Conserved Protein Domain Family
Ecotin

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pfam03974: Ecotin 
Ecotin
Ecotin is a broad range serine protease inhibitor, which forms homodimers. The C-terminal region contains the dimerization motif. Interestingly, the binding sites show a fluidity of protein contacts binding sites show a fluidity of protein contacts derived from ecotin's innate flexibility in fitting itself to proteases while.
Statistics
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PSSM-Id: 397876
Aligned: 47 rows
Threshold Bit Score: 126.911
Threshold Setting Gi: 644859256
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CAK24894           14 DLSGYPAPAPGLQRWVIQpsglLPKTSDplvSAhplDWRIQLIVGEEVTLDC-NLQRLSGPgMTM-----------RMLP 81  Synechococ...
jgi:Sama_1754      55 ASKMFPAPAAGMVQHILT----LPALEN---EG---NYMVEVQIGQTKLVDC-NKHGLRGE-LQT-----------RDLQ 111 Shewanella...
WP_011865842       54 ATKMFPAPTDGLVQHILT----LPKLAN---EG---DYRLEIAIGRSEEVDC-NKHGLSGE-ITQ-----------HTVK 110 Shewanella...
Q082P3             59 ASKMYPAPTEGMVQHVLT----LPALND---EQ---DYMLEVQIGQNKIVDC-NKTKLIGE-IDK-----------ISLA 115 Shewanella...
Q8EEQ7             54 TVKMFPAPKKGMVQHILT----LPKLEN---ET---DYMVEIQIGQTQLVDC-NKHGLNGQ-LKE-----------LTVE 110 Shewanella...
BAJ02686           39 ATKMFPAPEAGMVQHILT----LPKLDD---ES---NYMVEILIGQTQMVDC-NGTSLSGD-LKQ-----------ESVK 95  Shewanella...
tigr:CHAB381_0963  18 DFSIFPKAKNGEIMQILE----LAPLEN---ED---EKLVKIEFGKNLELDCnSYFFTDGN-LTN-----------QNLK 75  Campylobac...
WP_013634067       32 DLSIYPKPEKGYKQMVIE----VPYSKA---DN---NKRIEFTIGKWMEVDGcNSFGLQGE-LEK-----------KDLQ 89  Pseudopedo...
EHQ41156           24 DVSVFPKPEKGYKQMVIE----VPHSAQ---DG---NKKIEFRVGKMMEVDGcNNYGLMGT-LEK-----------KDLQ 81  Myroides o...
Q12N13             92 laANLPKPTANQAVHIIK----VDTLPE---AS---QYQLQVQIGLNIMQDC-NQRRLMGE-VQKiplafdanqaaKTSQ 159 Shewanella...
CAK24894           82 QAsGKALFEVKGPLRLISTKKACpP-GAPEKRSFLSLGLQPYLvPYNPSWPIVVDLPKGAELRWRLWKA 149 Synechococcus sp. WH ...
jgi:Sama_1754     112 GW-GYNYYEVTEIGEGPSTMMAC-F-DKAKTEAFVRIPGDYKF-AYNSKLPMVFYIPEGAELKYRVWRA 176 Shewanella amazonensi...
WP_011865842      111 GW-GYNYYQVDAIHQGPSTMMAC-F-DKAKKTAFLTLPEKLTL-AYDSRLPKVFYLPAGAQLRYRIWQA 175 Shewanella loihica
Q082P3            116 GW-GYVYYQVDKVMQGPTTKMMC---TNAKSAEFIVLNEAMTL-RYDSRQPKVFYLPEGTELRYRVWKt 179 Shewanella frigidimar...
Q8EEQ7            111 GW-GYNYYQVDEISEGPSTMMAC-F-ELAKKEAFVQIPDELTL-RYDSRLPKVFYLPEGAELRFRTWKA 175 Shewanella oneidensis...
BAJ02686           96 GW-GYSYYQVDSITQGPTTMMAC-F-KQAKKEAFVSIRADLKI-KYDSRLAKVFYLPKGSELRYRIWTV 160 Shewanella violacea D...
tigr:CHAB381_0963  76 GF-GYEYYKFKAKGLLAGTLMYCg--DGVKKEKFVKf-EPEIYkKYSSKLPFVFYTPKDVKVKYSIFSL 140 Campylobacter hominis...
WP_013634067       90 GW-GYNYYVFKTKGNVISTQMAC-P-GQPRRHLFVS-GQREFV-NYNGQLPIVIYVPEEYEVQFKIFKA 153 Pseudopedobacter saltans
EHQ41156           82 GW-GYDYYVFQSNGDAFSTQMGC-P-DAPKRNLFVS-SQPETT-RYNGRMPIVIYVPEGFDVKFKIFTA 145 Myroides odoratus DSM...
Q12N13            160 GV-THYYWLESLMEAPMVTL----PcIEAKKATFVQLGETLLI-ESGEFSENVFYLPQQAQLRYRLWRA 222 Shewanella denitrific...
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