Conserved Protein Domain Family
FapA

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pfam03961: FapA 
Flagellar Assembly Protein A
Members of this family include FapA (flagellar assembly protein A), found in Vibrio vulnificus. The synthesis of flagella allows bacteria to respond to chemotaxis by facilitating motility. Studies examining the role of FapA show that the loss or delocalization of FapA results in a complete failure of the flagellar biosynthesis and motility in response to glucose mediated chemotaxis. The polar localization of FapA is required for flagellar synthesis, and dephosphorylated EIIAGlc (Glucose-permease IIA component) inhibited the polar localization of FapA through direct interaction.
Statistics
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PSSM-Id: 397865
Aligned: 95 rows
Threshold Bit Score: 131.607
Threshold Setting Gi: 123337049
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_011878195   87 IKVQLSPDRMSAFL----------EIKNEc----LKSYELidcppstnlvlqarqtkqrifreTKDTIINLLNQNHI-SF 151 Desulfotomacul...
jgi:Cbei_1855 157 ISVNISVDKMKGYIkveykpayvyKLRDK-----PMAKDLilkamkve--------edypkkyTLTEIKEILRQNKI-TD 222 Clostridium be...
OOM48299       69 VNITISEDKMKAYMtveyipkteyKIKDR-----EFYINLavstevll--------keepeyfTVQELYKKLKEKGI-VF 134 Clostridium be...
Q8RAV8          3 IILEISDDEMIVTLr--------kTLFSS-----WGDIDIy---------------------eFLNIVESELRKNGI-IV 47  Caldanaerobact...
Q2RLG1         56 LQLEVLEQE-------------------------SHYPPF-----------------------TLEDLVRELKSQGI-QY 86  Moorella therm...
BAF59995      111 KDLVLSAVKII-----------------------EKKCPF-----------------------DLAGIMREIAGKNI-VY 143 Pelotomaculum ...
BAF60877      125 YLIDQEPHAHLYLK----------TLQKE-----ELKSPL-----------------------DVKQLMEMLFKENV-VV 165 Pelotomaculum ...
Q0PC82         88 FTVKLRSNSNLTHLk--------aSINLTenfkyYPNLKFd----------------------ILQNIYKIMIKQKFlIL 137 Campylobacter ...
Q7MSH2        100 FSLRLGEDFRELFL----------TLHKGs---qITYNAV-----------------------FLEELFERVRAQKAiMR 143 Wolinella succ...
WP_002849260  111 VVASIKEDSNVKYY--------------------PSFERD-----------------------LINFIQKKLLKANI-LI 146 Campylobacter ...
WP_011878195  152 GIDLQALED---IITQQLe----------gLLLVAQGLAPGETIDDDVELLFEh--------kIDSDlsnaldTIDFKEM 210 Desulfotomacul...
jgi:Cbei_1855 223 GIIYKNLIE---ACALGNg----------eEMLIAEGIGAIDDTPNEIKVLFDigekr-ivneNSNE------KIDYRNV 282 Clostridium be...
OOM48299      135 GIKEESLEL---ILK-GCs----------sEVLVAEGLEPVKDTPSEVKLFFTptqmv-fpepDSNE------KVDFKNL 193 Clostridium be...
Q8RAV8         48 GIDKSALIS---VYTQNKk-----------EAVIARGIPYKSGRDGYLEFIIKidkprilyteTFS-------EEDIFDM 106 Caldanaerobact...
Q2RLG1         87 GIDWQTCAR---LVEEPAe----------gTWTIARGQPAFPGKDATVQLLFTtqdrvpvtikEEDQ------QVNFRER 147 Moorella therm...
BAF59995      144 GIRHDEIRA---ILDRPEd----------gLYVIARGDPPGESVDERVELKFAagreepkagaVTGKd-----RIDFRDL 205 Pelotomaculum ...
BAF60877      166 GVDLSEVVK---VMDKPGk----------vRVTIARGEPPEPSVDEKVEIFFPqendfapvikEDG-------RVDYYNI 225 Pelotomaculum ...
Q0PC82        138 RLDKNLFDKiddFILSIQksps----ikeiELEIAKGVDKIEHKSDEIIYHRDvnee------------cfdeNINYDEG 201 Campylobacter ...
Q7MSH2        144 VLFRQEAKErerIASLLKelqnlpfldkdyEILLAQSAGGGRCVEATLILHF---------------------QEDPALQ 202 Wolinella succ...
WP_002849260  147 GIRDYIMLReinKVTSILrikei--idkafTFVVVTGVDPVVAVDDNMIFYYKsklknseknkDD--------KVNYSNR 216 Campylobacter ...
WP_011878195  211 HSIPSVNAGETLAQKIIGKEGTPGTTVTNQIY---KAREAKRITLLAGPGVEIV-DNGLRA-I-ANIEGLPRVQ-KSHnn 283 Desulfotomacul...
jgi:Cbei_1855 283 YSISSITEGQVLAEIIPGKNGQDGKNICGEVL---KKKTVKSRPIKIGDGCKV--EG-NSI-I-ATKTGRPSSK-NGI-- 351 Clostridium be...
OOM48299      194 FRISNVNAGDKIAEIIPEIPGKNGMNIFGKVI---EREYIRSLPIDASKGCKI--EN-NHI-I-SLIDGKAHIA-NRS-- 262 Clostridium be...
Q8RAV8        107 ASIPFARKGDVIGKLHKPIKGENGISVRGRII---NAPPVRDVEVKILSDSIVFkEDEDKI-V-AIADIRPVVH-KKDet 180 Caldanaerobact...
Q2RLG1        148 FQFTSVEPGTVLARKKPVTGGRPGRAVTGEII---LPPEPREIELVAGQGAILS-DNGLEV-V-ATRSGRPMAR-KTKdr 220 Moorella therm...
BAF59995      206 VEIPSVEPGALLAVKLPGAPGAPGKTVTGEII---PPRKPVVFELIAGKGAEVL-ADGSKV-Y-ARIGGRPVAK-KLGnk 278 Pelotomaculum ...
BAF60877      226 KNIICVEEGALLAQKHPGVMGRPGRNVCGEVV---LSPPPRNVILRAGKGAVLS-EDGSKV-V-ACKSGRPVLQ-RLGri 298 Pelotomaculum ...
Q0PC82        202 NYCKPIEKNELLFEYIYRILGKEGRNLRGEILh-lNPIAFLDNPFIIKDESIYTeELEDRIkYfSANYGFLNKDhTG--- 277 Campylobacter ...
Q7MSH2        203 GRFPTIKEEMLLATFLKPQKGGAGRDCLGNYIppkEPSASAQNPLRI-DESIEErDEGNKInYyAKESGYLLFEeYR--- 278 Wolinella succ...
WP_002849260  217 GFVQGVTEGEVIIEYIKPKTGIAGRNVKGDVIsvnEPKILIKEKINVSQNIDVKeDDDSIK-YiAKKNGYVNEEkGT--- 292 Campylobacter ...
WP_011878195  284 -wtISVD---PVLNLSGDVDVKT-GNIR---------------------------FKG-NVNIMGSVETDMNVSASGNIT 330 Desulfotomacul...
jgi:Cbei_1855 352 ---LSVN---SLYNIQ-DVDIKS-GNIF---------------------------FAG-GVHIKGNVKEGMKVKSGNSLT 395 Clostridium be...
OOM48299      263 ---VSVN---PIYTVE-SVNMET-CNIK---------------------------FYG-DVEVYDSVQDNMFVSAGGSLD 306 Clostridium be...
Q8RAV8        181 dkfVYLFysiPVFFYKGSIPKNS-RLVT---------------------------FEG-DVIINGNVEKGNQIIASGNVQ 231 Caldanaerobact...
Q2RLG1        221 -vtIEVV---PALIHDGNVNLSS-GNIN---------------------------FSG-DVIVTGQVEEGMAIEAGGNVY 267 Moorella therm...
BAF59995      279 -yvIDVD---PVLHKKGDVDISS-GNIR---------------------------FKG-DVVVHGNVCEGMTVQAAGRIN 325 Pelotomaculum ...
BAF60877      299 -ylISVE---DVLVHNGDVGIET-GNIL---------------------------FNGsLVIVRGNVRESMTVGTTGIIE 346 Pelotomaculum ...
Q0PC82        278 ---YCIA---NNLKLS-QIGLKTtGSIKtntdeninleitnfdisddaiksgivnVQAsNIKVNGNV--GATKLYGKNIS 348 Campylobacter ...
Q7MSH2        279 ---LSIT---QKIEIE-EVDIKTtGSLLggldaptsvvvkenhylkealgdgakiEAG-EVEIAGNIGSGSEIRAN-RVT 349 Wolinella succ...
WP_002849260  293 ---YDIK---DELDIN-EVSFKTtGSIEtslesdvkinikekdilkdavgagmsiETT-SINVEGNVAKGAHIVAK-DVI 363 Campylobacter ...
WP_011878195  331 ISNIV-TRCKITA-GGNVTIKGNIVNSEIisg--gfiVICNA-IKPLLSELLkTLEDLLISANLMLEKLPTNNKILFGNI 405 Desulfotomacul...
jgi:Cbei_1855 396 IEKNV-DISTIVA-GGEINIKGSVIK-----------STVLTgQVDMEKKMYlEK--------LNEYKDIISKLVSAVEK 454 Clostridium be...
OOM48299      307 VSQNV-NMANVVT-GGEITILGNTIN-----------SKILSgQVDIRKKEYsDV--------LTEFKNI---LVSMIEY 362 Clostridium be...
Q8RAV8        232 ILGSV-YESVVEG-GQNIIISGGIVD-----------SQLHA--GFLPGNIF-DKIELHAVNLIVEKLSAIFLHIRELPT 295 Caldanaerobact...
Q2RLG1        268 VGDTV-SRGIIRA-GGSIEVAGNIFV-----------SVLAAgGITAFQQRL-SPLLARIAEE-------LEQLITAIKQ 326 Moorella therm...
BAF59995      326 ITGMV-FGARIAA-QGNISVGQNVAG-----------SHIVAgGNNIFFREV-NKI-------LAKLQAGFSELLKMVPA 384 Pelotomaculum ...
BAF60877      347 VDGIV-SGARVAA-YDRVHIEGNAIN-----------SIVNAgLSREFLKEV------------LACIASLEKDIKKIIN 401 Pelotomaculum ...
Q0PC82        349 IKGLThAKSEIFAqDIFITTHKGTLQADTvyiknlenGTIIA--KNVFVENC-MGGKIEAEN-IYICNLLTDNTLYPRKN 424 Campylobacter ...
Q7MSH2        350 ISGQThQTSKIHAqSASIEAHKGWVEADEvkvmrleaGIIRA--QKVHIEHA-HGGKVYAKE-ISIRFLHSNLQAFASEK 425 Wolinella succ...
WP_002849260  364 IGGQThAKSVIKAqTAEISVHLGRLICDEakidrlesGYVRA--KKVFINSV-IGGEIIANE-VHIKRLFANSSITASTL 439 Campylobacter ...
WP_011878195  406 LMLliekkfTNf-GTIIDKV-SKKLKEVDLK-LLGTy------------gTLLEKALVNLtGINiLNFKSSLeyQALLTD 470 Desulfotomacul...
jgi:Cbei_1855 455 LNEss--nnSKkiSELVK---ILIENRYKSIpKLSLniithsicedsdnnDLVSFIRSKMmGLN-LSKIESI--DDLRNL 526 Clostridium be...
OOM48299      363 INGlnl-qnFEr-KDFVK---TLTEKNFGNFqKVALniislniknktkrsKLVDFIKGKIlGLN-ILEIKSI--YDLKTL 434 Clostridium be...
Q8RAV8        296 VMNnsrhlsEK----------IKLIETLKEE-------------------LKTSSTEISMiRSS----------NVLQNL 336 Caldanaerobact...
Q2RLG1        327 LLRhpsfkkDDlkGGI--GPlVLLLLEKKFQ-------------------GLSPAIELLQkEVQnLQTISLGepEGLIND 385 Moorella therm...
BAF59995      385 LAE------HPklKNVNAGQlVQLLIDRKYPgIPGL--------------ISEMVRLSSQnSFIlPREMVHLl-EKIEKN 443 Pelotomaculum ...
BAF60877      402 VMSlpafqsAVrkAGISYGYlLKLMIEKKLVsLPAIl------------eNLDNLFKTLFlGVP----------EELEKV 459 Pelotomaculum ...
Q0PC82        425 LII---------------TNnIKFKNNIVVSpLV----------------SIENNSDTECeNLKnLSLKIK---SKLDDT 470 Campylobacter ...
Q7MSH2        426 IEI----------FEIMGEDnKFTLTPEANP-------------------KIQSRLATLLrSFEeLSAALKTkiKKFNEE 476 Wolinella succ...
WP_002849260  440 VEI----------DELKGTNnRICIDSGEIL-------------------NYEGKLEEYSkTMSkLKTDILVipRELESK 490 Campylobacter ...
WP_011878195  471 LNNFyyyIESQVTSRSEihikvaLNSVIksSG-DVIVTGGCFNTHILAEGSVhidgIVRGGIIQAHDDIFIqQIGSEMGT 549 Desulfotomacul...
jgi:Cbei_1855 527 EELI---NNEIEMLEDN------MIISAdiYI-GYCQDSLIKSTGNIIITDK----GQYVSNLTALNDIIF-LRDDSVAR 591 Clostridium be...
OOM48299      435 LNIL---DNEIDYYDKN------IIVPLdiRI-GYCQECEIKSTGNIIIGGK----GEYTSKLTAMKDIIF-TRSDSVAR 499 Clostridium be...
Q8RAV8        337 LEDL---KSLVKTLNNIld--ydIIGLIk-----------HLNSLKEIYEKI----LFISRILTEEHENKGhILAKWVHD 396 Caldanaerobact...
Q2RLG1        386 LERL---TRSPLAVKNL---------------------------------------DYLETMLQKVAGWQE-GISAPLQG 422 Moorella therm...
BAF59995      444 LLGL-----NLMKVKTV---------------------------------------EEFGSFLSEIGQVRQ-IIDGMAGD 478 Pelotomaculum ...
BAF60877      460 FIACrrlLADPYQFISK---------------------------------------ENLCWILQSIKLAED-YFKSRKTK 499 Pelotomaculum ...
Q0PC82        471 ISKMqnyYDYLIKNQIK------IIKLQktKN-PSAIEMKFSNLYHDIIKKY----NHLSISYKKLVKLKY-QIDAKLNF 538 Campylobacter ...
Q7MSH2        477 AKEIkalRPLATKIKAM------IDLNRqeGVgTPAYLQEKLKSYINLLKYT----QAHKEEIEKLQGERH-ALSEEILS 545 Wolinella succ...
WP_002849260  491 KNIIdsnRESVNSIKRR------IEELRstGKaPPMSFLNKLKDFQALVYEY----NSMLKDLNGKKAALN-DLKEELKS 559 Campylobacter ...
WP_011878195  550 KsvvigSKDKk-IKINQ--AFDGVTIKIG---NMSRIIDRTmKNIVVLLD--EDGYL 598 Desulfotomaculum reducens
jgi:Cbei_1855 592 GgvisaRGNIklGIVGSp-SGVTTRLEVL---QGGIITAKIaYSNTVFCFggRIKTL 644 Clostridium beijerinckii NCIMB 8052
OOM48299      500 GgvlsaGQNIslGVVGSr-AYIPTTLMVP---QYGRITAAKaYANTVFCFgrTKVTL 552 Clostridium beijerinckii
Q8RAV8        397 Sk---iYAMKdvIITSEa-GCYNTKISTNgsvSINGKVRMStIEFKKNIFikEAGSL 449 Caldanaerobacter subterraneus subsp. ...
Q2RLG1        423 R-----ADVTvnYVVNSt-IMASGNIRVLgdgCYHSRLQAGkSVTINGVF--RGGEI 471 Moorella thermoacetica ATCC 39073
BAF59995      479 K-----ASITfsYSENSt-IEASGDVSVSgggCINTVIRAGgNVRVKGVF--RGGEI 527 Pelotomaculum thermopropionicum SI
BAF60877      500 K-----ANLEigGAINCh-IRATGDVTIRgkgCFNTVINAEgNVRINGVF--RGGEI 548 Pelotomaculum thermopropionicum SI
Q0PC82        539 Ln----------------eMVYNVKIYI------------------------KAENI 555 Campylobacter jejuni
Q7MSH2        546 Lqa--pTLASyiWSKNGwkGYNEVRFKLLlppKDLFIAPKTsIHHGLLRLdeHQQSI 600 Wolinella succinogenes
WP_002849260  560 Mqs---------------mVFKAKIINKDrwkELNEIKFRLiEPKKDITYstRENEL 601 Campylobacter fetus
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