERegendadfdg---------------------egdgnggdkpKHRddt 245 Trypanosoma cruzi
XP_001314695 177 GEFK-----LYIESD-SVTVETSF-SGLEIv-------------------------------------------GETdqa 206 Trichomonas vag...
Q6BMW1       205 GFLG-----FVLEEDgKFKVTISWnDKLEVQKPnrsnfdgeslrl-----------------anlhnpgsvlsqDVDedd 262 Debaryomyces ha...
XP_001384914 205 GFLG-----FVLEEEgKYRVTISWnDKLNVQRPnlasmdgeslr-------------------msvlrnttnsdVVDdnd 260 Scheffersomyces...
Q59P51       203 GFLG-----FILEESgKFKVTISWnDKLEVHKPtttendslret-------------------lrngpsqlgenEKDits 258 Candida albicans
EDK43697     203 GLLR-----FVLEEDgKFKVTVAWnNKLEVHRPtntdtdysvreslykngnlhllntengkeathhdyndnyeeEEEded 277 Lodderomyces el...
Q7XS44       209 GDLH-----LHVATS-LVTVGSEF-RKLRILGVratapvgd-------------------------qnlsastrTNMaie 256 Japanese rice
Q709F6       201 GDLQ-----VQVSTT-LIRLGIEF-QRLSVIGEksqapved-------------------------rnlsaqarSERaia 248 thale cress
XP_010654812 205 GDLH-----VQISTT-LITLGAEF-RKLLVVGEqeevpaed-------------------------rdlsaqsrTQRavq 252 wine grape
Q5AYL4       318 EAGWAKVRIDGRDWARVLSVGRLN-PKVVACVIHETALILYVYppsgydeEGSCLTYYINSYM 379 Aspergillus nidulans
Q4DCF3       246 SMAYASVSVEVRRFARFLAIKEATpLQFVLHLVDGKAVVLSVFa-----sGGTTLVGYMPAVA 303 Trypanosoma cruzi
XP_001314695 207 TMEEAEALVDLKKFKKVLKVGNLQgCTGEIHIFDKQMAKFNFIvptnipdQPTNLTY-VLNAS 268 Trichomonas vaginalis G3
Q6BMW1       263 IHEDKEILVRLKDWKMASK-IVATcKTVIFLLTHKEACVLHCLld---dtDDVEIIYYISGVK 321 Debaryomyces hansenii
XP_001384914 261 ESEDKEITVRLKDWQMASK-IVAScKTVVLVITSRD-CILHCLld---dsDDVEIIYYISGIR 318 Scheffersomyces stipitis CBS 6054
Q59P51       259 DIDEIEVNVKLKDWQSASK-IVGRcRTVILYIGERE-CSLHCLld---dtDDVEIVYFITGSR 316 Candida albicans
EDK43697     278 SLGEVEICVKLKDWQLASK-IVGRcRTVLLYIAPQK-CSLHCLld---dtDDVELIYFINGVR 335 Lodderomyces elongisporus NRRL Y...
Q7XS44       257 RGEALSVQVNMKHLAKSLQCHLAKpDCTFYGISPGGAC------------LTVIFQYFIPGTR 307 Japanese rice
Q709F6       249 RGDAQSVQVSVKHFSKSLQCHLTKpDSTFYGIAPQGAC------------LTVIFQFMVPGTR 299 thale cress
XP_010654812 253 RGDAQTVQVSMKHFAKSLQCHLAKpDCAFYGIAQEGAC------------LTVIFQFFIPGSR 303 wine grape
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