3VX8


Conserved Protein Domain Family
Autophagy_act_C

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pfam03987: Autophagy_act_C 
Autophagocytosis associated protein, active-site domain
Autophagocytosis is a starvation-induced process responsible for transport of cytoplasmic proteins to the vacuole. The cysteine residue within the HPC motif is the putative active-site residue for recognition of the Apg5 subunit of the autophagosome complex.
Statistics
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PSSM-Id: 397886
Aligned: 164 rows
Threshold Bit Score: 58.991
Threshold Setting Gi: 255714897
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3VX8_B                 16 EFVLAG---DNLVSKCP----------------TWSW--ESgdasKRKPYLPsdkqflitrnvpclrraasvaedyeaag 74 
GAA96361                6 AFNEAC---RAWLTTEGrs-------------tSWQW---------LTPSSL---------------------------- 32  Mixia ...
WGS:AAWC:PGTG_03026.3   6 EFNQGS---QRFINNSTdtpn--------rcnrGWKWkqYQ----NRTSRII---------------------------- 42  Puccin...
EFJ01763                6 DFDTAC---QSYVSARPtdr----------gicGWQW---------NAYSSP---------------------------- 35  Schizo...
XP_002911185            6 QFEAAC---KSLATKWSsespldp---rthaytDWVW------------HNP---------------------------- 39  Coprin...
EPY49653                7 SFQQHL---LQLIPTFTnrgilcelvevfepilQLQW------------------------------------------- 40  Schizo...
WGS:AATM:SJAG_01251     4 SFNKQLqklELQLKQCN----------------------------YDCKIVT---------------------------- 27  Schizo...
Q75CI5                  6 DFSDQV---LRLLPLLR----------------RWRR---C----EHALWDP---------------------------- 31  Eremot...
XP_003648498           50 EFREQCq--QELLPLIN----------------RWHM---C----QQACWSQ---------------------------- 76  Eremot...
XP_001030780           15 QFRQDC---QQLCKSINl--------------eGFEIs-YK----QIDDDFR---------------------------- 44  Tetrah...
3VX8_B                 75 gevlvdDEdnDGWLATH--GKPKDKgkeedNLPSM---------DAldinekntiqsiptyfgGEEDD-DIPDMEEFD-- 140
GAA96361               33 ------PD--YGYLQRA--QLHCAA-----RDVSA----------------------------------TAEDDLIG--- 60  Mixia ...
WGS:AAWC:PGTG_03026.3  43 ------IEqdLGCLY----HEPVDR-----RLFINt--------QD-----------------SEKCKeEEEGIVHEQ-- 80  Puccin...
EFJ01763               36 ------YQtsVGYLARTttEFALHD-----PSEPFataemeaisVG-----------------DAPVTeSWDEVVAEL-- 85  Schizo...
XP_002911185           40 ------YP--YGYLAR---TKRYAR-----TASPG----------------------------------AFEEELGQElg 69  Coprin...
EPY49653               41 ---------------------------------------------Q-----------------AKPYS-DEKTSFEED-- 55  Schizo...
WGS:AATM:SJAG_01251    28 ------QNesNSLYISW--QYSDFQ-----TCVEK-----------------------------------DEQCLDVV-- 57  Schizo...
Q75CI5                 32 ------RArrLQL------SVATAR-----NSARF--------------------------------------------- 49  Eremot...
XP_003648498           77 ------TLhcLDLVLF---LCKGRR-----RAPPF--------------------------------------------- 97  Eremot...
XP_001030780           45 ------SNenSEYLEINh-TFDYQE-----KMYLL--------------------------------------------- 67  Tetrah...
3VX8_B                141 ----EADNVV------ENDPATLQStylvahepdddnilrtRTYDLSITYDKYYQTPRVWLTGY--D-ESR--M--LL-Q 202
GAA96361               61 ----QEDTVQevadpsSANGTEYQS----------------LRLDCSICYSATFQVPVLYFRGF--S-QGG--A--PL-Q 112 Mixia ...
WGS:AAWC:PGTG_03026.3  81 ----EDEAATiripdcRPYVP--------------------IKYQASVVFSDTYRVPQLLFQAY--K-PDG--T--QL-N 128 Puccin...
EFJ01763               86 ----EDEAAA-------PRSTTKEP----------------LNCQQYVVYTPGFQVPAFYFSLH--D-ARG--S--PL-R 130 Schizo...
XP_002911185           70 qefgQEEVVCqddvatGSTPGDVES----------------VLSQQFVVFSATFQVPAFYFTVH--D-TTG--A--PL-S 125 Coprin...
EPY49653               56 ----ESEM---------------IYvl------------pdVSVQAWIRFSPSFQVPQFFFQLY--S-NGC--F--PLtK 97  Schizo...
WGS:AATM:SJAG_01251    58 ----HNRAPI-------------------------------INIREWIVYSKTFLVPVLYFQVY--C-NGH--F--VS-K 94  Schizo...
Q75CI5                 50 --------------------------------------------DVRVDLHPLYAVPQLLLRYW--E-PD------PAvS 76  Eremot...
XP_003648498           98 -----------------------------------------AKLDVRISYNQVYRTPQLQFRFWelDtSTAefEswRL-R 135 Eremot...
XP_001030780           68 --------------------------------------------KGSLVYSVAFKFPTLYFHIY--D-MD---YqkPL-D 96  Tetrah...
3VX8_B                203 PELVMED-------VSQD----------------------------H-ARKTVTIEDHPHl----PGK---HASVHPCRH 239
GAA96361              113 LKDILQSs-----fIKPD----------------------------ApSTLSISQGEHPVa----GTA---CHFLHPCNT 152 Mixia ...
WGS:AAWC:PGTG_03026.3 129 LDELIHTdifygdsLEYPmnliksstssskedkdkeeeeeeeegkrV-QLPILTRTIHPId----NQT---YWGLHPCNT 200 Puccin...
EFJ01763              131 VDDLIRT-------SLFRpsafdattr----------nsfaitpsaS-AFPLLSQGDHPVl----GTP---CWYIHPCET 185 Schizo...
XP_002911185          126 LDKLLAS-------PLFKfelpegaas----------tgfaltlpnA-PFPLLSQGEHPSl----GTP---CWYLHPCET 180 Coprin...
EPY49653               98 LENVTAL-------LRPEnr-------------------------eL-AMDALAIGDCPAs----NGI---AWYVHPCCT 137 Schizo...
WGS:AATM:SJAG_01251    95 LDELEQL-------LNCHd--------------------------eH-LHEAVGMGDHPIe----SGI---CWFIHPCQT 133 Schizo...
Q75CI5                 77 EYEVWKL-------HFVDpyql--------------------plwqP-GRFSIALDQVPAtsgsaYET---WYVVNSCDT 125 Eremot...
XP_003648498          136 FKDLSEI-------PLFN----------------------------R-ASFSITLGQTIH-----GNRteaWYLVNACDT 174 Eremot...
XP_001030780           97 LLKATEL-------IKQRelei---------------------ngaK-KNIELIQDIHPVl----GFS---YLTFHQCRM 140 Tetrah...
3VX8_B                240 GAVMKKIIDvl----mSRGVEPEVDKY--------LFLFLKFMASVIPTIEYDY 281
GAA96361              153 AELIREIKL---------ASADTSDAV--------LPTWLMILDQVDSTCDGQG 189 Mixia osmundae IAM 14324
WGS:AAWC:PGTG_03026.3 201 QTILKEILEee---hrNHPKKLPPQLV--------IESFFALVSSKIRPPQHCL 243 Puccinia graminis f. sp. tritici...
EFJ01763              186 ATALSEIMSemq-yddGGSRERRLKRT--------LEAWFMLLSSIVNLQHRTE 230 Schizophyllum commune H4-8
XP_002911185          181 ERAVEELVReae--qpDWTPEHRLERW--------LELWLMAVGAVLNLGAPCV 224 Coprinopsis cinerea okayama7#130
EPY49653              138 QTFFQTAQV-----------SKQDTSY--------LPMWILYIHRLLSPITTPM 172 Schizosaccharomyces cryophilus OY26
WGS:AATM:SJAG_01251   134 KSFFDNWSL-----------SINESRY--------LDTWLSYIQCKFAFLCVPF 168 Schizosaccharomyces japonicus yF...
Q75CI5                126 DANVGPETD----------------NY--------MLRWFSLYGQLLDENLGFT 155 Eremothecium gossypii ATCC 10895
XP_003648498          175 EDNVGPEPV----------------HY--------MHRWFSRYGTLFDDQLGVL 204 Eremothecium cymbalariae DBVPG#7215
XP_001030780          141 REVIEQIQQiqvhknqNKNNKETEDQYffsptitsLMILLKEFNIYLPKEIYKQ 194 Tetrahymena thermophila SB210
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