Conserved Protein Domain Family
PepSY_TM

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pfam03929: PepSY_TM 
PepSY-associated TM region
The PepSY_TM family is so named because it is an alignment of up to five transmembranes helices found in bacterial species some of which carry a nested PepSY domain, pfam03413.
Statistics
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PSSM-Id: 397836
Aligned: 492 rows
Threshold Bit Score: 41.0065
Threshold Setting Gi: 381378782
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_052342257           27 WRWHFYAALFVMPLLIVLGITGTIYLYKPQIEAIAYPSQLYVTPEDAPRL------------------------------ 76  Advene...
WP_006193257            5 YRLHRWISTVCAVFFLLLVLTGLPLLFNGDIARWNALEKRPAFGETSSRVlwaeaakgleri-----------erenpgr 73  Seleno...
calssnu:BYI23_A027370  10 SIVHRWTSLVCTAFMLLLCLTGLPLVFGHELDILTGDAIEAPALPASQAGarasydavlqaalkehaghvpqymiwepde 89  Burkho...
Q4K4R8                 10 SFIHTWTSLICTVFLLMLALTGLPLIFHHEIDHLLGDSPELREMPADTPHldlqqlvkaaeahrpge--vmqyfgwdede 87  Pseudo...
Q88AE4                 10 SIVHTWNSLICTLFLLMLAITGLPLIFHHEIDHLLGDAPHYKEMPADTPHlnleqlaraaeahrpge--vmqyfgwdded 87  Pseudo...
WP_016493203           10 SQVHTWTSLICTLFLLMLALTGLPLIFHHELEHLLGEAPELREMAPDTPHlglqqlveaaerhrpge--vvqyfgyekde 87  Pseudo...
Q88QY5                 10 SLIHTWSSLVCTLFLLLLAVTGLPLIFHHELEHLLGDAPELREMPAGTPHldlqqlvlkaeqhrpge--vmqyfgydede 87  Pseudo...
WP_011829334           11 TWLHKWSSLVCTVFMLLLCLTGLPLIFHHEIGHLLGTEVEAPPMPAGTPYanldrvlevararhpe---rvvqfasqped 87  Methyl...
jgi:Aave_3008          10 SWLHKWSSLVCTVFMLLLCLTGLPLIFHHEIGHLLGTEVEAPPMPGETRRvsldrvlevaraqhpd---rivqfasqded 86  Acidov...
jgi:Daci_1877          25 AWLHKWSSLVCTVFMLLLCLTGLPLIFHHEIGHLLGTEVEAPPMPQGTPHasldkvlevaraqhpd---rvvqfvsksdd 101 Delfti...
WP_052342257           77 -----PQQTLYDIARDSTPGGVPILTAEIHNAPdrsaqftYLDPVEGKSSIFLNPYTGE----------VLAkmptlnfn 141 Advene...
WP_006193257           74 rvqsiSAYPERGLLVYRFSHTGGGYGVSALAYAp-----qQDALVPWRSGGVKSPALAA----------FMG-------- 130 Seleno...
calssnu:BYI23_A027370  90 pllpiVVTAPRADTPPDDTLSTTV-----------------------------DARTAQplgmppgkgsLKF-------- 132 Burkho...
Q4K4R8                 88 pngvmTIMARTAGTEPNASHTFML-----------------------------DARTGEavampsanggLMM-------- 130 Pseudo...
Q88AE4                 88 pngvmAITAATAGTEPNSSHTFAL-----------------------------DARTGEalempsanggFMM-------- 130 Pseudo...
WP_016493203           88 pngvvAITAATAGTEPNSSHTFML-----------------------------DARTGEalampaanggILM-------- 130 Pseudo...
Q88QY5                 88 pngvvAITAATASTDPNLSHTFML-----------------------------DARTGEavampaanggFMM-------- 130 Pseudo...
WP_011829334           88 stdlwFVTLTPTPAPTEDFKSVAV-----------------------------DARTAEvlaepkfdegFMH-------- 130 Methyl...
jgi:Aave_3008          87 dpnvwFVTLTHTPDPTTDFRSVAV-----------------------------DGRTGAilaqprfdqgFMY-------- 129 Acidov...
jgi:Daci_1877         102 tddlwFVTMTPTPAPTDDFRSVVV-----------------------------DARTAEllaqprfdqgFMW-------- 144 Delfti...
WP_052342257          142 atywigLARQIHR----GLLlGKT-GEIIMELAACWTLIMIGTGVALWWPRRKKGlkqaVIPDVKKKG--RPFWR----- 209 Advene...
WP_006193257          131 ------WMHHLHL----RLA-MGQgGMIFLGVMCFLSFLSILGGVLLY------------------PSfmKRRLFggmrg 181 Seleno...
calssnu:BYI23_A027370 133 ------VLLKLHVdmfaG-----LfGKLFLGAMGVVFLAAIVSGIVVYLPFWRKV----GLGRVRLKKkrRIVWL----- 192 Burkho...
Q4K4R8                131 ------VMLRLHVdmfaG-----LpGKLLLAFMGILFVLAIISGTVLYLPFMRRL----KFATVRQDKssRLRWL----- 190 Pseudo...
Q88AE4                131 ------VMLRLHVdmyaE-----LpGKLLLAFMGLLFVVAIVSGTVLYSPFMRKL----EFGQVRVNKstRTRWL----- 190 Pseudo...
WP_016493203          131 ------FILRLHVdmfaG-----LpGKLLLAFMGLLFAVAIVSGVVLYSPFMRRL----KFAEVRQQRsnRARWL----- 190 Pseudo...
Q88QY5                131 ------VMLRLHVdmfaG-----LpGKLLLAFMGVLFIVAIVSGTVLYAPFMRRL----EFGTVRHKKsrRLRWL----- 190 Pseudo...
WP_011829334          131 ------VMFKLHVdlfaG-----LpGTLFLGFMGLLLLVAIVSGVVLYAPFMRKL----RFGEVRRERsaRVKWL----- 190 Methyl...
jgi:Aave_3008         130 ------VMYKLHVdlfaG-----LpGKLFLGFMGLLLLVAIVSGVVLYAPFMRKL----DFGTVREQRstRVKWL----- 189 Acidov...
jgi:Daci_1877         145 ------VMFKLHVdlfaG-----LpGKLFLGFMGLLLLIAIVSGVVLYAPFMRKL----DFGTVRRTRqpRLKWL----- 204 Delfti...
WP_052342257          210 --------EIHATMGIVLALGALFFVTSGLPWT--STwGAQFKQlvaqvnlgyppdppgatsarheghegheghegqpaa 279 Advene...
WP_006193257          182 gtsagsffDWHIFLGILTAVWASLLTLSGIAIVfgILgYSS--------------------------------------- 222 Seleno...
calssnu:BYI23_A027370 193 --------DWHNAIGMLTLAWALLVGATGSINTlaDLmLEAWRN------------------------------------ 228 Burkho...
Q4K4R8                191 --------DLHNLIGVVTLTWALVVGVTGVISAcaDLiIAAWRN------------------------------------ 226 Pseudo...
Q88AE4                191 --------DLHNLIGVVTLTWALVVGVTGVISAcaDLlIASWRN------------------------------------ 226 Pseudo...
WP_016493203          191 --------DLHNLIGIVTLTWALVVGVTGVVSAcaDLlISAWRQ------------------------------------ 226 Pseudo...
Q88QY5                191 --------DLHNLIGVVTLAWALTVSVTGVISAlsDLvIAAWRN------------------------------------ 226 Pseudo...
WP_011829334          191 --------DLHNLLGIVTLVWAFVVGATGVINTwaDPlVKYWQY------------------------------------ 226 Methyl...
jgi:Aave_3008         190 --------DLHNLLGIVTLVWAFVVGGTGMINTwaDLvIKYWQH------------------------------------ 225 Acidov...
jgi:Daci_1877         205 --------DLHNLLGIVTLVWLFVVGATGMINTwaDLlIKYWQH------------------------------------ 240 Delfti...
WP_052342257          280 ptrvqdlpldktawgaglltvpqsavsagqtasahaHAGHQDAGSDTDPAHQAGRPVGQDHDAHGAHGAAQMDMNGDMSm 359 Advene...
WP_006193257          223 ------------------------------------YAEDVMTSVPQRESAPPAITFAEMIAYAEEHFPAQ--------- 257 Seleno...
calssnu:BYI23_A027370 229 ------------------------------------DQLAQMVAPYRGQPPVTVRASIDDAVKTAQGVAPAMIPSFVA-- 270 Burkho...
Q4K4R8                227 ------------------------------------DSLSAMVAPYRDAPPLTSLAPASRLLDIAREAAPGMQPDFIA-- 268 Pseudo...
Q88AE4                227 ------------------------------------DALASMIAPYKDAPPLTQRAAPTRLLEIAESAAPGMQADFIA-- 268 Pseudo...
WP_016493203          227 ------------------------------------DALTALVEPYRNAPPLTERAPVDNVLNIASAALPGMQADFIA-- 268 Pseudo...
Q88QY5                227 ------------------------------------DSLAAMVAPYRDAPPLVERAPATRLLDIAEQAAPGMRPDFIA-- 268 Pseudo...
WP_011829334          227 ------------------------------------DQLGALLAPYQGQPPVSVGERGSVQRSLDGALAHAPGRKLSFI- 269 Methyl...
jgi:Aave_3008         226 ------------------------------------DQLSALLAPYAGQPVTPQAERGSLQKSLDAALERAPGTRLSFI- 268 Acidov...
jgi:Daci_1877         241 ------------------------------------DQLSSVLAPYQGQDTVPVAERASLQQSLQAAQQQVPGTKLYFI- 283 Delfti...
WP_052342257          360 sgdhnmhampaepvtldqimtlaqsshipdeysialPANRNGVYSVSYYPGDPTGEKVINVDQYSGKVINGVSYNEYGVI 439 Advene...
WP_006193257          258 -------------------------------------------EILYLDAAEGSTPAALTLADAERPQMFRGQDVYLLRT 294 Seleno...
calssnu:BYI23_A027370 271 -------------------------------------FPGTRFASPHHYAVWMRGDGILTTRIMRPVLVDASTGAVTDSR 313 Burkho...
Q4K4R8                269 -------------------------------------FPGTRFSSEHHYAVFLKGSSHLTSHLLTPVLIDASSLQVTAVA 311 Pseudo...
Q88AE4                269 -------------------------------------FPGTRFSSEHHYAVFLKGNTHLTAHLATPVLIDAQTLQVTAVV 311 Pseudo...
WP_016493203          269 -------------------------------------FPGTRFSSEHHYTVFMVGSSHLTAHLWTPVLIDARTLEVTAIA 311 Pseudo...
Q88QY5                269 -------------------------------------FPGTRFSSEHHYAVFMNGATHLSSHLFTPVLIDARTLEVTAVG 311 Pseudo...
WP_011829334          270 ------------------------------------AFPGTAFSSPHHTTFFLRGDEPLTSKLLQPVLVDAKTTEVTAAP 313 Methyl...
jgi:Aave_3008         269 ------------------------------------AFPGTAFSSPHHNTFFLRGSEPLTSRLYQPVLVDARTAQVTAAP 312 Acidov...
jgi:Daci_1877         284 ------------------------------------AFPGTTFSSPHHHTFFLRGNEPLTSRLFLPVLVDAKTAQVTAAP 327 Delfti...
WP_052342257          440 -----AKIISFAVS---------------LHMGTYFGWVNQLLCAIIALGLCAMAVTGFvMWWKR 484 Advenella mimigardefo...
WP_006193257          295 a---gGEIENFTKPlprwlvfcdavrdlhLHNHST--MFLKIVWAVLDLLCAAVIVTGFcGWLQR 354 Selenomonas sputigena
calssnu:BYI23_A027370 314 elpwyLKVLLGSQP---------------LHFGDFGGMPLKIFWAAFDVLTIVVLGSGLyLWMTR 363 Burkholderia sp. YI23
Q4K4R8                312 grpwyMDAMGMSQP---------------LHFGDYGGMPMKVLWAAMDMLTIIVLGSGLyLWLAR 361 Pseudomonas protegens...
Q88AE4                312 erpwyMDALGMSQP---------------LHFGDYGGMPMKVLWAVLDVLTIIVLGSGVyLWWVR 361 Pseudomonas syringae ...
WP_016493203          312 qrpwyMDALAMSQP---------------LHFGDYGGRPMQVLWAVLDVLTIIVLGSGLyLWWVR 361 Pseudomonas resinovorans
Q88QY5                312 drpwyMDAMGLSQP---------------LHFGDYGGRPMQILWALLDVLTIIVLGSGLyLWWSK 361 Pseudomonas putida KT...
WP_011829334          314 alpwyLTALLVSQP---------------LHFGDYAGLPMKILWALLDIATIIVLGSGLyLWLQR 363 Methylibium petroleip...
jgi:Aave_3008         313 alpwyLTALLISQP---------------LHFGDYAGMPMQILWALLDIATIIVLGSGLyLWLKK 362 Acidovorax citrulli A...
jgi:Daci_1877         328 alpwyLTALLVSQP---------------LHFGDYGGRAMQILWALLDIASIIVLGTGLyLWVKK 377 Delftia acidovorans S...
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